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PubMed:8480425 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-17 protein denotes HIV-1 Nef protein
T2 46-50 protein denotes AP-1
T3 75-88 cell_type denotes human T-cells
T4 94-150 DNA denotes human immunodeficiency virus type 1 long terminal repeat
T5 152-161 DNA denotes HIV-1-LTR
T6 249-259 DNA denotes HIV-1 gene
T7 316-341 protein denotes HIV-1-encoded Nef protein
T8 357-360 protein denotes Nef
T9 423-426 protein denotes Nef
T10 450-466 protein denotes cellular factors
T11 614-641 cell_line denotes Nef-expressing T-cell lines
T12 691-706 protein denotes T-cell mitogens
T13 722-725 protein denotes Nef
T14 755-759 protein denotes AP-1
T15 803-816 cell_type denotes human T-cells
T16 832-852 cell_line denotes Nef expressing cells
T17 906-942 DNA denotes HIV-1 AP-1 DNA recognition sequences
T18 973-1006 protein denotes chloramphenicol acetyltransferase
T19 1008-1011 protein denotes CAT
T20 1070-1078 DNA denotes CAT gene
T21 1114-1134 cell_line denotes Nef-expressing cells
T22 1203-1207 protein denotes AP-1
T23 1220-1223 protein denotes Nef
T24 1254-1264 DNA denotes HIV-1 gene
T25 1279-1295 cell_type denotes infected T-cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-89 Sentence denotes HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells.
S2 90-271 Sentence denotes The human immunodeficiency virus type 1 long terminal repeat, HIV-1-LTR, contains binding sites for several cellular transcription factors which contribute to HIV-1 gene expression.
S3 272-401 Sentence denotes Our previous studies on the function of the HIV-1-encoded Nef protein suggested that Nef may be an inhibitor HIV-1 transcription.
S4 402-707 Sentence denotes To determine whether Nef affects the binding of cellular factors implicated in HIV-1 regulation, 32P-labeled oligonucleotides corresponding to the binding sites were incubated with nuclear extracts prepared from Nef-expressing T-cell lines that were not stimulated or were stimulated with T-cell mitogens.
S5 708-817 Sentence denotes We found that Nef inhibited the recruitment of AP-1 DNA-binding activity in mitogen-stimulated human T-cells.
S6 818-1018 Sentence denotes Additionally, Nef expressing cells were transiently transfected with a plasmid in which HIV-1 AP-1 DNA recognition sequences were cloned downstream of the chloramphenicol acetyltransferase (CAT) gene.
S7 1019-1160 Sentence denotes Mitogen-mediated transcriptional activation of the CAT gene in this construct was inhibited in Nef-expressing cells but not in control cells.
S8 1161-1296 Sentence denotes These studies suggest that, by inhibiting AP-1 activation, Nef may play a role in regulating HIV-1 gene expression in infected T-cells.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-17 NP denotes HIV-1 Nef protein
C2 90-150 NP denotes The human immunodeficiency virus type 1 long terminal repeat
C3 152-161 NP denotes HIV-1-LTR
C4 190-228 NP denotes several cellular transcription factors
C5 229-234 NP denotes which
C6 249-270 NP denotes HIV-1 gene expression
C7 312-341 NP denotes the HIV-1-encoded Nef protein
C8 357-360 NP denotes Nef
C9 423-426 NP denotes Nef
C10 614-641 NP denotes Nef-expressing T-cell lines
C11 642-646 NP denotes that
C12 722-725 NP denotes Nef
C13 832-852 NP denotes Nef expressing cells
C14 887-896 NP denotes a plasmid
C15 900-905 NP denotes which
C16 969-1017 NP denotes the chloramphenicol acetyltransferase (CAT) gene
C17 1066-1078 NP denotes the CAT gene
C18 1114-1134 NP denotes Nef-expressing cells
C19 1220-1223 NP denotes Nef
C20 1254-1275 NP denotes HIV-1 gene expression
R1 C3 C2 coref-appos HIV-1-LTR,The human immunodeficiency virus type 1 long terminal repeat
R2 C5 C4 coref-relat which,several cellular transcription factors
R3 C7 C1 coref-other the HIV-1-encoded Nef protein,HIV-1 Nef protein
R4 C9 C8 coref-ident Nef,Nef
R5 C11 C10 coref-relat that,Nef-expressing T-cell lines
R6 C12 C9 coref-ident Nef,Nef
R7 C13 C10 coref-other Nef expressing cells,Nef-expressing T-cell lines
R8 C15 C14 coref-relat which,a plasmid
R9 C17 C16 coref-ident the CAT gene,the chloramphenicol acetyltransferase (CAT) gene
R10 C18 C13 coref-ident Nef-expressing cells,Nef expressing cells
R11 C19 C12 coref-ident Nef,Nef
R12 C20 C6 coref-ident HIV-1 gene expression,HIV-1 gene expression

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-17 protein_molecule denotes HIV-1 Nef protein
T2 46-50 protein_molecule denotes AP-1
T3 75-88 cell_type denotes human T-cells
T4 94-129 virus denotes human immunodeficiency virus type 1
T5 152-161 DNA_domain_or_region denotes HIV-1-LTR
T6 249-259 DNA_molecule denotes HIV-1 gene
T7 316-341 protein_molecule denotes HIV-1-encoded Nef protein
T8 357-360 protein_family_or_group denotes Nef
T9 381-400 other_name denotes HIV-1 transcription
T10 423-426 protein_family_or_group denotes Nef
T11 450-466 protein_family_or_group denotes cellular factors
T12 481-497 other_name denotes HIV-1 regulation
T13 499-527 polynucleotide denotes 32P-labeled oligonucleotides
T14 583-599 cell_component denotes nuclear extracts
T15 614-641 cell_line denotes Nef-expressing T-cell lines
T16 691-706 protein_family_or_group denotes T-cell mitogens
T17 722-725 protein_family_or_group denotes Nef
T18 755-759 protein_molecule denotes AP-1
T19 803-816 cell_type denotes human T-cells
T20 832-835 protein_family_or_group denotes Nef
T21 906-942 DNA_domain_or_region denotes HIV-1 AP-1 DNA recognition sequences
T22 973-1006 protein_molecule denotes chloramphenicol acetyltransferase
T23 1008-1011 protein_molecule denotes CAT
T24 1070-1078 DNA_domain_or_region denotes CAT gene
T25 1114-1117 protein_family_or_group denotes Nef
T26 1203-1207 protein_molecule denotes AP-1
T27 1220-1223 protein_family_or_group denotes Nef
T28 1254-1264 DNA_molecule denotes HIV-1 gene
T29 1279-1295 cell_type denotes infected T-cells