PubMed:9127005 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9127005","sourcedb":"PubMed","sourceid":"9127005","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9127005","text":"Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent.\nAssembly of terminal complement complexes (TCC) C5b-7, C5b-8, and C5b-9 on target cells during acute and chronic inflammation induces hydrolysis of plasma membrane phospholipids and heterotrimeric G protein activation. TCC also stimulate a variety of cellular activities, which include cytokine synthesis, proto-oncogene activation, and mitotic signaling. Now we report that sublytic TCC induced Ras, Raf-1, and extracellular signal-regulated kinase (ERK) 1 activation in JY25 B cell line. When cells were exposed to C5b-9, GTP-bound Ras in anti-C5b-9 immunoprecipitates was increased 3.2-fold at 2 min, while GTP-bound Ras in anti-Ras immunoprecipitates was increased 2-fold at 10 min. Both C5b-9 and C5b-7, but not C5b6, increased Raf-1 kinase activity maximum 3.3-fold at 2 min and 2.8-fold at 5 min, respectively. ERK1 activity was 2-fold increased by C5b-9 at 2 min and by C5b-7 at 10 min, over the C5b6 level. The role of mitogen-activated protein kinase (MAPK) pathway on TCC-inducible mitotic signaling was evaluated by assessing DNA synthesis and activator protein 1 (AP-1) DNA-binding activity. The MAPK/ERK-specific inhibitor PD 098,059 abolished the C5b-9-induced DNA synthesis. Involvement of G protein in the activation of MAPK pathway by TCC was indicated by inhibition of Raf-1 and ERK1 kinase activity, as well as the DNA synthesis by pretreatment of cells with pertussis toxin. Overexpression of beta-adrenergic receptor kinase 1 carboxyl-terminal peptide in JY25 cells also inhibited Raf-1 and ERK1 activity, indicating a direct involvement of G betagamma subunits in the signal transduction generated through activation of MAPK pathway by TCC assembly in the plasma membrane.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":22,"end":62},"obj":"NP"},{"id":"C2","span":{"begin":66,"end":95},"obj":"NP"},{"id":"C3","span":{"begin":339,"end":342},"obj":"NP"},{"id":"C4","span":{"begin":371,"end":390},"obj":"NP"},{"id":"C5","span":{"begin":392,"end":397},"obj":"NP"},{"id":"C6","span":{"begin":592,"end":608},"obj":"NP"},{"id":"C7","span":{"begin":637,"end":642},"obj":"NP"},{"id":"C8","span":{"begin":644,"end":657},"obj":"NP"},{"id":"C9","span":{"begin":730,"end":743},"obj":"NP"},{"id":"C10","span":{"begin":812,"end":817},"obj":"NP"},{"id":"C11","span":{"begin":822,"end":827},"obj":"NP"},{"id":"C12","span":{"begin":976,"end":981},"obj":"NP"},{"id":"C13","span":{"begin":998,"end":1003},"obj":"NP"},{"id":"C14","span":{"begin":1048,"end":1095},"obj":"NP"},{"id":"C16","span":{"begin":1357,"end":1369},"obj":"NP"},{"id":"C17","span":{"begin":1373,"end":1376},"obj":"NP"},{"id":"C15","span":{"begin":1339,"end":1376},"obj":"NP"},{"id":"C18","span":{"begin":1408,"end":1438},"obj":"NP"},{"id":"C19","span":{"begin":1597,"end":1607},"obj":"NP"},{"id":"C20","span":{"begin":1623,"end":1646},"obj":"NP"},{"id":"C22","span":{"begin":1763,"end":1775},"obj":"NP"},{"id":"C21","span":{"begin":1749,"end":1791},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-relat","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C9","obj":"C8"},{"id":"R4","pred":"coref-ident","subj":"C10","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C12","obj":"C10"},{"id":"R6","pred":"coref-ident","subj":"C13","obj":"C11"},{"id":"R7","pred":"coref-ident","subj":"C14","obj":"C1"},{"id":"R8","pred":"coref-ident","subj":"C16","obj":"C14"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C3"},{"id":"R10","pred":"coref-ident","subj":"C19","obj":"C6"},{"id":"R11","pred":"