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sentences

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element.
T2 141-317 Sentence denotes To identify osteoblast-specific cis-acting elements and trans-acting factors, we initiated an analysis of the promoter of a mouse osteocalcin gene, an osteoblast-specific gene.
T3 318-432 Sentence denotes In this promoter, we identified two osteoblast-specific cis-acting elements (Ducy, P. and Karsenty, G. (1995) Mol.
T4 433-438 Sentence denotes Cell.
T5 439-444 Sentence denotes Biol.
T6 445-460 Sentence denotes 15, 1858-1869).
T7 461-647 Sentence denotes The sequence of one of these elements, OSE2, is identical to the DNA-binding site of the PEBP2 alpha/AML-1 transcription factors, the mammalian homologues of the Drosophila Runt protein.
T8 648-954 Sentence denotes Here we show, using nuclear extracts, recombinant protein, and a specific antiserum against AML-1 proteins in DNA-binding assays, that one member of this family, AML-1B, binds specifically to OSE2 and is immunologically related to OSF2, the factor present in osteoblast nuclear extracts that binds to OSE2.
T9 955-1108 Sentence denotes By DNA cotransfection experiments, we also demonstrate that AML-1B can increase the activity of a short osteocalcin promoter through its binding to OSE2.
T10 1109-1419 Sentence denotes Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes, along with the inability of OSF2 to be upregulated by retinoic acid, unlike the other PEBP2 alpha factors, suggest that OSF2 is a new member of this family of transcription factors.
T11 1420-1688 Sentence denotes Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the PEBP2 alpha/AML-1 family of transcription factors.
T1 0-140 Sentence denotes A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element.
T2 141-317 Sentence denotes To identify osteoblast-specific cis-acting elements and trans-acting factors, we initiated an analysis of the promoter of a mouse osteocalcin gene, an osteoblast-specific gene.
T3 318-432 Sentence denotes In this promoter, we identified two osteoblast-specific cis-acting elements (Ducy, P. and Karsenty, G. (1995) Mol.
T4 433-438 Sentence denotes Cell.
T5 439-444 Sentence denotes Biol.
T6 445-460 Sentence denotes 15, 1858-1869).
T7 461-647 Sentence denotes The sequence of one of these elements, OSE2, is identical to the DNA-binding site of the PEBP2 alpha/AML-1 transcription factors, the mammalian homologues of the Drosophila Runt protein.
T8 648-954 Sentence denotes Here we show, using nuclear extracts, recombinant protein, and a specific antiserum against AML-1 proteins in DNA-binding assays, that one member of this family, AML-1B, binds specifically to OSE2 and is immunologically related to OSF2, the factor present in osteoblast nuclear extracts that binds to OSE2.
T9 955-1108 Sentence denotes By DNA cotransfection experiments, we also demonstrate that AML-1B can increase the activity of a short osteocalcin promoter through its binding to OSE2.
T10 1109-1419 Sentence denotes Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes, along with the inability of OSF2 to be upregulated by retinoic acid, unlike the other PEBP2 alpha factors, suggest that OSF2 is a new member of this family of transcription factors.
T11 1420-1688 Sentence denotes Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the PEBP2 alpha/AML-1 family of transcription factors.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 2-34 protein denotes PEBP2 alpha/AML-1-related factor
T2 45-65 DNA denotes osteocalcin promoter
T3 101-139 DNA denotes osteoblast-specific cis-acting element
T4 153-192 DNA denotes osteoblast-specific cis-acting elements
T5 197-217 protein denotes trans-acting factors
T6 251-259 DNA denotes promoter
T7 265-287 DNA denotes mouse osteocalcin gene
T8 292-316 DNA denotes osteoblast-specific gene
T9 354-393 DNA denotes osteoblast-specific cis-acting elements
T10 490-498 DNA denotes elements
T11 526-542 DNA denotes DNA-binding site
T12 550-589 protein denotes PEBP2 alpha/AML-1 transcription factors
T13 595-615 protein denotes mammalian homologues
T14 623-646 protein denotes Drosophila Runt protein
T15 686-705 protein denotes recombinant protein
T16 740-754 protein denotes AML-1 proteins
T17 810-816 protein denotes AML-1B
T18 879-883 protein denotes OSF2
T19 1015-1021 protein denotes AML-1B
T20 1059-1079 DNA denotes osteocalcin promoter
T21 1145-1185 protein denotes osteoblast nuclear extract-DNA complexes
T22 1200-1236 protein denotes T-cell nuclear extract-DNA complexes
T23 1266-1270 protein denotes OSF2
T24 1324-1343 protein denotes PEBP2 alpha factors
T25 1358-1362 protein denotes OSF2
T26 1397-1418 protein denotes transcription factors
T27 1455-1461 protein denotes AML-1B
T28 1497-1521 DNA denotes osteoblast-specific gene
T29 1548-1586 DNA denotes osteoblast-specific cis-acting element
