> top > docs > PubMed:8621390 > annotations

PubMed:8621390 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells.
T2 95-173 Sentence denotes Convergence of costimulatory signals and differences from transformed T cells.
T3 174-291 Sentence denotes To study transcriptional regulation in normal human T cells, we have optimized conditions for transient transfection.
T4 292-440 Sentence denotes Interleukin-2 (IL-2) promoter-reporter gene behavior closely parallels the endogenous gene in response to T cell receptor and costimulatory signals.
T5 441-598 Sentence denotes As assessed with mutagenized promoters, the most important IL-2 cis-regulatory elements in normal T cells are the proximal AP-1 site and the NF- kappaB site.
T6 599-839 Sentence denotes Both primary activation, with phytohemagglutinin or antibodies to CD3, and costimulation, provided by pairs of CD2 antibodies or B7-positive (B cells) or B7-negative (endothelial) accessory cells, are mediated through the same cis-elements.
T7 840-965 Sentence denotes Interestingly, the nuclear factor of activated T cell sites are much less important in normal T cells than in Jurkat T cells.
T8 966-1168 Sentence denotes We conclude that IL-2 transcriptional regulation differs in tumor cell lines compared with normal T cells and that different costimulatory signals converge on the same cis-elements in the IL-2 promoter.
T1 0-94 Sentence denotes Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells.
T2 95-173 Sentence denotes Convergence of costimulatory signals and differences from transformed T cells.
T3 174-291 Sentence denotes To study transcriptional regulation in normal human T cells, we have optimized conditions for transient transfection.
T4 292-440 Sentence denotes Interleukin-2 (IL-2) promoter-reporter gene behavior closely parallels the endogenous gene in response to T cell receptor and costimulatory signals.
T5 441-598 Sentence denotes As assessed with mutagenized promoters, the most important IL-2 cis-regulatory elements in normal T cells are the proximal AP-1 site and the NF- kappaB site.
T6 599-839 Sentence denotes Both primary activation, with phytohemagglutinin or antibodies to CD3, and costimulation, provided by pairs of CD2 antibodies or B7-positive (B cells) or B7-negative (endothelial) accessory cells, are mediated through the same cis-elements.
T7 840-965 Sentence denotes Interestingly, the nuclear factor of activated T cell sites are much less important in normal T cells than in Jurkat T cells.
T8 966-1168 Sentence denotes We conclude that IL-2 transcriptional regulation differs in tumor cell lines compared with normal T cells and that different costimulatory signals converge on the same cis-elements in the IL-2 promoter.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 80-85 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 80-85 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 555-563 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 34-52 DNA denotes interleukin-2 gene
T2 63-93 cell_type denotes human peripheral blood T cells
T3 153-172 cell_type denotes transformed T cells
T4 213-233 cell_type denotes normal human T cells
T5 292-321 DNA denotes Interleukin-2 (IL-2) promoter
T6 321-335 DNA denotes -reporter gene
T7 367-382 DNA denotes endogenous gene
T8 398-413 protein denotes T cell receptor
T9 458-479 DNA denotes mutagenized promoters
T10 500-528 DNA denotes IL-2 cis-regulatory elements
T11 532-546 cell_type denotes normal T cells
T12 555-573 DNA denotes proximal AP-1 site
T13 582-597 DNA denotes NF- kappaB site
T14 629-647 protein denotes phytohemagglutinin
T15 651-668 protein denotes antibodies to CD3
T16 710-724 protein denotes CD2 antibodies
T17 728-749 cell_type denotes B7-positive (B cells)
T18 753-795 cell_type denotes B7-negative (endothelial) accessory cells,
T19 826-838 DNA denotes cis-elements
T20 859-899 DNA denotes nuclear factor of activated T cell sites
T21 927-941 cell_type denotes normal T cells
T22 950-964 cell_line denotes Jurkat T cells
T23 983-987 protein denotes IL-2
T24 1026-1042 cell_line denotes tumor cell lines
T25 1057-1071 cell_type denotes normal T cells
T26 1134-1146 DNA denotes cis-elements
T27 1154-1167 DNA denotes IL-2 promoter

