PubMed:8724135 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8724135","sourcedb":"PubMed","sourceid":"8724135","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8724135","text":"Transcription of the beta-galactoside alpha 2,6-sialyltransferase gene in B lymphocytes is directed by a separate and distinct promoter.\nA single human gene, SIAT1, encodes the beta-galactoside alpha 2,6-sialyltransferase from which multiple mRNA isoforms are generated. In rat, expression of the hepatic mRNA isoform (Form 1) has been defined with respect to the transcriptional initiation site and promoter region. We show here that a similar hepatic SIAT1 mRNA isoform exists in human. Another human mRNA isoform, a mature B-cell-specific mRNA isoform (Form 2), was previously reported. Here, we used 5'-RACE and S1 nuclease protection analysis to define the 5'-untranslated region of Form 2 human SIAT1 mRNA. We demonstrate conclusively that Form 2 mRNA is initiated from a point completely distinct from that of Form 1 mRNA. A number of cis-acting regulatory elements residing immediately 5'of the Form 2 initiation site includes AP-1, AP-2, NF-kappa B, NF-IL6, C/EBP, and CREB. A TATAA box is also present 29 bp 5' of the transcriptional initiation site. CAT reporter gene expression from serially-truncated segments of the 5'-flanking region of the Form 2 initiation site indicates that the segment between -784 and +125 was sufficient to promote high level CAT expression in Louckes, a mature B-cell line. The 5'-flanking region to the human Form 1 initiation site is competent in expression of CAT upon transfection of the fusion construct into HepG2, a human hepatoma cell line. Cellular specificity of expression is apparently retained. Louckes cells expressed CAT efficiently from Form 2 promoter but only marginally from the Form 1 promoter. In contrast, CAT expression from Form 1 promoter is more efficient than from the Form 2 promoter in HepG2 cells.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":137,"end":270},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":271,"end":416},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":417,"end":488},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":489,"end":589},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":590,"end":712},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":713,"end":829},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":830,"end":983},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":984,"end":1060},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1061,"end":1313},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1314,"end":1488},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1489,"end":1547},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1548,"end":1654},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1655,"end":1767},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"T2","span":{"begin":137,"end":270},"obj":"Sentence"},{"id":"T3","span":{"begin":271,"end":416},"obj":"Sentence"},{"id":"T4","span":{"begin":417,"end":488},"obj":"Sentence"},{"id":"T5","span":{"begin":489,"end":589},"obj":"Sentence"},{"id":"T6","span":{"begin":590,"end":712},"obj":"Sentence"},{"id":"T7","span":{"begin":713,"end":829},"obj":"Sentence"},{"id":"T8","span":{"begin":830,"end":983},"obj":"Sentence"},{"id":"T9","span":{"begin":984,"end":1060},"obj":"Sentence"},{"id":"T10","span":{"begin":1061,"end":1313},"obj":"Sentence"},{"id":"T11","span":{"begin":1314,"end":1488},"obj":"Sentence"},{"id":"T12","span":{"begin":1489,"end":1547},"obj":"Sentence"},{"id":"T13","span":{"begin":1548,"end":1654},"obj":"Sentence"},{"id":"T14","span":{"begin":1655,"end":