T30 1614-1618 protein denotes OSF2
T31 1638-1662 protein denotes PEBP2 alpha/AML-1 family
T32 1666-1687 protein denotes transcription factors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-140 Sentence denotes A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element.
S2 141-317 Sentence denotes To identify osteoblast-specific cis-acting elements and trans-acting factors, we initiated an analysis of the promoter of a mouse osteocalcin gene, an osteoblast-specific gene.
S3 318-460 Sentence denotes In this promoter, we identified two osteoblast-specific cis-acting elements (Ducy, P. and Karsenty, G. (1995) Mol. Cell. Biol. 15, 1858-1869).
S4 461-647 Sentence denotes The sequence of one of these elements, OSE2, is identical to the DNA-binding site of the PEBP2 alpha/AML-1 transcription factors, the mammalian homologues of the Drosophila Runt protein.
S5 648-954 Sentence denotes Here we show, using nuclear extracts, recombinant protein, and a specific antiserum against AML-1 proteins in DNA-binding assays, that one member of this family, AML-1B, binds specifically to OSE2 and is immunologically related to OSF2, the factor present in osteoblast nuclear extracts that binds to OSE2.
S6 955-1108 Sentence denotes By DNA cotransfection experiments, we also demonstrate that AML-1B can increase the activity of a short osteocalcin promoter through its binding to OSE2.
S7 1109-1419 Sentence denotes Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes, along with the inability of OSF2 to be upregulated by retinoic acid, unlike the other PEBP2 alpha factors, suggest that OSF2 is a new member of this family of transcription factors.
S8 1420-1688 Sentence denotes Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the PEBP2 alpha/AML-1 family of transcription factors.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-34 NP denotes A PEBP2 alpha/AML-1-related factor
C2 83-86 NP denotes its
C4 263-287 NP denotes a mouse osteocalcin gene
C5 289-316 NP denotes an osteoblast-specific gene
C3 247-316 NP denotes the promoter of a mouse osteocalcin gene, an osteoblast-specific gene
C6 321-334 NP denotes this promoter
C7 350-393 NP denotes two osteoblast-specific cis-acting elements
C9 484-498 NP denotes these elements
C8 477-498 NP denotes one of these elements
C10 500-504 NP denotes OSE2
C11 546-589 NP denotes the PEBP2 alpha/AML-1 transcription factors
C12 591-646 NP denotes the mammalian homologues of the Drosophila Runt protein
C14 797-808 NP denotes this family
C13 783-808 NP denotes one member of this family
C15 810-816 NP denotes AML-1B
C16 840-844 NP denotes OSE2
C17 879-883 NP denotes OSF2
C19 907-934 NP denotes osteoblast nuclear extracts
C20 935-939 NP denotes that
C21 949-953 NP denotes OSE2
C18 885-953 NP denotes the factor present in osteoblast nuclear extracts that binds to OSE2
C22 1015-1021 NP denotes AML-1B
C23 1088-1091 NP denotes its
C24 1103-1107 NP denotes OSE2
C25 1266-1270 NP denotes OSF2
C26 1358-1362 NP denotes OSF2
C27 1382-1418 NP denotes this family of transcription factors
C28 1455-1461 NP denotes AML-1B
C29 1494-1521 NP denotes an osteoblast-specific gene
C30 1530-1533 NP denotes its
C31 1545-1586 NP denotes an osteoblast-specific cis-acting element
C32 1614-1618 NP denotes OSF2
C33 1634-1687 NP denotes the PEBP2 alpha/AML-1 family of transcription factors
R1 C2 C1 coref-pron its,A PEBP2 alpha/AML-1-related factor
R2 C5 C4 coref-appos an osteoblast-specific gene,a mouse osteocalcin gene
R3 C6 C3 coref-ident this promoter,"the promoter of a mouse osteocalcin gene, an osteoblast-specific gene"
R4 C9 C7 coref-ident these elements,two osteoblast-specific cis-acting elements
R5 C10 C8 coref-appos OSE2,one of these elements
R6 C12 C11 coref-appos the mammalian homologues of the Drosophila Runt protein,the PEBP2 alpha/AML-1 transcription factors
R7 C14 C11 coref-ident this family,the PEBP2 alpha/AML-1 transcription factors
R8 C15 C13 coref-appos AML-1B,one member of this family
R9 C16 C8 coref-ident OSE2,one of these elements
R10 C20 C19 coref-relat that,osteoblast nuclear extracts
R11 C21 C16 coref-ident OSE2,OSE2
R12 C18 C17 coref-appos the factor present in osteoblast nuclear extracts that binds to OSE2,OSF2
R13 C22 C13 coref-ident AML-1B,one member of this family
R14 C23 C22 coref-pron its,AML-1B
R15 C24 C21 coref-ident OSE2,OSE2
R16 C25 C17 coref-ident OSF2,OSF2
R17 C26 C25 coref-ident OSF2,OSF2
R18 C27 C14 coref-ident this family of transcription factors,this family
R19 C28 C22 coref-ident AML-1B,AML-1B
R20 C29 C4 coref-ident an osteoblast-specific gene,a mouse osteocalcin gene
R21 C30 C28 coref-pron its,AML-1B
R22 C31 C24 coref-ident an osteoblast-specific cis-acting element,OSE2
R23 C32 C26 coref-ident OSF2,OSF2
R24 C33 C27 coref-ident the PEBP2 alpha/AML-1 family of transcription factors,this family of transcription factors

