PubMed:8376399
Annnotations
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 1683-1694 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-158 | Sentence | denotes | Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. |
T2 | 159-272 | Sentence | denotes | A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. |
T3 | 273-542 | Sentence | denotes | Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase). |
T4 | 543-607 | Sentence | denotes | The interplay of these factors was investigated in cell culture. |
T5 | 608-949 | Sentence | denotes | Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy. |
T6 | 950-989 | Sentence | denotes | This aggregation required both enzymes. |
T7 | 990-1041 | Sentence | denotes | Studies with 125I-LDL confirmed these observations: |
T8 | 1042-1233 | Sentence | denotes | 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone. |
T9 | 1234-1356 | Sentence | denotes | A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein. |
T10 | 1357-1454 | Sentence | denotes | In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material). |
T11 | 1455-1583 | Sentence | denotes | LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used. |
T12 | 1584-1867 | Sentence | denotes | The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans. |
T13 | 1868-2101 | Sentence | denotes | When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation. |
T14 | 2102-2336 | Sentence | denotes | Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates. |
T15 | 2337-2536 | Sentence | denotes | Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes. |
T16 | 2537-2864 | Sentence | denotes | Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation. |
T1 | 0-158 | Sentence | denotes | Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. |
T2 | 159-272 | Sentence | denotes | A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. |
T3 | 273-542 | Sentence | denotes | Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase). |
T4 | 543-607 | Sentence | denotes | The interplay of these factors was investigated in cell culture. |
T5 | 608-949 | Sentence | denotes | Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy. |
T6 | 950-989 | Sentence | denotes | This aggregation required both enzymes. |
T7 | 990-1041 | Sentence | denotes | Studies with 125I-LDL confirmed these observations: |
T8 | 1042-1233 | Sentence | denotes | 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone. |
T9 | 1234-1356 | Sentence | denotes | A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein. |
T10 | 1357-1454 | Sentence | denotes | In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material). |
T11 | 1455-1583 | Sentence | denotes | LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used. |
T12 | 1584-1867 | Sentence | denotes | The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans. |
T13 | 1868-2101 | Sentence | denotes | When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation. |
T14 | 2102-2336 | Sentence | denotes | Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates. |
T15 | 2337-2536 | Sentence | denotes | Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes. |
T16 | 2537-2864 | Sentence | denotes | Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1683-1694 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1683-1694 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 113-126 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T2 | 120-126 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T3 | 314-327 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T4 | 321-327 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T5 | 636-649 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T6 | 643-649 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T7 | 1503-1516 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T8 | 1510-1516 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T9 | 1628-1641 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T10 | 1635-1641 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T11 | 1873-1886 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T12 | 1880-1886 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T13 | 2205-2218 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T14 | 2212-2218 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T15 | 2291-2304 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T16 | 2298-2304 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T17 | 2369-2382 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T18 | 2376-2382 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T19 | 2615-2628 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
T20 | 2622-2628 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T21 | 2803-2811 | http://purl.obolibrary.org/obo/MAT_0000034 | denotes | arterial |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 113-126 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T2 | 314-327 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T3 | 636-649 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T4 | 1503-1516 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T5 | 1628-1641 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T6 | 1873-1886 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T7 | 2205-2218 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T8 | 2291-2304 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T9 | 2369-2382 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T10 | 2615-2628 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T11 | 2803-2811 | Body_part | denotes | arterial | http://purl.obolibrary.org/obo/MAT_0000034 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 1683-1694 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 252-261 | Phenotype | denotes | foam cell | HP:0003651 |
T2 | 371-381 | Phenotype | denotes | foam cells | HP:0003651 |
T3 | 2168-2185 | Phenotype | denotes | foamy macrophages | HP:0003651 |
T4 | 2844-2853 | Phenotype | denotes | foam cell | HP:0003651 |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 1683-1694 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 252-261 | Phenotype | denotes | foam cell | HP:0003651 |
T2 | 371-381 | Phenotype | denotes | foam cells | HP:0003651 |
T3 | 2168-2185 | Phenotype | denotes | foamy macrophages | HP:0003651 |
T4 | 2844-2853 | Phenotype | denotes | foam cell | HP:0003651 |
GlyCosmos15-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 273-282 | OrganismTaxon | denotes | Prominent | 37571 |
T2 | 622-628 | OrganismTaxon | denotes | bovine | 9913 |
T3 | 1737-1752 | OrganismTaxon | denotes | Chinese hamster | 10029 |
T4 | 1970-1975 | OrganismTaxon | denotes | mouse | 10088|10090 |
GlyCosmos15-CL
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 113-132 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T2 | 241-251 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T4 | 252-261 | Cell | denotes | foam cell | http://purl.obolibrary.org/obo/CL:0000891 |
