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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-72 Sentence denotes Engagement of the Lewis X antigen (CD15) results in monocyte activation.
T2 73-248 Sentence denotes We previously reported that monocyte adhesion to tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells increased expression of tissue factor and CD36 on monocytes.
T3 249-452 Sentence denotes Using immunological cross-linking to mimic receptor engagement by natural ligands, we now show that CD15 (Lewis X), a monocyte counter-receptor for endothelial selectins may participate in this response.
T4 453-653 Sentence denotes We used cytokine production as a readout for monocyte activation and found that CD15 cross-linking induced TNF-alpha release from peripheral blood monocytes and cells from the monocytic cell line MM6.
T5 654-810 Sentence denotes Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-alpha mRNA after 3 to 4 hours of cross-linking.
T6 811-991 Sentence denotes CD15 cross-linking also concomitantly increased interleukin-1 beta (IL-1 beta) mRNA, while no apparent change was observed in the levels of beta-actin mRNA, indicating specificity.
T7 992-1174 Sentence denotes To examine transcriptional regulation of cytokine genes by CD15 engagement, a CAT plasmid reporter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6.
T8 1175-1231 Sentence denotes Subsequent cross-linking of CD15 increased CAT activity.
T9 1232-1396 Sentence denotes CD15 engagement by monoclonal antibody also attenuated IL-1 beta transcript degradation, demonstrating that signaling via CD15 also had posttranscriptional effects.
T10 1397-1620 Sentence denotes Nuclear extracts of anti-CD15 cross-linked cells demonstrated enhanced levels of the transcriptional factor activator protein-1, minimally changed nuclear factor-kappa B, and did not affect SV40 promoter specific protein-1.
T11 1621-1701 Sentence denotes We conclude that engagement of CD15 on monocytes results in monocyte activation.
T12 1702-1913 Sentence denotes In addition to its well-recognized adhesive role, CD15 may function as an important signaling molecule capable of initiating proinflammatory events in monocytes that come into contact with activated endothelium.
T1 0-72 Sentence denotes Engagement of the Lewis X antigen (CD15) results in monocyte activation.
T2 73-248 Sentence denotes We previously reported that monocyte adhesion to tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells increased expression of tissue factor and CD36 on monocytes.
T3 249-452 Sentence denotes Using immunological cross-linking to mimic receptor engagement by natural ligands, we now show that CD15 (Lewis X), a monocyte counter-receptor for endothelial selectins may participate in this response.
T4 453-653 Sentence denotes We used cytokine production as a readout for monocyte activation and found that CD15 cross-linking induced TNF-alpha release from peripheral blood monocytes and cells from the monocytic cell line MM6.
T5 654-810 Sentence denotes Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-alpha mRNA after 3 to 4 hours of cross-linking.
T6 811-991 Sentence denotes CD15 cross-linking also concomitantly increased interleukin-1 beta (IL-1 beta) mRNA, while no apparent change was observed in the levels of beta-actin mRNA, indicating specificity.
T7 992-1174 Sentence denotes To examine transcriptional regulation of cytokine genes by CD15 engagement, a CAT plasmid reporter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6.
T8 1175-1231 Sentence denotes Subsequent cross-linking of CD15 increased CAT activity.
T9 1232-1396 Sentence denotes CD15 engagement by monoclonal antibody also attenuated IL-1 beta transcript degradation, demonstrating that signaling via CD15 also had posttranscriptional effects.
T10 1397-1620 Sentence denotes Nuclear extracts of anti-CD15 cross-linked cells demonstrated enhanced levels of the transcriptional factor activator protein-1, minimally changed nuclear factor-kappa B, and did not affect SV40 promoter specific protein-1.
T11 1621-1701 Sentence denotes We conclude that engagement of CD15 on monocytes results in monocyte activation.