coref-ident","subj":"C20","obj":"C18"},{"id":"R12","pred":"coref-ident","subj":"C22","obj":"C16"},{"id":"R13","pred":"coref-ident","subj":"C21","obj":"C15"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":22,"end":54},"obj":"protein"},{"id":"T2","span":{"begin":66,"end":95},"obj":"protein"},{"id":"T3","span":{"begin":99,"end":108},"obj":"protein"},{"id":"T4","span":{"begin":132,"end":161},"obj":"protein"},{"id":"T5","span":{"begin":163,"end":166},"obj":"protein"},{"id":"T6","span":{"begin":168,"end":173},"obj":"protein"},{"id":"T7","span":{"begin":175,"end":180},"obj":"protein"},{"id":"T8","span":{"begin":186,"end":191},"obj":"protein"},{"id":"T9","span":{"begin":317,"end":326},"obj":"protein"},{"id":"T10","span":{"begin":339,"end":342},"obj":"protein"},{"id":"T11","span":{"begin":406,"end":414},"obj":"protein"},{"id":"T12","span":{"begin":426,"end":440},"obj":"DNA"},{"id":"T13","span":{"begin":504,"end":507},"obj":"protein"},{"id":"T14","span":{"begin":516,"end":519},"obj":"protein"},{"id":"T15","span":{"begin":521,"end":526},"obj":"protein"},{"id":"T16","span":{"begin":532,"end":577},"obj":"protein"},{"id":"T17","span":{"begin":637,"end":642},"obj":"protein"},{"id":"T18","span":{"begin":644,"end":657},"obj":"protein"},{"id":"T19","span":{"begin":661,"end":690},"obj":"protein"},{"id":"T20","span":{"begin":730,"end":743},"obj":"protein"},{"id":"T21","span":{"begin":747,"end":774},"obj":"protein"},{"id":"T22","span":{"begin":812,"end":817},"obj":"protein"},{"id":"T23","span":{"begin":822,"end":827},"obj":"protein"},{"id":"T24","span":{"begin":837,"end":841},"obj":"protein"},{"id":"T25","span":{"begin":853,"end":858},"obj":"protein"},{"id":"T26","span":{"begin":938,"end":942},"obj":"protein"},{"id":"T27","span":{"begin":976,"end":981},"obj":"protein"},{"id":"T28","span":{"begin":998,"end":1003},"obj":"protein"},{"id":"T29","span":{"begin":1024,"end":1028},"obj":"protein"},{"id":"T30","span":{"begin":1048,"end":1080},"obj":"protein"},{"id":"T31","span":{"begin":1082,"end":1086},"obj":"protein"},{"id":"T32","span":{"begin":1099,"end":1102},"obj":"protein"},{"id":"T33","span":{"begin":1176,"end":1195},"obj":"protein"},{"id":"T34","span":{"begin":1197,"end":1201},"obj":"protein"},{"id":"T35","span":{"begin":1282,"end":1287},"obj":"protein"},{"id":"T36","span":{"begin":1326,"end":1335},"obj":"protein"},{"id":"T37","span":{"begin":1357,"end":1361},"obj":"protein"},{"id":"T38","span":{"begin":1373,"end":1376},"obj":"protein"},{"id":"T39","span":{"begin":1408,"end":1413},"obj":"protein"},{"id":"T40","span":{"begin":1418,"end":1422},"obj":"protein"},{"id":"T41","span":{"begin":1499,"end":1514},"obj":"protein"},{"id":"T42","span":{"begin":1597,"end":1607},"obj":"cell_line"},{"id":"T43","span":{"begin":1623,"end":1628},"obj":"protein"},{"id":"T44","span":{"begin":1633,"end":1637},"obj":"protein"},{"id":"T45","span":{"begin":1763,"end":1767},"obj":"protein"},{"id":"T46","span":{"begin":1779,"end":1782},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"},{"subj":"T29","pred":"source","obj":"jnlpba-st-training"},{"subj":"T30","pred":"source","obj":"jnlpba-st-training"},{"subj":"T31","pred":"source","obj":"jnlpba-st-training"},{"subj":"T32","pred":"source","obj":"jnlpba-st-training"},{"subj":"T33","pred":"source","obj":"jnlpba-st-training"},{"subj":"T34","pred":"source","obj":"jnlpba-st-training"},{"subj":"T35","pred":"source","obj":"jnlpba-st-training"},{"subj":"T36","pred":"source","obj":"jnlpba-st-training"},{"subj":"T37","pred":"source","obj":"jnlpba-st-training"},{"subj":"T38","pred":"source","obj":"jnlpba-st-training"},{"subj":"T39","pred":"source","obj":"jnlpba-st-training"},{"subj":"T40","pred":"source","obj":"jnlpba-st-training"},{"subj":"T41","pred":"source","