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PubMed:8274409 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-58 Sentence denotes Androgen receptor gene mutations in human prostate cancer.
TextSentencer_T2 59-353 Sentence denotes To investigate the structural abnormality of the androgen receptor (AR) in human prostate cancers, exons B-H encoding DNA- and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products using originally designed oligoprimers.
TextSentencer_T3 354-530 Sentence denotes Tissues from 7 cases of untreated stage B prostate cancer surgically removed and from 8 cases of endocrine therapy-resistant cancers obtained at autopsy were used in the study.
TextSentencer_T4 531-650 Sentence denotes Two different mutations were identified in exons D and H in the different cancer foci of the same cancer death patient.
TextSentencer_T5 651-814 Sentence denotes One mutation in exon D (at codon 701, Leu to His) was detected in the prostate, and the other in exon H (at codon 877, Thr to Ala) was found in metastatic tissues.
TextSentencer_T6 815-901 Sentence denotes In untreated cancer tissues and the other autopsy samples, no mutations were detected.
TextSentencer_T7 902-971 Sentence denotes The mutation in exon H was identical to that reported in LNCaP cells.
TextSentencer_T8 972-1150 Sentence denotes These results indicate that AR gene mutations occur in relation to endocrine therapy-resistance, although the mutation was found in 1 out of 8 resistant cases (12.5%) at autopsy.
T1 0-58 Sentence denotes Androgen receptor gene mutations in human prostate cancer.
T2 59-353 Sentence denotes To investigate the structural abnormality of the androgen receptor (AR) in human prostate cancers, exons B-H encoding DNA- and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products using originally designed oligoprimers.
T3 354-530 Sentence denotes Tissues from 7 cases of untreated stage B prostate cancer surgically removed and from 8 cases of endocrine therapy-resistant cancers obtained at autopsy were used in the study.
T4 531-650 Sentence denotes Two different mutations were identified in exons D and H in the different cancer foci of the same cancer death patient.
T5 651-814 Sentence denotes One mutation in exon D (at codon 701, Leu to His) was detected in the prostate, and the other in exon H (at codon 877, Thr to Ala) was found in metastatic tissues.
T6 815-901 Sentence denotes In untreated cancer tissues and the other autopsy samples, no mutations were detected.
T7 902-971 Sentence denotes The mutation in exon H was identical to that reported in LNCaP cells.
T8 972-1150 Sentence denotes These results indicate that AR gene mutations occur in relation to endocrine therapy-resistance, although the mutation was found in 1 out of 8 resistant cases (12.5%) at autopsy.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-17 gene:367 denotes Androgen receptor
T1 42-57 disease:C0376358 denotes prostate cancer
T2 0-17 gene:367 denotes Androgen receptor
T3 42-57 disease:C0600139 denotes prostate cancer
T4 108-125 gene:367 denotes androgen receptor
T5 140-156 disease:C0376358 denotes prostate cancers
T6 127-129 gene:367 denotes AR
T7 140-156 disease:C0376358 denotes prostate cancers
R1 T0 T1 associated_with Androgen receptor,prostate cancer
R2 T2 T3 associated_with Androgen receptor,prostate cancer
R3 T4 T5 associated_with androgen receptor,prostate cancers
R4 T6 T7 associated_with AR,prostate cancers

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T947 179-307 gene:367 denotes A- and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction pr
T948 642-822 disease:C0376358 denotes patient. One mutation in exon D (at codon 701, Leu to His) was detected in the prostate, and the other in exon H (at codon 877, Thr to Ala) was found in metastatic tissues. In untr
R1 T947 T948 associated_with A- and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction pr,"patient. One mutation in exon D (at codon 701, Leu to His) was detected in the prostate, and the other in exon H (at codon 877, Thr to Ala) was found in metastatic tissues. In untr"
R2 T947 T948 associated_with A- and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction pr,"patient. One mutation in exon D (at codon 701, Leu to His) was detected in the prostate, and the other in exon H (at codon 877, Thr to Ala) was found in metastatic tissues. In untr"

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 806-813 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 835-842 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 354-361 http://purl.obolibrary.org/obo/UBERON_0000479 denotes Tissues
PD-UBERON-AE-B_T2 806-813 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 835-842 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues