PubMed:9119228
Annnotations
relna
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-3 | Protein | denotes | ALY |
| T2 | 40-45 | DNA | denotes | LEF-1 |
| T3 | 50-55 | DNA | denotes | AML-1 |
| T4 | 73-81 | Protein | denotes | TCRalpha |
| T5 | 101-106 | DNA | denotes | LEF-1 |
| T6 | 199-208 | Protein | denotes | TCR alpha |
| T7 | 328-333 | DNA | denotes | LEF-1 |
| T8 | 641-644 | Protein | denotes | ALY |
| T9 | 654-659 | DNA | denotes | LEF-1 |
| T10 | 681-684 | Protein | denotes | ALY |
| T11 | 790-795 | DNA | denotes | LEF-1 |
| T12 | 800-805 | DNA | denotes | AML-1 |
| T13 | 807-817 | DNA | denotes | CBF alpha2 |
| T14 | 819-833 | DNA | denotes | PEBP2 alpha(B) |
| T15 | 918-921 | Protein | denotes | ALY |
| T16 | 955-960 | DNA | denotes | LEF-1 |
| T17 | 997-1000 | Protein | denotes | ALY |
| T18 | 1139-1142 | Protein | denotes | ALY |
| T19 | 1246-1251 | DNA | denotes | LEF-1 |
| T20 | 1253-1256 | Protein | denotes | ALY |
| T21 | 1426-1429 | Protein | denotes | ALY |
| R0 | T1 | T2 | linked | ALY,LEF-1 |
| R1 | T1 | T3 | linked | ALY,AML-1 |
| R2 | T5 | T6 | linked | LEF-1,TCR alpha |
| R3 | T8 | T9 | linked | ALY,LEF-1 |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-3 | protein | denotes | ALY |
| T2 | 7-36 | protein | denotes | context-dependent coactivator |
| T3 | 40-45 | protein | denotes | LEF-1 |
| T4 | 50-55 | protein | denotes | AML-1 |
| T5 | 73-90 | DNA | denotes | TCRalpha enhancer |
| T6 | 101-106 | protein | denotes | LEF-1 |
| T7 | 176-218 | DNA | denotes | T-cell receptor alpha (TCR alpha) enhancer |
| T8 | 251-268 | protein | denotes | multiple proteins |
| T9 | 289-310 | protein | denotes | nucleoprotein complex |
| T10 | 328-333 | protein | denotes | LEF-1 |
| T11 | 364-374 | protein | denotes | HMG domain |
| T12 | 429-446 | protein | denotes | activation domain |
| T13 | 513-538 | protein | denotes | enhancer-binding proteins |
| T14 | 593-629 | protein | denotes | context-dependent activation domains |
| T15 | 641-644 | protein | denotes | ALY |
| T16 | 654-679 | protein | denotes | LEF-1-interacting protein |
| T17 | 681-684 | protein | denotes | ALY |
| T18 | 768-786 | protein | denotes | activation domains |
| T19 | 790-795 | protein | denotes | LEF-1 |
| T20 | 800-805 | protein | denotes | AML-1 |
| T21 | 807-817 | protein | denotes | CBF alpha2 |
| T22 | 819-830 | protein | denotes | PEBP2 alpha |
| T23 | 877-903 | protein | denotes | TCR alpha enhancer complex |
| T24 | 918-921 | protein | denotes | ALY |
| T25 | 955-960 | protein | denotes | LEF-1 |
| T26 | 965-977 | protein | denotes | AML proteins |
| T27 | 997-1000 | protein | denotes | ALY |
| T28 | 1032-1058 | protein | denotes | TCR alpha enhancer complex |
| T29 | 1076-1110 | cell_line | denotes | transfected nonlymphoid HeLa cells |
| T30 | 1139-1142 | protein | denotes | ALY |
| T31 | 1195-1213 | DNA | denotes | TCR alpha enhancer |
| T32 | 1226-1233 | cell_type | denotes | T cells |
| T33 | 1246-1251 | protein | denotes | LEF-1 |
| T34 | 1253-1256 | protein | denotes | ALY |
| T35 | 1307-1325 | DNA | denotes | TCR alpha enhancer |
| T36 | 1377-1408 | protein | denotes | heterologous DNA-binding domain |
| T37 | 1426-1429 | protein | denotes | ALY |
| T38 | 1532-1549 | protein | denotes | multiple proteins |
| T39 | 1557-1583 | protein | denotes | TCR alpha enhancer complex |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-3 | NP | denotes | ALY |
| C3 | 40-45 | NP | denotes | LEF-1 |
| C4 | 50-55 | NP | denotes | AML-1 |
| C2 | 5-55 | NP | denotes | a context-dependent coactivator of LEF-1 and AML-1 |
| C5 | 101-106 | NP | denotes | LEF-1 |
