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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 9-38 DNA denotes prolactin-responsive elements
T2 80-115 DNA denotes interferon regulatory factor-1 gene
T3 121-164 DNA denotes interferon regulatory factor-1 (IRF-1) gene
T4 176-205 DNA denotes immediate-early G1 phase gene
T5 213-225 DNA denotes S phase gene
T6 239-242 protein denotes PRL
T7 246-267 cell_line denotes rat Nb2 T lymphocytes
T8 306-309 protein denotes PRL
T9 347-352 protein denotes IRF-1
T10 368-382 DNA denotes rat IRF-1 gene
T11 418-432 DNA denotes IRF-1 promoter
T12 457-468 cell_line denotes Nb2 T cells
T13 492-513 DNA denotes IRF-1 5'-flanking DNA
T14 526-580 DNA denotes chloramphenicol acetyl transferase (CAT) reporter gene
T15 613-623 protein denotes CAT enzyme
T16 656-659 protein denotes PRL
T17 701-737 DNA denotes 1.3, 0.6, and 0.2 kb 5'-flanking DNA
T18 842-845 protein denotes PRL
T19 897-935 DNA denotes heterologous thymidine kinase promoter
T20 957-960 protein denotes PRL
T21 1006-1036 DNA denotes upstream PRL response elements
T22 1069-1095 DNA denotes promoter-proximal elements
T23 1109-1119 protein denotes CAT enzyme
T24 1143-1146 protein denotes PRL
T25 1208-1211 protein denotes PRL
T26 1229-1239 DNA denotes IRF-1 gene
T27 1268-1273 protein denotes IRF-1
T28 1274-1285 DNA denotes 5'-flanking
T29 1290-1302 DNA denotes promoter DNA
T30 1315-1332 DNA denotes IRF-CAT construct
T31 1348-1351 protein denotes PRL
T32 1431-1434 protein denotes CAT
T33 1462-1465 protein denotes PRL
T34 1523-1526 protein denotes PRL
T35 1562-1572 DNA denotes IRF-1 gene
T36 1610-1633 DNA denotes PRL-responsive elements
T37 1671-1692 DNA denotes IRF-1 promoter region

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-116 Sentence denotes Multiple prolactin-responsive elements mediate G1 and S phase expression of the interferon regulatory factor-1 gene.
S2 117-268 Sentence denotes The interferon regulatory factor-1 (IRF-1) gene is both an immediate-early G1 phase gene and an S phase gene inducible by PRL in rat Nb2 T lymphocytes.
S3 269-433 Sentence denotes To understand the mechanism by which PRL regulates the biphasic expression of IRF-1, we cloned the rat IRF-1 gene and functionally characterized the IRF-1 promoter.
S4 434-672 Sentence denotes Upon transfection into Nb2 T cells, 1.7 kilobases (kb) of IRF-1 5'-flanking DNA linked to a chloramphenicol acetyl transferase (CAT) reporter gene mediated a 30-fold induction of CAT enzyme activity in response to 24 h of PRL stimulation.
S5 673-846 Sentence denotes Deletion mutants containing 1.3, 0.6, and 0.2 kb 5'-flanking DNA were incrementally less transcriptionally active, although 0.2 kb still mediated a 12-fold induction by PRL.
S6 847-1096 Sentence denotes The sequence between -1.7 and -0.2 kb linked to a heterologous thymidine kinase promoter failed to respond to PRL stimulation, suggesting that the activity of upstream PRL response elements may require an interaction with promoter-proximal elements.
S7 1097-1303 Sentence denotes By assaying CAT enzyme activity across a 24-h PRL induction time course, we were able to assign G1 vs. S phase PRL responses of the IRF-1 gene to different regions of the IRF-1 5'-flanking and promoter DNA.
S8 1304-1402 Sentence denotes The 0.2-kb IRF-CAT construct was induced by PRL stimulation during the G1 phase of the cell cycle.
S9 1403-1511 Sentence denotes In contrast, the 1.7-kb IRF-CAT construct was inducible by PRL during both G1 and S phase of the cell cycle.
