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sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Mechanism of formation of reovirus mRNA 5'-terminal blocked and methylated sequence, m7GpppGmpC.
T2 97-209 Sentence denotes Blocked and methylated 5' termini of reovirus mRNA are formed by viral cores at an early stage of transcription.
T3 210-379 Sentence denotes Cores incubated in a complete transcription reaction mixture for 30 s, or in a mixture lacking UTP and ATP for a longer time, synthesize the "cap" structure, m7GpppGmpC.
T4 380-523 Sentence denotes The dinucleotide ppGpC functions as substrate for a core-associated guanylyltransferase and is converted to GpppGpC by addition of pG from GTP.
T5 524-738 Sentence denotes For optimal conversion, both the diphosphate terminus and phosphodiester bond are required. pGpC is not a substrate, but pppGpC is utilized after removal of the gamma-phosphate by a core nucleotide phospohydrolase.
T6 739-950 Sentence denotes Methyltransferases also present in cores transfer methyl groups sequentially from S-adenosylmethionine (AdoMet) to the N7-position of the 5'-terminal guanosine followed by the 2'-OH of the penultimate guanosine.
T7 951-1124 Sentence denotes GpppGpC is hydrolyzed by cores in the presence of pyrophosphate to ppGpC, the predominant 5'-terminal structure of reovirus mRNA made in the absence of S-adenosylmethionine.
T8 1125-1325 Sentence denotes N7-methylation prevents pyrophosphorolysis of m7GpppGpC, which may explain the increased proportion of blocked, methylated 5' termini in viral mRNA synthesized in the presence of S-adenosylmethionine.
T9 1326-1440 Sentence denotes On the basis of these findings, the following reaction series is proposed for the synthesis of reovirus mRNA caps.
T10 1441-1524 Sentence denotes In the series, AdoHcy is the abbreviation for S-adenosylhomocysteine (see article)9
T1 0-96 Sentence denotes Mechanism of formation of reovirus mRNA 5'-terminal blocked and methylated sequence, m7GpppGmpC.
T2 97-209 Sentence denotes Blocked and methylated 5' termini of reovirus mRNA are formed by viral cores at an early stage of transcription.
T3 210-379 Sentence denotes Cores incubated in a complete transcription reaction mixture for 30 s, or in a mixture lacking UTP and ATP for a longer time, synthesize the "cap" structure, m7GpppGmpC.
T4 380-523 Sentence denotes The dinucleotide ppGpC functions as substrate for a core-associated guanylyltransferase and is converted to GpppGpC by addition of pG from GTP.
T5 524-738 Sentence denotes For optimal conversion, both the diphosphate terminus and phosphodiester bond are required. pGpC is not a substrate, but pppGpC is utilized after removal of the gamma-phosphate by a core nucleotide phospohydrolase.
T6 739-950 Sentence denotes Methyltransferases also present in cores transfer methyl groups sequentially from S-adenosylmethionine (AdoMet) to the N7-position of the 5'-terminal guanosine followed by the 2'-OH of the penultimate guanosine.
T7 951-1124 Sentence denotes GpppGpC is hydrolyzed by cores in the presence of pyrophosphate to ppGpC, the predominant 5'-terminal structure of reovirus mRNA made in the absence of S-adenosylmethionine.
T8 1125-1325 Sentence denotes N7-methylation prevents pyrophosphorolysis of m7GpppGpC, which may explain the increased proportion of blocked, methylated 5' termini in viral mRNA synthesized in the presence of S-adenosylmethionine.
T9 1326-1440 Sentence denotes On the basis of these findings, the following reaction series is proposed for the synthesis of reovirus mRNA caps.
T10 1441-1524 Sentence denotes In the series, AdoHcy is the abbreviation for S-adenosylhomocysteine (see article)9