T5 | 314-333 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T6 | 360-370 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T8 | 371-381 | Cell | denotes | foam cells | http://purl.obolibrary.org/obo/CL:0000891 |
T9 | 629-655 | Cell | denotes | aortic smooth muscle cells | http://purl.obolibrary.org/obo/CL:0002539 |
T10 | 636-655 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T11 | 1503-1522 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T12 | 1628-1647 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T13 | 1873-1892 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T14 | 1976-1998 | Cell | denotes | peritoneal macrophages | http://purl.obolibrary.org/obo/CL:0000581 |
T15 | 2174-2185 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T17 | 2205-2224 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T18 | 2246-2257 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T20 | 2291-2309 | Cell | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL:0000192 |
T21 | 2298-2309 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
T22 | 2369-2387 | Cell | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL:0000192 |
T23 | 2376-2387 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
T24 | 2615-2634 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T25 | 2833-2843 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T27 | 2844-2853 | Cell | denotes | foam cell | http://purl.obolibrary.org/obo/CL:0000891 |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 113-132 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T2 | 137-157 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T3 | 241-251 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
T4 | 314-333 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T5 | 360-370 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
T6 | 383-403 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T7 | 405-420 | Body_part | denotes | extracellularly | http://purl.obolibrary.org/obo/GO_0005576 |
T8 | 629-655 | Body_part | denotes | aortic smooth muscle cells | http://purl.obolibrary.org/obo/CL_0002539 |
T9 | 1503-1522 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T10 | 1628-1647 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T11 | 1753-1758 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
T12 | 1873-1892 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T13 | 1987-1998 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T14 | 2174-2185 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T15 | 2205-2224 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T16 | 2246-2257 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T17 | 2291-2309 | Body_part | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL_0000192 |
T18 | 2369-2387 | Body_part | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL_0000192 |
T19 | 2388-2408 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T20 | 2615-2634 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T21 | 2636-2656 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T22 | 2803-2816 | Body_part | denotes | arterial wall | http://purl.obolibrary.org/obo/UBERON_0000415 |
T23 | 2833-2843 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
GlyCosmos15-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 113-126 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T2 | 314-327 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T3 | 636-649 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T4 | 1503-1516 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T5 | 1628-1641 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T6 | 1873-1886 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T7 | 2205-2218 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T8 | 2291-2304 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T9 | 2369-2382 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T10 | 2615-2628 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
T11 | 2803-2811 | Body_part | denotes | arterial | http://purl.obolibrary.org/obo/MAT_0000034 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-158 | Sentence | denotes | Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. |
T2 | 159-272 | Sentence | denotes | A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. |
T3 | 273-542 | Sentence | denotes | Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase). |
T4 | 543-607 | Sentence | denotes | The interplay of these factors was investigated in cell culture. |
T5 | 608-949 | Sentence | denotes | Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy. |
T6 | 950-989 | Sentence | denotes | This aggregation required both enzymes. |
T7 | 990-1041 | Sentence | denotes | Studies with 125I-LDL confirmed these observations: |
T8 | 1042-1233 | Sentence | denotes | 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone. |
T9 | 1234-1356 | Sentence | denotes | A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein. |
T10 | 1357-1454 | Sentence | denotes | In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material). |
T11 | 1455-1583 | Sentence | denotes | LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used. |
T12 | 1584-1867 | Sentence | denotes | The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans. |
T13 | 1868-2101 | Sentence | denotes | When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation. |
T14 | 2102-2336 | Sentence | denotes | Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates. |
T15 | 2337-2536 | Sentence | denotes | Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes. |
T16 | 2537-2864 | Sentence | denotes | Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation. |
T1 | 0-158 | Sentence | denotes | Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. |
T2 | 159-272 | Sentence | denotes | A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. |
T3 | 273-542 | Sentence | denotes | Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase). |
T4 | 543-607 | Sentence | denotes | The interplay of these factors was investigated in cell culture. |
T5 | 608-949 | Sentence | denotes | Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy. |
T6 | 950-989 | Sentence | denotes | This aggregation required both enzymes. |
T7 | 990-1041 | Sentence | denotes | Studies with 125I-LDL confirmed these observations: |
T8 | 1042-1233 | Sentence | denotes | 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone. |
T9 | 1234-1356 | Sentence | denotes | A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein. |
T10 | 1357-1454 | Sentence | denotes | In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material). |
T11 | 1455-1583 | Sentence | denotes | LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used. |
T12 | 1584-1867 | Sentence | denotes | The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans. |
T13 | 1868-2101 | Sentence | denotes | When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation. |
T14 | 2102-2336 | Sentence | denotes | Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates. |
T15 | 2337-2536 | Sentence | denotes | Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes. |
