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PubMed:8065331 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 57-80 gene:3131 denotes hepatic leukemia factor
T1 104-132 disease:C0023449 denotes acute lymphoblastic leukemia
T2 57-80 gene:3131 denotes hepatic leukemia factor
T3 104-132 disease:C1961102 denotes acute lymphoblastic leukemia
T4 416-419 gene:6929 denotes E2A
T5 180-209 disease:C0023449 denotes acute lymphoblastic leukemias
T6 609-612 gene:3131 denotes HLF
T7 661-670 disease:C0023418 denotes leukemias
R1 T0 T1 associated_with hepatic leukemia factor,acute lymphoblastic leukemia
R2 T2 T3 associated_with hepatic leukemia factor,acute lymphoblastic leukemia
R3 T4 T5 associated_with E2A,acute lymphoblastic leukemias
R4 T6 T7 associated_with HLF,leukemias

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 57-80 protein denotes hepatic leukemia factor
T2 82-85 protein denotes HLF
T3 104-148 protein denotes acute lymphoblastic leukemia chimera E2A-HLF
T4 154-162 DNA denotes t(17;19)
T5 233-260 protein denotes E2A-hepatic leukemia factor
T6 262-265 protein denotes HLF
T7 267-284 protein denotes chimeric proteins
T8 302-346 protein denotes DNA-binding and protein dimerization domains
T9 354-389 protein denotes basic leucine zipper (bZIP) protein
T10 390-393 protein denotes HLF
T11 416-428 protein denotes E2A proteins
T12 578-591 protein denotes wild-type HLF
T13 596-612 protein denotes chimeric E2A-HLF
T14 644-670 cell_line denotes t(17;19)-bearing leukemias
T15 711-729 DNA denotes consensus sequence
T16 781-802 protein denotes chimeric HLF proteins
T17 862-875 protein denotes bZIP proteins
T18 888-895 protein denotes proline
T19 925-928 protein denotes PAR
T20 934-951 protein denotes C/EBP subfamilies
T21 962-969 protein denotes E2A-HLF
T22 1043-1069 DNA denotes HLF consensus binding site
T23 1130-1162 DNA denotes HLF ancillary DNA-binding domain
T24 1170-1186 protein denotes E2A-HLF chimeras
T25 1258-1267 protein denotes wild-type
T26 1272-1293 protein denotes chimeric HLF proteins
T27 1304-1329 protein denotes transcriptional activator
T28 1344-1374 cell_type denotes lymphoid and nonlymphoid cells
T29 1378-1392 DNA denotes reporter genes
T30 1404-1440 DNA denotes HLF or C/EBP consensus binding sites
T31 1449-1463 DNA denotes reporter genes
T32 1469-1493 DNA denotes nonoptimal binding sites
T33 1541-1548 protein denotes E2A-HLF
T34 1587-1609 protein denotes wild-type PAR proteins
T35 1703-1710 protein denotes E2A-HLF

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8065331-1#266#269#gene6929 416-419 gene6929 denotes E2A
8065331-1#30#59#diseaseC0023449 180-209 diseaseC0023449 denotes acute lymphoblastic leukemias
8065331-2#136#139#gene3131 609-612 gene3131 denotes HLF
8065331-2#188#197#diseaseC0023418 661-670 diseaseC0023418 denotes leukemias
266#269#gene692930#59#diseaseC0023449 8065331-1#266#269#gene6929 8065331-1#30#59#diseaseC0023449 associated_with E2A,acute lymphoblastic leukemias
136#139#gene3131188#197#diseaseC0023418 8065331-2#136#139#gene3131 8065331-2#188#197#diseaseC0023418 associated_with HLF,leukemias