1767},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"T2","span":{"begin":137,"end":270},"obj":"Sentence"},{"id":"T3","span":{"begin":271,"end":416},"obj":"Sentence"},{"id":"T4","span":{"begin":417,"end":488},"obj":"Sentence"},{"id":"T5","span":{"begin":489,"end":589},"obj":"Sentence"},{"id":"T6","span":{"begin":590,"end":712},"obj":"Sentence"},{"id":"T7","span":{"begin":713,"end":829},"obj":"Sentence"},{"id":"T8","span":{"begin":830,"end":983},"obj":"Sentence"},{"id":"T9","span":{"begin":984,"end":1060},"obj":"Sentence"},{"id":"T10","span":{"begin":1061,"end":1313},"obj":"Sentence"},{"id":"T11","span":{"begin":1314,"end":1488},"obj":"Sentence"},{"id":"T12","span":{"begin":1489,"end":1547},"obj":"Sentence"},{"id":"T13","span":{"begin":1548,"end":1654},"obj":"Sentence"},{"id":"T14","span":{"begin":1655,"end":1767},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T13","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T14","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":1403,"end":1406},"obj":"gene:847"},{"id":"T1","span":{"begin":1469,"end":1477},"obj":"disease:C0023903"},{"id":"T2","span":{"begin":1403,"end":1406},"obj":"gene:847"},{"id":"T3","span":{"begin":1469,"end":1477},"obj":"disease:C2239176"},{"id":"T4","span":{"begin":1403,"end":1406},"obj":"gene:1384"},{"id":"T5","span":{"begin":1469,"end":1477},"obj":"disease:C0023903"},{"id":"T6","span":{"begin":1403,"end":1406},"obj":"gene:1384"},{"id":"T7","span":{"begin":1469,"end":1477},"obj":"disease:C2239176"},{"id":"T8","span":{"begin":1403,"end":1406},"obj":"gene:10249"},{"id":"T9","span":{"begin":1469,"end":1477},"obj":"disease:C0023903"},{"id":"T10","span":{"begin":1403,"end":1406},"obj":"gene:10249"},{"id":"T11","span":{"begin":1469,"end":1477},"obj":"disease:C2239176"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"}]},{"project":"GlycoBiology-FMA","denotations":[{"id":"_T1","span":{"begin":66,"end":70},"obj":"FMAID:198663"},{"id":"_T2","span":{"begin":74,"end":87},"obj":"FMAID:167173"},{"id":"_T3","span":{"begin":74,"end":87},"obj":"FMAID:62869"},{"id":"_T4","span":{"begin":74,"end":87},"obj":"FMAID:167174"},{"id":"_T5","span":{"begin":74,"end":87},"obj":"FMAID:167176"},{"id":"_T6","span":{"begin":74,"end":87},"obj":"FMAID:167171"},{"id":"_T7","span":{"begin":74,"end":87},"obj":"FMAID:62870"},{"id":"_T8","span":{"begin":76,"end":87},"obj":"FMAID:167163"},{"id":"_T9","span":{"begin":76,"end":87},"obj":"FMAID:62863"},{"id":"_T10","span":{"begin":152,"end":156},"obj":"FMAID:198663"},{"id":"_T11","span":{"begin":616,"end":618},"obj":"FMAID:63522"},{"id":"_T12","span":{"begin":616,"end":618},"obj":"FMAID:167750"},{"id":"_T13","span":{"begin":778,"end":783},"obj":"FMAID:146304"},{"id":"_T14","span":{"begin":778,"end":783},"obj":"FMAID:50596"},{"id":"_T15","span":{"begin":1074,"end":1078},"obj":"FMAID:198663"},{"id":"_T16","span":{"begin":1114,"end":1122},"obj":"FMAID:256626"},{"id":"_T17","span":{"begin":1114,"end":1122},"obj":"FMAID:11367"},{"id":"_T18","span":{"begin":1114,"end":1122},"obj":"FMAID:99729"},{"id":"_T19","span":{"begin":1114,"end":1122},"obj":"FMAID:256624"},{"id":"_T20","span":{"begin":1114,"end":1122},"obj":"FMAID:256625"},{"id":"_T21","span":{"begin":1114,"end":1122},"obj":"FMAID:256632"},{"id":"_T22","span":{"begin":1114,"end":1122},"obj":"FMAID:256633"},{"id":"_T23","span":{"begin":1114,"end":1122},"obj":"FMAID:256627"},{"id":"_T24","span":{"begin":1114,"end":1122},"obj":"FMAID:256630"},{"id":"_T25","span":{"begin":1114,"end":1122},"obj":"FMAID:256631"},{"id":"_T26","span":{"begin":1114,"end":1122},"obj":"FMAID:256628"},{"id":"_T27","span":{"begin":1114,"end":1122},"obj":"FMAID:256629"},{"id":"_T28","span":{"begin":1114,"