PubMed:8943243 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8943243","sourcedb":"PubMed","sourceid":"8943243","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8943243","text":"The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells.\nInterferon-gamma (IFN-gamma) is produced by natural killer cells and certain subsets of T cells, but the basis for its selective expression is unknown. Within the region between -108 and -40 base pairs of the IFN-gamma promoter are two conserved and essential regulatory elements, which confer activation-specific expression in T cells. This report describes studies indicating that the most proximal of these two regulatory elements is an important determinant of its restricted expression. The proximal element is a composite site that binds members of the CREB/ATF, AP-1, and octamer families of transcription factors. Jun is essential for activation-induced transcription and binds preferably as a heterodimer with ATF-2. In contrast, CREB appears to dampen transcription from this element. The CpG dinucleotide in this element is selectively methylated in Th2 T cells and other cells that do not express IFN-gamma, and methylation markedly reduces transcription factor binding. As a target for DNA methylation and for binding of transcription factors that mediate or impede transcription, this element appears to play a central role in controlling IFN-gamma expression.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C5","span":{"begin":35,"end":64},"obj":"NP"},{"id":"C2","span":{"begin":98,"end":105},"obj":"NP"},{"id":"C1","span":{"begin":107,"end":135},"obj":"NP"},{"id":"C3","span":{"begin":195,"end":202},"obj":"NP"},{"id":"C4","span":{"begin":222,"end":225},"obj":"NP"},{"id":"C6","span":{"begin":312,"end":334},"obj":"NP"},{"id":"C7","span":{"begin":339,"end":386},"obj":"NP"},{"id":"C8","span":{"begin":388,"end":393},"obj":"NP"},{"id":"C9","span":{"begin":435,"end":442},"obj":"NP"},{"id":"C11","span":{"begin":511,"end":540},"obj":"NP"},{"id":"C13","span":{"begin":490,"end":540},"obj":"NP"},{"id":"C12","span":{"begin":572,"end":575},"obj":"NP"},{"id":"C14","span":{"begin":599,"end":619},"obj":"NP"},{"id":"C15","span":{"begin":623,"end":639},"obj":"NP"},{"id":"C16","span":{"begin":640,"end":644},"obj":"NP"},{"id":"C17","span":{"begin":888,"end":900},"obj":"NP"},{"id":"C18","span":{"begin":926,"end":938},"obj":"NP"},{"id":"C19","span":{"begin":984,"end":995},"obj":"NP"},{"id":"C20","span":{"begin":996,"end":1000},"obj":"NP"},{"id":"C21","span":{"begin":1016,"end":1025},"obj":"NP"},{"id":"C22","span":{"begin":1141,"end":1162},"obj":"NP"},{"id":"C23","span":{"begin":1163,"end":1167},"obj":"NP"},{"id":"C24","span":{"begin":1201,"end":1213},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-pron","subj":"C4","obj":"C1"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R4","pred":"coref-relat","subj":"C8","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C3"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C7"},{"id":"R7","pred":"coref-pron","subj":"C12","obj":"C13"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C13"},{"id":"R9","pred":"coref-relat","subj":"C16","obj":"C15"},{"id":"R10","pred":"coref-ident","subj":"C17","obj":"C14"},{"id":"R11","pred":"coref-ident","subj":"C18","obj":"C17"},{"id":"R12","pred":"coref-relat","subj":"C20","obj":"C19"},{"id":"R13","pred":"coref-ident","subj":"C21","obj":"C1"},{"id":"R14","pred":"coref-relat","subj":"C23","obj":"C22"},{"id":"R15","pred":"coref-ident","subj":"C24","obj":"C18"}],"attributes":[{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C24","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":39,"end":64},"obj":"DNA"},{"id":"T2","span":{"begin":98,"end":105},"obj":"cell_type"},{"id":"T3","span":{"begin":107,"end":123},"obj":"protein"},{"id":"T4","span":{"begin":125,"end":134},"obj":"protein"},{"id":"T5","span":{"begin":151,"end":171},"obj":"cell_type"},{"id":"T6","span":{"begin":195,"end":202},"obj":"cell_type"},{"id":"T7","span":{"begin":316,"end":325},"obj":"protein"},{"id":"T8","span":{"begin":367,"end":386},"obj":"DNA"},{"id":"T9","span":{"begin":435,"end":442},"obj":"cell_type"},{"id":"T10","span":{"begin":521,"end":540},"obj":"DNA"},{"id":"T11","span":{"begin":666,"end":674},"obj":"protein"},{"id":"T12","span":{"begin":676,"end":680},"obj":"protein"},{"id":"T13","span":{"begin":686,"end":702},"obj":"protein"},{"id":"T14","span":{"begin":706,"end":727},"obj":"protein"},{"id":"T15","span":{"begin":729,"end":732},"obj":"protein"},{"id":"T16","span":{"begin":826,"end":831},"obj":"protein"},{"id":"T17","span":{"begin":846,"end":850},"obj":"protein"},{"id":"T18","span":{"begin":931,"end":938},"obj":"DNA"},{"id":"T19","span":{"begin":968,"end":979},"obj":"cell_type"},{"id":"T20","span":{"begin":1016,"end":1025},"obj":"protein"},{"id":"T21","span":{"begin":1060,"end":1080},"obj":"protein"},{"id":"T22","span":{"begin":1141,"end":1162},"obj":"protein"},{"id":"T23","span":{"begin":1260,"end":1269},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"T2","span":{"begin":107,"end":258},"obj":"Sentence"},{"id":"T3","span":{"begin":259,"end":443},"obj":