obj":"jnlpba-st-training"},{"subj":"T42","pred":"source","obj":"jnlpba-st-training"},{"subj":"T43","pred":"source","obj":"jnlpba-st-training"},{"subj":"T44","pred":"source","obj":"jnlpba-st-training"},{"subj":"T45","pred":"source","obj":"jnlpba-st-training"},{"subj":"T46","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":119},"obj":"Sentence"},{"id":"S2","span":{"begin":120,"end":338},"obj":"Sentence"},{"id":"S3","span":{"begin":339,"end":475},"obj":"Sentence"},{"id":"S4","span":{"begin":476,"end":609},"obj":"Sentence"},{"id":"S5","span":{"begin":610,"end":806},"obj":"Sentence"},{"id":"S6","span":{"begin":807,"end":937},"obj":"Sentence"},{"id":"S7","span":{"begin":938,"end":1035},"obj":"Sentence"},{"id":"S8","span":{"begin":1036,"end":1224},"obj":"Sentence"},{"id":"S9","span":{"begin":1225,"end":1310},"obj":"Sentence"},{"id":"S10","span":{"begin":1311,"end":1515},"obj":"Sentence"},{"id":"S11","span":{"begin":1516,"end":1815},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S11","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":22,"end":54},"obj":"protein_family_or_group"},{"id":"T2","span":{"begin":66,"end":95},"obj":"protein_complex"},{"id":"T3","span":{"begin":99,"end":108},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":132,"end":161},"obj":"protein_complex"},{"id":"T5","span":{"begin":163,"end":166},"obj":"protein_complex"},{"id":"T6","span":{"begin":168,"end":173},"obj":"protein_complex"},{"id":"T7","span":{"begin":175,"end":180},"obj":"protein_complex"},{"id":"T8","span":{"begin":186,"end":191},"obj":"protein_complex"},{"id":"T9","span":{"begin":225,"end":245},"obj":"other_name"},{"id":"T10","span":{"begin":268,"end":297},"obj":"lipid"},{"id":"T11","span":{"begin":302,"end":316},"obj":"other_name"},{"id":"T12","span":{"begin":317,"end":326},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":339,"end":342},"obj":"protein_complex"},{"id":"T14","span":{"begin":406,"end":414},"obj":"protein_family_or_group"},{"id":"T15","span":{"begin":426,"end":440},"obj":"DNA_family_or_group"},{"id":"T16","span":{"begin":457,"end":474},"obj":"other_name"},{"id":"T17","span":{"begin":504,"end":507},"obj":"protein_complex"},{"id":"T18","span":{"begin":516,"end":519},"obj":"protein_molecule"},{"id":"T19","span":{"begin":521,"end":526},"obj":"protein_molecule"},{"id":"T20","span":{"begin":532,"end":577},"obj":"protein_molecule"},{"id":"T21","span":{"begin":637,"end":642},"obj":"protein_complex"},{"id":"T22","span":{"begin":644,"end":653},"obj":"protein_molecule"},{"id":"T23","span":{"begin":654,"end":657},"obj":"protein_molecule"},{"id":"T24","span":{"begin":661,"end":666},"obj":"protein_complex"},{"id":"T25","span":{"begin":666,"end":671},"obj":"protein_complex"},{"id":"T26","span":{"begin":730,"end":739},"obj":"protein_molecule"},{"id":"T27","span":{"begin":740,"end":743},"obj":"protein_molecule"},{"id":"T28","span":{"begin":747,"end":752},"obj":"protein_complex"},{"id":"T29","span":{"begin":752,"end":755},"obj":"protein_molecule"},{"id":"T30","span":{"begin":812,"end":817},"obj":"protein_complex"},{"id":"T31","span":{"begin":822,"end":827},"obj":"protein_complex"},{"id":"T32","span":{"begin":837,"end":841},"obj":"protein_complex"},{"id":"T33","span":{"begin":853,"end":858},"obj":"protein_molecule"},{"id":"T34","span":{"begin":938,"end":942},"obj":"protein_molecule"},{"id":"T35","span":{"begin":976,"end":981},"obj":"protein_complex"},{"id":"T36","span":{"begin":998,"end":1003},"obj":"protein_complex"},{"id":"T37","span":{"begin":1024,"end":1028},"obj":"protein_complex"},{"id":"T38","span":{"begin":1048,"end":1080},"obj":"protein_family_or_group"},{"id":"T39","span":{"begin":1082,"end":1086},"obj":"protein_family_or_group"},{"id":"T40","span":{"begin":