| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-128 |
Sentence |
denotes |
trk and ret proto-oncogene expression in human neuroblastoma specimens: high frequency of trk expression in non-advanced stages. |
| TextSentencer_T2 |
129-427 |
Sentence |
denotes |
Forty-three fresh tumor specimens of human neuroblastoma belonging to different clinical stages were analyzed for the expression of 2 proto-oncogenes: trk, which encodes a tyrosine-kinase receptor for nerve growth factor (NGF) and ret, another receptor-type tyrosine kinase whose ligand is unknown. |
| TextSentencer_T3 |
428-633 |
Sentence |
denotes |
The mRNA expression of the trk gene was detected in 67.4% of cases, with increased frequency in I, II and IVs Evans' stages and in patients with favorable prognosis according to the Shimada classification. |
| TextSentencer_T4 |
634-795 |
Sentence |
denotes |
Moreover, trk expression inversely correlated with Nmyc-gene amplification. ret mRNA was found in 36.8% of cases and equally distributed in the different stages. |
| TextSentencer_T5 |
796-891 |
Sentence |
denotes |
In addition, ngfR (low-affinity NGF receptor)-gene expression was present in 9 out of 25 cases. |
| TextSentencer_T6 |
892-1116 |
Sentence |
denotes |
The simultaneous presence of mRNA related to both forms of the NGF receptor, while not proving the presence of a functional receptor, indicates the existence of a sub-set of neuroblastoma cells potentially responsive to NGF. |
| T1 |
0-128 |
Sentence |
denotes |
trk and ret proto-oncogene expression in human neuroblastoma specimens: high frequency of trk expression in non-advanced stages. |
| T2 |
129-427 |
Sentence |
denotes |
Forty-three fresh tumor specimens of human neuroblastoma belonging to different clinical stages were analyzed for the expression of 2 proto-oncogenes: trk, which encodes a tyrosine-kinase receptor for nerve growth factor (NGF) and ret, another receptor-type tyrosine kinase whose ligand is unknown. |
| T3 |
428-633 |
Sentence |
denotes |
The mRNA expression of the trk gene was detected in 67.4% of cases, with increased frequency in I, II and IVs Evans' stages and in patients with favorable prognosis according to the Shimada classification. |
| T4 |
634-795 |
Sentence |
denotes |
Moreover, trk expression inversely correlated with Nmyc-gene amplification. ret mRNA was found in 36.8% of cases and equally distributed in the different stages. |
| T5 |
796-891 |
Sentence |
denotes |
In addition, ngfR (low-affinity NGF receptor)-gene expression was present in 9 out of 25 cases. |
| T6 |
892-1116 |
Sentence |
denotes |
The simultaneous presence of mRNA related to both forms of the NGF receptor, while not proving the presence of a functional receptor, indicates the existence of a sub-set of neuroblastoma cells potentially responsive to NGF. |
