PubMed:8052854
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8052854","sourcedb":"PubMed","sourceid":"8052854","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8052854","text":"Inhibition of NF-kappa B by sodium salicylate and aspirin.\nThe transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T 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