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PubMed:8444876 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene.
T2 116-230 Sentence denotes The expression of thrombospondin 1 (TSP 1), a member of the TSP gene family, is rapidly induced by growth factors.
T3 231-369 Sentence denotes We tested the ability of human TSP 1-chloramphenicol acetyltransferase constructs to respond to serum in stably transfected NIH-3T3 cells.
T4 370-543 Sentence denotes Two transcriptional elements in the TSP 1 promoter, a distal element at -1280 and a proximal element at -65, were required for the response of the human TSP 1 gene to serum.
T5 544-663 Sentence denotes The distal element contains the 5'-CC(A + T)6GG-3' consensus sequence characteristic of a serum-response element (SRE).
T6 664-758 Sentence denotes Deletions or mutations in this element reduced the serum response of the TSP 1 gene by 80-90%.
T7 759-885 Sentence denotes In gel-shift assays, the -1280 element and the c-fos SRE cross-competed, whereas their functional and binding mutants did not.
T8 886-1055 Sentence denotes The proximal element contains the sequence 5'-GGCCAATGGG-3', which closely resembles the consensus binding motif for the CCAAT-binding factor NF-Y (CBF, CP1, alpha CP1).
T9 1056-1137 Sentence denotes Deletions or mutations in this element also reduced the serum response by 80-90%.
T10 1138-1400 Sentence denotes Methylation interference analysis of the -65 region identified a pattern of contacts with nuclear factors resembling that for NF-Y, and an NF-Y-binding site and the proximal TSP 1 element cross-competed in gel-shift assays, whereas their binding mutants did not.
T11 1401-1579 Sentence denotes Finally, an abbreviated TSP 1 promoter/5'-flank, containing the SRE- and NF-Y-binding sites, mediated a serum response that was close in magnitude to that of the parent promoter.
T12 1580-1707 Sentence denotes We conclude that the serum response of the human TSP 1 gene requires the coordinated function of an SRE- and NF-Y-binding site.
T1 0-115 Sentence denotes A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene.
T2 116-230 Sentence denotes The expression of thrombospondin 1 (TSP 1), a member of the TSP gene family, is rapidly induced by growth factors.
T3 231-369 Sentence denotes We tested the ability of human TSP 1-chloramphenicol acetyltransferase constructs to respond to serum in stably transfected NIH-3T3 cells.
T4 370-543 Sentence denotes Two transcriptional elements in the TSP 1 promoter, a distal element at -1280 and a proximal element at -65, were required for the response of the human TSP 1 gene to serum.
T5 544-663 Sentence denotes The distal element contains the 5'-CC(A + T)6GG-3' consensus sequence characteristic of a serum-response element (SRE).
T6 664-758 Sentence denotes Deletions or mutations in this element reduced the serum response of the TSP 1 gene by 80-90%.
T7 759-885 Sentence denotes In gel-shift assays, the -1280 element and the c-fos SRE cross-competed, whereas their functional and binding mutants did not.
T8 886-1055 Sentence denotes The proximal element contains the sequence 5'-GGCCAATGGG-3', which closely resembles the consensus binding motif for the CCAAT-binding factor NF-Y (CBF, CP1, alpha CP1).
T9 1056-1137 Sentence denotes Deletions or mutations in this element also reduced the serum response by 80-90%.
T10 1138-1400 Sentence denotes Methylation interference analysis of the -65 region identified a pattern of contacts with nuclear factors resembling that for NF-Y, and an NF-Y-binding site and the proximal TSP 1 element cross-competed in gel-shift assays, whereas their binding mutants did not.
T11 1401-1579 Sentence denotes Finally, an abbreviated TSP 1 promoter/5'-flank, containing the SRE- and NF-Y-binding sites, mediated a serum response that was close in magnitude to that of the parent promoter.
