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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1683-1694 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT

sentences

Id Subject Object Predicate Lexical cue
T1 0-158 Sentence denotes Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix.
T2 159-272 Sentence denotes A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.
T3 273-542 Sentence denotes Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase).
T4 543-607 Sentence denotes The interplay of these factors was investigated in cell culture.
T5 608-949 Sentence denotes Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy.
T6 950-989 Sentence denotes This aggregation required both enzymes.
T7 990-1041 Sentence denotes Studies with 125I-LDL confirmed these observations:
T8 1042-1233 Sentence denotes 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone.
T9 1234-1356 Sentence denotes A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein.
T10 1357-1454 Sentence denotes In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material).
T11 1455-1583 Sentence denotes LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used.
T12 1584-1867 Sentence denotes The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans.
T13 1868-2101 Sentence denotes When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation.
T14 2102-2336 Sentence denotes Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates.
T15 2337-2536 Sentence denotes Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes.
T16 2537-2864 Sentence denotes Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation.
T1 0-158 Sentence denotes Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix.
T2 159-272 Sentence denotes A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.
T3 273-542 Sentence denotes Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase).
T4 543-607 Sentence denotes The interplay of these factors was investigated in cell culture.
T5 608-949 Sentence denotes Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy.
T6 950-989 Sentence denotes This aggregation required both enzymes.
T7 990-1041 Sentence denotes Studies with 125I-LDL confirmed these observations:
T8 1042-1233 Sentence denotes 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone.
T9 1234-1356 Sentence denotes A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein.
T10 1357-1454 Sentence denotes In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material).
T11 1455-1583 Sentence denotes LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used.
T12 1584-1867 Sentence denotes The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans.
T13 1868-2101 Sentence denotes When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation.
T14 2102-2336 Sentence denotes Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates.
T15 2337-2536 Sentence denotes Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes.
T16 2537-2864 Sentence denotes Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1683-1694 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1683-1694 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 113-126 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T2 120-126 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T3 314-327 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T4 321-327 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T5 636-649 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T6 643-649 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T7 1503-1516 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T8 1510-1516 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T9 1628-1641 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T10 1635-1641 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T11 1873-1886 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T12 1880-1886 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T13 2205-2218 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T14 2212-2218 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T15 2291-2304 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T16 2298-2304 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T17 2369-2382 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T18 2376-2382 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T19 2615-2628 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T20 2622-2628 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T21 2803-2811 http://purl.obolibrary.org/obo/MAT_0000034 denotes arterial

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 113-126 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T2 314-327 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T3 636-649 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T4 1503-1516 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T5 1628-1641 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T6 1873-1886 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T7 2205-2218 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T8 2291-2304 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T9 2369-2382 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T10 2615-2628 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T11 2803-2811 Body_part denotes arterial http://purl.obolibrary.org/obo/MAT_0000034

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1683-1694 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 252-261 Phenotype denotes foam cell HP:0003651
T2 371-381 Phenotype denotes foam cells HP:0003651
T3 2168-2185 Phenotype denotes foamy macrophages HP:0003651
T4 2844-2853 Phenotype denotes foam cell HP:0003651

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1683-1694 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 252-261 Phenotype denotes foam cell HP:0003651
T2 371-381 Phenotype denotes foam cells HP:0003651
T3 2168-2185 Phenotype denotes foamy macrophages HP:0003651
T4 2844-2853 Phenotype denotes foam cell HP:0003651

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 273-282 OrganismTaxon denotes Prominent 37571
T2 622-628 OrganismTaxon denotes bovine 9913
T3 1737-1752 OrganismTaxon denotes Chinese hamster 10029
T4 1970-1975 OrganismTaxon denotes mouse 10088|10090