T12 1702-1913 Sentence denotes In addition to its well-recognized adhesive role, CD15 may function as an important signaling molecule capable of initiating proinflammatory events in monocytes that come into contact with activated endothelium.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 122-187 cell_line denotes tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells
T2 230-234 protein denotes CD36
T3 367-392 protein denotes monocyte counter-receptor
T4 397-418 protein denotes endothelial selectins
T5 560-569 protein denotes TNF-alpha
T6 583-609 cell_type denotes peripheral blood monocytes
T7 629-652 cell_line denotes monocytic cell line MM6
T8 667-688 protein denotes reverse transcriptase
T9 759-773 RNA denotes TNF-alpha mRNA
T10 859-894 RNA denotes interleukin-1 beta (IL-1 beta) mRNA
T11 951-966 RNA denotes beta-actin mRNA
T12 1033-1047 DNA denotes cytokine genes
T13 1112-1149 DNA denotes IL-1 beta promoter/enhancer sequences
T14 1170-1173 cell_line denotes MM6
T15 1218-1221 protein denotes CAT
T16 1251-1270 protein denotes monoclonal antibody
T17 1287-1296 protein denotes IL-1 beta
T18 1422-1445 cell_type denotes CD15 cross-linked cells
T19 1482-1524 protein denotes transcriptional factor activator protein-1
T20 1544-1566 protein denotes nuclear factor-kappa B
T21 1587-1619 protein denotes SV40 promoter specific protein-1
T22 1853-1862 cell_type denotes monocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-72 Sentence denotes Engagement of the Lewis X antigen (CD15) results in monocyte activation.
S2 73-248 Sentence denotes We previously reported that monocyte adhesion to tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells increased expression of tissue factor and CD36 on monocytes.
S3 249-452 Sentence denotes Using immunological cross-linking to mimic receptor engagement by natural ligands, we now show that CD15 (Lewis X), a monocyte counter-receptor for endothelial selectins may participate in this response.
S4 453-653 Sentence denotes We used cytokine production as a readout for monocyte activation and found that CD15 cross-linking induced TNF-alpha release from peripheral blood monocytes and cells from the monocytic cell line MM6.
S5 654-810 Sentence denotes Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-alpha mRNA after 3 to 4 hours of cross-linking.
S6 811-991 Sentence denotes CD15 cross-linking also concomitantly increased interleukin-1 beta (IL-1 beta) mRNA, while no apparent change was observed in the levels of beta-actin mRNA, indicating specificity.
S7 992-1174 Sentence denotes To examine transcriptional regulation of cytokine genes by CD15 engagement, a CAT plasmid reporter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6.
S8 1175-1231 Sentence denotes Subsequent cross-linking of CD15 increased CAT activity.
S9 1232-1396 Sentence denotes CD15 engagement by monoclonal antibody also attenuated IL-1 beta transcript degradation, demonstrating that signaling via CD15 also had posttranscriptional effects.
S10 1397-1620 Sentence denotes Nuclear extracts of anti-CD15 cross-linked cells demonstrated enhanced levels of the transcriptional factor activator protein-1, minimally changed nuclear factor-kappa B, and did not affect SV40 promoter specific protein-1.
S11 1621-1701 Sentence denotes We conclude that engagement of CD15 on monocytes results in monocyte activation.