end":1129},"obj":"FMAID:258811"},{"id":"_T29","span":{"begin":1114,"end":1129},"obj":"FMAID:74845"},{"id":"_T30","span":{"begin":1133,"end":1141},"obj":"FMAID:104341"},{"id":"_T31","span":{"begin":1198,"end":1205},"obj":"FMAID:256633"},{"id":"_T32","span":{"begin":1198,"end":1205},"obj":"FMAID:256627"},{"id":"_T33","span":{"begin":1198,"end":1205},"obj":"FMAID:256630"},{"id":"_T34","span":{"begin":1198,"end":1205},"obj":"FMAID:256631"},{"id":"_T35","span":{"begin":1198,"end":1205},"obj":"FMAID:256625"},{"id":"_T36","span":{"begin":1198,"end":1205},"obj":"FMAID:256624"},{"id":"_T37","span":{"begin":1198,"end":1205},"obj":"FMAID:256632"},{"id":"_T38","span":{"begin":1198,"end":1205},"obj":"FMAID:256626"},{"id":"_T39","span":{"begin":1198,"end":1205},"obj":"FMAID:256629"},{"id":"_T40","span":{"begin":1198,"end":1205},"obj":"FMAID:256628"},{"id":"_T41","span":{"begin":1198,"end":1205},"obj":"FMAID:99729"},{"id":"_T42","span":{"begin":1198,"end":1205},"obj":"FMAID:11367"},{"id":"_T43","span":{"begin":1321,"end":1329},"obj":"FMAID:104341"},{"id":"_T44","span":{"begin":1556,"end":1561},"obj":"FMAID:68646"},{"id":"_T45","span":{"begin":1556,"end":1561},"obj":"FMAID:169002"},{"id":"_T46","span":{"begin":1761,"end":1766},"obj":"FMAID:68646"},{"id":"_T47","span":{"begin":1761,"end":1766},"obj":"FMAID:169002"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"attributes":[{"subj":"_T1","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T2","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T3","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T4","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T5","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T6","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T7","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T8","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T9","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T10","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T11","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T12","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T13","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T14","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T15","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T16","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T17","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T18","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T19","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T20","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T21","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T22","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T23","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T24","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T25","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T26","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T27","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T28","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T29","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T30","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T31","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T32","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T33","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T34","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T35","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T36","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T37","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T38","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T39","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T