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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent.
T2 120-338 Sentence denotes Assembly of terminal complement complexes (TCC) C5b-7, C5b-8, and C5b-9 on target cells during acute and chronic inflammation induces hydrolysis of plasma membrane phospholipids and heterotrimeric G protein activation.
T3 339-475 Sentence denotes TCC also stimulate a variety of cellular activities, which include cytokine synthesis, proto-oncogene activation, and mitotic signaling.
T4 476-609 Sentence denotes Now we report that sublytic TCC induced Ras, Raf-1, and extracellular signal-regulated kinase (ERK) 1 activation in JY25 B cell line.
T5 610-806 Sentence denotes When cells were exposed to C5b-9, GTP-bound Ras in anti-C5b-9 immunoprecipitates was increased 3.2-fold at 2 min, while GTP-bound Ras in anti-Ras immunoprecipitates was increased 2-fold at 10 min.
T6 807-937 Sentence denotes Both C5b-9 and C5b-7, but not C5b6, increased Raf-1 kinase activity maximum 3.3-fold at 2 min and 2.8-fold at 5 min, respectively.
T7 938-1035 Sentence denotes ERK1 activity was 2-fold increased by C5b-9 at 2 min and by C5b-7 at 10 min, over the C5b6 level.
T8 1036-1224 Sentence denotes The role of mitogen-activated protein kinase (MAPK) pathway on TCC-inducible mitotic signaling was evaluated by assessing DNA synthesis and activator protein 1 (AP-1) DNA-binding activity.
T9 1225-1310 Sentence denotes The MAPK/ERK-specific inhibitor PD 098,059 abolished the C5b-9-induced DNA synthesis.
T10 1311-1515 Sentence denotes Involvement of G protein in the activation of MAPK pathway by TCC was indicated by inhibition of Raf-1 and ERK1 kinase activity, as well as the DNA synthesis by pretreatment of cells with pertussis toxin.
T11 1516-1815 Sentence denotes Overexpression of beta-adrenergic receptor kinase 1 carboxyl-terminal peptide in JY25 cells also inhibited Raf-1 and ERK1 activity, indicating a direct involvement of G betagamma subunits in the signal transduction generated through activation of MAPK pathway by TCC assembly in the plasma membrane.
T1 0-119 Sentence denotes Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent.
T2 120-338 Sentence denotes Assembly of terminal complement complexes (TCC) C5b-7, C5b-8, and C5b-9 on target cells during acute and chronic inflammation induces hydrolysis of plasma membrane phospholipids and heterotrimeric G protein activation.
T3 339-475 Sentence denotes TCC also stimulate a variety of cellular activities, which include cytokine synthesis, proto-oncogene activation, and mitotic signaling.
T4 476-609 Sentence denotes Now we report that sublytic TCC induced Ras, Raf-1, and extracellular signal-regulated kinase (ERK) 1 activation in JY25 B cell line.
T5 610-806 Sentence denotes When cells were exposed to C5b-9, GTP-bound Ras in anti-C5b-9 immunoprecipitates was increased 3.2-fold at 2 min, while GTP-bound Ras in anti-Ras immunoprecipitates was increased 2-fold at 10 min.
T6 807-937 Sentence denotes Both C5b-9 and C5b-7, but not C5b6, increased Raf-1 kinase activity maximum 3.3-fold at 2 min and 2.8-fold at 5 min, respectively.
T7 938-1035 Sentence denotes ERK1 activity was 2-fold increased by C5b-9 at 2 min and by C5b-7 at 10 min, over the C5b6 level.
T8 1036-1224 Sentence denotes The role of mitogen-activated protein kinase (MAPK) pathway on TCC-inducible mitotic signaling was evaluated by assessing DNA synthesis and activator protein 1 (AP-1) DNA-binding activity.
T9 1225-1310 Sentence denotes The MAPK/ERK-specific inhibitor PD 098,059 abolished the C5b-9-induced DNA synthesis.
T10 1311-1515 Sentence denotes Involvement of G protein in the activation of MAPK pathway by TCC was indicated by inhibition of Raf-1 and ERK1 kinase activity, as well as the DNA synthesis by pretreatment of cells with pertussis toxin.