| C6 | 110-132 | NP | denotes | a transcription factor |
| C7 | 133-137 | NP | denotes | that |
| C8 | 172-218 | NP | denotes | the T-cell receptor alpha (TCR alpha) enhancer |
| C9 | 328-333 | NP | denotes | LEF-1 |
| C10 | 360-374 | NP | denotes | the HMG domain |
| C11 | 375-379 | NP | denotes | that |
| C12 | 426-446 | NP | denotes | an activation domain |
| C13 | 447-451 | NP | denotes | that |
| C14 | 641-644 | NP | denotes | ALY |
| C15 | 646-679 | NP | denotes | a novel LEF-1-interacting protein |
| C16 | 681-684 | NP | denotes | ALY |
| C17 | 688-729 | NP | denotes | a ubiquitously expressed, nuclear protein |
| C18 | 730-734 | NP | denotes | that |
| C19 | 790-795 | NP | denotes | LEF-1 |
| C20 | 800-805 | NP | denotes | AML-1 |
| C21 | 835-840 | NP | denotes | which |
| C22 | 873-903 | NP | denotes | the TCR alpha enhancer complex |
| C23 | 918-921 | NP | denotes | ALY |
| C24 | 997-1000 | NP | denotes | ALY |
| C25 | 1028-1058 | NP | denotes | the TCR alpha enhancer complex |
| C26 | 1139-1142 | NP | denotes | ALY |
| C27 | 1246-1251 | NP | denotes | LEF-1 |
| C28 | 1253-1256 | NP | denotes | ALY |
| C29 | 1303-1325 | NP | denotes | the TCR alpha enhancer |
| C30 | 1426-1429 | NP | denotes | ALY |
| C31 | 1553-1583 | NP | denotes | the TCR alpha enhancer complex |
| R1 | C2 | C1 | coref-appos | a context-dependent coactivator of LEF-1 and AML-1,ALY |
| R2 | C5 | C3 | coref-ident | LEF-1,LEF-1 |
| R3 | C7 | C6 | coref-relat | that,a transcription factor |
| R4 | C9 | C5 | coref-ident | LEF-1,LEF-1 |
| R5 | C11 | C10 | coref-relat | that,the HMG domain |
| R6 | C13 | C12 | coref-relat | that,an activation domain |
| R7 | C14 | C1 | coref-ident | ALY,ALY |
| R8 | C15 | C14 | coref-appos | a novel LEF-1-interacting protein,ALY |
| R9 | C16 | C14 | coref-ident | ALY,ALY |
| R10 | C18 | C17 | coref-relat | that,"a ubiquitously expressed, nuclear protein" |
| R11 | C19 | C9 | coref-ident | LEF-1,LEF-1 |
| R12 | C20 | C4 | coref-ident | AML-1,AML-1 |
| R13 | C21 | C20 | coref-relat | which,AML-1 |
| R14 | C23 | C16 | coref-ident | ALY,ALY |
| R15 | C24 | C23 | coref-ident | ALY,ALY |
| R16 | C25 | C22 | coref-ident | the TCR alpha enhancer complex,the TCR alpha enhancer complex |
| R17 | C26 | C24 | coref-ident | ALY,ALY |
| R18 | C27 | C19 | coref-ident | LEF-1,LEF-1 |
| R19 | C28 | C26 | coref-ident | ALY,ALY |
| R20 | C29 | C8 | coref-ident | the TCR alpha enhancer,the T-cell receptor alpha (TCR alpha) enhancer |
| R21 | C30 | C28 | coref-ident | ALY,ALY |
| R22 | C31 | C25 | coref-ident | the TCR alpha enhancer complex,the TCR alpha enhancer complex |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-100 | Sentence | denotes | ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. |
| S2 | 101-311 | Sentence | denotes | LEF-1 is a transcription factor that participates in the regulation of the T-cell receptor alpha (TCR alpha) enhancer by facilitating the assembly of multiple proteins into a higher order nucleoprotein complex. |
| S3 | 312-539 | Sentence | denotes | The function of LEF-1 is dependent, in part, on the HMG domain that induces a sharp bend in the DNA helix, and on an activation domain that stimulates transcription only in a specific context of other enhancer-binding proteins. |
| S4 | 540-680 | Sentence | denotes | With the aim of gaining insight into the function of context-dependent activation domains, we cloned ALY, a novel LEF-1-interacting protein. |
| S5 | 681-904 | Sentence | denotes | ALY is a ubiquitously expressed, nuclear protein that specifically associates with the activation domains of LEF-1 and AML-1 (CBF alpha2, PEBP2 alpha(B), which is another protein component of the TCR alpha enhancer complex. |
