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PubMed:8394344 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP.
T2 97-216 Sentence denotes We examined the effects of increasing intracellular cyclic AMP levels on the expression of human PAF receptor (hPAF-R).
T3 217-293 Sentence denotes Peripheral blood monocytes constitutively expressed hPAF-R mRNA transcripts.
T4 294-463 Sentence denotes A transiently elevated intracellular concentration of AMP induced with prostaglandin E2, cholera toxin, or forskolin was a sufficient signal to inhibit PAF-R expression.
T5 464-680 Sentence denotes To determine the mechanisms of this inhibition, human monocytes were treated with dibutyryl cAMP, a cell-permeable cAMP analogue. cAMP reduced the expression of hPAF-R in a concentration- and a time-dependent manner.
T6 681-750 Sentence denotes The effect was seen as early as 1 h and was essentially total by 4 h.
T7 751-871 Sentence denotes Stability of hPAF-R mRNA was not markedly decreased by cAMP, as assessed by measuring the half-lives of the transcripts.
T8 872-991 Sentence denotes Moreover, the nuclear transcription rate of the hPAF-R gene was reduced as early as 30 min after stimulation with cAMP.
T9 992-1296 Sentence denotes The inhibition of hPAF-R mRNA accumulation was associated with diminished responsiveness to PAF, as assayed by intracellular Ca2+ fluxes, decreased number of binding sites, and decreased hPAF-R protein expression on the cell surface, as assessed by flow cytometry using a polyclonal anti-hPAF-R antibody.
T10 1297-1455 Sentence denotes These data indicate that PAF-R expression can be regulated at the transcriptional and possibly post-transcriptional levels by elevation of intracellular cAMP.
T1 0-96 Sentence denotes Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP.
T2 97-216 Sentence denotes We examined the effects of increasing intracellular cyclic AMP levels on the expression of human PAF receptor (hPAF-R).
T3 217-293 Sentence denotes Peripheral blood monocytes constitutively expressed hPAF-R mRNA transcripts.
T4 294-463 Sentence denotes A transiently elevated intracellular concentration of AMP induced with prostaglandin E2, cholera toxin, or forskolin was a sufficient signal to inhibit PAF-R expression.
T5 464-680 Sentence denotes To determine the mechanisms of this inhibition, human monocytes were treated with dibutyryl cAMP, a cell-permeable cAMP analogue. cAMP reduced the expression of hPAF-R in a concentration- and a time-dependent manner.
T6 681-750 Sentence denotes The effect was seen as early as 1 h and was essentially total by 4 h.
T7 751-871 Sentence denotes Stability of hPAF-R mRNA was not markedly decreased by cAMP, as assessed by measuring the half-lives of the transcripts.
T8 872-991 Sentence denotes Moreover, the nuclear transcription rate of the hPAF-R gene was reduced as early as 30 min after stimulation with cAMP.
T9 992-1296 Sentence denotes The inhibition of hPAF-R mRNA accumulation was associated with diminished responsiveness to PAF, as assayed by intracellular Ca2+ fluxes, decreased number of binding sites, and decreased hPAF-R protein expression on the cell surface, as assessed by flow cytometry using a polyclonal anti-hPAF-R antibody.
T10 1297-1455 Sentence denotes These data indicate that PAF-R expression can be regulated at the transcriptional and possibly post-transcriptional levels by elevation of intracellular cAMP.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 228-233 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 228-233 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 383-390 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 228-233 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 188-193 OrganismTaxon denotes human 9606
T2 512-517 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 30-38 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T2 135-148 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T3 228-233 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 234-243 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T6 317-330 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T7 518-527 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T9 1103-1116 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T10 1436-1449 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 30-38 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T2 234-243 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T4 518-527 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054