T11 1516-1815 Sentence denotes Overexpression of beta-adrenergic receptor kinase 1 carboxyl-terminal peptide in JY25 cells also inhibited Raf-1 and ERK1 activity, indicating a direct involvement of G betagamma subunits in the signal transduction generated through activation of MAPK pathway by TCC assembly in the plasma membrane.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-54 protein denotes mitogen-activated protein kinase
T2 66-95 protein denotes terminal complement complexes
T3 99-108 protein denotes G protein
T4 132-161 protein denotes terminal complement complexes
T5 163-166 protein denotes TCC
T6 168-173 protein denotes C5b-7
T7 175-180 protein denotes C5b-8
T8 186-191 protein denotes C5b-9
T9 317-326 protein denotes G protein
T10 339-342 protein denotes TCC
T11 406-414 protein denotes cytokine
T12 426-440 DNA denotes proto-oncogene
T13 504-507 protein denotes TCC
T14 516-519 protein denotes Ras
T15 521-526 protein denotes Raf-1
T16 532-577 protein denotes extracellular signal-regulated kinase (ERK) 1
T17 637-642 protein denotes C5b-9
T18 644-657 protein denotes GTP-bound Ras
T19 661-690 protein denotes anti-C5b-9 immunoprecipitates
T20 730-743 protein denotes GTP-bound Ras
T21 747-774 protein denotes anti-Ras immunoprecipitates
T22 812-817 protein denotes C5b-9
T23 822-827 protein denotes C5b-7
T24 837-841 protein denotes C5b6
T25 853-858 protein denotes Raf-1
T26 938-942 protein denotes ERK1
T27 976-981 protein denotes C5b-9
T28 998-1003 protein denotes C5b-7
T29 1024-1028 protein denotes C5b6
T30 1048-1080 protein denotes mitogen-activated protein kinase
T31 1082-1086 protein denotes MAPK
T32 1099-1102 protein denotes TCC
T33 1176-1195 protein denotes activator protein 1
T34 1197-1201 protein denotes AP-1
T35 1282-1287 protein denotes C5b-9
T36 1326-1335 protein denotes G protein
T37 1357-1361 protein denotes MAPK
T38 1373-1376 protein denotes TCC
T39 1408-1413 protein denotes Raf-1
T40 1418-1422 protein denotes ERK1
T41 1499-1514 protein denotes pertussis toxin
T42 1597-1607 cell_line denotes JY25 cells
T43 1623-1628 protein denotes Raf-1
T44 1633-1637 protein denotes ERK1
T45 1763-1767 protein denotes MAPK
T46 1779-1782 protein denotes TCC

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 22-62 NP denotes mitogen-activated protein kinase pathway
C2 66-95 NP denotes terminal complement complexes
C3 339-342 NP denotes TCC
C4 371-390 NP denotes cellular activities
C5 392-397 NP denotes which
C6 592-608 NP denotes JY25 B cell line
C7 637-642 NP denotes C5b-9
C8 644-657 NP denotes GTP-bound Ras
C9 730-743 NP denotes GTP-bound Ras
C10 812-817 NP denotes C5b-9
C11 822-827 NP denotes C5b-7
C12 976-981 NP denotes C5b-9
C13 998-1003 NP denotes C5b-7
C14 1048-1095 NP denotes mitogen-activated protein kinase (MAPK) pathway
C16 1357-1369 NP denotes MAPK pathway
C17 1373-1376 NP denotes TCC
C15 1339-1376 NP denotes the activation of MAPK pathway by TCC
C18 1408-1438 NP denotes Raf-1 and ERK1 kinase activity
C19 1597-1607 NP denotes JY25 cells
C20 1623-1646 NP denotes Raf-1 and ERK1 activity
C22 1763-1775 NP denotes MAPK pathway
C21 1749-1791 NP denotes activation of MAPK pathway by TCC assembly
R1 C3 C2 coref-ident TCC,terminal complement complexes
R2 C5 C4 coref-relat which,cellular activities
R3 C9 C8 coref-ident GTP-bound Ras,GTP-bound Ras
R4 C10 C7 coref-ident C5b-9,C5b-9
R5 C12 C10 coref-ident C5b-9,C5b-9
R6 C13 C11 coref-ident C5b-7,C5b-7
R7 C14 C1 coref-ident mitogen-activated protein kinase (MAPK) pathway,mitogen-activated protein kinase pathway
R8 C16 C14 coref-ident MAPK pathway,mitogen-activated protein kinase (MAPK) pathway
R9 C17 C3 coref-ident TCC,TCC
R10 C19 C6 coref-ident JY25 cells,JY25 B cell line
R11 C20 C18 coref-ident Raf-1 and ERK1 activity,Raf-1 and ERK1 kinase activity
R12 C22 C16 coref-ident MAPK pathway,MAPK pathway
R13 C21 C15 coref-ident activation of MAPK pathway by TCC assembly,the activation of MAPK pathway by TCC

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-119 Sentence denotes Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent.
S2 120-338 Sentence denotes Assembly of terminal complement complexes (TCC) C5b-7, C5b-8, and C5b-9 on target cells during acute and chronic inflammation induces hydrolysis of plasma membrane phospholipids and heterotrimeric G protein activation.
S3 339-475 Sentence denotes TCC also stimulate a variety of cellular activities, which include cytokine synthesis, proto-oncogene activation, and mitotic signaling.
S4 476-609 Sentence denotes Now we report that sublytic TCC induced Ras, Raf-1, and extracellular signal-regulated kinase (ERK) 1 activation in JY25 B cell line.
S5 610-806 Sentence denotes When cells were exposed to C5b-9, GTP-bound Ras in anti-C5b-9 immunoprecipitates was increased 3.2-fold at 2 min, while GTP-bound Ras in anti-Ras immunoprecipitates was increased 2-fold at 10 min.