"Sentence"},{"id":"T4","span":{"begin":444,"end":598},"obj":"Sentence"},{"id":"T5","span":{"begin":599,"end":728},"obj":"Sentence"},{"id":"T6","span":{"begin":729,"end":832},"obj":"Sentence"},{"id":"T7","span":{"begin":833,"end":901},"obj":"Sentence"},{"id":"T8","span":{"begin":902,"end":1089},"obj":"Sentence"},{"id":"T9","span":{"begin":1090,"end":1281},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"T2","span":{"begin":107,"end":258},"obj":"Sentence"},{"id":"T3","span":{"begin":259,"end":443},"obj":"Sentence"},{"id":"T4","span":{"begin":444,"end":598},"obj":"Sentence"},{"id":"T5","span":{"begin":599,"end":728},"obj":"Sentence"},{"id":"T6","span":{"begin":729,"end":832},"obj":"Sentence"},{"id":"T7","span":{"begin":833,"end":901},"obj":"Sentence"},{"id":"T8","span":{"begin":902,"end":1089},"obj":"Sentence"},{"id":"T9","span":{"begin":1090,"end":1281},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"S2","span":{"begin":107,"end":258},"obj":"Sentence"},{"id":"S3","span":{"begin":259,"end":443},"obj":"Sentence"},{"id":"S4","span":{"begin":444,"end":598},"obj":"Sentence"},{"id":"S5","span":{"begin":599,"end":728},"obj":"Sentence"},{"id":"S6","span":{"begin":729,"end":832},"obj":"Sentence"},{"id":"S7","span":{"begin":833,"end":901},"obj":"Sentence"},{"id":"S8","span":{"begin":902,"end":1089},"obj":"Sentence"},{"id":"S9","span":{"begin":1090,"end":1281},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":39,"end":55},"obj":"protein_molecule"},{"id":"T2","span":{"begin":98,"end":105},"obj":"cell_type"},{"id":"T3","span":{"begin":107,"end":123},"obj":"protein_molecule"},{"id":"T4","span":{"begin":125,"end":134},"obj":"protein_molecule"},{"id":"T5","span":{"begin":151,"end":171},"obj":"cell_type"},{"id":"T6","span":{"begin":195,"end":202},"obj":"cell_type"},{"id":"T7","span":{"begin":316,"end":325},"obj":"protein_molecule"},{"id":"T8","span":{"begin":367,"end":386},"obj":"DNA_family_or_group"},{"id":"T9","span":{"begin":435,"end":442},"obj":"cell_type"},{"id":"T10","span":{"begin":521,"end":540},"obj":"DNA_family_or_group"},{"id":"T11","span":{"begin":576,"end":597},"obj":"other_name"},{"id":"T12","span":{"begin":666,"end":674},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":676,"end":680},"obj":"protein_family_or_group"},{"id":"T14","span":{"begin":686,"end":702},"obj":"protein_family_or_group"},{"id":"T15","span":{"begin":706,"end":727},"obj":"protein_family_or_group"},{"id":"T16","span":{"begin":729,"end":732},"obj":"protein_family_or_group"},{"id":"T17","span":{"begin":750,"end":782},"obj":"other_name"},{"id":"T18","span":{"begin":826,"end":831},"obj":"protein_molecule"},{"id":"T19","span":{"begin":846,"end":850},"obj":"protein_family_or_group"},{"id":"T20","span":{"begin":906,"end":922},"obj":"nucleotide"},{"id":"T21","span":{"begin":931,"end":938},"obj":"DNA_domain_or_region"},{"id":"T22","span":{"begin":968,"end":979},"obj":"cell_type"},{"id":"T23","span":{"begin":1016,"end":1025},"obj":"protein_molecule"},{"id":"T24","span":{"begin":1060,"end":1080},"obj":"protein_family_or_group"},{"id":"T25","span":{"begin":1106,"end":1121},"obj":"other_name"},{"id":"T26","span":{"begin":1141,"end":1162},"obj":"protein_family_or_group"},{"id":"T27","span":{"begin":1260,"end":1269},"obj":"protein_molecule"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":4,"end":12},"obj":"http://purl.obolibrary.org/obo/MAT_0000491"},{"id":"T2","span":{"begin":499,"end":507},"obj":"http://purl.obolibrary.org/obo/MAT_0000491"},{"id":"T3","span":{"begin":603,"end":611},"obj":"http://purl.obolibrary.org/obo/MAT_0000491"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T2","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T3","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":4,"end":12},"obj":"Body_part"},{"id":"T2","span":{"begin":499,"end":507},"obj":"Body_part"},{"id":"T3","span":{"begin":603,"end":611},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000491"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000491"},{"id":"A3","pred":"mat_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MAT_0000491"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"},{"subj":"T3","pred":"source","obj":"Anatomy-MAT"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":98,"end":105},"obj":"Cell"},{"id":"T2","span":{"begin":151,"end":171},"obj":"Cell"},{"id":"T3","span":{"begin":195,"end":202},"obj":"Cell"},{"id":"T4","span":{"begin":435,"end":442},"obj":"Cell"},{"id":"T5","span":{"begin":968,"end":979},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000623"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000546"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"},{"subj":"T3","pred":"source","obj":"CL-cell"},{"subj":"T4","pred":"source","obj":"CL-cell"},{"subj":"T5","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#93c4ec","default":true},{"id":"jnlpba-st-training","color":"#deec93"},{"id":"sentences","color":"#e093ec"},{"id":"pubmed-sentences-benchmark","color":"#93ecc6"},{"id":"GENIAcorpus","color":"#ecac93"},{"id":"Glycosmos6-MAT","color":"#9393ec"},{"id":"Anatomy-MAT","color":"#adec93"},{"id":"CL-cell","color":"#ec93c7"}]}]}}