T12 1580-1707 Sentence denotes We conclude that the serum response of the human TSP 1 gene requires the coordinated function of an SRE- and NF-Y-binding site.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 454-462 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T2 890-898 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T3 1303-1311 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 2-24 DNA denotes serum response element
T2 31-52 DNA denotes binding site for NF-Y
T3 87-114 DNA denotes human thrombospondin 1 gene
T4 134-150 protein denotes thrombospondin 1
T5 152-157 protein denotes TSP 1
T6 176-191 DNA denotes TSP gene family
T7 256-312 DNA denotes human TSP 1-chloramphenicol acetyltransferase constructs
T8 406-411 protein denotes TSP 1
T9 737-747 DNA denotes TSP 1 gene
T10 784-797 DNA denotes -1280 element
T11 806-821 DNA denotes c-fos SRE cross
T12 861-876 DNA denotes binding mutants
T13 890-906 DNA denotes proximal element
T14 1007-1027 DNA denotes CCAAT-binding factor
T15 1028-1032 protein denotes NF-Y
T16 1034-1037 protein denotes CBF
T17 1039-1042 protein denotes CP1
T18 1044-1053 protein denotes alpha CP1
T19 1179-1189 DNA denotes -65 region
T20 1228-1243 protein denotes nuclear factors
T21 1264-1268 protein denotes NF-Y
T22 1277-1294 DNA denotes NF-Y-binding site
T23 1303-1325 DNA denotes proximal TSP 1 element
T24 1376-1391 DNA denotes binding mutants
T25 1413-1448 DNA denotes abbreviated TSP 1 promoter/5'-flank
T26 1465-1492 DNA denotes SRE- and NF-Y-binding sites
T27 1563-1578 DNA denotes parent promoter
T28 1629-1639 DNA denotes TSP 1 gene
T29 1680-1706 DNA denotes SRE- and NF-Y-binding site

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-115 Sentence denotes A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene.
S2 116-230 Sentence denotes The expression of thrombospondin 1 (TSP 1), a member of the TSP gene family, is rapidly induced by growth factors.
S3 231-369 Sentence denotes We tested the ability of human TSP 1-chloramphenicol acetyltransferase constructs to respond to serum in stably transfected NIH-3T3 cells.
S4 370-543 Sentence denotes Two transcriptional elements in the TSP 1 promoter, a distal element at -1280 and a proximal element at -65, were required for the response of the human TSP 1 gene to serum.
S5 544-663 Sentence denotes The distal element contains the 5'-CC(A + T)6GG-3' consensus sequence characteristic of a serum-response element (SRE).
S6 664-758 Sentence denotes Deletions or mutations in this element reduced the serum response of the TSP 1 gene by 80-90%.
S7 759-885 Sentence denotes In gel-shift assays, the -1280 element and the c-fos SRE cross-competed, whereas their functional and binding mutants did not.
S8 886-1055 Sentence denotes The proximal element contains the sequence 5'-GGCCAATGGG-3', which closely resembles the consensus binding motif for the CCAAT-binding factor NF-Y (CBF, CP1, alpha CP1).
S9 1056-1137 Sentence denotes Deletions or mutations in this element also reduced the serum response by 80-90%.
S10 1138-1400 Sentence denotes Methylation interference analysis of the -65 region identified a pattern of contacts with nuclear factors resembling that for NF-Y, and an NF-Y-binding site and the proximal TSP 1 element cross-competed in gel-shift assays, whereas their binding mutants did not.
S11 1401-1579 Sentence denotes Finally, an abbreviated TSP 1 promoter/5'-flank, containing the SRE- and NF-Y-binding sites, mediated a serum response that was close in magnitude to that of the parent promoter.