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 2-34 protein_molecule denotes PEBP2 alpha/AML-1-related factor
T2 45-65 DNA_domain_or_region denotes osteocalcin promoter
T3 101-139 DNA_domain_or_region denotes osteoblast-specific cis-acting element
T4 153-192 DNA_domain_or_region denotes osteoblast-specific cis-acting elements
T5 197-217 protein_family_or_group denotes trans-acting factors
T6 251-259 DNA_domain_or_region denotes promoter
T7 265-287 DNA_domain_or_region denotes mouse osteocalcin gene
T8 292-316 DNA_family_or_group denotes osteoblast-specific gene
T9 354-393 DNA_domain_or_region denotes osteoblast-specific cis-acting elements
T10 490-498 DNA_domain_or_region denotes elements
T11 500-504 DNA_substructure denotes OSE2
T12 526-542 DNA_domain_or_region denotes DNA-binding site
T13 550-589 protein_family_or_group denotes PEBP2 alpha/AML-1 transcription factors
T14 595-615 protein_family_or_group denotes mammalian homologues
T15 623-646 protein_molecule denotes Drosophila Runt protein
T16 668-684 cell_component denotes nuclear extracts
T17 686-705 protein_family_or_group denotes recombinant protein
T18 722-731 other_organic_compound denotes antiserum
T19 740-754 protein_family_or_group denotes AML-1 proteins
T20 758-776 other_name denotes DNA-binding assays
T21 810-816 protein_molecule denotes AML-1B
T22 840-844 DNA_substructure denotes OSE2
T23 879-883 protein_molecule denotes OSF2
T24 907-917 cell_component denotes osteoblast
T25 918-934 cell_component denotes nuclear extracts
T26 949-953 DNA_substructure denotes OSE2
T27 958-988 other_name denotes DNA cotransfection experiments
T28 1015-1021 protein_molecule denotes AML-1B
T29 1059-1079 DNA_domain_or_region denotes osteocalcin promoter
T30 1103-1107 DNA_substructure denotes OSE2
T31 1145-1185 protein_complex denotes osteoblast nuclear extract-DNA complexes
T32 1200-1236 protein_complex denotes T-cell nuclear extract-DNA complexes
T33 1266-1270 protein_molecule denotes OSF2
T34 1292-1305 other_organic_compound denotes retinoic acid
T35 1324-1343 protein_family_or_group denotes PEBP2 alpha factors
T36 1358-1362 protein_molecule denotes OSF2
T37 1397-1418 protein_family_or_group denotes transcription factors
T38 1455-1461 protein_molecule denotes AML-1B
T39 1475-1490 other_name denotes gene expression
T40 1497-1521 DNA_family_or_group denotes osteoblast-specific gene
T41 1548-1586 DNA_domain_or_region denotes osteoblast-specific cis-acting element
T42 1614-1618 protein_molecule denotes OSF2
T43 1638-1662 protein_family_or_group denotes PEBP2 alpha/AML-1 family
T44 1666-1687 protein_family_or_group denotes transcription factors

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 14-17 Disease denotes AML http://purl.obolibrary.org/obo/MONDO_0018874
T2 562-565 Disease denotes AML http://purl.obolibrary.org/obo/MONDO_0018874
T3 740-743 Disease denotes AML http://purl.obolibrary.org/obo/MONDO_0018874
T4 810-813 Disease denotes AML http://purl.obolibrary.org/obo/MONDO_0018874
T5 1015-1018 Disease denotes AML http://purl.obolibrary.org/obo/MONDO_0018874
T6 1455-1458 Disease denotes AML http://purl.obolibrary.org/obo/MONDO_0018874
T7 1650-1653 Disease denotes AML http://purl.obolibrary.org/obo/MONDO_0018874

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 265-270 OrganismTaxon denotes mouse 10088|10090
T3 623-633 OrganismTaxon denotes Drosophila 2081351|32281|7215

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 101-111 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062
T2 153-163 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062
T3 292-302 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062
T4 354-364 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062
T5 907-917 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062
T6 1145-1155 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062
T7 1200-1206 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T8 1497-1507 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062
T9 1548-1558 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 14-17 Phenotype denotes AML HP:0004808
T2 562-565 Phenotype denotes AML HP:0004808
T3 740-743 Phenotype denotes AML HP:0004808
T4 810-813 Phenotype denotes AML HP:0004808
T5 1015-1018 Phenotype denotes AML HP:0004808
T6 1455-1458 Phenotype denotes AML HP:0004808
T7 1650-1653 Phenotype denotes AML HP:0004808

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 101-111 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062
T2 153-163 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062
T3 292-302 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062
T4 354-364 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062
T5 907-917 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062
T6 1145-1155 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062
T7 1200-1206 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T8 1497-1507 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062
T9 1548-1558 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062