PubMed:8691123 JSONTXT

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    jnlpba-st-training

    {"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":20},"obj":"protein"},{"id":"T2","span":{"begin":61,"end":79},"obj":"DNA"},{"id":"T3","span":{"begin":83,"end":116},"obj":"protein"},{"id":"T4","span":{"begin":122,"end":180},"obj":"protein"},{"id":"T5","span":{"begin":209,"end":222},"obj":"cell_type"},{"id":"T6","span":{"begin":264,"end":287},"obj":"protein"},{"id":"T7","span":{"begin":289,"end":292},"obj":"protein"},{"id":"T8","span":{"begin":387,"end":390},"obj":"protein"},{"id":"T9","span":{"begin":421,"end":430},"obj":"protein"},{"id":"T10","span":{"begin":443,"end":484},"obj":"protein"},{"id":"T11","span":{"begin":486,"end":490},"obj":"protein"},{"id":"T12","span":{"begin":517,"end":532},"obj":"protein"},{"id":"T13","span":{"begin":546,"end":564},"obj":"protein"},{"id":"T14","span":{"begin":566,"end":576},"obj":"protein"},{"id":"T15","span":{"begin":636,"end":641},"obj":"DNA"},{"id":"T16","span":{"begin":664,"end":670},"obj":"DNA"},{"id":"T17","span":{"begin":674,"end":685},"obj":"protein"},{"id":"T18","span":{"begin":687,"end":691},"obj":"protein"},{"id":"T19","span":{"begin":724,"end":790},"obj":"protein"},{"id":"T20","span":{"begin":814,"end":832},"obj":"DNA"},{"id":"T21","span":{"begin":847,"end":854},"obj":"cell_type"},{"id":"T22","span":{"begin":876,"end":885},"obj":"protein"},{"id":"T23","span":{"begin":943,"end":947},"obj":"protein"},{"id":"T24","span":{"begin":977,"end":987},"obj":"DNA"},{"id":"T25","span":{"begin":995,"end":1002},"obj":"cell_type"},{"id":"T26","span":{"begin":1044,"end":1053},"obj":"protein"},{"id":"T27","span":{"begin":1111,"end":1124},"obj":"cell_type"}],"text":"Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.\nThe Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes."}

    genia-medco-coref

    {"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":83,"end":116},"obj":"NP"},{"id":"C2","span":{"begin":118,"end":180},"obj":"NP"},{"id":"C3","span":{"begin":209,"end":222},"obj":"NP"},{"id":"C4","span":{"begin":311,"end":313},"obj":"NP"},{"id":"C5","span":{"begin":331,"end":374},"obj":"NP"},{"id":"C6","span":{"begin":375,"end":379},"obj":"NP"},{"id":"C7","span":{"begin":421,"end":430},"obj":"NP"},{"id":"C8","span":{"begin":439,"end":491},"obj":"NP"},{"id":"C9","span":{"begin":542,"end":564},"obj":"NP"},{"id":"C10","span":{"begin":664,"end":670},"obj":"NP"},{"id":"C11","span":{"begin":687,"end":691},"obj":"NP"},{"id":"C12","span":{"begin":720,"end":790},"obj":"NP"},{"id":"C13","span":{"begin":792,"end":797},"obj":"NP"},{"id":"C14","span":{"begin":876,"end":885},"obj":"NP"},{"id":"C15","span":{"begin":1044,"end":1053},"obj":"NP"},{"id":"C16","span":{"begin":1111,"end":1124},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-pron","subj":"C4","obj":"C2"},{"id":"R3","pred":"coref-relat","subj":"C6","obj":"C5"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C2"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C9"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C8"},{"id":"R7","pred":"coref-relat","subj":"C13","obj":"C12"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C7"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C14"},{"id":"R10","pred":"coref-ident","subj":"C16","obj":"C3"}],"text":"Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.\nThe Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes."}

    pubmed-sentences-benchmark

    {"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":117},"obj":"Sentence"},{"id":"S2","span":{"begin":118,"end":402},"obj":"Sentence"},{"id":"S3","span":{"begin":403,"end":565},"obj":"Sentence"},{"id":"S4","span":{"begin":566,"end":686},"obj":"Sentence"},{"id":"S5","span":{"begin":687,"end":855},"obj":"Sentence"},{"id":"S6","span":{"begin":856,"end":1003},"obj":"Sentence"},{"id":"S7","span":{"begin":1004,"end":1125},"obj":"Sentence"}],"text":"Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.\nThe Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes."}

    GENIAcorpus

    {"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":20},"obj":"protein_molecule"},{"id":"T2","span":{"begin":31,"end":57},"obj":"other_name"},{"id":"T3","span":{"begin":61,"end":79},"obj":"DNA_domain_or_region"},{"id":"T4","span":{"begin":83,"end":87},"obj":"atom"},{"id":"T5","span":{"begin":122,"end":126},"obj":"atom"},{"id":"T6","span":{"begin":209,"end":222},"obj":"cell_type"},{"id":"T7","span":{"begin":264,"end":287},"obj":"protein_family_or_group"},{"id":"T8","span":{"begin":289,"end":292},"obj":"protein_family_or_group"},{"id":"T9","span":{"begin":335,"end":374},"obj":"other_name"},{"id":"T10","span":{"begin":387,"end":390},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":421,"end":430},"obj":"protein_molecule"},{"id":"T12","span":{"begin":443,"end":463},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":486,"end":490},"obj":"protein_molecule"},{"id":"T14","span":{"begin":517,"end":532},"obj":"protein_family_or_group"},{"id":"T15","span":{"begin":546,"end":564},"obj":"protein_molecule"},{"id":"T16","span":{"begin":566,"end":576},"obj":"protein_molecule"},{"id":"T17","span":{"begin":606,"end":632},"obj":"other_name"},{"id":"T18","span":{"begin":636,"end":641},"obj":"DNA_domain_or_region"},{"id":"T19","span":{"begin":664,"end":670},"obj":"DNA_domain_or_region"},{"id":"T20","span":{"begin":674,"end":685},"obj":"protein_molecule"},{"id":"T21","span":{"begin":687,"end":691},"obj":"protein_molecule"},{"id":"T22","span":{"begin":724,"end":751},"obj":"protein_complex"},{"id":"T23","span":{"begin":752,"end":759},"obj":"cell_type"},{"id":"T24","span":{"begin":814,"end":832},"obj":"DNA_domain_or_region"},{"id":"T25","span":{"begin":847,"end":854},"obj":"cell_type"},{"id":"T26","span":{"begin":876,"end":885},"obj":"protein_molecule"},{"id":"T27","span":{"begin":943,"end":947},"obj":"protein_complex"},{"id":"T28","span":{"begin":977,"end":981},"obj":"protein_complex"},{"id":"T29","span":{"begin":995,"end":1002},"obj":"cell_type"},{"id":"T30","span":{"begin":1044,"end":1053},"obj":"protein_molecule"},{"id":"T31","span":{"begin":1059,"end":1065},"obj":"atom"},{"id":"T32","span":{"begin":1089,"end":1107},"obj":"other_name"},{"id":"T33","span":{"begin":1111,"end":1124},"obj":"cell_type"}],"text":"Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.\nThe Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes."}