S12 1580-1707 Sentence denotes We conclude that the serum response of the human TSP 1 gene requires the coordinated function of an SRE- and NF-Y-binding site.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-24 NP denotes A serum response element
C3 48-52 NP denotes NF-Y
C2 29-52 NP denotes a binding site for NF-Y
C5 83-114 NP denotes the human thrombospondin 1 gene
C4 61-114 NP denotes the serum response of the human thrombospondin 1 gene
C6 134-158 NP denotes thrombospondin 1 (TSP 1)
C7 160-191 NP denotes a member of the TSP gene family
C8 327-332 NP denotes serum
C10 406-411 NP denotes TSP 1
C9 370-420 NP denotes Two transcriptional elements in the TSP 1 promoter
C12 422-447 NP denotes a distal element at -1280
C13 452-477 NP denotes a proximal element at -65
C11 422-477 NP denotes a distal element at -1280 and a proximal element at -65
C15 513-533 NP denotes the human TSP 1 gene
C16 537-542 NP denotes serum
C14 497-542 NP denotes the response of the human TSP 1 gene to serum
C17 544-562 NP denotes The distal element
C18 632-662 NP denotes a serum-response element (SRE)
C19 690-702 NP denotes this element
C21 733-747 NP denotes the TSP 1 gene
C20 711-747 NP denotes the serum response of the TSP 1 gene
C23 780-797 NP denotes the -1280 element
C22 780-815 NP denotes the -1280 element and the c-fos SRE
C24 840-845 NP denotes their
C25 886-906 NP denotes The proximal element
C26 916-945 NP denotes the sequence 5'-GGCCAATGGG-3'
C27 947-952 NP denotes which
C28 1003-1032 NP denotes the CCAAT-binding factor NF-Y
C29 1082-1094 NP denotes this element
C30 1108-1126 NP denotes the serum response
C31 1201-1243 NP denotes a pattern of contacts with nuclear factors
C32 1255-1259 NP denotes that
C33 1264-1268 NP denotes NF-Y
C35 1274-1294 NP denotes an NF-Y-binding site
C37 1312-1317 NP denotes TSP 1
C36 1299-1325 NP denotes the proximal TSP 1 element
C34 1274-1325 NP denotes an NF-Y-binding site and the proximal TSP 1 element
C38 1370-1375 NP denotes their
C39 1425-1430 NP denotes TSP 1
C40 1461-1492 NP denotes the SRE- and NF-Y-binding sites
C41 1503-1519 NP denotes a serum response
C42 1520-1524 NP denotes that
C43 1551-1555 NP denotes that
C45 1619-1639 NP denotes the human TSP 1 gene
C44 1597-1639 NP denotes the serum response of the human TSP 1 gene
C46 1677-1706 NP denotes an SRE- and NF-Y-binding site
R1 C6 C5 coref-ident thrombospondin 1 (TSP 1),the human thrombospondin 1 gene
R2 C7 C6 coref-appos a member of the TSP gene family,thrombospondin 1 (TSP 1)
R3 C10 C6 coref-ident TSP 1,thrombospondin 1 (TSP 1)
R4 C11 C9 coref-appos a distal element at -1280 and a proximal element at -65,Two transcriptional elements in the TSP 1 promoter
R5 C15 C10 coref-ident the human TSP 1 gene,TSP 1
R6 C16 C8 coref-ident serum,serum
R7 C14 C4 coref-ident the response of the human TSP 1 gene to serum,the serum response of the human thrombospondin 1 gene
R8 C17 C12 coref-ident The distal element,a distal element at -1280
R9 C18 C1 coref-other a serum-response element (SRE),A serum response element
R10 C19 C17 coref-ident this element,The distal element
R11 C21 C15 coref-ident the TSP 1 gene,the human TSP 1 gene
R12 C20 C14 coref-ident the serum response of the TSP 1 gene,the response of the human TSP 1 gene to serum
R13 C23 C19 coref-ident the -1280 element,this element
R14 C24 C22 coref-pron their,the -1280 element and the c-fos SRE
R15 C25 C13 coref-ident The proximal element,a proximal element at -65
R16 C27 C26 coref-relat which,the sequence 5'-GGCCAATGGG-3'
R17 C28 C3 coref-ident the CCAAT-binding factor NF-Y,NF-Y
R18 C29 C25 coref-ident this element,The proximal element
R19 C30 C20 coref-ident the serum response,the serum response of the TSP 1 gene
R20 C32 C31 coref-pron that,a pattern of contacts with nuclear factors
R21 C33 C28 coref-ident NF-Y,the CCAAT-binding factor NF-Y