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-149 Sentence denotes DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF.
S2 150-472 Sentence denotes The t(17;19) translocation in acute lymphoblastic leukemias results in creation of E2A-hepatic leukemia factor (HLF) chimeric proteins that contain the DNA-binding and protein dimerization domains of the basic leucine zipper (bZIP) protein HLF fused to a portion of E2A proteins with transcriptional activation properties.
S3 473-671 Sentence denotes An in vitro binding site selection procedure was used to determine DNA sequences preferentially bound by wild-type HLF and chimeric E2A-HLF proteins isolated from various t(17;19)-bearing leukemias.
S4 672-766 Sentence denotes All were found to selectively bind the consensus sequence 5'-GTTACGTAAT-3' with high affinity.
S5 767-1070 Sentence denotes Wild-type and chimeric HLF proteins also bound closely related sites identified previously for bZIP proteins of both the proline- and acidic amino acid-rich (PAR) and C/EBP subfamilies; however, E2A-HLF proteins were significantly less tolerant of certain deviations from the HLF consensus binding site.
S6 1071-1252 Sentence denotes These differences were directly attributable to loss of an HLF ancillary DNA-binding domain in all E2A-HLF chimeras and were further exacerbated by a zipper mutation in one isolate.
S7 1253-1441 Sentence denotes Both wild-type and chimeric HLF proteins displayed transcriptional activator properties in lymphoid and nonlymphoid cells on reporter genes containing HLF or C/EBP consensus binding sites.
S8 1442-1610 Sentence denotes But on reporter genes with nonoptimal binding sites, their transcriptional properties diverged and E2A-HLF competitively inhibited activation by wild-type PAR proteins.
S9 1611-1880 Sentence denotes These findings establish a spectrum of binding site-specific transcriptional properties for E2A-HLF which may preferentially activate expression of select subordinate genes as a homodimer and potentially antagonize expression of others through heteromeric interactions.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-11 NP denotes DNA-binding
C2 91-148 NP denotes the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF
C3 233-284 NP denotes E2A-hepatic leukemia factor (HLF) chimeric proteins
C4 285-289 NP denotes that
C5 298-313 NP denotes the DNA-binding
C6 416-428 NP denotes E2A proteins
C8 596-621 NP denotes chimeric E2A-HLF proteins
C7 578-621 NP denotes wild-type HLF and chimeric E2A-HLF proteins
C9 672-675 NP denotes All
C10 767-802 NP denotes Wild-type and chimeric HLF proteins
C11 962-978 NP denotes E2A-HLF proteins
C12 1166-1186 NP denotes all E2A-HLF chimeras
C13 1253-1293 NP denotes Both wild-type and chimeric HLF proteins
C14 1378-1440 NP denotes reporter genes containing HLF or C/EBP consensus binding sites
C15 1449-1493 NP denotes reporter genes with nonoptimal binding sites
C16 1495-1500 NP denotes their
C17 1541-1548 NP denotes E2A-HLF
C19 1703-1710 NP denotes E2A-HLF
C18 1636-1710 NP denotes a spectrum of binding site-specific transcriptional properties for E2A-HLF
C20 1711-1716 NP denotes which
R1 C3 C2 coref-ident E2A-hepatic leukemia factor (HLF) chimeric proteins,the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF
R2 C4 C3 coref-relat that,E2A-hepatic leukemia factor (HLF) chimeric proteins
R3 C5 C1 coref-ident the DNA-binding,DNA-binding
R4 C6 C3 coref-ident E2A proteins,E2A-hepatic leukemia factor (HLF) chimeric proteins
R5 C8 C3 coref-ident chimeric E2A-HLF proteins,E2A-hepatic leukemia factor (HLF) chimeric proteins
R6 C9 C7 coref-ident All,wild-type HLF and chimeric E2A-HLF proteins
R7 C10 C7 coref-ident Wild-type and chimeric HLF proteins,wild-type HLF and chimeric E2A-HLF proteins
R8 C11 C10 coref-ident E2A-HLF proteins,Wild-type and chimeric HLF proteins
R9 C13 C10 coref-ident Both wild-type and chimeric HLF proteins,Wild-type and chimeric HLF proteins
R10 C15 C14 coref-ident reporter genes with nonoptimal binding sites,reporter genes containing HLF or C/EBP consensus binding sites
R11 C16 C12 coref-pron their,all E2A-HLF chimeras
R12 C17 C12 coref-ident E2A-HLF,all E2A-HLF chimeras
R13 C19 C17 coref-ident E2A-HLF,E2A-HLF
R14 C20 C18 coref-relat which,a spectrum of binding site-specific transcriptional properties for E2A-HLF