1099,"end":1102},"obj":"protein_complex"},{"id":"T41","span":{"begin":1113,"end":1130},"obj":"other_name"},{"id":"T42","span":{"begin":1176,"end":1195},"obj":"protein_molecule"},{"id":"T43","span":{"begin":1197,"end":1201},"obj":"protein_molecule"},{"id":"T44","span":{"begin":1229,"end":1256},"obj":"other_organic_compound"},{"id":"T45","span":{"begin":1257,"end":1267},"obj":"other_organic_compound"},{"id":"T46","span":{"begin":1282,"end":1287},"obj":"protein_complex"},{"id":"T47","span":{"begin":1326,"end":1335},"obj":"protein_family_or_group"},{"id":"T48","span":{"begin":1357,"end":1361},"obj":"protein_family_or_group"},{"id":"T49","span":{"begin":1373,"end":1376},"obj":"protein_complex"},{"id":"T50","span":{"begin":1408,"end":1413},"obj":"protein_molecule"},{"id":"T51","span":{"begin":1418,"end":1422},"obj":"protein_molecule"},{"id":"T52","span":{"begin":1455,"end":1468},"obj":"other_name"},{"id":"T53","span":{"begin":1499,"end":1514},"obj":"protein_molecule"},{"id":"T54","span":{"begin":1534,"end":1593},"obj":"peptide"},{"id":"T55","span":{"begin":1597,"end":1607},"obj":"cell_line"},{"id":"T56","span":{"begin":1623,"end":1628},"obj":"protein_molecule"},{"id":"T57","span":{"begin":1633,"end":1637},"obj":"protein_molecule"},{"id":"T58","span":{"begin":1763,"end":1767},"obj":"protein_family_or_group"},{"id":"T59","span":{"begin":1779,"end":1782},"obj":"protein_complex"},{"id":"T60","span":{"begin":1799,"end":1814},"obj":"cell_component"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"},{"subj":"T49","pred":"source","obj":"GENIAcorpus"},{"subj":"T50","pred":"source","obj":"GENIAcorpus"},{"subj":"T51","pred":"source","obj":"GENIAcorpus"},{"subj":"T52","pred":"source","obj":"GENIAcorpus"},{"subj":"T53","pred":"source","obj":"GENIAcorpus"},{"subj":"T54","pred":"source","obj":"GENIAcorpus"},{"subj":"T55","pred":"source","obj":"GENIAcorpus"},{"subj":"T56","pred":"source","obj":"GENIAcorpus"},{"subj":"T57","pred":"source","obj":"GENIAcorpus"},{"subj":"T58","pred":"source","obj":"GENIAcorpus"},{"subj":"T59","pred":"source","obj":"GENIAcorpus"},{"subj":"T60","pred":"source","obj":"GENIAcorpus"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":119},"obj":"Sentence"},{"id":"T2","span":{"begin":120,"end":338},"obj":"Sentence"},{"id":"T3","span":{"begin":339,"end":475},"obj":"Sentence"},{"id":"T4","span":{"begin":476,"end":609},"obj":"Sentence"},{"id":"T5","span":{"begin":610,"end":806},"obj":"Sentence"},{"id":"T6","span":{"begin":807,"end":937},"obj":"Sentence"},{"id":"T7","span":{"begin":938,"end":1035},"obj":"Sentence"},{"id":"T8","span":{"begin":1036,"end":1224},"obj":"Sentence"},{"id":"T9","span":{"begin":1225,"end":1310},"obj":"Sentence"},{"id":"T10","span":{"begin":1311,"end":1515},"obj":"Sentence"},{"id":"T11","span":{"begin":1516,"end":1815},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":119},"obj":"Sentence"},{"id":"T2","span":{"begin":120,"end":338},"obj":"Sentence"},{"id":"T3","span":{"begin":339,"end":475},"obj":"Sentence"},{"id":"T4","span":{"begin":476,"end":609},"obj":"Sentence"},{"id":"T5","span":{"begin":610,"end":806},"obj":"Sentence"},{"id":"T6","span":{"begin":807,"end":937},"obj":"Sentence"},{"id":"T7","span":{"begin":938,"end":1035},"obj":"Sentence"},{"id":"T8","span":{"begin":1036,"end":1224},"obj":"Sentence"},{"id":"T9","span":{"begin":1225,"end":1310},"obj":"Sentence"},{"id":"T10","span":{"begin":1311,"end":1515},"obj":"Sentence"},{"id":"T11","span":{"begin":1516,"end":1815},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#ec9b93","default":true},{"id":"jnlpba-st-training","color":"#93a5ec"},{"id":"pubmed-sentences-benchmark","color":"#bfec93"},{"id":"GENIAcorpus","color":"#ec93d9"},{"id":"Inflammaging","color":"#93ece5"}]}]}}