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PubMed:8054477 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 992-996 gene:3558 denotes IL-2
T1 1028-1036 disease:C0023418 denotes leukemia
R1 T0 T1 associated_with IL-2,leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 36-40 protein denotes IL-2
T2 108-112 protein denotes IL-2
T3 130-140 protein denotes lymphokine
T4 244-253 DNA denotes IL-2 gene
T5 334-346 cell_type denotes CD4+ T cells
T6 397-424 DNA denotes cis-acting regulatory sites
T7 459-468 DNA denotes IL-2 gene
T8 542-569 DNA denotes cis-acting regulatory sites
T9 599-612 DNA denotes IL-2 enhancer
T10 617-634 DNA denotes promoter sequence
T11 679-683 protein denotes NFAT
T12 685-697 DNA denotes -276 to -261
T13 704-718 DNA denotes distal octamer
T14 720-732 DNA denotes -256 to -248
T15 742-758 DNA denotes proximal octamer
T16 760-770 DNA denotes -75 to -66
T17 807-816 DNA denotes IL-2 gene
T18 908-917 DNA denotes IL-2 gene
T19 992-1001 DNA denotes IL-2 gene
T20 1026-1047 cell_line denotes T leukemia cell lines
T21 1053-1070 DNA denotes distal purine box
T22 1072-1084 DNA denotes -291 to -277
T23 1094-1119 DNA denotes proximal purine box sites
T24 1121-1133 DNA denotes -145 to -128
T25 1149-1190 DNA denotes AP-1 (-186 to -176) and the kappa B sites
T26 1192-1204 DNA denotes -206 to -195
T27 1250-1259 cell_line denotes EL4 cells
T28 1265-1274 DNA denotes AP-1 site
T29 1326-1338 DNA denotes kappa B site
T30 1352-1356 protein denotes IL-1
T31 1412-1421 DNA denotes IL-2 gene
T32 1467-1494 DNA denotes cis-acting regulatory sites
T33 1534-1541 cell_type denotes T cells

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8054477-6#45#49#gene3558 992-996 gene3558 denotes IL-2
8054477-6#81#89#diseaseC0023418 1028-1036 diseaseC0023418 denotes leukemia
45#49#gene355881#89#diseaseC0023418 8054477-6#45#49#gene3558 8054477-6#81#89#diseaseC0023418 associated_with IL-2,leukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-92 Sentence denotes Positive and negative regulation of IL-2 gene expression: role of multiple regulatory sites.
S2 93-239 Sentence denotes Interleukin 2 (IL-2) is an important lymphokine required in the process of T cell activation, proliferation, clonal expansion and differentiation.
S3 240-388 Sentence denotes The IL-2 gene displays both T cell specific and inducible expression: it is only expressed in CD4+ T cells after antigenic or mitogenic stimulation.
S4 389-487 Sentence denotes Several cis-acting regulatory sites are required for induction of the IL-2 gene after stimulation.
S5 488-635 Sentence denotes In this study, we have analysed the function of these cis-acting regulatory sites in the context of the native IL-2 enhancer and promoter sequence.
S6 636-946 Sentence denotes The results of this study suggest that the NFAT (-276 to -261), the distal octamer (-256 to -248) and the proximal octamer (-75 to -66) sites not only act as enhancers of IL-2 gene transcription in the presence of cellular stimulation, but also have a silencing effect on IL-2 gene expression in resting cells.
S7 947-1135 Sentence denotes Two other sites display disparate effects on IL-2 gene expression in different T leukemia cell lines: the distal purine box (-291 to -277) and the proximal purine box sites (-145 to -128).
S8 1136-1260 Sentence denotes Finally, the AP-1 (-186 to -176) and the kappa B sites (-206 to -195) respond to different cellular activation in EL4 cells.
S9 1261-1369 Sentence denotes The AP-1 site mediated the response to PMA stimulation while the kappa B site responded to IL-1 stimulation.
