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PubMed:9092562 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes The Pax-5 gene is alternatively spliced during B-cell development.
T2 67-224 Sentence denotes The transcription factor Pax-5 is expressed during the early stages of B-cell differentiation and influences the expression of several B-cell-specific genes.
T3 225-477 Sentence denotes In addition to the existing isoform (Pax-5, which we have named Pax-5a), we have isolated three new isoforms, Pax-5b, Pax-5d, and Pax-5e, from murine spleen and B-lymphoid cell lines using library screenings and polymerase chain reaction amplification.
T4 478-602 Sentence denotes Isoforms Pax-5b and Pax-5e have spliced out their second exon, resulting in proteins with only a partial DNA-binding domain.
T5 603-738 Sentence denotes Isoforms Pax-5d and Pax-5e have deleted the 3'-region, which encodes the transactivating domain, and replaced it with a novel sequence.
T6 739-830 Sentence denotes The existence of alternative Pax-5 transcripts was confirmed using RNase protection assays.
T7 831-913 Sentence denotes Furthermore, Pax-5a and Pax-5b proteins were detected using Western blot analysis.
T8 914-1156 Sentence denotes Pax-5a was detectable in pro-, pre-, and mature B-cell lines, but not in two plasmacytomas; Pax-5b was shown to be present at low levels in mature B-cell lines and, unexpectedly, in one plasma cell line, but not in pro-B-cell or T-cell lines.
T9 1157-1345 Sentence denotes Mobility shift assays showed that in vitro translated Pax-5a and Pax-5d, but not Pax-5b or Pax-5e, could interact with a B-cell-specific activator protein-binding site on the blk promoter.
T10 1346-1532 Sentence denotes Using this assay, we also showed that Pax-5d was present in nuclear extracts of some (but not all) B-lymphoid lines and interacts with the B-cell-specific activator protein-binding site.
T11 1533-1701 Sentence denotes The pattern of differential expression of alternatively spliced Pax-5 isoforms suggests that they may be important regulators of transcription during B-cell maturation.
T1 0-66 Sentence denotes The Pax-5 gene is alternatively spliced during B-cell development.
T2 67-224 Sentence denotes The transcription factor Pax-5 is expressed during the early stages of B-cell differentiation and influences the expression of several B-cell-specific genes.
T3 225-477 Sentence denotes In addition to the existing isoform (Pax-5, which we have named Pax-5a), we have isolated three new isoforms, Pax-5b, Pax-5d, and Pax-5e, from murine spleen and B-lymphoid cell lines using library screenings and polymerase chain reaction amplification.
T4 478-602 Sentence denotes Isoforms Pax-5b and Pax-5e have spliced out their second exon, resulting in proteins with only a partial DNA-binding domain.
T5 603-738 Sentence denotes Isoforms Pax-5d and Pax-5e have deleted the 3'-region, which encodes the transactivating domain, and replaced it with a novel sequence.
T6 739-830 Sentence denotes The existence of alternative Pax-5 transcripts was confirmed using RNase protection assays.
T7 831-913 Sentence denotes Furthermore, Pax-5a and Pax-5b proteins were detected using Western blot analysis.
T8 914-1156 Sentence denotes Pax-5a was detectable in pro-, pre-, and mature B-cell lines, but not in two plasmacytomas; Pax-5b was shown to be present at low levels in mature B-cell lines and, unexpectedly, in one plasma cell line, but not in pro-B-cell or T-cell lines.
T9 1157-1345 Sentence denotes Mobility shift assays showed that in vitro translated Pax-5a and Pax-5d, but not Pax-5b or Pax-5e, could interact with a B-cell-specific activator protein-binding site on the blk promoter.
T10 1346-1532 Sentence denotes Using this assay, we also showed that Pax-5d was present in nuclear extracts of some (but not all) B-lymphoid lines and interacts with the B-cell-specific activator protein-binding site.
T11 1533-1701 Sentence denotes The pattern of differential expression of alternatively spliced Pax-5 isoforms suggests that they may be important regulators of transcription during B-cell maturation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 375-381 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-14 DNA denotes Pax-5 gene
T2 71-97 protein denotes transcription factor Pax-5
T3 202-223 DNA denotes B-cell-specific genes
T4 262-267 protein denotes Pax-5
T5 289-295 protein denotes Pax-5a
T6 335-341 protein denotes Pax-5b
T7 343-349 protein denotes Pax-5d
T8 355-361 protein denotes Pax-5e
T9 386-407 cell_line denotes B-lymphoid cell lines
T10 487-493 protein denotes Pax-5b
T11 498-504 protein denotes Pax-5e
T12 583-601 protein denotes DNA-binding domain
T13 623-629 protein denotes Pax-5e
T14 647-656 protein denotes 3'-region
T15 768-785 RNA denotes Pax-5 transcripts
T16 806-811 protein denotes RNase
T17 844-850 protein denotes Pax-5a
T18 855-870 protein denotes Pax-5b proteins
T19 914-920 protein denotes Pax-5a
T20 939-974 cell_line denotes pro-, pre-, and mature B-cell lines
T21 1006-1012 protein denotes Pax-5b
T22 1054-1073 cell_line denotes mature B-cell lines
T23 1129-1155 cell_line denotes pro-B-cell or T-cell lines
T24 1211-1217 protein denotes Pax-5a
T25 1222-1228 protein denotes Pax-5d
T26 1238-1244 protein denotes Pax-5b
T27 1248-1254 protein denotes Pax-5e
T28 1278-1324 DNA denotes B-cell-specific activator protein-binding site
T29 1332-1344 DNA denotes blk promoter
T30 1384-1390 protein denotes Pax-5d
T31 1445-1461 cell_line denotes B-lymphoid lines
T32 1485-1531 DNA denotes B-cell-specific activator protein-binding site
T33 1575-1611 protein denotes alternatively spliced Pax-5 isoforms
T34 1648-1675 protein denotes regulators of transcription

