PubMed:8085155 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":57},"obj":"Sentence"},{"id":"T2","span":{"begin":58,"end":174},"obj":"Sentence"},{"id":"T3","span":{"begin":175,"end":313},"obj":"Sentence"},{"id":"T4","span":{"begin":314,"end":456},"obj":"Sentence"},{"id":"T5","span":{"begin":457,"end":576},"obj":"Sentence"},{"id":"T6","span":{"begin":577,"end":641},"obj":"Sentence"},{"id":"T7","span":{"begin":642,"end":860},"obj":"Sentence"},{"id":"T8","span":{"begin":861,"end":1107},"obj":"Sentence"},{"id":"T9","span":{"begin":1108,"end":1225},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":57},"obj":"Sentence"},{"id":"T2","span":{"begin":58,"end":174},"obj":"Sentence"},{"id":"T3","span":{"begin":175,"end":313},"obj":"Sentence"},{"id":"T4","span":{"begin":314,"end":456},"obj":"Sentence"},{"id":"T5","span":{"begin":457,"end":576},"obj":"Sentence"},{"id":"T6","span":{"begin":577,"end":641},"obj":"Sentence"},{"id":"T7","span":{"begin":642,"end":860},"obj":"Sentence"},{"id":"T8","span":{"begin":861,"end":1107},"obj":"Sentence"},{"id":"T9","span":{"begin":1108,"end":1225},"obj":"Sentence"}],"text":"An interleukin-4-induced transcription factor: IL-4 Stat.\nInterleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell subsets, favoring expansion of the Th2 lineage relative to Th1. Imbalance of these T lymphocyte subsets has been implicated in immunological diseases including allergy, inflammation, and autoimmune disease. IL-4 may mediate its biological effects, at least in part, by activating a tyrosine-phosphorylated DNA binding protein. This protein has now been purified and its encoding gene cloned. Examination of the primary amino acid sequence of this protein indicates that it is a member of the signal transducers and activators of transcription (Stat) family of DNA binding proteins, hereby designated IL-4 Stat. Study of the inhibitory activities of phosphotyrosine-containing peptides derived from the intracellular domain of the IL-4 receptor provided evidence for direct coupling of receptor and transcription factor during the IL-4 Stat activation cycle. Such observations indicate that IL-4 Stat has the same functional domain for both receptor coupling and dimerization."}

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":57},"obj":"Sentence"},{"id":"S2","span":{"begin":58,"end":174},"obj":"Sentence"},{"id":"S3","span":{"begin":175,"end":313},"obj":"Sentence"},{"id":"S4","span":{"begin":314,"end":456},"obj":"Sentence"},{"id":"S5","span":{"begin":457,"end":576},"obj":"Sentence"},{"id":"S6","span":{"begin":577,"end":641},"obj":"Sentence"},{"id":"S7","span":{"begin":642,"end":860},"obj":"Sentence"},{"id":"S8","span":{"begin":861,"end":1107},"obj":"Sentence"},{"id":"S9","span":{"begin":1108,"end":1225},"obj":"Sentence"}],"text":"An interleukin-4-induced transcription factor: IL-4 Stat.\nInterleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell subsets, favoring expansion of the Th2 lineage relative to Th1. Imbalance of these T lymphocyte subsets has been implicated in immunological diseases including allergy, inflammation, and autoimmune disease. IL-4 may mediate its biological effects, at least in part, by activating a tyrosine-phosphorylated DNA binding protein. This protein has now been purified and its encoding gene cloned. Examination of the primary amino acid sequence of this protein indicates that it is a member of the signal transducers and activators of transcription (Stat) family of DNA binding proteins, hereby designated IL-4 Stat. Study of the inhibitory activities of phosphotyrosine-containing peptides derived from the intracellular domain of the IL-4 receptor provided evidence for direct coupling of receptor and transcription factor during the IL-4 Stat activation cycle. Such observations indicate that IL-4 Stat has the same functional domain for both receptor coupling and dimerization."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":45},"obj":"NP"},{"id":"C2","span":{"begin":47,"end":56},"obj":"NP"},{"id":"C3","span":{"begin":58,"end":78},"obj":"NP"},{"id":"C4","span":{"begin":175,"end":177},"obj":"NP"},{"id":"C5","span":{"begin":231,"end":257},"obj":"NP"},{"id":"C6","span":{"begin":327,"end":353},"obj":"NP"},{"id":"C7","span":{"begin":457,"end":461},"obj":"NP"},{"id":"C8","span":{"begin":474,"end":477},"obj":"NP"},{"id":"C9","span":{"begin":530,"end":575},"obj":"NP"},{"id":"C10","span":{"begin":577,"end":589},"obj":"NP"},{"id":"C11","span":{"begin":616,"end":619},"obj":"NP"},{"id":"C12","span":{"begin":692,"end":704},"obj":"NP"},{"id":"C13","span":{"begin":720,"end":722},"obj":"NP"},{"id":"C14","span":{"begin":726,"end":830},"obj":"NP"},{"id":"C15","span":{"begin":850,"end":859},"obj":"NP"},{"id":"C16","span":{"begin":1140,"end":1149},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-pron","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C3"},{"id":"R5","pred":"coref-pron","subj":"C8","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C9"},{"id":"R7","pred":"coref-pron","subj":"C11","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C12","obj":"C10"},{"id":"R9","pred":"coref-pron","subj":"C13","obj":"C12"},{"id":"R10","pred":"coref-ident","subj":"C15","obj":"C14"},{"id":"R11","pred":"coref-ident","subj":"C16","obj":"C15"}],"text":"An interleukin-4-induced transcription factor: IL-4 Stat.\nInterleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell subsets, favoring expansion of the Th2 lineage relative to Th1. Imbalance of these T lymphocyte subsets has been implicated in immunological diseases including allergy, inflammation, and autoimmune disease. IL-4 may mediate its biological effects, at least in part, by activating a tyrosine-phosphorylated DNA binding protein. This protein has now been purified and its encoding gene cloned. Examination of the primary amino acid sequence of this protein indicates that it is a member of the signal transducers and activators of transcription (Stat) family of DNA binding proteins, hereby designated IL-4 Stat. Study of the inhibitory activities of phosphotyrosine-containing peptides derived from the intracellular domain of the IL-4 receptor provided evidence for direct coupling of receptor and transcription factor during the IL-4 Stat activation cycle. Such observations indicate that IL-4 Stat has the same functional domain for both receptor coupling and dimerization."}

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