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PubMed:8605359 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 101-104 gene:6900 denotes Tax
T1 54-75 disease:C0023493 denotes human T-cell leukemia
T2 1806-1824 gene:1401 denotes C-reactive protein
T3 1884-1914 disease:C0023493 denotes adult T-cell leukemia/lymphoma
R1 T0 T1 associated_with Tax,human T-cell leukemia
R2 T2 T3 associated_with C-reactive protein,adult T-cell leukemia/lymphoma

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 23-50 DNA denotes interleukin-1alpha promoter
T2 54-113 protein denotes human T-cell leukemia virus type I and type II Tax proteins
T3 115-180 cell_line denotes Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines
T4 219-237 protein denotes interleukin-1alpha
T5 239-248 protein denotes IL-1alpha
T6 308-317 protein denotes IL-1alpha
T7 321-347 cell_line denotes HTLV-I-infected cell lines
T8 392-410 DNA denotes IL-1alpha promoter
T9 441-455 DNA denotes IL-1alpha gene
T10 457-486 DNA denotes IL-1alpha promoter constructs
T11 514-567 DNA denotes chloramphenicol acetyltransferase (CAT) reporter gene
T12 571-597 cell_line denotes HTLV-I-positive MT-2 cells
T13 628-637 protein denotes IL-1alpha
T14 670-681 protein denotes Tax protein
T15 755-773 DNA denotes IL-1alpha promoter
T16 780-807 cell_line denotes uninfected Jurkat cell line
T17 818-829 protein denotes Tax protein
T18 875-901 protein denotes nuclear factor (NF)-kappaB
T19 959-992 DNA denotes IL-1alpha promoter-CAT constructs
T20 1036-1043 protein denotes p65/p50
T21 1044-1053 protein denotes NF-kappaB
T22 1073-1100 DNA denotes IL-1alpha kappaB-like sites
T23 1112-1128 DNA denotes -1,065 to -1,056
T24 1133-1145 DNA denotes +646 to +655
T25 1182-1191 protein denotes NF-kappaB
T26 1224-1234 cell_line denotes MT-2 cells
T27 1244-1253 protein denotes NF-kappaB
T28 1288-1313 DNA denotes 3' NF-kappaB binding site
T29 1326-1343 DNA denotes 5' NF-kappaB site
T30 1374-1398 DNA denotes 5' or 3' NF-kappaB sites
T31 1407-1425 DNA denotes IL-1alpha promoter
T32 1438-1448 cell_line denotes MT-2 cells
T33 1476-1494 DNA denotes IL-1alpha promoter
T34 1508-1517 protein denotes NF-kappaB
T35 1522-1525 protein denotes Tax
T36 1529-1541 cell_line denotes Jurkat cells
T37 1581-1584 protein denotes Tax
T38 1598-1612 DNA denotes IL-1alpha gene
T39 1634-1643 protein denotes NF-kappaB
T40 1667-1676 protein denotes IL-1alpha
T41 1700-1714 cell_type denotes infected cells
T42 1806-1824 protein denotes C-reactive protein

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8605359-0#101#104#gene6900 101-104 gene6900 denotes Tax
8605359-0#54#75#diseaseC0023493 54-75 diseaseC0023493 denotes human T-cell leukemia
8605359-9#153#171#gene1401 1806-1824 gene1401 denotes C-reactive protein
8605359-9#231#261#diseaseC0023493 1884-1914 diseaseC0023493 denotes adult T-cell leukemia/lymphoma
101#104#gene690054#75#diseaseC0023493 8605359-0#101#104#gene6900 8605359-0#54#75#diseaseC0023493 associated_with Tax,human T-cell leukemia
153#171#gene1401231#261#diseaseC0023493 8605359-9#153#171#gene1401 8605359-9#231#261#diseaseC0023493 associated_with C-reactive protein,adult T-cell leukemia/lymphoma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-114 Sentence denotes Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins.
S2 115-250 Sentence denotes Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of interleukin-1alpha (IL-1alpha).
S3 251-456 Sentence denotes To analyze the mechanisms that lead to the expression of IL-1alpha in HTLV-I-infected cell lines, we studied regulatory regions of the human IL-1alpha promoter involved in activation of the IL-1alpha gene.
