PubMed:8691123 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-20	protein	denotes	Activation protein 1
T2	61-79	DNA	denotes	interleukin 2 gene
T3	83-116	protein	denotes	Ca2+/calmodulin kinase type IV/Gr
T4	122-180	protein	denotes	Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr
T5	209-222	cell_type	denotes	T lymphocytes
T6	264-287	protein	denotes	T cell antigen receptor
T7	289-292	protein	denotes	TCR
T8	387-390	protein	denotes	TCR
T9	421-430	protein	denotes	CaMKIV/Gr
T10	443-484	protein	denotes	transcription factor activation protein 1
T11	486-490	protein	denotes	AP-1
T12	517-532	protein	denotes	T cell mitogens
T13	546-564	protein	denotes	p21ras oncoprotein
T14	566-576	protein	denotes	CaMKIV/ Gr
T15	636-641	DNA	denotes	c-fos
T16	664-670	DNA	denotes	p21ras
T17	674-685	protein	denotes	calcineurin
T18	687-691	protein	denotes	AP-1
T19	724-790	protein	denotes	nuclear factor of activated T cells (NFAT) transcriptional complex
T20	814-832	DNA	denotes	interleukin 2 gene
T21	847-854	cell_type	denotes	T cells
T22	876-885	protein	denotes	CaMKIV/Gr
T23	943-947	protein	denotes	NFAT
T24	977-987	DNA	denotes	NFAT sites
T25	995-1002	cell_type	denotes	T cells
T26	1044-1053	protein	denotes	CaMKIV/Gr
T27	1111-1124	cell_type	denotes	T lymphocytes

Id	Subject	Object	Predicate	Lexical cue
C1	83-116	NP	denotes	Ca2+/calmodulin kinase type IV/Gr
C2	118-180	NP	denotes	The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr
C3	209-222	NP	denotes	T lymphocytes
C4	311-313	NP	denotes	it
C5	331-374	NP	denotes	the Ca(2+)-dependent transcriptional events
C6	375-379	NP	denotes	that
C7	421-430	NP	denotes	CaMKIV/Gr
C8	439-491	NP	denotes	the transcription factor activation protein 1 (AP-1)
C9	542-564	NP	denotes	the p21ras oncoprotein
C10	664-670	NP	denotes	p21ras
C11	687-691	NP	denotes	AP-1
C12	720-790	NP	denotes	the nuclear factor of activated T cells (NFAT) transcriptional complex
C13	792-797	NP	denotes	which
C14	876-885	NP	denotes	CaMKIV/Gr
C15	1044-1053	NP	denotes	CaMKIV/Gr
C16	1111-1124	NP	denotes	T lymphocytes
R1	C2	C1	coref-ident	The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr,Ca2+/calmodulin kinase type IV/Gr
R2	C4	C2	coref-pron	it,The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr
R3	C6	C5	coref-relat	that,the Ca(2+)-dependent transcriptional events
R4	C7	C2	coref-ident	CaMKIV/Gr,The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr
R5	C10	C9	coref-ident	p21ras,the p21ras oncoprotein
R6	C11	C8	coref-ident	AP-1,the transcription factor activation protein 1 (AP-1)
R7	C13	C12	coref-relat	which,the nuclear factor of activated T cells (NFAT) transcriptional complex
R8	C14	C7	coref-ident	CaMKIV/Gr,CaMKIV/Gr
R9	C15	C14	coref-ident	CaMKIV/Gr,CaMKIV/Gr
R10	C16	C3	coref-ident	T lymphocytes,T lymphocytes

Id	Subject	Object	Predicate	Lexical cue
S1	0-117	Sentence	denotes	Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.
S2	118-402	Sentence	denotes	The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement.
S3	403-565	Sentence	denotes	Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein.
S4	566-686	Sentence	denotes	CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin.
S5	687-855	Sentence	denotes	AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells.
S6	856-1003	Sentence	denotes	We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells.
S7	1004-1125	Sentence	denotes	These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.

Id	Subject	Object	Predicate	Lexical cue
T1	0-20	protein_molecule	denotes	Activation protein 1
T2	31-57	other_name	denotes	transcriptional activation
T3	61-79	DNA_domain_or_region	denotes	interleukin 2 gene
T4	83-87	atom	denotes	Ca2+
T5	122-126	atom	denotes	Ca2+
T6	209-222	cell_type	denotes	T lymphocytes
T7	264-287	protein_family_or_group	denotes	T cell antigen receptor
T8	289-292	protein_family_or_group	denotes	TCR
T9	335-374	other_name	denotes	Ca(2+)-dependent transcriptional events
T10	387-390	protein_family_or_group	denotes	TCR
T11	421-430	protein_molecule	denotes	CaMKIV/Gr
T12	443-463	protein_family_or_group	denotes	transcription factor
T13	486-490	protein_molecule	denotes	AP-1
T14	517-532	protein_family_or_group	denotes	T cell mitogens
T15	546-564	protein_molecule	denotes	p21ras oncoprotein
T16	566-576	protein_molecule	denotes	CaMKIV/ Gr
T17	606-632	other_name	denotes	transcriptional activation
T18	636-641	DNA_domain_or_region	denotes	c-fos
T19	664-670	DNA_domain_or_region	denotes	p21ras
T20	674-685	protein_molecule	denotes	calcineurin
T21	687-691	protein_molecule	denotes	AP-1
T22	724-751	protein_complex	denotes	nuclear factor of activated
T23	752-759	cell_type	denotes	T cells
T24	814-832	DNA_domain_or_region	denotes	interleukin 2 gene
T25	847-854	cell_type	denotes	T cells
T26	876-885	protein_molecule	denotes	CaMKIV/Gr
T27	943-947	protein_complex	denotes	NFAT
T28	977-981	protein_complex	denotes	NFAT
T29	995-1002	cell_type	denotes	T cells
T30	1044-1053	protein_molecule	denotes	CaMKIV/Gr
T31	1059-1065	atom	denotes	Ca(2+)
T32	1089-1107	other_name	denotes	gene transcription
T33	1111-1124	cell_type	denotes	T lymphocytes