PubMed:8980878 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":15,"end":55},"obj":"cell_type"},{"id":"T2","span":{"begin":276,"end":294},"obj":"protein"},{"id":"T3","span":{"begin":296,"end":305},"obj":"protein"},{"id":"T4","span":{"begin":311,"end":339},"obj":"protein"},{"id":"T5","span":{"begin":341,"end":350},"obj":"protein"},{"id":"T6","span":{"begin":391,"end":395},"obj":"RNA"},{"id":"T7","span":{"begin":399,"end":439},"obj":"cell_type"},{"id":"T8","span":{"begin":441,"end":445},"obj":"cell_type"},{"id":"T9","span":{"begin":633,"end":637},"obj":"RNA"},{"id":"T10","span":{"begin":641,"end":650},"obj":"protein"}],"text":"Stimulation of human peripheral blood mononuclear cells by zinc and related cations.\nZinc is an important trace element for immune function. Here, we show that zinc addition in a serum- and lipopolysaccharide-free cell culture system leads to significantly enhanced levels of interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) and to expression of the corresponding mRNA in human peripheral blood mononuclear cells (PBMC). Structurally related divalent cations like cobalt, nickel, and mercury also partially increase monokine secretion but to a much lower and thus insignificant extent. They fail to induce mRNA of TNF-alpha after 3 h of culture. Therefore, monokine induction is a zinc-specific effect influenced by the physicochemical properties of the ion. Confirmation of the unique significance of zinc for immune function provides a better understanding of the mechanisms of specific zinc-mediated immune modulation."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"S2","span":{"begin":85,"end":140},"obj":"Sentence"},{"id":"S3","span":{"begin":141,"end":447},"obj":"Sentence"},{"id":"S4","span":{"begin":448,"end":612},"obj":"Sentence"},{"id":"S5","span":{"begin":613,"end":672},"obj":"Sentence"},{"id":"S6","span":{"begin":673,"end":785},"obj":"Sentence"},{"id":"S7","span":{"begin":786,"end":948},"obj":"Sentence"}],"text":"Stimulation of human peripheral blood mononuclear cells by zinc and related cations.\nZinc is an important trace element for immune function. Here, we show that zinc addition in a serum- and lipopolysaccharide-free cell culture system leads to significantly enhanced levels of interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) and to expression of the corresponding mRNA in human peripheral blood mononuclear cells (PBMC). Structurally related divalent cations like cobalt, nickel, and mercury also partially increase monokine secretion but to a much lower and thus insignificant extent. They fail to induce mRNA of TNF-alpha after 3 h of culture. Therefore, monokine induction is a zinc-specific effect influenced by the physicochemical properties of the ion. Confirmation of the unique significance of zinc for immune function provides a better understanding of the mechanisms of specific zinc-mediated immune modulation."}

{"project":"genia-medco-coref","denotations":[{"id":"C3","span":{"begin":15,"end":55},"obj":"NP"},{"id":"C1","span":{"begin":59,"end":63},"obj":"NP"},{"id":"C2","span":{"begin":85,"end":89},"obj":"NP"},{"id":"C7","span":{"begin":124,"end":139},"obj":"NP"},{"id":"C4","span":{"begin":399,"end":446},"obj":"NP"},{"id":"C5","span":{"begin":708,"end":713},"obj":"NP"},{"id":"C6","span":{"begin":829,"end":833},"obj":"NP"},{"id":"C8","span":{"begin":838,"end":853},"obj":"NP"},{"id":"C9","span":{"begin":916,"end":921},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C5","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C9","obj":"C6"}],"text":"Stimulation of human peripheral blood mononuclear cells by zinc and related cations.\nZinc is an important trace element for immune function. Here, we show that zinc addition in a serum- and lipopolysaccharide-free cell culture system leads to significantly enhanced levels of interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) and to expression of the corresponding mRNA in human peripheral blood mononuclear cells (PBMC). Structurally related divalent cations like cobalt, nickel, and mercury also partially increase monokine secretion but to a much lower and thus insignificant extent. They fail to induce mRNA of TNF-alpha after 3 h of culture. Therefore, monokine induction is a zinc-specific effect influenced by the physicochemical properties of the ion. Confirmation of the unique significance of zinc for immune function provides a better understanding of the mechanisms of specific zinc-mediated immune modulation."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":15,"end":55},"obj":"cell_type"},{"id":"T2","span":{"begin":59,"end":63},"obj":"atom"},{"id":"T3","span":{"begin":76,"end":83},"obj":"atom"},{"id":"T4","span":{"begin":85,"end":89},"obj":"atom"},{"id":"T5","span":{"begin":106,"end":119},"obj":"atom"},{"id":"T6","span":{"begin":124,"end":139},"obj":"other_name"},{"id":"T7","span":{"begin":160,"end":164},"obj":"atom"},{"id":"T8","span":{"begin":276,"end":294},"obj":"protein_molecule"},{"id":"T9","span":{"begin":296,"end":305},"obj":"protein_molecule"},{"id":"T10","span":{"begin":311,"end":339},"obj":"protein_molecule"},{"id":"T11","span":{"begin":341,"end":350},"obj":"protein_molecule"},{"id":"T12","span":{"begin":391,"end":395},"obj":"RNA_family_or_group"},{"id":"T13","span":{"begin":399,"end":439},"obj":"cell_type"},{"id":"T14","span":{"begin":441,"end":445},"obj":"cell_type"},{"id":"T15","span":{"begin":478,"end":485},"obj":"atom"},{"id":"T16","span":{"begin":633,"end":637},"obj":"RNA_family_or_group"},{"id":"T17","span":{"begin":641,"end":650},"obj":"protein_molecule"},{"id":"T18","span":{"begin":684,"end":702},"obj":"other_name"},{"id":"T19","span":{"begin":708,"end":712},"obj":"atom"},{"id":"T20","span":{"begin":829,"end":833},"obj":"atom"},{"id":"T21","span":{"begin":838,"end":853},"obj":"other_name"},{"id":"T22","span":{"begin":916,"end":920},"obj":"atom"}],"text":"Stimulation of human peripheral blood mononuclear cells by zinc and related cations.\nZinc is an important trace element for immune function. Here, we show that zinc addition in a serum- and lipopolysaccharide-free cell culture system leads to significantly enhanced levels of interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) and to expression of the corresponding mRNA in human peripheral blood mononuclear cells (PBMC). Structurally related divalent cations like cobalt, nickel, and mercury also partially increase monokine secretion but to a much lower and thus insignificant extent. They fail to induce mRNA of TNF-alpha after 3 h of culture. Therefore, monokine induction is a zinc-specific effect influenced by the physicochemical properties of the ion. Confirmation of the unique significance of zinc for immune function provides a better understanding of the mechanisms of specific zinc-mediated immune modulation."}