PubMed:8638121 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8638121","sourcedb":"PubMed","sourceid":"8638121","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8638121","text":"Enhanced degradation of EGF receptors by a sorting nexin, SNX1.\nThe vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":24,"end":27},"obj":"protein"},{"id":"T2","span":{"begin":51,"end":56},"obj":"protein"},{"id":"T3","span":{"begin":58,"end":62},"obj":"protein"},{"id":"T4","span":{"begin":194,"end":209},"obj":"protein"},{"id":"T5","span":{"begin":211,"end":215},"obj":"protein"},{"id":"T6","span":{"begin":284,"end":316},"obj":"protein"},{"id":"T7","span":{"begin":318,"end":322},"obj":"protein"},{"id":"T8","span":{"begin":365,"end":369},"obj":"protein"},{"id":"T9","span":{"begin":459,"end":463},"obj":"protein"},{"id":"T10","span":{"begin":488,"end":492},"obj":"protein"},{"id":"T11","span":{"begin":597,"end":601},"obj":"protein"},{"id":"T12","span":{"begin":638,"end":642},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"},{"subj":"T6","pred":"source","obj":"AIMed"},{"subj":"T7","pred":"source","obj":"AIMed"},{"subj":"T8","pred":"source","obj":"AIMed"},{"subj":"T9","pred":"source","obj":"AIMed"},{"subj":"T10","pred":"source","obj":"AIMed"},{"subj":"T11","pred":"source","obj":"AIMed"},{"subj":"T12","pred":"source","obj":"AIMed"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#93ecc8","default":true}]}]}}