T16 | 2537-2864 | Sentence | denotes | Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-158 | Sentence | denotes | Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. |
T2 | 159-272 | Sentence | denotes | A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. |
T3 | 273-542 | Sentence | denotes | Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated lipoproteins, and various enzymes including lipoprotein lipase (LpL) and sphingomyelinase (SMase). |
T4 | 543-607 | Sentence | denotes | The interplay of these factors was investigated in cell culture. |
T5 | 608-949 | Sentence | denotes | Incubation of bovine aortic smooth muscle cells for 18 h at 37 degrees C with low density lipoprotein (LDL) in the presence of LpL and SMase led to massive aggregation of LDL on the surface of the cells as viewed by phase, fluorescence (using 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate-LDL), and electron microscopy. |
T6 | 950-989 | Sentence | denotes | This aggregation required both enzymes. |
T7 | 990-1041 | Sentence | denotes | Studies with 125I-LDL confirmed these observations: |
T8 | 1042-1233 | Sentence | denotes | 125I-LDL cell association in the presence of LpL plus SMase was 50-100-fold greater than in the absence of the two enzymes and was 10-fold greater than in the presence of either enzyme alone. |
T9 | 1234-1356 | Sentence | denotes | A similar effect (68-fold enhancement) was seen with 125I-labeled lipoprotein(a) (Lp(a)), another atherogenic lipoprotein. |
T10 | 1357-1454 | Sentence | denotes | In all cases, 125I-lipoprotein degradation was relatively low (< 5% of cell-associated material). |
T11 | 1455-1583 | Sentence | denotes | LpL/SMase-mediated association of 125I-LDL with smooth muscle cells was still observed when enzymatically inactive LpL was used. |
T12 | 1584-1867 | Sentence | denotes | The effect was markedly diminished when the smooth muscle cells were treated with a combination of chondroitin ABC lyase and heparitinase or when mutant Chinese hamster ovary cells that lack cell-surface proteoglycans were used, indicating a specific role for cellular proteoglycans. |
T13 | 1868-2101 | Sentence | denotes | When smooth muscle cells with 125I-LDL or 125I-Lp(a) aggregates were rinsed and then coincubated with mouse peritoneal macrophages for a further 24 h, visible aggregates disappeared, and there was marked 125I-lipoprotein degradation. |
T14 | 2102-2336 | Sentence | denotes | Electron micrographs after 24 h of co-culture showed lipid-laden, foamy macrophages situated on top of smooth muscle cells, suggesting that the macrophages phagocytosed and metabolized the smooth muscle cell-associated LDL aggregates. |
T15 | 2337-2536 | Sentence | denotes | Last, 125I-LDL association with smooth muscle cell extracellular matrix was also synergistically enhanced by LpL and SMase, to a level that was 19-fold greater than in the absence of the two enzymes. |
T16 | 2537-2864 | Sentence | denotes | Thus, the interaction of LDL and Lp(a) with four atheroma components, namely, smooth muscle cells, extracellular matrix, LpL, and SMase, represents a physiologically plausible mechanism for massive, focal retention and aggregation of atherogenic lipoproteins in the arterial wall with subsequent macrophage foam cell formation. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 1683-1694 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 1683-1694 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 273-282 | OrganismTaxon | denotes | Prominent | 37571 |
T2 | 622-628 | OrganismTaxon | denotes | bovine | 9913 |
T3 | 1737-1752 | OrganismTaxon | denotes | Chinese hamster | 10029 |
T4 | 1970-1975 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 113-132 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T2 | 137-157 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T3 | 241-251 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
T4 | 314-333 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T5 | 360-370 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
T6 | 383-403 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T7 | 405-420 | Body_part | denotes | extracellularly | http://purl.obolibrary.org/obo/GO_0005576 |
T8 | 629-655 | Body_part | denotes | aortic smooth muscle cells | http://purl.obolibrary.org/obo/CL_0002539 |
T9 | 1503-1522 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T10 | 1628-1647 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T11 | 1753-1758 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
T12 | 1873-1892 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T13 | 1987-1998 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T14 | 2174-2185 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T15 | 2205-2224 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T16 | 2246-2257 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T17 | 2291-2309 | Body_part | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL_0000192 |
T18 | 2369-2387 | Body_part | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL_0000192 |
T19 | 2388-2408 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T20 | 2615-2634 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
T21 | 2636-2656 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T22 | 2803-2816 | Body_part | denotes | arterial wall | http://purl.obolibrary.org/obo/UBERON_0000415 |
T23 | 2833-2843 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 113-132 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T2 | 241-251 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T4 | 252-261 | Cell | denotes | foam cell | http://purl.obolibrary.org/obo/CL:0000891 |
T5 | 314-333 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T6 | 360-370 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T8 | 371-381 | Cell | denotes | foam cells | http://purl.obolibrary.org/obo/CL:0000891 |
T9 | 629-655 | Cell | denotes | aortic smooth muscle cells | http://purl.obolibrary.org/obo/CL:0002539 |
T10 | 636-655 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T11 | 1503-1522 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T12 | 1628-1647 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T13 | 1873-1892 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T14 | 1976-1998 | Cell | denotes | peritoneal macrophages | http://purl.obolibrary.org/obo/CL:0000581 |
T15 | 2174-2185 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T17 | 2205-2224 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T18 | 2246-2257 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T20 | 2291-2309 | Cell | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL:0000192 |
T21 | 2298-2309 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
T22 | 2369-2387 | Cell | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL:0000192 |
T23 | 2376-2387 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
T24 | 2615-2634 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
T25 | 2833-2843 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T27 | 2844-2853 | Cell | denotes | foam cell | http://purl.obolibrary.org/obo/CL:0000891 |