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 240-296 NP denotes the existing isoform (Pax-5, which we have named Pax-5a)
C2 315-333 NP denotes three new isoforms
C3 335-361 NP denotes Pax-5b, Pax-5d, and Pax-5e
C4 478-504 NP denotes Isoforms Pax-5b and Pax-5e
C5 522-527 NP denotes their
C6 643-656 NP denotes the 3'-region
C7 658-663 NP denotes which
C8 713-715 NP denotes it
C9 914-920 NP denotes Pax-5a
C10 1006-1012 NP denotes Pax-5b
C11 1238-1244 NP denotes Pax-5b
C12 1276-1344 NP denotes a B-cell-specific activator protein-binding site on the blk promoter
C13 1481-1531 NP denotes the B-cell-specific activator protein-binding site
C14 1575-1611 NP denotes alternatively spliced Pax-5 isoforms
C15 1626-1630 NP denotes they
R1 C3 C2 coref-appos "Pax-5b, Pax-5d, and Pax-5e",three new isoforms
R2 C5 C4 coref-pron their,Isoforms Pax-5b and Pax-5e
R3 C7 C6 coref-relat which,the 3'-region
R4 C8 C6 coref-pron it,the 3'-region
R5 C9 C1 coref-ident Pax-5a,"the existing isoform (Pax-5, which we have named Pax-5a)"
R6 C11 C10 coref-ident Pax-5b,Pax-5b
R7 C13 C12 coref-ident the B-cell-specific activator protein-binding site,a B-cell-specific activator protein-binding site on the blk promoter
R8 C15 C14 coref-pron they,alternatively spliced Pax-5 isoforms

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-66 Sentence denotes The Pax-5 gene is alternatively spliced during B-cell development.
S2 67-224 Sentence denotes The transcription factor Pax-5 is expressed during the early stages of B-cell differentiation and influences the expression of several B-cell-specific genes.
S3 225-477 Sentence denotes In addition to the existing isoform (Pax-5, which we have named Pax-5a), we have isolated three new isoforms, Pax-5b, Pax-5d, and Pax-5e, from murine spleen and B-lymphoid cell lines using library screenings and polymerase chain reaction amplification.
S4 478-602 Sentence denotes Isoforms Pax-5b and Pax-5e have spliced out their second exon, resulting in proteins with only a partial DNA-binding domain.
S5 603-738 Sentence denotes Isoforms Pax-5d and Pax-5e have deleted the 3'-region, which encodes the transactivating domain, and replaced it with a novel sequence.
S6 739-830 Sentence denotes The existence of alternative Pax-5 transcripts was confirmed using RNase protection assays.
S7 831-913 Sentence denotes Furthermore, Pax-5a and Pax-5b proteins were detected using Western blot analysis.
S8 914-1156 Sentence denotes Pax-5a was detectable in pro-, pre-, and mature B-cell lines, but not in two plasmacytomas; Pax-5b was shown to be present at low levels in mature B-cell lines and, unexpectedly, in one plasma cell line, but not in pro-B-cell or T-cell lines.
S9 1157-1345 Sentence denotes Mobility shift assays showed that in vitro translated Pax-5a and Pax-5d, but not Pax-5b or Pax-5e, could interact with a B-cell-specific activator protein-binding site on the blk promoter.
S10 1346-1532 Sentence denotes Using this assay, we also showed that Pax-5d was present in nuclear extracts of some (but not all) B-lymphoid lines and interacts with the B-cell-specific activator protein-binding site.
S11 1533-1701 Sentence denotes The pattern of differential expression of alternatively spliced Pax-5 isoforms suggests that they may be important regulators of transcription during B-cell maturation.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-14 DNA_domain_or_region denotes Pax-5 gene
T2 47-65 other_name denotes B-cell development
T3 71-91 protein_family_or_group denotes transcription factor
T4 138-160 other_name denotes B-cell differentiation
T5 202-223 DNA_family_or_group denotes B-cell-specific genes
T6 262-267 protein_molecule denotes Pax-5
T7 289-295 protein_molecule denotes Pax-5a
T8 335-341 protein_molecule denotes Pax-5b
T9 343-349 protein_molecule denotes Pax-5d
T10 355-361 protein_molecule denotes Pax-5e
T11 386-407 cell_line denotes B-lymphoid cell lines
T12 414-432 other_name denotes library screenings
T13 437-476 other_name denotes polymerase chain reaction amplification
T14 487-493 protein_molecule denotes Pax-5b
T15 498-504 protein_molecule denotes Pax-5e
T16 583-601 protein_domain_or_region denotes DNA-binding domain
T17 623-629 protein_molecule denotes Pax-5e
T18 647-656 protein_domain_or_region denotes 3'-region
T19 768-773 protein_molecule denotes Pax-5
T20 806-811 protein_molecule denotes RNase
T21 844-850 protein_molecule denotes Pax-5a
T22 855-861 protein_molecule denotes Pax-5b
T23 891-912 other_name denotes Western blot analysis
T24 914-920 protein_molecule denotes Pax-5a
T25 991-1004 tissue denotes plasmacytomas
T26 1006-1012 protein_molecule denotes Pax-5b
T27 1054-1073 cell_line denotes mature B-cell lines
T28 1157-1178 other_name denotes Mobility shift assays
T29 1211-1217 protein_molecule denotes Pax-5a
T30 1222-1228 protein_molecule denotes Pax-5d
T31 1238-1244 protein_molecule denotes Pax-5b
T32 1248-1254 protein_molecule denotes Pax-5e
T33 1278-1324 DNA_domain_or_region denotes B-cell-specific activator protein-binding site
T34 1332-1344 DNA_domain_or_region denotes blk promoter
T35 1384-1390 protein_molecule denotes Pax-5d
T36 1406-1422 cell_component denotes nuclear extracts
T37 1445-1461 cell_line denotes B-lymphoid lines
T38 1485-1531 DNA_domain_or_region denotes B-cell-specific activator protein-binding site
T39 1575-1611 protein_family_or_group denotes alternatively spliced Pax-5 isoforms
T40 1648-1675 protein_family_or_group denotes regulators of transcription
T41 1683-1700 other_name denotes B-cell maturation

