PubMed:8638121 JSONTXT

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":24,"end":27},"obj":"protein"},{"id":"T2","span":{"begin":51,"end":56},"obj":"protein"},{"id":"T3","span":{"begin":58,"end":62},"obj":"protein"},{"id":"T4","span":{"begin":194,"end":209},"obj":"protein"},{"id":"T5","span":{"begin":211,"end":215},"obj":"protein"},{"id":"T6","span":{"begin":284,"end":316},"obj":"protein"},{"id":"T7","span":{"begin":318,"end":322},"obj":"protein"},{"id":"T8","span":{"begin":365,"end":369},"obj":"protein"},{"id":"T9","span":{"begin":459,"end":463},"obj":"protein"},{"id":"T10","span":{"begin":488,"end":492},"obj":"protein"},{"id":"T11","span":{"begin":597,"end":601},"obj":"protein"},{"id":"T12","span":{"begin":638,"end":642},"obj":"protein"}],"text":"Enhanced degradation of EGF receptors by a sorting nexin, SNX1.\nThe vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes."}