PubMed:8980878 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	15-55	cell_type	denotes	human peripheral blood mononuclear cells
T2	276-294	protein	denotes	interleukin 1 beta
T3	296-305	protein	denotes	IL-1 beta
T4	311-339	protein	denotes	tumour necrosis factor alpha
T5	341-350	protein	denotes	TNF-alpha
T6	391-395	RNA	denotes	mRNA
T7	399-439	cell_type	denotes	human peripheral blood mononuclear cells
T8	441-445	cell_type	denotes	PBMC
T9	633-637	RNA	denotes	mRNA
T10	641-650	protein	denotes	TNF-alpha

Id	Subject	Object	Predicate	Lexical cue
S1	0-84	Sentence	denotes	Stimulation of human peripheral blood mononuclear cells by zinc and related cations.
S2	85-140	Sentence	denotes	Zinc is an important trace element for immune function.
S3	141-447	Sentence	denotes	Here, we show that zinc addition in a serum- and lipopolysaccharide-free cell culture system leads to significantly enhanced levels of interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) and to expression of the corresponding mRNA in human peripheral blood mononuclear cells (PBMC).
S4	448-612	Sentence	denotes	Structurally related divalent cations like cobalt, nickel, and mercury also partially increase monokine secretion but to a much lower and thus insignificant extent.
S5	613-672	Sentence	denotes	They fail to induce mRNA of TNF-alpha after 3 h of culture.
S6	673-785	Sentence	denotes	Therefore, monokine induction is a zinc-specific effect influenced by the physicochemical properties of the ion.
S7	786-948	Sentence	denotes	Confirmation of the unique significance of zinc for immune function provides a better understanding of the mechanisms of specific zinc-mediated immune modulation.

Id	Subject	Object	Predicate	Lexical cue
C3	15-55	NP	denotes	human peripheral blood mononuclear cells
C1	59-63	NP	denotes	zinc
C2	85-89	NP	denotes	Zinc
C7	124-139	NP	denotes	immune function
C4	399-446	NP	denotes	human peripheral blood mononuclear cells (PBMC)
C5	708-713	NP	denotes	zinc-
C6	829-833	NP	denotes	zinc
C8	838-853	NP	denotes	immune function
C9	916-921	NP	denotes	zinc-
R1	C2	C1	coref-ident	Zinc,zinc
R2	C4	C3	coref-ident	human peripheral blood mononuclear cells (PBMC),human peripheral blood mononuclear cells
R3	C5	C2	coref-ident	zinc-,Zinc
R4	C6	C5	coref-ident	zinc,zinc-
R5	C8	C7	coref-ident	immune function,immune function
R6	C9	C6	coref-ident	zinc-,zinc

Id	Subject	Object	Predicate	Lexical cue
T1	15-55	cell_type	denotes	human peripheral blood mononuclear cells
T2	59-63	atom	denotes	zinc
T3	76-83	atom	denotes	cations
T4	85-89	atom	denotes	Zinc
T5	106-119	atom	denotes	trace element
T6	124-139	other_name	denotes	immune function
T7	160-164	atom	denotes	zinc
T8	276-294	protein_molecule	denotes	interleukin 1 beta
T9	296-305	protein_molecule	denotes	IL-1 beta
T10	311-339	protein_molecule	denotes	tumour necrosis factor alpha
T11	341-350	protein_molecule	denotes	TNF-alpha
T12	391-395	RNA_family_or_group	denotes	mRNA
T13	399-439	cell_type	denotes	human peripheral blood mononuclear cells
T14	441-445	cell_type	denotes	PBMC
T15	478-485	atom	denotes	cations
T16	633-637	RNA_family_or_group	denotes	mRNA
T17	641-650	protein_molecule	denotes	TNF-alpha
T18	684-702	other_name	denotes	monokine induction
T19	708-712	atom	denotes	zinc
T20	829-833	atom	denotes	zinc
T21	838-853	other_name	denotes	immune function
T22	916-920	atom	denotes	zinc