S10 1370-1598 Sentence denotes These data suggest that the regulation of IL-2 gene expression is a complex process and multiple cis-acting regulatory sites interact to exert different effects in T cells representative of alternative stages of differentiation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 36-56 NP denotes IL-2 gene expression
C2 93-113 NP denotes Interleukin 2 (IL-2)
C3 240-253 NP denotes The IL-2 gene
C4 353-387 NP denotes antigenic or mitogenic stimulation
C5 389-424 NP denotes Several cis-acting regulatory sites
C6 455-468 NP denotes the IL-2 gene
C7 475-486 NP denotes stimulation
C8 536-569 NP denotes these cis-acting regulatory sites
C9 908-928 NP denotes IL-2 gene expression
C10 947-962 NP denotes Two other sites
C11 992-1012 NP denotes IL-2 gene expression
C12 1049-1134 NP denotes the distal purine box (-291 to -277) and the proximal purine box sites (-145 to -128)
C13 1412-1432 NP denotes IL-2 gene expression
C14 1458-1494 NP denotes multiple cis-acting regulatory sites
R1 C3 C2 coref-ident The IL-2 gene,Interleukin 2 (IL-2)
R2 C6 C3 coref-ident the IL-2 gene,The IL-2 gene
R3 C7 C4 coref-ident stimulation,antigenic or mitogenic stimulation
R4 C8 C5 coref-ident these cis-acting regulatory sites,Several cis-acting regulatory sites
R5 C9 C1 coref-ident IL-2 gene expression,IL-2 gene expression
R6 C11 C9 coref-ident IL-2 gene expression,IL-2 gene expression
R7 C12 C10 coref-ident the distal purine box (-291 to -277) and the proximal purine box sites (-145 to -128),Two other sites
R8 C13 C11 coref-ident IL-2 gene expression,IL-2 gene expression
R9 C14 C5 coref-ident multiple cis-acting regulatory sites,Several cis-acting regulatory sites

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 36-40 protein_molecule denotes IL-2
T2 41-56 other_name denotes gene expression
T3 108-112 protein_molecule denotes IL-2
T4 130-140 protein_family_or_group denotes lymphokine
T5 168-185 other_name denotes T cell activation
T6 187-200 other_name denotes proliferation
T7 202-218 other_name denotes clonal expansion
T8 223-238 other_name denotes differentiation
T9 244-248 protein_molecule denotes IL-2
T10 334-346 cell_type denotes CD4+ T cells
T11 397-424 DNA_domain_or_region denotes cis-acting regulatory sites
T12 459-463 protein_molecule denotes IL-2
T13 542-569 DNA_domain_or_region denotes cis-acting regulatory sites
T14 599-603 protein_molecule denotes IL-2
T15 617-634 DNA_domain_or_region denotes promoter sequence
T16 679-683 protein_molecule denotes NFAT
T17 685-697 DNA_domain_or_region denotes -276 to -261
T18 704-718 DNA_domain_or_region denotes distal octamer
T19 720-732 DNA_domain_or_region denotes -256 to -248
T20 742-758 DNA_domain_or_region denotes proximal octamer
T21 760-770 DNA_domain_or_region denotes -75 to -66
T22 807-811 protein_molecule denotes IL-2
T23 850-870 other_name denotes cellular stimulation
T24 908-912 protein_molecule denotes IL-2
T25 992-996 protein_molecule denotes IL-2
T26 1026-1047 cell_line denotes T leukemia cell lines
T27 1053-1070 DNA_domain_or_region denotes distal purine box
T28 1072-1084 DNA_domain_or_region denotes -291 to -277
T29 1094-1119 DNA_domain_or_region denotes proximal purine box sites
T30 1121-1133 DNA_domain_or_region denotes -145 to -128
T31 1192-1204 DNA_domain_or_region denotes -206 to -195
T32 1250-1259 cell_line denotes EL4 cells
T33 1265-1274 DNA_domain_or_region denotes AP-1 site
T34 1300-1303 other_organic_compound denotes PMA
T35 1326-1338 DNA_domain_or_region denotes kappa B site
T36 1352-1356 protein_molecule denotes IL-1
T37 1412-1416 protein_molecule denotes IL-2
T38 1467-1494 DNA_domain_or_region denotes cis-acting regulatory sites
T39 1534-1541 cell_type denotes T cells
T40 1582-1597 other_name denotes differentiation