PubMed:8514446 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8514446","sourcedb":"PubMed","sourceid":"8514446","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8514446","text":"trk and ret proto-oncogene expression in human neuroblastoma specimens: high frequency of trk expression in non-advanced stages.\nForty-three fresh tumor specimens of human neuroblastoma belonging to different clinical stages were analyzed for the expression of 2 proto-oncogenes: trk, which encodes a tyrosine-kinase receptor for nerve growth factor (NGF) and ret, another receptor-type tyrosine kinase whose ligand is unknown. The mRNA expression of the trk gene was detected in 67.4% of cases, with increased frequency in I, II and IVs Evans' stages and in patients with favorable prognosis according to the Shimada classification. Moreover, trk expression inversely correlated with Nmyc-gene amplification. ret mRNA was found in 36.8% of cases and equally distributed in the different stages. In addition, ngfR (low-affinity NGF receptor)-gene expression was present in 9 out of 25 cases. The simultaneous presence of mRNA related to both forms of the NGF receptor, while not proving the presence of a functional receptor, indicates the existence of a sub-set of neuroblastoma cells potentially responsive to NGF.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":330,"end":335},"obj":"http://purl.obolibrary.org/obo/UBERON_0001021"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":8,"end":26},"obj":"gene:5979"},{"id":"T1","span":{"begin":47,"end":60},"obj":"disease:C0027819"},{"id":"T2","span":{"begin":8,"end":26},"obj":"gene:5979"},{"id":"T3","span":{"begin":47,"end":60},"obj":"disease:C0700095"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":128},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":129,"end":427},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":428,"end":633},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":634,"end":795},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":796,"end":891},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":892,"end":1116},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":128},"obj":"Sentence"},{"id":"T2","span":{"begin":129,"end":427},"obj":"Sentence"},{"id":"T3","span":{"begin":428,"end":633},"obj":"Sentence"},{"id":"T4","span":{"begin":634,"end":795},"obj":"Sentence"},{"id":"T5","span":{"begin":796,"end":891},"obj":"Sentence"},{"id":"T6","span":{"begin":892,"end":1116},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":330,"end":335},"obj":"http://purl.obolibrary.org/obo/UBERON_0001021"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"}]},{"project":"DisGeNet-2017-sample","denotations":[{"id":"T1374","span":{"begin":8,"end":26},"obj":"gene:5979"},{"id":"T1375","span":{"begin":47,"end":60},"obj":"disease:C0027819"},{"id":"T1376","span":{"begin":1112,"end":1115},"obj":"gene:4803"},{"id":"T1377","span":{"begin":1066,"end":1079},"obj":"disease:C0027819"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T1374","obj":"T1375"},{"id":"R2","pred":"associated_with","subj":"T1374","obj":"T1375"},{"id":"R3","pred":"associated_with","subj":"T1376","obj":"T1377"},{"id":"R4","pred":"associated_with","subj":"T1376","obj":"T1377"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T1374","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T1375","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T1376","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T1377","pred":"source","obj":"DisGeNet-2017-sample"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#bd93ec","default":true},{"id":"DisGeNET","color":"#93eca3"},{"id":"sentences","color":"#ec939c"},{"id":"UBERON-AE","color":"#93b6ec"},{"id":"DisGeNet-2017-sample","color":"#d1ec93"}]}]}}