40","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T41","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T42","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T43","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T44","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T45","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T46","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T47","pred":"source","obj":"GlycoBiology-FMA"}]},{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":158,"end":163},"obj":"http://www.uniprot.org/uniprot/P15907"},{"id":"T2","span":{"begin":453,"end":458},"obj":"http://www.uniprot.org/uniprot/P15907"},{"id":"T3","span":{"begin":701,"end":706},"obj":"http://www.uniprot.org/uniprot/P15907"},{"id":"T4","span":{"begin":941,"end":945},"obj":"http://www.uniprot.org/uniprot/P05549"},{"id":"T5","span":{"begin":962,"end":965},"obj":"http://www.uniprot.org/uniprot/P05231"},{"id":"T6","span":{"begin":969,"end":972},"obj":"http://www.uniprot.org/uniprot/Q15125"},{"id":"T7","span":{"begin":969,"end":972},"obj":"http://www.uniprot.org/uniprot/Q5HYK7"},{"id":"T8","span":{"begin":1061,"end":1064},"obj":"http://www.uniprot.org/uniprot/P04040"},{"id":"T9","span":{"begin":1265,"end":1268},"obj":"http://www.uniprot.org/uniprot/P04040"},{"id":"T10","span":{"begin":1403,"end":1406},"obj":"http://www.uniprot.org/uniprot/P04040"},{"id":"T11","span":{"begin":1572,"end":1575},"obj":"http://www.uniprot.org/uniprot/P04040"},{"id":"T12","span":{"begin":1668,"end":1671},"obj":"http://www.uniprot.org/uniprot/P04040"},{"id":"T13","span":{"begin":1061,"end":1064},"obj":"http://www.uniprot.org/uniprot/Q6IB77"},{"id":"T14","span":{"begin":1265,"end":1268},"obj":"http://www.uniprot.org/uniprot/Q6IB77"},{"id":"T15","span":{"begin":1403,"end":1406},"obj":"http://www.uniprot.org/uniprot/Q6IB77"},{"id":"T16","span":{"begin":1572,"end":1575},"obj":"http://www.uniprot.org/uniprot/Q6IB77"},{"id":"T17","span":{"begin":1668,"end":1671},"obj":"http://www.uniprot.org/uniprot/Q6IB77"},{"id":"T18","span":{"begin":1061,"end":1064},"obj":"http://www.uniprot.org/uniprot/P43155"},{"id":"T19","span":{"begin":1265,"end":1268},"obj":"http://www.uniprot.org/uniprot/P43155"},{"id":"T20","span":{"begin":1403,"end":1406},"obj":"http://www.uniprot.org/uniprot/P43155"},{"id":"T21","span":{"begin":1572,"end":1575},"obj":"http://www.uniprot.org/uniprot/P43155"},{"id":"T22","span":{"begin":1668,"end":1671},"obj":"http://www.uniprot.org/uniprot/P43155"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-human"},{"subj":"T2","pred":"source","obj":"uniprot-human"},{"subj":"T3","pred":"source","obj":"uniprot-human"},{"subj":"T4","pred":"source","obj":"uniprot-human"},{"subj":"T5","pred":"source","obj":"uniprot-human"},{"subj":"T6","pred":"source","obj":"uniprot-human"},{"subj":"T7","pred":"source","obj":"uniprot-human"},{"subj":"T8","pred":"source","obj":"uniprot-human"},{"subj":"T9","pred":"source","obj":"uniprot-human"},{"subj":"T10","pred":"source","obj":"uniprot-human"},{"subj":"T11","pred":"source","obj":"uniprot-human"},{"subj":"T12","pred":"source","obj":"uniprot-human"},{"subj":"T13","pred":"source","obj":"uniprot-human"},{"subj":"T14","pred":"source","obj":"uniprot-human"},{"subj":"T15","pred":"source","obj":"uniprot-human"},{"subj":"T16","pred":"source","obj":"uniprot-human"},{"subj":"T17","pred":"source","obj":"uniprot-human"},{"subj":"T18","pred":"source","obj":"uniprot-human"},{"subj":"T19","pred":"source","obj":"uniprot-human"},{"subj":"T20","pred":"source","obj":"uniprot-human"},{"subj":"T21","pred":"source","obj":"uniprot-human"},{"subj":"T22","pred":"source","obj":"uniprot-human"}]},{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