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PubMed:8288592 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 496-503 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T2 1275-1282 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG

sentences

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.
T2 151-242 Sentence denotes Insulin secretion from pancreatic islets is controlled by peptides as well as by nutrients.
T3 243-334 Sentence denotes We report here a novel, extraordinarily potent peptidergic regulation of insulin secretion.
T4 335-521 Sentence denotes A 27-residue form of pituitary adenylate cyclase activating polypeptide (PACAP27) as low as 10(-14) to 10(-13) M stimulated insulin release from rat islets in a glucose-dependent manner.
T5 522-609 Sentence denotes PACAP27 also increased cytosolic free Ca2+ concentration ([Ca2+]i) in islet beta-cells.
T6 610-707 Sentence denotes Nitrendipine, a blocker of the L-type Ca2+ channel, abolished both [Ca2+]i and insulin responses.
T7 708-930 Sentence denotes Vasoactive intestinal peptide, a peptide exhibiting 68% amino acid homology with PACAP, also increased [Ca2+]i in beta-cells but only at concentrations in the nanomolar range, indicating that PACAP27 is 4 logs more potent.
T8 931-1072 Sentence denotes A 38-residue form of the peptide (PACAP38) stimulated insulin release and increased beta-cell [Ca2+]i in a manner similar to that of PACAP27.
T9 1073-1170 Sentence denotes PACAP-like immunoreactivity was demonstrated in pancreatic nerve fibers, islets, and capillaries.
T10 1171-1490 Sentence denotes The results indicate that PACAP is a physiologically occurring peptide in pancreas and that PACAP, in a glucose-dependent manner, activates beta-cells presumably via a high affinity PACAP-selective receptor, raises [Ca2+]i by increasing the activity of L-type Ca2+ channels, and consequently stimulates insulin release.
T11 1491-1563 Sentence denotes PACAP appears to be by far the most potent insulinotropic peptide known.
T1 0-150 Sentence denotes Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.
T2 151-242 Sentence denotes Insulin secretion from pancreatic islets is controlled by peptides as well as by nutrients.
T3 243-334 Sentence denotes We report here a novel, extraordinarily potent peptidergic regulation of insulin secretion.
T4 335-521 Sentence denotes A 27-residue form of pituitary adenylate cyclase activating polypeptide (PACAP27) as low as 10(-14) to 10(-13) M stimulated insulin release from rat islets in a glucose-dependent manner.
T5 522-609 Sentence denotes PACAP27 also increased cytosolic free Ca2+ concentration ([Ca2+]i) in islet beta-cells.
T6 610-707 Sentence denotes Nitrendipine, a blocker of the L-type Ca2+ channel, abolished both [Ca2+]i and insulin responses.
T7 708-930 Sentence denotes Vasoactive intestinal peptide, a peptide exhibiting 68% amino acid homology with PACAP, also increased [Ca2+]i in beta-cells but only at concentrations in the nanomolar range, indicating that PACAP27 is 4 logs more potent.
T8 931-1072 Sentence denotes A 38-residue form of the peptide (PACAP38) stimulated insulin release and increased beta-cell [Ca2+]i in a manner similar to that of PACAP27.
T9 1073-1170 Sentence denotes PACAP-like immunoreactivity was demonstrated in pancreatic nerve fibers, islets, and capillaries.
T10 1171-1490 Sentence denotes The results indicate that PACAP is a physiologically occurring peptide in pancreas and that PACAP, in a glucose-dependent manner, activates beta-cells presumably via a high affinity PACAP-selective receptor, raises [Ca2+]i by increasing the activity of L-type Ca2+ channels, and consequently stimulates insulin release.
T11 1491-1563 Sentence denotes PACAP appears to be by far the most potent insulinotropic peptide known.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 496-503 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T2 1275-1282 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 0-9 http://purl.obolibrary.org/obo/MAT_0000077 denotes Pituitary
T2 174-191 http://purl.obolibrary.org/obo/MAT_0000076 denotes pancreatic islets
T3 356-365 http://purl.obolibrary.org/obo/MAT_0000077 denotes pituitary
T4 719-729 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T5 1245-1253 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 0-9 Disease denotes Pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T2 356-365 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T3 1245-1253 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 480-483 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-9 Body_part denotes Pituitary http://purl.obolibrary.org/obo/UBERON_0000007
T2 174-191 Body_part denotes pancreatic islets http://purl.obolibrary.org/obo/UBERON_0000006
T3 356-365 Body_part denotes pituitary http://purl.obolibrary.org/obo/UBERON_0000007
T4 1015-1024 Body_part denotes beta-cell http://purl.obolibrary.org/obo/CL_0000169
T5 1132-1144 Body_part denotes nerve fibers http://purl.obolibrary.org/obo/UBERON_0006134
T6 1245-1253 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 0-9 Body_part denotes Pituitary http://purl.obolibrary.org/obo/MAT_0000077
T2 174-191 Body_part denotes pancreatic islets http://purl.obolibrary.org/obo/MAT_0000076
T3 356-365 Body_part denotes pituitary http://purl.obolibrary.org/obo/MAT_0000077
T4 719-729 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T5 1245-1253 Body_part denotes pancreas http://purl.obolibrary.org/obo/MAT_0000075

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 139-149 Cell denotes beta-cells http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639
T3 598-608 Cell denotes beta-cells http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639
T5 822-832 Cell denotes beta-cells http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639
T7 1015-1024 Cell denotes beta-cell http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639
T9 1311-1321 Cell denotes beta-cells http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639