R22 C35 C2 coref-ident an NF-Y-binding site,a binding site for NF-Y
R23 C37 C21 coref-ident TSP 1,the TSP 1 gene
R24 C36 C29 coref-ident the proximal TSP 1 element,this element
R25 C38 C34 coref-pron their,an NF-Y-binding site and the proximal TSP 1 element
R26 C39 C37 coref-ident TSP 1,TSP 1
R27 C42 C41 coref-relat that,a serum response
R28 C43 C41 coref-pron that,a serum response
R29 C45 C39 coref-ident the human TSP 1 gene,TSP 1
R30 C44 C30 coref-ident the serum response of the human TSP 1 gene,the serum response
R31 C46 C40 coref-other an SRE- and NF-Y-binding site,the SRE- and NF-Y-binding sites

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 2-24 DNA_domain_or_region denotes serum response element
T2 31-47 DNA_domain_or_region denotes binding site for
T3 48-52 protein_family_or_group denotes NF-Y
T4 65-79 other_name denotes serum response
T5 87-114 DNA_domain_or_region denotes human thrombospondin 1 gene
T6 134-150 protein_molecule denotes thrombospondin 1
T7 152-157 protein_molecule denotes TSP 1
T8 176-191 DNA_family_or_group denotes TSP gene family
T9 256-261 DNA_molecule denotes human
T10 262-267 protein_molecule denotes TSP 1
T11 267-301 protein_molecule denotes -chloramphenicol acetyltransferase
T12 327-332 tissue denotes serum
T13 406-411 protein_molecule denotes TSP 1
T14 537-542 tissue denotes serum
T15 715-720 tissue denotes serum
T16 737-747 DNA_domain_or_region denotes TSP 1 gene
T17 762-778 other_name denotes gel-shift assays
T18 784-797 DNA_domain_or_region denotes -1280 element
T19 806-821 DNA_molecule denotes c-fos SRE cross
T20 861-876 DNA_molecule denotes binding mutants
T21 890-906 DNA_domain_or_region denotes proximal element
T22 929-945 polynucleotide denotes 5'-GGCCAATGGG-3'
T23 1007-1027 DNA_family_or_group denotes CCAAT-binding factor
T24 1028-1032 protein_family_or_group denotes NF-Y
T25 1034-1037 protein_molecule denotes CBF
T26 1039-1042 protein_molecule denotes CP1
T27 1044-1053 protein_molecule denotes alpha CP1
T28 1112-1126 other_name denotes serum response
T29 1138-1171 other_name denotes Methylation interference analysis
T30 1179-1189 DNA_domain_or_region denotes -65 region
T31 1228-1243 protein_family_or_group denotes nuclear factors
T32 1264-1268 protein_family_or_group denotes NF-Y
T33 1277-1281 protein_family_or_group denotes NF-Y
T34 1303-1325 DNA_domain_or_region denotes proximal TSP 1 element
T35 1344-1360 other_name denotes gel-shift assays
T36 1376-1391 DNA_molecule denotes binding mutants
T37 1413-1448 DNA_domain_or_region denotes abbreviated TSP 1 promoter/5'-flank
T38 1505-1519 other_name denotes serum response
T39 1563-1578 DNA_domain_or_region denotes parent promoter
T40 1601-1615 other_name denotes serum response
T41 1629-1639 DNA_domain_or_region denotes TSP 1 gene

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 454-462 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491
T2 890-898 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491
T3 1303-1311 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 152-155 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T2 176-179 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T3 262-265 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T4 406-409 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T5 523-526 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T6 737-740 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T7 1312-1315 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T8 1425-1428 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T9 1629-1632 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 87-92 OrganismTaxon denotes human 9606
T2 256-261 OrganismTaxon denotes human 9606
T3 517-522 OrganismTaxon denotes human 9606
T4 1623-1628 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1443-1448 Body_part denotes flank http://purl.obolibrary.org/obo/UBERON_0000180