S4 457-638 Sentence denotes IL-1alpha promoter constructs drive transcription of the chloramphenicol acetyltransferase (CAT) reporter gene in HTLV-I-positive MT-2 cells, which constitutively produce IL-1alpha.
S5 639-808 Sentence denotes In a cotransfection assay, the Tax protein of both HTLV-I and HTLV-II specifically activated transcription from the IL-1alpha promoter in an uninfected Jurkat cell line.
S6 809-1054 Sentence denotes A mutant Tax protein deficient in transactivation of genes by the nuclear factor (NF)-kappaB pathway was unable to induce transcriptional activity of IL-1alpha promoter-CAT constructs, but was rescued by exogenous provision of p65/p50 NF-kappaB.
S7 1055-1344 Sentence denotes We found that two IL-1alpha kappaB-like sites (positions -1,065 to -1,056 and +646 to +655) specifically formed a complex with NF-kappaB-containing nuclear extract from MT-2 cells and that NF-kappaB bound with higher affinity to the 3' NF-kappaB binding site than to the 5' NF-kappaB site.
S8 1345-1542 Sentence denotes Moreover, deletion of either 5' or 3' NF-kappaB sites reduced IL-1alpha promoter activity in MT-2 cells and transactivation of the IL-1alpha promoter by exogenous NF-kappaB and Tax in Jurkat cells.
S9 1543-1652 Sentence denotes These data suggest a general role for Tax induction of IL-1alpha gene transcription by the NF-kappaB pathway.
S10 1653-1915 Sentence denotes Expression of IL-1alpha by HTLV-I productively infected cells may be important in the hypercalcemia, osteolytic bone lesions, neutrophilia, elevation of C-reactive protein, and fever frequently seen in patients with HTLV-I-induced adult T-cell leukemia/lymphoma.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 19-50 NP denotes the interleukin-1alpha promoter
C1 0-50 NP denotes Transactivation of the interleukin-1alpha promoter
C4 54-88 NP denotes human T-cell leukemia virus type I
C3 54-113 NP denotes human T-cell leukemia virus type I and type II Tax proteins
C6 115-159 NP denotes Human T-cell leukemia virus type I (HTLV-I)-
C5 115-180 NP denotes Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines
C7 219-249 NP denotes interleukin-1alpha (IL-1alpha)
C8 262-276 NP denotes the mechanisms
C9 277-281 NP denotes that
C10 308-317 NP denotes IL-1alpha
C12 321-328 NP denotes HTLV-I-
C11 321-347 NP denotes HTLV-I-infected cell lines
C13 382-410 NP denotes the human IL-1alpha promoter
C14 437-455 NP denotes the IL-1alpha gene
C15 457-475 NP denotes IL-1alpha promoter
C17 571-578 NP denotes HTLV-I-
C16 571-597 NP denotes HTLV-I-positive MT-2 cells
C18 599-604 NP denotes which
C19 628-637 NP denotes IL-1alpha
C20 666-708 NP denotes the Tax protein of both HTLV-I and HTLV-II
C21 751-773 NP denotes the IL-1alpha promoter
C22 871-909 NP denotes the nuclear factor (NF)-kappaB pathway
C23 959-978 NP denotes IL-1alpha promoter-
C24 1224-1234 NP denotes MT-2 cells
C25 1438-1448 NP denotes MT-2 cells
C27 1472-1494 NP denotes the IL-1alpha promoter
C26 1453-1494 NP denotes transactivation of the IL-1alpha promoter
C28 1630-1651 NP denotes the NF-kappaB pathway
C29 1667-1676 NP denotes IL-1alpha
C30 1869-1876 NP denotes HTLV-I-
R1 C6 C4 coref-ident Human T-cell leukemia virus type I (HTLV-I)-,human T-cell leukemia virus type I
R2 C9 C8 coref-relat that,the mechanisms
R3 C10 C7 coref-ident IL-1alpha,interleukin-1alpha (IL-1alpha)
R4 C12 C5 coref-ident HTLV-I-,Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines
R5 C11 C6 coref-ident HTLV-I-infected cell lines,Human T-cell leukemia virus type I (HTLV-I)-
