PubMed:8215620 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8215620","sourcedb":"PubMed","sourceid":"8215620","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8215620","text":"Methotrexate osteopathy in rheumatic disease.\nOBJECTIVE: To determine whether two adults with stress fractures receiving low weekly doses of methotrexate had methotrexate osteopathy.\nCASE REPORTS: Two adult patients developed features consistent with methotrexate osteopathy while receiving low weekly doses of methotrexate.\nMETHODS: Iliac crest biopsy samples were taken and bone histomorphometry carried out.\nRESULTS: Symptoms resolved when the methotrexate was discontinued. Bone histology showed changes consistent with osteoblast inhibition by methotrexate.\nCONCLUSIONS: When given in low doses for prolonged periods, methotrexate may have adverse effects on bone, particularly in post-menopausal women.","tracks":[{"project":"AnEM_abstracts","denotations":[{"id":"T1","span":{"begin":334,"end":360},"obj":"Multi-tissue_structure"},{"id":"T2","span":{"begin":376,"end":380},"obj":"Tissue"},{"id":"T3","span":{"begin":478,"end":482},"obj":"Tissue"},{"id":"T4","span":{"begin":524,"end":534},"obj":"Cell"},{"id":"T5","span":{"begin":664,"end":668},"obj":"Organ"}],"attributes":[{"subj":"T1","pred":"source","obj":"AnEM_abstracts"},{"subj":"T2","pred":"source","obj":"AnEM_abstracts"},{"subj":"T3","pred":"source","obj":"AnEM_abstracts"},{"subj":"T4","pred":"source","obj":"AnEM_abstracts"},{"subj":"T5","pred":"source","obj":"AnEM_abstracts"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AnEM_abstracts","color":"#d493ec","default":true}]}]}}