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 113-132 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T2 241-251 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T4 252-261 Cell denotes foam cell http://purl.obolibrary.org/obo/CL:0000891
T5 314-333 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T6 360-370 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T8 371-381 Cell denotes foam cells http://purl.obolibrary.org/obo/CL:0000891
T9 629-655 Cell denotes aortic smooth muscle cells http://purl.obolibrary.org/obo/CL:0002539
T10 636-655 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T11 1503-1522 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T12 1628-1647 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T13 1873-1892 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T14 1976-1998 Cell denotes peritoneal macrophages http://purl.obolibrary.org/obo/CL:0000581
T15 2174-2185 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T17 2205-2224 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T18 2246-2257 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T20 2291-2309 Cell denotes smooth muscle cell http://purl.obolibrary.org/obo/CL:0000192
T21 2298-2309 Cell denotes muscle cell http://purl.obolibrary.org/obo/CL:0000187
T22 2369-2387 Cell denotes smooth muscle cell http://purl.obolibrary.org/obo/CL:0000192
T23 2376-2387 Cell denotes muscle cell http://purl.obolibrary.org/obo/CL:0000187
T24 2615-2634 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T25 2833-2843 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T27 2844-2853 Cell denotes foam cell http://purl.obolibrary.org/obo/CL:0000891

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 113-132 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T2 137-157 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T3 241-251 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T4 314-333 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T5 360-370 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T6 383-403 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T7 405-420 Body_part denotes extracellularly http://purl.obolibrary.org/obo/GO_0005576
T8 629-655 Body_part denotes aortic smooth muscle cells http://purl.obolibrary.org/obo/CL_0002539
T9 1503-1522 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T10 1628-1647 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T11 1753-1758 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T12 1873-1892 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T13 1987-1998 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T14 2174-2185 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T15 2205-2224 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T16 2246-2257 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T17 2291-2309 Body_part denotes smooth muscle cell http://purl.obolibrary.org/obo/CL_0000192
T18 2369-2387 Body_part denotes smooth muscle cell http://purl.obolibrary.org/obo/CL_0000192
T19 2388-2408 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T20 2615-2634 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T21 2636-2656 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T22 2803-2816 Body_part denotes arterial wall http://purl.obolibrary.org/obo/UBERON_0000415
T23 2833-2843 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 113-126 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T2 314-327 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T3 636-649 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T4 1503-1516 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T5 1628-1641 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T6 1873-1886 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T7 2205-2218 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T8 2291-2304 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T9 2369-2382 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T10 2615-2628 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T11 2803-2811 Body_part denotes arterial http://purl.obolibrary.org/obo/MAT_0000034