R6 C13 C2 coref-xxx the human IL-1alpha promoter,the interleukin-1alpha promoter
R7 C14 C10 coref-ident the IL-1alpha gene,IL-1alpha
R8 C15 C13 coref-ident IL-1alpha promoter,the human IL-1alpha promoter
R9 C17 C11 coref-ident HTLV-I-,HTLV-I-infected cell lines
R10 C18 C16 coref-relat which,HTLV-I-positive MT-2 cells
R11 C19 C10 coref-ident IL-1alpha,IL-1alpha
R12 C20 C3 coref-ident the Tax protein of both HTLV-I and HTLV-II,human T-cell leukemia virus type I and type II Tax proteins
R13 C21 C15 coref-ident the IL-1alpha promoter,IL-1alpha promoter
R14 C23 C21 coref-ident IL-1alpha promoter-,the IL-1alpha promoter
R15 C25 C24 coref-ident MT-2 cells,MT-2 cells
R16 C27 C21 coref-ident the IL-1alpha promoter,the IL-1alpha promoter
R17 C26 C1 coref-ident transactivation of the IL-1alpha promoter,Transactivation of the interleukin-1alpha promoter
R18 C28 C22 coref-ident the NF-kappaB pathway,the nuclear factor (NF)-kappaB pathway
R19 C29 C19 coref-ident IL-1alpha,IL-1alpha
R20 C30 C11 coref-ident HTLV-I-,HTLV-I-infected cell lines

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 23-50 DNA_domain_or_region denotes interleukin-1alpha promoter
T2 115-149 virus denotes Human T-cell leukemia virus type I
T3 151-157 virus denotes HTLV-I
T4 219-237 protein_molecule denotes interleukin-1alpha
T5 239-248 protein_molecule denotes IL-1alpha
T6 308-317 protein_molecule denotes IL-1alpha
T7 321-327 virus denotes HTLV-I
T8 392-401 protein_molecule denotes IL-1alpha
T9 441-450 protein_molecule denotes IL-1alpha
T10 457-486 DNA_family_or_group denotes IL-1alpha promoter constructs
T11 514-547 protein_molecule denotes chloramphenicol acetyltransferase
T12 571-577 virus denotes HTLV-I
T13 628-637 protein_molecule denotes IL-1alpha
T14 670-681 protein_molecule denotes Tax protein
T15 690-696 virus denotes HTLV-I
T16 701-708 virus denotes HTLV-II
T17 755-764 protein_molecule denotes IL-1alpha
T18 780-807 cell_line denotes uninfected Jurkat cell line
T19 818-829 protein_molecule denotes Tax protein
T20 875-901 protein_complex denotes nuclear factor (NF)-kappaB
T21 959-968 protein_molecule denotes IL-1alpha
T22 1036-1043 protein_complex denotes p65/p50
T23 1044-1053 protein_complex denotes NF-kappaB
T24 1073-1082 protein_molecule denotes IL-1alpha
T25 1112-1128 DNA_domain_or_region denotes -1,065 to -1,056
T26 1133-1145 DNA_domain_or_region denotes +646 to +655
T27 1182-1191 protein_complex denotes NF-kappaB
T28 1224-1234 cell_line denotes MT-2 cells
T29 1244-1253 protein_complex denotes NF-kappaB
T30 1288-1290 DNA_domain_or_region denotes 3'
T31 1291-1300 protein_complex denotes NF-kappaB
T32 1326-1328 DNA_domain_or_region denotes 5'
T33 1329-1338 protein_complex denotes NF-kappaB
T34 1407-1416 protein_molecule denotes IL-1alpha
T35 1438-1448 cell_line denotes MT-2 cells
T36 1476-1485 protein_molecule denotes IL-1alpha
T37 1508-1517 protein_complex denotes NF-kappaB
T38 1522-1525 protein_molecule denotes Tax
T39 1529-1541 cell_line denotes Jurkat cells
T40 1581-1584 protein_molecule denotes Tax
T41 1598-1607 protein_molecule denotes IL-1alpha
T42 1634-1643 protein_complex denotes NF-kappaB
T43 1667-1676 protein_molecule denotes IL-1alpha
T44 1680-1686 virus denotes HTLV-I
T45 1700-1714 cell_type denotes infected cells
T46 1739-1752 other_name denotes hypercalcemia
T47 1754-1777 other_name denotes osteolytic bone lesions
T48 1779-1791 other_name denotes neutrophilia
T49 1806-1824 protein_family_or_group denotes C-reactive protein
T50 1869-1875 virus denotes HTLV-I