| S6 | 905-978 | Sentence | denotes | In addition, ALY can increase DNA binding by both LEF-1 and AML proteins. |
| S7 | 979-1234 | Sentence | denotes | Overexpression of ALY stimulates the activity of the TCR alpha enhancer complex reconstituted in transfected nonlymphoid HeLa cells, whereas down-regulation of ALY by anti-sense oligonucleotides virtually eliminates TCR alpha enhancer activity in T cells. |
| S8 | 1235-1409 | Sentence | denotes | Similar to LEF-1, ALY can stimulate transcription in the context of the TCR alpha enhancer but apparently not when tethered to DNA through an heterologous DNA-binding domain. |
| S9 | 1410-1584 | Sentence | denotes | We propose that ALY mediates context-dependent transcriptional activation by facilitating the functional collaboration of multiple proteins in the TCR alpha enhancer complex. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-3 | protein_molecule | denotes | ALY |
| T2 | 7-36 | protein_family_or_group | denotes | context-dependent coactivator |
| T3 | 40-45 | protein_molecule | denotes | LEF-1 |
| T4 | 50-55 | protein_molecule | denotes | AML-1 |
| T5 | 73-90 | DNA_domain_or_region | denotes | TCRalpha enhancer |
| T6 | 101-106 | protein_molecule | denotes | LEF-1 |
| T7 | 176-218 | DNA_domain_or_region | denotes | T-cell receptor alpha (TCR alpha) enhancer |
| T8 | 251-268 | protein_family_or_group | denotes | multiple proteins |
| T9 | 289-310 | protein_complex | denotes | nucleoprotein complex |
| T10 | 328-333 | protein_molecule | denotes | LEF-1 |
| T11 | 364-374 | protein_domain_or_region | denotes | HMG domain |
| T12 | 429-446 | protein_domain_or_region | denotes | activation domain |
| T13 | 513-538 | protein_family_or_group | denotes | enhancer-binding proteins |
| T14 | 593-629 | protein_domain_or_region | denotes | context-dependent activation domains |
| T15 | 641-644 | protein_molecule | denotes | ALY |
| T16 | 654-659 | protein_family_or_group | denotes | LEF-1 |
| T17 | 681-684 | protein_molecule | denotes | ALY |
| T18 | 768-786 | protein_domain_or_region | denotes | activation domains |
| T19 | 790-795 | protein_molecule | denotes | LEF-1 |
| T20 | 800-805 | protein_molecule | denotes | AML-1 |
| T21 | 807-817 | protein_molecule | denotes | CBF alpha2 |
| T22 | 819-830 | protein_molecule | denotes | PEBP2 alpha |
| T23 | 877-903 | protein_complex | denotes | TCR alpha enhancer complex |
| T24 | 918-921 | protein_molecule | denotes | ALY |
| T25 | 955-960 | protein_molecule | denotes | LEF-1 |
| T26 | 965-977 | protein_family_or_group | denotes | AML proteins |
| T27 | 997-1000 | protein_molecule | denotes | ALY |
| T28 | 1032-1058 | protein_complex | denotes | TCR alpha enhancer complex |
| T29 | 1076-1110 | cell_line | denotes | transfected nonlymphoid HeLa cells |
| T30 | 1139-1142 | protein_molecule | denotes | ALY |
| T31 | 1195-1213 | DNA_domain_or_region | denotes | TCR alpha enhancer |
| T32 | 1226-1233 | cell_type | denotes | T cells |
| T33 | 1246-1251 | protein_molecule | denotes | LEF-1 |
| T34 | 1253-1256 | protein_molecule | denotes | ALY |
| T35 | 1307-1325 | DNA_domain_or_region | denotes | TCR alpha enhancer |
| T36 | 1377-1408 | protein_domain_or_region | denotes | heterologous DNA-binding domain |
| T37 | 1426-1429 | protein_molecule | denotes | ALY |
| T38 | 1439-1483 | other_name | denotes | context-dependent transcriptional activation |
| T39 | 1532-1549 | protein_family_or_group | denotes | multiple proteins |
| T40 | 1557-1575 | DNA_domain_or_region | denotes | TCR alpha enhancer |