":842,"end":845},"obj":"http://www.uniprot.org/uniprot/Q62225"},{"id":"T2","span":{"begin":935,"end":939},"obj":"http://www.uniprot.org/uniprot/P05627"},{"id":"T3","span":{"begin":941,"end":945},"obj":"http://www.uniprot.org/uniprot/Q91VX0"},{"id":"T4","span":{"begin":1061,"end":1064},"obj":"http://www.uniprot.org/uniprot/P47934"},{"id":"T5","span":{"begin":1265,"end":1268},"obj":"http://www.uniprot.org/uniprot/P47934"},{"id":"T6","span":{"begin":1403,"end":1406},"obj":"http://www.uniprot.org/uniprot/P47934"},{"id":"T7","span":{"begin":1572,"end":1575},"obj":"http://www.uniprot.org/uniprot/P47934"},{"id":"T8","span":{"begin":1668,"end":1671},"obj":"http://www.uniprot.org/uniprot/P47934"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-mouse"},{"subj":"T2","pred":"source","obj":"uniprot-mouse"},{"subj":"T3","pred":"source","obj":"uniprot-mouse"},{"subj":"T4","pred":"source","obj":"uniprot-mouse"},{"subj":"T5","pred":"source","obj":"uniprot-mouse"},{"subj":"T6","pred":"source","obj":"uniprot-mouse"},{"subj":"T7","pred":"source","obj":"uniprot-mouse"},{"subj":"T8","pred":"source","obj":"uniprot-mouse"}]},{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":21,"end":25},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T2","span":{"begin":21,"end":25},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T3","span":{"begin":177,"end":181},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T4","span":{"begin":177,"end":181},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T5","span":{"begin":842,"end":845},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/245896"},{"id":"T6","span":{"begin":1556,"end":1561},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T7","span":{"begin":1761,"end":1766},"obj":"http://purl.bioontology.org/ontology/STY/T025"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T2","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T3","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T4","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T5","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T6","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T7","pred":"source","obj":"GlycoBiology-NCBITAXON"}]},{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T2","span":{"begin":364,"end":379},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T3","span":{"begin":1028,"end":1043},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T4","span":{"begin":1061,"end":1064},"obj":"http://purl.obolibrary.org/obo/GO_0004096"},{"id":"T5","span":{"begin":1265,"end":1268},"obj":"http://purl.obolibrary.org/obo/GO_0004096"},{"id":"T6","span":{"begin":1403,"end":1406},"obj":"http://purl.obolibrary.org/obo/GO_0004096"},{"id":"T7","span":{"begin":1572,"end":1575},"obj":"http://purl.obolibrary.org/obo/GO_0004096"},{"id":"T8","span":{"begin":1668,"end":1671},"obj":"http://purl.obolibrary.org/obo/GO_0004096"},{"id":"T9","span":{"begin":1074,"end":1089},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T10","span":{"begin":1114,"end":1122},"obj":"http://purl.obolibrary.org/obo/GO_0035282"},{"id":"T11","span":{"begin":1198,"end":1205},"obj":"http://purl.obolibrary.org/obo/GO_0035282"},{"id":"T12","span":{"begin":1489,"end":1497},"obj":"http://purl.obolibrary.org/obo/GO_0007349"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-BP"},{"subj":"T2","pred":"source","obj":"GO-BP"},{"subj":"T3","pred":"source","obj":"GO-BP"},{"subj":"T4","pred":"source","obj":"GO-BP"},{"subj":"T5","pred":"source","obj":"GO-BP"},{"subj":"T6","pred":"source","obj":"GO-BP"},{"subj":"T7","pred":"source","obj":"GO-BP"},{"subj":"T8","pred":"source","obj":"GO-BP"},{"subj":"T9","pred":"source","