PubMed:8809111
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8809111","sourcedb":"PubMed","sourceid":"8809111","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8809111","text":"Characterization of the human myeloid cell nuclear differentiation antigen gene promoter.\nMNDA (myeloid cell nuclear differentiation antigen) is an interferon alpha regulated nuclear protein expressed only in cells of the human myelomonocytic lineage. To identify mechanisms responsible for this lineage-specific and interferon-regulated expression, the 5' flanking sequence of the gene has been characterized. Two interferon-stimulated response elements (ISRE) flank a multiple transcription start site region identifying MNDA as a TATA-less interferon-regulated gene. Other DNA elements present include a cluster of Myb sites, several Ets, an Ets related PU.1 site and an Sp1 site located within 600 bp of the transcription start sites. In addition, DNA methylation was revealed as one of the possible factors in establishing MNDA expression. The 5' flanking sequence has promoter activity which is elevated by interferon alpha. The findings indicate that MNDA expression is regulated by mechanisms similar to other myelomonocytic cell specific genes and genes up-regulated by interferon alpha.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":90,"end":141},"obj":"NP"},{"id":"C3","span":{"begin":291,"end":348},"obj":"NP"},{"id":"C5","span":{"begin":378,"end":386},"obj":"NP"},{"id":"C6","span":{"begin":350,"end":386},"obj":"NP"},{"id":"C2","span":{"begin":523,"end":527},"obj":"NP"},{"id":"C4","span":{"begin":828,"end":843},"obj":"NP"},{"id":"C7","span":{"begin":845,"end":869},"obj":"NP"},{"id":"C8","span":{"begin":874,"end":891},"obj":"NP"},{"id":"C9","span":{"begin":892,"end":897},"obj":"NP"},{"id":"C11","span":{"begin":913,"end":929},"obj":"NP"},{"id":"C10","span":{"begin":958,"end":973},"obj":"NP"},{"id":"C12","span":{"begin":1079,"end":1095},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C5","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R3","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-relat","subj":"C9","obj":"C8"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C4"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C11"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":24,"end":88},"obj":"DNA"},{"id":"T2","span":{"begin":90,"end":94},"obj":"protein"},{"id":"T3","span":{"begin":96,"end":140},"obj":"protein"},{"id":"T4","span":{"begin":148,"end":190},"obj":"protein"},{"id":"T5","span":{"begin":222,"end":250},"obj":"cell_type"},{"id":"T6","span":{"begin":354,"end":374},"obj":"DNA"},{"id":"T7","span":{"begin":415,"end":454},"obj":"DNA"},{"id":"T8","span":{"begin":456,"end":460},"obj":"DNA"},{"id":"T9","span":{"begin":523,"end":527},"obj":"protein"},{"id":"T10","span":{"begin":533,"end":568},"obj":"DNA"},{"id":"T11","span":{"begin":576,"end":588},"obj":"DNA"},{"id":"T12","span":{"begin":618,"end":627},"obj":"DNA"},{"id":"T13","span":{"begin":637,"end":640},"obj":"DNA"},{"id":"T14","span":{"begin":645,"end":666},"obj":"DNA"},{"id":"T15","span":{"begin":674,"end":682},"obj":"DNA"},{"id":"T16","span":{"begin":712,"end":737},"obj":"DNA"},{"id":"T17","span":{"begin":828,"end":832},"obj":"protein"},{"id":"T18","span":{"begin":849,"end":869},"obj":"DNA"},{"id":"T19","span":{"begin":913,"end":929},"obj":"protein"},{"id":"T20","span":{"begin":958,"end":962},"obj":"protein"},{"id":"T21","span":{"begin":1018,"end":1052},"obj":"DNA"},{"id":"T22","span":{"begin":1079,"end":1095},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":24,"end":29},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":222,"end":227},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":89},"obj":"Sentence"},{"id":"S2","span":{"begin":90,"end":251},"obj":"Sentence"},{"id":"S3","span":{"begin":252,"end":410},"obj":"Sentence"},{"id":"S4","span":{"begin":411,"end":569},"obj":"Sentence"},{"id":"S5","span":{"begin":570,"end":738},"obj":"Sentence"},{"id":"S6","span":{"begin":739,"end":844},"obj":"Sentence"},{"id":"S7","span":{"begin":845,"end":930},"obj":"Sentence"},{"id":"S8","span":{"begin":931,"end":1096},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":24,"end":66},"obj":"other_name"},{"id":"T2","span":{"begin":90,"end":94},"obj":"protein_molecule"},{"id":"T3","span":{"begin":96,"end":140},"obj":"protein_molecule"},{"id":"T4","span":{"begin":148,"end":190},"obj":"protein_family_or_group"},{"id":"T5","span":{"begin":222,"end":250},"obj":"cell_type"},{"id":"T6","span":{"begin":354,"end":374},"obj":"DNA_domain_or_region"},{"id":"T7","span":{"begin":415,"end":454},"obj":"DNA_domain_or_region"},{"id":"T8","span":{"begin":456,"end":460},"obj":"DNA_domain_or_region"},{"id":"T9","span":{"begin":523,"end":527},"obj":"protein_molecule"},{"id":"T10","span":{"begin":533,"end":568},"obj":"DNA_domain_or_region"},{"id":"T11","span":{"begin":576,"end":588},"obj":"DNA_family_or_group"},{"id":"T12","span":{"begin":618,"end":627},"obj":"DNA_domain_or_region"},{"id":"T13","span":{"begin":637,"end":640},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":645,"end":666},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":674,"end":682},"obj":"DNA_domain_or_region"},{"id":"T16","span":{"begin":698,"end":704},"obj":"polynucleotide"},{"id":"T17","span":{"begin":712,"end":737},"obj":"DNA_domain_or_region"},{"id":"T18","span":{"begin":752,"end":767},"obj":"other_name"},{"id":"T19","span":{"begin":828,"end":832},"obj":"protein_molecule"},{"id":"T20","span":{"begin":849,"end":869},"obj":"DNA_domain_or_region"},{"id":"T21","span":{"begin":874,"end":891},"obj":"other_name"},{"id":"T22","span":{"begin":913,"end":929},"obj":"protein_molecule"},{"id":"T23","span":{"begin":958,"end":962},"obj":"protein_molecule"},{"id":"T24","span":{"begin":1018,"end":1052},"obj":"DNA_family_or_group"},{"id":"T25","span":{"begin":1079,"end":1095},"obj":"protein_molecule"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":30,"end":42},"obj":"Body_part"},{"id":"T2","span":{"begin":96,"end":108},"obj":"Body_part"},{"id":"T3","span":{"begin":462,"end":467},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000763"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000763"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000180"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":30,"end":42},"obj":"Cell"},{"id":"T2","span":{"begin":96,"end":108},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000763"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000763"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#93b6ec","default":true},{"id":"jnlpba-st-training","color":"#d0ec93"},{"id":"NCBITAXON","color":"#ec93ea"},{"id":"pubmed-sentences-benchmark","color":"#93ecd4"},{"id":"GENIAcorpus","color":"#ecba93"},{"id":"Anatomy-UBERON","color":"#a093ec"},{"id":"CL-cell","color":"#a0ec93"}]}]}}