S10 1512-1832 Sentence denotes Hence, the PRL-induced biphasic expression of the IRF-1 gene appears to be controlled by separate PRL-responsive elements: elements in the first 0.2 kb of the IRF-1 promoter region act during early activation, and elements between 0.2 and 1.7 kb act in concert with the proximal 0.2-kb region during S phase progression.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 76-115 NP denotes the interferon regulatory factor-1 gene
C2 117-164 NP denotes The interferon regulatory factor-1 (IRF-1) gene
C3 239-242 NP denotes PRL
C4 246-267 NP denotes rat Nb2 T lymphocytes
C5 283-296 NP denotes the mechanism
C6 300-305 NP denotes which
C7 306-309 NP denotes PRL
C8 347-352 NP denotes IRF-1
C9 364-382 NP denotes the rat IRF-1 gene
C10 457-468 NP denotes Nb2 T cells
C11 656-671 NP denotes PRL stimulation
C12 842-845 NP denotes PRL
C13 957-972 NP denotes PRL stimulation
C14 1225-1239 NP denotes the IRF-1 gene
C15 1348-1363 NP denotes PRL stimulation
C16 1387-1401 NP denotes the cell cycle
C17 1462-1465 NP denotes PRL
C18 1496-1510 NP denotes the cell cycle
C19 1523-1527 NP denotes PRL-
C20 1558-1572 NP denotes the IRF-1 gene
C21 1610-1614 NP denotes PRL-
R1 C2 C1 coref-ident The interferon regulatory factor-1 (IRF-1) gene,the interferon regulatory factor-1 gene
R2 C6 C5 coref-relat which,the mechanism
R3 C7 C3 coref-ident PRL,PRL
R4 C8 C2 coref-ident IRF-1,The interferon regulatory factor-1 (IRF-1) gene
R5 C9 C8 coref-ident the rat IRF-1 gene,IRF-1
R6 C10 C4 coref-ident Nb2 T cells,rat Nb2 T lymphocytes
R7 C12 C7 coref-ident PRL,PRL
R8 C13 C11 coref-ident PRL stimulation,PRL stimulation
R9 C14 C9 coref-ident the IRF-1 gene,the rat IRF-1 gene
R10 C15 C13 coref-ident PRL stimulation,PRL stimulation
R11 C17 C12 coref-ident PRL,PRL
R12 C18 C16 coref-ident the cell cycle,the cell cycle
R13 C19 C17 coref-ident PRL-,PRL
R14 C20 C14 coref-ident the IRF-1 gene,the IRF-1 gene
R15 C21 C19 coref-ident PRL-,PRL-

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 9-38 DNA_family_or_group denotes prolactin-responsive elements
T2 80-115 DNA_domain_or_region denotes interferon regulatory factor-1 gene
T3 121-153 DNA_domain_or_region denotes interferon regulatory factor-1 (
T4 153-158 protein_molecule denotes IRF-1
T5 176-205 DNA_family_or_group denotes immediate-early G1 phase gene
T6 213-225 DNA_family_or_group denotes S phase gene
T7 239-242 protein_molecule denotes PRL
T8 246-267 cell_line denotes rat Nb2 T lymphocytes
T9 306-309 protein_molecule denotes PRL
T10 347-352 protein_molecule denotes IRF-1
T11 368-371 DNA_domain_or_region denotes rat
T12 372-377 protein_molecule denotes IRF-1
T13 418-423 protein_molecule denotes IRF-1
T14 457-468 cell_line denotes Nb2 T cells
T15 492-497 protein_molecule denotes IRF-1
T16 526-560 protein_molecule denotes chloramphenicol acetyl transferase
T17 562-565 protein_molecule denotes CAT
T18 613-616 protein_molecule denotes CAT
T19 656-659 protein_molecule denotes PRL
T20 842-845 protein_molecule denotes PRL
T21 897-935 DNA_domain_or_region denotes heterologous thymidine kinase promoter
T22 957-960 protein_molecule denotes PRL
T23 1006-1014 DNA_family_or_group denotes upstream
T24 1015-1018 protein_molecule denotes PRL
T25 1069-1095 DNA_family_or_group denotes promoter-proximal elements
T26 1109-1112 protein_molecule denotes CAT
T27 1143-1146 protein_molecule denotes PRL
T28 1200-1207 other_name denotes S phase
T29 1208-1211 protein_molecule denotes PRL
T30 1229-1234 protein_molecule denotes IRF-1
T31 1268-1273 protein_molecule denotes IRF-1
T32 1274-1285 DNA_domain_or_region denotes 5'-flanking
T33 1290-1302 DNA_domain_or_region denotes promoter DNA
T34 1315-1319 DNA_molecule denotes IRF-
T35 1319-1322 protein_molecule denotes CAT
T36 1348-1351 protein_molecule denotes PRL
T37 1375-1383 other_name denotes G1 phase
T38 1391-1401 other_name denotes cell cycle
T39 1431-1434 protein_molecule denotes CAT
T40 1462-1465 protein_molecule denotes PRL
T41 1500-1510 other_name denotes cell cycle
T42 1523-1526 protein_molecule denotes PRL
T43 1562-1567 protein_molecule denotes IRF-1
T44 1610-1613 protein_molecule denotes PRL
T45 1671-1676 protein_molecule denotes IRF-1
T46 1704-1720 other_name denotes early activation
T47 1812-1831 other_name denotes S phase progression