obj":"GO-BP"},{"subj":"T10","pred":"source","obj":"GO-BP"},{"subj":"T11","pred":"source","obj":"GO-BP"},{"subj":"T12","pred":"source","obj":"GO-BP"}]},{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":528,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":1303,"end":1307},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3","span":{"begin":1478,"end":1482},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4","span":{"begin":1556,"end":1561},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T5","span":{"begin":1761,"end":1766},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-CC"},{"subj":"T2","pred":"source","obj":"GO-CC"},{"subj":"T3","pred":"source","obj":"GO-CC"},{"subj":"T4","pred":"source","obj":"GO-CC"},{"subj":"T5","pred":"source","obj":"GO-CC"}]},{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"http://edamontology.org/topic_0110"},{"id":"T2","span":{"begin":0,"end":13},"obj":"http://edamontology.org/topic_3308"},{"id":"T3","span":{"begin":0,"end":13},"obj":"http://edamontology.org/topic_0203"},{"id":"T4","span":{"begin":0,"end":13},"obj":"http://edamontology.org/topic_3512"},{"id":"T5","span":{"begin":127,"end":135},"obj":"http://edamontology.org/topic_0749"},{"id":"T6","span":{"begin":127,"end":135},"obj":"http://edamontology.org/topic_1312"},{"id":"T7","span":{"begin":127,"end":135},"obj":"http://edamontology.org/topic_0111"},{"id":"T8","span":{"begin":146,"end":151},"obj":"http://edamontology.org/topic_2815"},{"id":"T9","span":{"begin":146,"end":156},"obj":"http://edamontology.org/topic_3574"},{"id":"T10","span":{"begin":364,"end":379},"obj":"http://edamontology.org/topic_3308"},{"id":"T11","span":{"begin":364,"end":379},"obj":"http://edamontology.org/topic_0110"},{"id":"T12","span":{"begin":364,"end":379},"obj":"http://edamontology.org/topic_3512"},{"id":"T13","span":{"begin":364,"end":379},"obj":"http://edamontology.org/topic_0203"},{"id":"T14","span":{"begin":400,"end":408},"obj":"http://edamontology.org/topic_0111"},{"id":"T15","span":{"begin":400,"end":408},"obj":"http://edamontology.org/topic_1312"},{"id":"T16","span":{"begin":400,"end":408},"obj":"http://edamontology.org/topic_0749"},{"id":"T17","span":{"begin":482,"end":487},"obj":"http://edamontology.org/topic_2815"},{"id":"T18","span":{"begin":497,"end":502},"obj":"http://edamontology.org/topic_2815"},{"id":"T19","span":{"begin":695,"end":700},"obj":"http://edamontology.org/topic_2815"},{"id":"T20","span":{"begin":1028,"end":1043},"obj":"http://edamontology.org/topic_3512"},{"id":"T21","span":{"begin":1028,"end":1043},"obj":"http://edamontology.org/topic_3308"},{"id":"T22","span":{"begin":1028,"end":1043},"obj":"http://edamontology.org/topic_0110"},{"id":"T23","span":{"begin":1028,"end":1043},"obj":"http://edamontology.org/topic_0203"},{"id":"T24","span":{"begin":1074,"end":1089},"obj":"http://edamontology.org/topic_0203"},{"id":"T25","span":{"begin":1246,"end":1253},"obj":"http://edamontology.org/topic_1312"},{"id":"T26","span":{"begin":1246,"end":1253},"obj":"http://edamontology.org/topic_0749"},{"id":"T27","span":{"begin":1246,"end":1253},"obj":"http://edamontology.org/topic_0111"},{"id":"T28","span":{"begin":1344,"end":1349},"obj":"http://edamontology.org/topic_2815"},{"id":"T29","span":{"begin":1463,"end":1468},"obj":"http://edamontology.org/topic_2815"},{"id":"T30","span":{"begin":1600,"end":1608},"obj":"http://edamontology.org/topic_0111"},{"id":"T31","span":{"begin":1600,"end":1608},"obj":"http://edamontology.org/topic_1312"},{"id":"T32","span":{"begin":1600,"end":1608},"obj":"http://edamontology.org/topic_0749"},{"id":"T33","span":{"begin":1645,"end":1653},"obj":"http://edamontology.org/topic_0749"},{"id":"T34","