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-94 Sentence denotes Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells.
S2 95-173 Sentence denotes Convergence of costimulatory signals and differences from transformed T cells.
S3 174-291 Sentence denotes To study transcriptional regulation in normal human T cells, we have optimized conditions for transient transfection.
S4 292-440 Sentence denotes Interleukin-2 (IL-2) promoter-reporter gene behavior closely parallels the endogenous gene in response to T cell receptor and costimulatory signals.
S5 441-598 Sentence denotes As assessed with mutagenized promoters, the most important IL-2 cis-regulatory elements in normal T cells are the proximal AP-1 site and the NF- kappaB site.
S6 599-839 Sentence denotes Both primary activation, with phytohemagglutinin or antibodies to CD3, and costimulation, provided by pairs of CD2 antibodies or B7-positive (B cells) or B7-negative (endothelial) accessory cells, are mediated through the same cis-elements.
S7 840-965 Sentence denotes Interestingly, the nuclear factor of activated T cell sites are much less important in normal T cells than in Jurkat T cells.
S8 966-1168 Sentence denotes We conclude that IL-2 transcriptional regulation differs in tumor cell lines compared with normal T cells and that different costimulatory signals converge on the same cis-elements in the IL-2 promoter.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 56-93 NP denotes normal human peripheral blood T cells
C2 213-233 NP denotes normal human T cells
C4 532-546 NP denotes normal T cells
C3 481-546 NP denotes the most important IL-2 cis-regulatory elements in normal T cells
C5 551-597 NP denotes the proximal AP-1 site and the NF- kappaB site
C6 817-838 NP denotes the same cis-elements
C7 927-941 NP denotes normal T cells
C8 1057-1071 NP denotes normal T cells
C9 1125-1167 NP denotes the same cis-elements in the IL-2 promoter
R1 C2 C1 coref-ident normal human T cells,normal human peripheral blood T cells
R2 C4 C2 coref-ident normal T cells,normal human T cells
R3 C5 C3 coref-ident the proximal AP-1 site and the NF- kappaB site,the most important IL-2 cis-regulatory elements in normal T cells
R4 C6 C3 coref-ident the same cis-elements,the most important IL-2 cis-regulatory elements in normal T cells
R5 C7 C4 coref-ident normal T cells,normal T cells
R6 C8 C7 coref-ident normal T cells,normal T cells
R7 C9 C6 coref-ident the same cis-elements in the IL-2 promoter,the same cis-elements

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-26 other_name denotes Transcriptional regulation
T2 34-47 protein_molecule denotes interleukin-2
T3 63-93 cell_type denotes human peripheral blood T cells
T4 153-172 cell_type denotes transformed T cells
T5 213-233 cell_type denotes normal human T cells
T6 268-290 other_name denotes transient transfection
T7 292-307 DNA_domain_or_region denotes Interleukin-2 (
T8 307-311 protein_molecule denotes IL-2
T9 321-335 DNA_family_or_group denotes -reporter gene
T10 367-382 DNA_family_or_group denotes endogenous gene
T11 398-413 protein_molecule denotes T cell receptor
T12 418-439 other_name denotes costimulatory signals
T13 458-479 DNA_family_or_group denotes mutagenized promoters
T14 500-504 protein_molecule denotes IL-2
T15 532-546 cell_type denotes normal T cells
T16 555-563 DNA_domain_or_region denotes proximal
T17 564-568 protein_molecule denotes AP-1
T18 582-592 protein_molecule denotes NF- kappaB
T19 629-647 protein_molecule denotes phytohemagglutinin
T20 651-668 protein_family_or_group denotes antibodies to CD3
T21 674-687 other_name denotes costimulation
T22 710-724 protein_family_or_group denotes CD2 antibodies
T23 728-749 cell_type denotes B7-positive (B cells)
T24 753-795 cell_type denotes B7-negative (endothelial) accessory cells,
T25 826-838 DNA_family_or_group denotes cis-elements
T26 859-899 DNA_domain_or_region denotes nuclear factor of activated T cell sites
T27 927-941 cell_type denotes normal T cells
T28 950-964 cell_line denotes Jurkat T cells
T29 983-987 protein_molecule denotes IL-2
T30 1026-1042 cell_line denotes tumor cell lines
T31 1057-1071 cell_type denotes normal T cells
T32 1091-1112 other_name denotes costimulatory signals
T33 1134-1146 DNA_family_or_group denotes cis-elements
T34 1154-1158 protein_molecule denotes IL-2

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 80-85 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 555-563 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1026-1031 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1026-1031 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 63-68 OrganismTaxon denotes human 9606
T2 220-225 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 80-85 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 398-404 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 887-893 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 86-93 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 165-172 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 226-233 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 398-404 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T5 539-546 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T6 741-748 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T7 887-893 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T8 934-941 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T9 957-964 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T10 1026-1036 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T11 1064-1071 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084