S12 1702-1913 Sentence denotes In addition to its well-recognized adhesive role, CD15 may function as an important signaling molecule capable of initiating proinflammatory events in monocytes that come into contact with activated endothelium.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 14-40 NP denotes the Lewis X antigen (CD15)
C1 0-40 NP denotes Engagement of the Lewis X antigen (CD15)
C3 52-71 NP denotes monocyte activation
C4 238-247 NP denotes monocytes
C5 349-363 NP denotes CD15 (Lewis X)
C6 365-418 NP denotes a monocyte counter-receptor for endothelial selectins
C7 498-517 NP denotes monocyte activation
C8 533-551 NP denotes CD15 cross-linking
C9 625-652 NP denotes the monocytic cell line MM6
C10 811-829 NP denotes CD15 cross-linking
C11 1051-1066 NP denotes CD15 engagement
C12 1170-1173 NP denotes MM6
C13 1203-1207 NP denotes CD15
C14 1232-1247 NP denotes CD15 engagement
C15 1354-1358 NP denotes CD15
C17 1652-1656 NP denotes CD15
C16 1638-1656 NP denotes engagement of CD15
C18 1660-1669 NP denotes monocytes
C19 1681-1700 NP denotes monocyte activation
C20 1717-1720 NP denotes its
C21 1752-1756 NP denotes CD15
C22 1853-1862 NP denotes monocytes
C23 1863-1867 NP denotes that
R1 C5 C2 coref-ident CD15 (Lewis X),the Lewis X antigen (CD15)
R2 C6 C5 coref-appos a monocyte counter-receptor for endothelial selectins,CD15 (Lewis X)
R3 C7 C3 coref-ident monocyte activation,monocyte activation
R4 C10 C8 coref-ident CD15 cross-linking,CD15 cross-linking
R5 C11 C1 coref-ident CD15 engagement,Engagement of the Lewis X antigen (CD15)
R6 C12 C9 coref-ident MM6,the monocytic cell line MM6
R7 C13 C5 coref-ident CD15,CD15 (Lewis X)
R8 C14 C11 coref-ident CD15 engagement,CD15 engagement
R9 C15 C13 coref-ident CD15,CD15
R10 C17 C15 coref-ident CD15,CD15
R11 C16 C14 coref-ident engagement of CD15,CD15 engagement
R12 C18 C4 coref-ident monocytes,monocytes
R13 C19 C7 coref-ident monocyte activation,monocyte activation
R14 C20 C17 coref-pron its,CD15
R15 C21 C17 coref-ident CD15,CD15
R16 C23 C22 coref-relat that,monocytes

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-33 carbohydrate denotes Lewis X antigen
T2 35-39 carbohydrate denotes CD15
T3 52-71 other_name denotes monocyte activation
T4 122-151 cell_line denotes tumor necrosis factor-alpha (
T5 151-160 protein_molecule denotes TNF-alpha
T6 170-187 cell_type denotes endothelial cells
T7 230-234 protein_molecule denotes CD36
T8 349-353 carbohydrate denotes CD15
T9 355-362 carbohydrate denotes Lewis X
T10 367-392 protein_molecule denotes monocyte counter-receptor
T11 397-418 protein_family_or_group denotes endothelial selectins
T12 498-517 other_name denotes monocyte activation
T13 533-537 carbohydrate denotes CD15
T14 560-569 protein_molecule denotes TNF-alpha
T15 583-609 cell_type denotes peripheral blood monocytes
T16 629-652 cell_line denotes monocytic cell line MM6
T17 667-688 protein_molecule denotes reverse transcriptase
T18 716-722 other_name denotes RT-PCR
T19 759-768 protein_molecule denotes TNF-alpha
T20 811-815 carbohydrate denotes CD15
T21 859-877 protein_molecule denotes interleukin-1 beta
T22 879-888 protein_molecule denotes IL-1 beta
T23 951-966 RNA_molecule denotes beta-actin mRNA
T24 1033-1047 DNA_family_or_group denotes cytokine genes
T25 1051-1055 carbohydrate denotes CD15
T26 1112-1121 protein_molecule denotes IL-1 beta
T27 1170-1173 cell_line denotes MM6
T28 1203-1207 carbohydrate denotes CD15
T29 1218-1221 protein_molecule denotes CAT
T30 1232-1236 carbohydrate denotes CD15
T31 1251-1270 protein_family_or_group denotes monoclonal antibody
T32 1287-1296 protein_molecule denotes IL-1 beta
T33 1354-1358 carbohydrate denotes CD15
T34 1368-1395 other_name denotes posttranscriptional effects
T35 1422-1426 carbohydrate denotes CD15
T36 1482-1524 protein_molecule denotes transcriptional factor activator protein-1
T37 1544-1566 protein_complex denotes nuclear factor-kappa B
T38 1587-1600 DNA_domain_or_region denotes SV40 promoter
T39 1652-1656 carbohydrate denotes CD15
T40 1681-1700 other_name denotes monocyte activation
T41 1752-1756 carbohydrate denotes CD15
T42 1827-1849 other_name denotes proinflammatory events
T43 1853-1862 cell_type denotes monocytes
T44 1891-1912 tissue denotes activated endothelium