PubMed:8493578 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8493578","sourcedb":"PubMed","sourceid":"8493578","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8493578","text":"Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.\nThe retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates cell cycle progression. Elf-1 is a lymphoid-specific Ets transcription factor that regulates inducible gene expression during T cell activation. In this report, it is demonstrated that Elf-1 contains a sequence motif that is highly related to the Rb binding sites of several viral oncoproteins and binds to the pocket region of Rb both in vitro and in vivo. Elf-1 binds exclusively to the underphosphorylated form of Rb and fails to bind to Rb mutants derived from patients with retinoblastoma. Co-immunoprecipitation experiments demonstrated an association between Elf-1 and Rb in resting normal human T cells. 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