GENIAcorpus

Id Subject Object Predicate Lexical cue
T20 588-591 protein_molecule denotes HLF
T51 1541-1545 protein_molecule denotes E2A-
T1 16-53 other_name denotes transcriptional regulatory properties
T2 57-80 protein_molecule denotes hepatic leukemia factor
T3 82-85 protein_molecule denotes HLF
T4 104-140 protein_molecule denotes acute lymphoblastic leukemia chimera
T5 141-145 protein_molecule denotes E2A-
T6 145-148 protein_molecule denotes HLF
T7 154-162 DNA_domain_or_region denotes t(17;19)
T8 180-209 other_name denotes acute lymphoblastic leukemias
T9 233-237 protein_molecule denotes E2A-
T10 237-260 protein_molecule denotes hepatic leukemia factor
T11 262-265 protein_molecule denotes HLF
T12 267-284 protein_family_or_group denotes chimeric proteins
T13 302-346 protein_domain_or_region denotes DNA-binding and protein dimerization domains
T14 354-389 protein_family_or_group denotes basic leucine zipper (bZIP) protein
T15 390-393 protein_molecule denotes HLF
T16 416-428 protein_family_or_group denotes E2A proteins
T17 434-471 other_name denotes transcriptional activation properties
T18 476-517 other_name denotes in vitro binding site selection procedure
T19 578-587 protein_molecule denotes wild-type
T21 596-604 protein_molecule denotes chimeric
T22 605-609 protein_molecule denotes E2A-
T23 609-612 protein_molecule denotes HLF
T24 644-670 cell_line denotes t(17;19)-bearing leukemias
T25 711-729 DNA_domain_or_region denotes consensus sequence
T26 730-746 polynucleotide denotes 5'-GTTACGTAAT-3'
T27 781-789 protein_family_or_group denotes chimeric
T28 790-793 protein_molecule denotes HLF
T29 862-875 protein_family_or_group denotes bZIP proteins
T30 888-895 amino_acid_monomer denotes proline
T31 925-928 protein_family_or_group denotes PAR
T32 934-951 protein_family_or_group denotes C/EBP subfamilies
T33 962-966 protein_molecule denotes E2A-
T34 966-969 protein_molecule denotes HLF
T35 1043-1046 protein_molecule denotes HLF
T36 1130-1133 protein_molecule denotes HLF
T37 1170-1174 protein_molecule denotes E2A-
T38 1174-1177 protein_molecule denotes HLF
T39 1258-1267 protein_molecule denotes wild-type
T40 1272-1280 protein_family_or_group denotes chimeric
T41 1281-1284 protein_molecule denotes HLF
T42 1304-1329 protein_family_or_group denotes transcriptional activator
T43 1344-1352 other_name denotes lymphoid
T44 1357-1368 other_name denotes nonlymphoid
T45 1369-1374 other_name denotes cells
T46 1378-1392 DNA_family_or_group denotes reporter genes
T47 1404-1440 DNA_domain_or_region denotes HLF or C/EBP consensus binding sites
T48 1411-1416 protein_molecule denotes C/EBP
T49 1449-1463 DNA_family_or_group denotes reporter genes
T50 1469-1493 DNA_domain_or_region denotes nonoptimal binding sites
T52 1545-1548 protein_molecule denotes HLF
T53 1587-1609 protein_family_or_group denotes wild-type PAR proteins
T54 1650-1698 other_name denotes binding site-specific transcriptional properties
T55 1703-1707 protein_molecule denotes E2A-
T56 1707-1710 protein_molecule denotes HLF
T57 1855-1879 other_name denotes heteromeric interactions