S6 807-937 Sentence denotes Both C5b-9 and C5b-7, but not C5b6, increased Raf-1 kinase activity maximum 3.3-fold at 2 min and 2.8-fold at 5 min, respectively.
S7 938-1035 Sentence denotes ERK1 activity was 2-fold increased by C5b-9 at 2 min and by C5b-7 at 10 min, over the C5b6 level.
S8 1036-1224 Sentence denotes The role of mitogen-activated protein kinase (MAPK) pathway on TCC-inducible mitotic signaling was evaluated by assessing DNA synthesis and activator protein 1 (AP-1) DNA-binding activity.
S9 1225-1310 Sentence denotes The MAPK/ERK-specific inhibitor PD 098,059 abolished the C5b-9-induced DNA synthesis.
S10 1311-1515 Sentence denotes Involvement of G protein in the activation of MAPK pathway by TCC was indicated by inhibition of Raf-1 and ERK1 kinase activity, as well as the DNA synthesis by pretreatment of cells with pertussis toxin.
S11 1516-1815 Sentence denotes Overexpression of beta-adrenergic receptor kinase 1 carboxyl-terminal peptide in JY25 cells also inhibited Raf-1 and ERK1 activity, indicating a direct involvement of G betagamma subunits in the signal transduction generated through activation of MAPK pathway by TCC assembly in the plasma membrane.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 22-54 protein_family_or_group denotes mitogen-activated protein kinase
T2 66-95 protein_complex denotes terminal complement complexes
T3 99-108 protein_family_or_group denotes G protein
T4 132-161 protein_complex denotes terminal complement complexes
T5 163-166 protein_complex denotes TCC
T6 168-173 protein_complex denotes C5b-7
T7 175-180 protein_complex denotes C5b-8
T8 186-191 protein_complex denotes C5b-9
T9 225-245 other_name denotes chronic inflammation
T10 268-297 lipid denotes plasma membrane phospholipids
T11 302-316 other_name denotes heterotrimeric
T12 317-326 protein_family_or_group denotes G protein
T13 339-342 protein_complex denotes TCC
T14 406-414 protein_family_or_group denotes cytokine
T15 426-440 DNA_family_or_group denotes proto-oncogene
T16 457-474 other_name denotes mitotic signaling
T17 504-507 protein_complex denotes TCC
T18 516-519 protein_molecule denotes Ras
T19 521-526 protein_molecule denotes Raf-1
T20 532-577 protein_molecule denotes extracellular signal-regulated kinase (ERK) 1
T21 637-642 protein_complex denotes C5b-9
T22 644-653 protein_molecule denotes GTP-bound
T23 654-657 protein_molecule denotes Ras
T24 661-666 protein_complex denotes anti-
T25 666-671 protein_complex denotes C5b-9
T26 730-739 protein_molecule denotes GTP-bound
T27 740-743 protein_molecule denotes Ras
T28 747-752 protein_complex denotes anti-
T29 752-755 protein_molecule denotes Ras
T30 812-817 protein_complex denotes C5b-9
T31 822-827 protein_complex denotes C5b-7
T32 837-841 protein_complex denotes C5b6
T33 853-858 protein_molecule denotes Raf-1
T34 938-942 protein_molecule denotes ERK1
T35 976-981 protein_complex denotes C5b-9
T36 998-1003 protein_complex denotes C5b-7
T37 1024-1028 protein_complex denotes C5b6
T38 1048-1080 protein_family_or_group denotes mitogen-activated protein kinase
T39 1082-1086 protein_family_or_group denotes MAPK
T40 1099-1102 protein_complex denotes TCC
T41 1113-1130 other_name denotes mitotic signaling
T42 1176-1195 protein_molecule denotes activator protein 1
T43 1197-1201 protein_molecule denotes AP-1
T44 1229-1256 other_organic_compound denotes MAPK/ERK-specific inhibitor
T45 1257-1267 other_organic_compound denotes PD 098,059
T46 1282-1287 protein_complex denotes C5b-9
T47 1326-1335 protein_family_or_group denotes G protein
T48 1357-1361 protein_family_or_group denotes MAPK
T49 1373-1376 protein_complex denotes TCC
T50 1408-1413 protein_molecule denotes Raf-1
T51 1418-1422 protein_molecule denotes ERK1
T52 1455-1468 other_name denotes DNA synthesis
T53 1499-1514 protein_molecule denotes pertussis toxin
T54 1534-1593 peptide denotes beta-adrenergic receptor kinase 1 carboxyl-terminal peptide
T55 1597-1607 cell_line denotes JY25 cells
T56 1623-1628 protein_molecule denotes Raf-1
T57 1633-1637 protein_molecule denotes ERK1
T58 1763-1767 protein_family_or_group denotes MAPK
T59 1779-1782 protein_complex denotes TCC
T60 1799-1814 cell_component denotes plasma membrane