sentences

Id Subject Object Predicate Lexical cue
T1 0-158 Sentence denotes Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix.
T2 159-272 Sentence denotes A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.
T3 273-542 Sentence denotes Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase).
T4 543-607 Sentence denotes The interplay of these factors was investigated in cell culture.
T5 608-949 Sentence denotes Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy.
T6 950-989 Sentence denotes This aggregation required both enzymes.
T7 990-1041 Sentence denotes Studies with 125I-LDL confirmed these observations:
T8 1042-1233 Sentence denotes 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone.
T9 1234-1356 Sentence denotes A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein.
T10 1357-1454 Sentence denotes In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material).
T11 1455-1583 Sentence denotes LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used.
T12 1584-1867 Sentence denotes The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans.
T13 1868-2101 Sentence denotes When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation.
T14 2102-2336 Sentence denotes Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates.
T15 2337-2536 Sentence denotes Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes.
T16 2537-2864 Sentence denotes Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation.
T1 0-158 Sentence denotes Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix.
T2 159-272 Sentence denotes A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.
T3 273-542 Sentence denotes Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase).
T4 543-607 Sentence denotes The interplay of these factors was investigated in cell culture.
T5 608-949 Sentence denotes Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy.
T6 950-989 Sentence denotes This aggregation required both enzymes.
T7 990-1041 Sentence denotes Studies with 125I-LDL confirmed these observations:
T8 1042-1233 Sentence denotes 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone.
T9 1234-1356 Sentence denotes A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein.
T10 1357-1454 Sentence denotes In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material).
T11 1455-1583 Sentence denotes LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used.
T12 1584-1867 Sentence denotes The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans.
T13 1868-2101 Sentence denotes When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation.
T14 2102-2336 Sentence denotes Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates.
T15 2337-2536 Sentence denotes Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes.
T16 2537-2864 Sentence denotes Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-158 Sentence denotes Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix.
T2 159-272 Sentence denotes A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.
T3 273-542 Sentence denotes Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase).
T4 543-607 Sentence denotes The interplay of these factors was investigated in cell culture.
T5 608-949 Sentence denotes Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy.
T6 950-989 Sentence denotes This aggregation required both enzymes.
T7 990-1041 Sentence denotes Studies with 125I-LDL confirmed these observations:
T8 1042-1233 Sentence denotes 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone.
T9 1234-1356 Sentence denotes A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein.
T10 1357-1454 Sentence denotes In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material).
T11 1455-1583 Sentence denotes LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used.
T12 1584-1867 Sentence denotes The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans.
T13 1868-2101 Sentence denotes When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation.
T14 2102-2336 Sentence denotes Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates.
T15 2337-2536 Sentence denotes Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes.
T16 2537-2864 Sentence denotes Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1683-1694 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1683-1694 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 273-282 OrganismTaxon denotes Prominent 37571
T2 622-628 OrganismTaxon denotes bovine 9913
T3 1737-1752 OrganismTaxon denotes Chinese hamster 10029
T4 1970-1975 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 113-132 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T2 137-157 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T3 241-251 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T4 314-333 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T5 360-370 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T6 383-403 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T7 405-420 Body_part denotes extracellularly http://purl.obolibrary.org/obo/GO_0005576
T8 629-655 Body_part denotes aortic smooth muscle cells http://purl.obolibrary.org/obo/CL_0002539
T9 1503-1522 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T10 1628-1647 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T11 1753-1758 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T12 1873-1892 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T13 1987-1998 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T14 2174-2185 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T15 2205-2224 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T16 2246-2257 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T17 2291-2309 Body_part denotes smooth muscle cell http://purl.obolibrary.org/obo/CL_0000192
T18 2369-2387 Body_part denotes smooth muscle cell http://purl.obolibrary.org/obo/CL_0000192
T19 2388-2408 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T20 2615-2634 Body_part denotes smooth muscle cells http://purl.obolibrary.org/obo/CL_0000192
T21 2636-2656 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T22 2803-2816 Body_part denotes arterial wall http://purl.obolibrary.org/obo/UBERON_0000415
T23 2833-2843 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 113-132 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T2 241-251 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T4 252-261 Cell denotes foam cell http://purl.obolibrary.org/obo/CL:0000891
T5 314-333 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T6 360-370 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T8 371-381 Cell denotes foam cells http://purl.obolibrary.org/obo/CL:0000891
T9 629-655 Cell denotes aortic smooth muscle cells http://purl.obolibrary.org/obo/CL:0002539
T10 636-655 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T11 1503-1522 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T12 1628-1647 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T13 1873-1892 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T14 1976-1998 Cell denotes peritoneal macrophages http://purl.obolibrary.org/obo/CL:0000581
T15 2174-2185 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T17 2205-2224 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T18 2246-2257 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T20 2291-2309 Cell denotes smooth muscle cell http://purl.obolibrary.org/obo/CL:0000192
T21 2298-2309 Cell denotes muscle cell http://purl.obolibrary.org/obo/CL:0000187
T22 2369-2387 Cell denotes smooth muscle cell http://purl.obolibrary.org/obo/CL:0000192
T23 2376-2387 Cell denotes muscle cell http://purl.obolibrary.org/obo/CL:0000187
T24 2615-2634 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T25 2833-2843 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T27 2844-2853 Cell denotes foam cell http://purl.obolibrary.org/obo/CL:0000891