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 991-1004 Phenotype denotes plasmacytomas HP:0011857

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 991-1004 Disease denotes plasmacytomas http://purl.obolibrary.org/obo/MONDO_0005615

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 4-7 OrganismTaxon denotes Pax 2033138
T2 92-95 OrganismTaxon denotes Pax 2033138
T3 262-265 OrganismTaxon denotes Pax 2033138
T4 289-292 OrganismTaxon denotes Pax 2033138
T5 335-338 OrganismTaxon denotes Pax 2033138
T6 343-346 OrganismTaxon denotes Pax 2033138
T7 355-358 OrganismTaxon denotes Pax 2033138
T8 487-490 OrganismTaxon denotes Pax 2033138
T9 498-501 OrganismTaxon denotes Pax 2033138
T10 612-615 OrganismTaxon denotes Pax 2033138
T11 623-626 OrganismTaxon denotes Pax 2033138
T12 768-771 OrganismTaxon denotes Pax 2033138
T13 844-847 OrganismTaxon denotes Pax 2033138
T14 855-858 OrganismTaxon denotes Pax 2033138
T15 914-917 OrganismTaxon denotes Pax 2033138
T16 1006-1009 OrganismTaxon denotes Pax 2033138
T17 1211-1214 OrganismTaxon denotes Pax 2033138
T18 1222-1225 OrganismTaxon denotes Pax 2033138
T19 1238-1241 OrganismTaxon denotes Pax 2033138
T20 1248-1251 OrganismTaxon denotes Pax 2033138
T21 1384-1387 OrganismTaxon denotes Pax 2033138
T22 1597-1600 OrganismTaxon denotes Pax 2033138

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 47-53 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236
T2 138-144 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236
T3 202-208 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236
T4 375-381 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T5 955-968 Body_part denotes mature B-cell http://purl.obolibrary.org/obo/CL_0000785
T6 1054-1067 Body_part denotes mature B-cell http://purl.obolibrary.org/obo/CL_0000785
T7 1100-1111 Body_part denotes plasma cell http://purl.obolibrary.org/obo/CL_0000786
T8 1129-1139 Body_part denotes pro-B-cell http://purl.obolibrary.org/obo/CL_0000826
T9 1143-1149 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T10 1278-1284 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236
T11 1485-1491 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236
T12 1683-1689 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 375-381 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 47-53 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T2 138-144 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T3 202-208 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T4 955-968 Cell denotes mature B-cell http://purl.obolibrary.org/obo/CL:0000785
T5 962-968 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T6 1054-1067 Cell denotes mature B-cell http://purl.obolibrary.org/obo/CL:0000785
T7 1061-1067 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T8 1100-1111 Cell denotes plasma cell http://purl.obolibrary.org/obo/CL:0000786
T9 1129-1139 Cell denotes pro-B-cell http://purl.obolibrary.org/obo/CL:0000826
T10 1133-1139 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T11 1143-1149 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T12 1276-1284 Cell denotes a B-cell http://purl.obolibrary.org/obo/CL:4023097
T13 1278-1284 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T14 1485-1491 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T15 1683-1689 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236