span":{"begin":1645,"end":1653},"obj":"http://edamontology.org/topic_0111"},{"id":"T35","span":{"begin":1645,"end":1653},"obj":"http://edamontology.org/topic_1312"},{"id":"T36","span":{"begin":1695,"end":1703},"obj":"http://edamontology.org/topic_0749"},{"id":"T37","span":{"begin":1695,"end":1703},"obj":"http://edamontology.org/topic_0111"},{"id":"T38","span":{"begin":1695,"end":1703},"obj":"http://edamontology.org/topic_1312"},{"id":"T39","span":{"begin":1743,"end":1751},"obj":"http://edamontology.org/topic_0749"},{"id":"T40","span":{"begin":1743,"end":1751},"obj":"http://edamontology.org/topic_0111"},{"id":"T41","span":{"begin":1743,"end":1751},"obj":"http://edamontology.org/topic_1312"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-topics"},{"subj":"T2","pred":"source","obj":"EDAM-topics"},{"subj":"T3","pred":"source","obj":"EDAM-topics"},{"subj":"T4","pred":"source","obj":"EDAM-topics"},{"subj":"T5","pred":"source","obj":"EDAM-topics"},{"subj":"T6","pred":"source","obj":"EDAM-topics"},{"subj":"T7","pred":"source","obj":"EDAM-topics"},{"subj":"T8","pred":"source","obj":"EDAM-topics"},{"subj":"T9","pred":"source","obj":"EDAM-topics"},{"subj":"T10","pred":"source","obj":"EDAM-topics"},{"subj":"T11","pred":"source","obj":"EDAM-topics"},{"subj":"T12","pred":"source","obj":"EDAM-topics"},{"subj":"T13","pred":"source","obj":"EDAM-topics"},{"subj":"T14","pred":"source","obj":"EDAM-topics"},{"subj":"T15","pred":"source","obj":"EDAM-topics"},{"subj":"T16","pred":"source","obj":"EDAM-topics"},{"subj":"T17","pred":"source","obj":"EDAM-topics"},{"subj":"T18","pred":"source","obj":"EDAM-topics"},{"subj":"T19","pred":"source","obj":"EDAM-topics"},{"subj":"T20","pred":"source","obj":"EDAM-topics"},{"subj":"T21","pred":"source","obj":"EDAM-topics"},{"subj":"T22","pred":"source","obj":"EDAM-topics"},{"subj":"T23","pred":"source","obj":"EDAM-topics"},{"subj":"T24","pred":"source","obj":"EDAM-topics"},{"subj":"T25","pred":"source","obj":"EDAM-topics"},{"subj":"T26","pred":"source","obj":"EDAM-topics"},{"subj":"T27","pred":"source","obj":"EDAM-topics"},{"subj":"T28","pred":"source","obj":"EDAM-topics"},{"subj":"T29","pred":"source","obj":"EDAM-topics"},{"subj":"T30","pred":"source","obj":"EDAM-topics"},{"subj":"T31","pred":"source","obj":"EDAM-topics"},{"subj":"T32","pred":"source","obj":"EDAM-topics"},{"subj":"T33","pred":"source","obj":"EDAM-topics"},{"subj":"T34","pred":"source","obj":"EDAM-topics"},{"subj":"T35","pred":"source","obj":"EDAM-topics"},{"subj":"T36","pred":"source","obj":"EDAM-topics"},{"subj":"T37","pred":"source","obj":"EDAM-topics"},{"subj":"T38","pred":"source","obj":"EDAM-topics"},{"subj":"T39","pred":"source","obj":"EDAM-topics"},{"subj":"T40","pred":"source","obj":"EDAM-topics"},{"subj":"T41","pred":"source","obj":"EDAM-topics"}]},{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":260,"end":269},"obj":"http://edamontology.org/operation_3429"},{"id":"T2","span":{"begin":580,"end":588},"obj":"http://edamontology.org/data_2048"},{"id":"T3","span":{"begin":628,"end":647},"obj":"http://edamontology.org/operation_2502"},{"id":"T4","span":{"begin":639,"end":647},"obj":"http://edamontology.org/operation_2945"},{"id":"T5","span":{"begin":716,"end":727},"obj":"http://edamontology.org/operation_2246"},{"id":"T6","span":{"begin":853,"end":872},"obj":"http://edamontology.org/operation_0438"},{"id":"T7","span":{"begin":873,"end":881},"obj":"http://edamontology.org/data_2619"},{"id":"T8","span":{"begin":1065,"end":1073},"obj":"http://edamontology.org/data_2048"},{"id":"T9","span":{"begin":1439,"end":1448},"obj":"http://edamontology.org/operation_3429"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-DFO"},{"subj":