PubMed:8215620 JSONTXT

{"project":"AnEM_abstracts","denotations":[{"id":"T1","span":{"begin":334,"end":360},"obj":"Multi-tissue_structure"},{"id":"T2","span":{"begin":376,"end":380},"obj":"Tissue"},{"id":"T3","span":{"begin":478,"end":482},"obj":"Tissue"},{"id":"T4","span":{"begin":524,"end":534},"obj":"Cell"},{"id":"T5","span":{"begin":664,"end":668},"obj":"Organ"}],"text":"Methotrexate osteopathy in rheumatic disease.\nOBJECTIVE: To determine whether two adults with stress fractures receiving low weekly doses of methotrexate had methotrexate osteopathy.\nCASE REPORTS: Two adult patients developed features consistent with methotrexate osteopathy while receiving low weekly doses of methotrexate.\nMETHODS: Iliac crest biopsy samples were taken and bone histomorphometry carried out.\nRESULTS: Symptoms resolved when the methotrexate was discontinued. Bone histology showed changes consistent with osteoblast inhibition by methotrexate.\nCONCLUSIONS: When given in low doses for prolonged periods, methotrexate may have adverse effects on bone, particularly in post-menopausal women."}