"T2","pred":"source","obj":"EDAM-DFO"},{"subj":"T3","pred":"source","obj":"EDAM-DFO"},{"subj":"T4","pred":"source","obj":"EDAM-DFO"},{"subj":"T5","pred":"source","obj":"EDAM-DFO"},{"subj":"T6","pred":"source","obj":"EDAM-DFO"},{"subj":"T7","pred":"source","obj":"EDAM-DFO"},{"subj":"T8","pred":"source","obj":"EDAM-DFO"},{"subj":"T9","pred":"source","obj":"EDAM-DFO"}]},{"project":"GlycoBiology-Epitope","denotations":[{"id":"PD-GlycoEpitope-B_T1","span":{"begin":616,"end":618},"obj":"http://www.glycoepitope.jp/epitopes/AN0638"}],"attributes":[{"subj":"PD-GlycoEpitope-B_T1","pred":"source","obj":"GlycoBiology-Epitope"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":1469,"end":1477},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0007256"},{"subj":"T1","pred":"source","obj":"mondo_disease"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":146,"end":151},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":274,"end":277},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":482,"end":487},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":497,"end":502},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":695,"end":700},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":1344,"end":1349},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":1463,"end":1468},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"10114"},{"id":"A3","pred":"db_id","subj":"T2","obj":"10116"},{"id":"A4","pred":"db_id","subj":"T4","obj":"9606"},{"id":"A5","pred":"db_id","subj":"T5","obj":"9606"},{"id":"A6","pred":"db_id","subj":"T6","obj":"9606"},{"id":"A7","pred":"db_id","subj":"T7","obj":"9606"},{"id":"A8","pred":"db_id","subj":"T8","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T4","pred":"source","obj":"NCBITAXON"},{"subj":"T5","pred":"source","obj":"NCBITAXON"},{"subj":"T6","pred":"source","obj":"NCBITAXON"},{"subj":"T7","pred":"source","obj":"NCBITAXON"},{"subj":"T8","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":74,"end":87},"obj":"Body_part"},{"id":"T2","span":{"begin":519,"end":532},"obj":"Body_part"},{"id":"T3","span":{"begin":1114,"end":1122},"obj":"Body_part"},{"id":"T4","span":{"begin":1198,"end":1205},"obj":"Body_part"},{"id":"T5","span":{"begin":1294,"end":1307},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000785"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000914"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000914"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000785"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":74,"end":87},"obj":"Cell"},{"id":"T2","span":{"begin":519,"end":532},"obj":"Cell"},{"id":"T3","span":{"begin":526,"end":532},"obj":"Cell"},{"id":"T4","span":{"begin":1294,"end":1307},"obj":"Cell"},{"id":"T5","span":{"begin":1301,"end":1307},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000785"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000785"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"},{"subj":"T3","pred":"source","obj":"CL-cell"},{"subj":"T4","pred":"source","obj":"CL-cell"},{"subj":"T5","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#93daec","default":true},{"id":"DisGeNET","color":"#ece493"},{"id":"GlycoBiology-FMA","color":"#ca93ec"},{"id":"uniprot-human","color":"#93ecaf"},{"id":"uniprot-mouse","color":"#ec9593"},{"id":"GlycoBiology-NCBITAXON","color":"#93aaec"},{"id":"GO-BP","color":"#c4ec93"},{"id":"GO-CC","color":"#ec93de"},{"id":"EDAM-topics","color":"#93ece0"},{"id":"EDAM-DFO","color":"#ecc693"},{"id":"GlycoBiology-Epitope","color":"#ac93ec"},{"id":"mondo_disease","color":"#94ec93"},{"id":"NCBITAXON","color":"#ec93ae"},{"id":"Anatomy-UBERON","color":"#93c8ec"},{"id":"CL-cell","color":"#e2ec93"}]}]}}