PubMed:8014029
Annnotations
jnlpba-st-training
{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":10,"end":23},"obj":"protein"},{"id":"T2","span":{"begin":41,"end":59},"obj":"cell_type"},{"id":"T3","span":{"begin":160,"end":173},"obj":"protein"},{"id":"T4","span":{"begin":175,"end":179},"obj":"protein"},{"id":"T5","span":{"begin":185,"end":201},"obj":"protein"},{"id":"T6","span":{"begin":203,"end":212},"obj":"protein"},{"id":"T7","span":{"begin":228,"end":262},"obj":"cell_type"},{"id":"T8","span":{"begin":312,"end":316},"obj":"protein"},{"id":"T9","span":{"begin":321,"end":330},"obj":"RNA"},{"id":"T10","span":{"begin":378,"end":393},"obj":"protein"},{"id":"T11","span":{"begin":397,"end":409},"obj":"protein"},{"id":"T12","span":{"begin":411,"end":429},"obj":"cell_type"},{"id":"T13","span":{"begin":452,"end":475},"obj":"cell_line"},{"id":"T14","span":{"begin":604,"end":621},"obj":"cell_type"},{"id":"T15","span":{"begin":623,"end":632},"obj":"protein"},{"id":"T16","span":{"begin":662,"end":676},"obj":"RNA"},{"id":"T17","span":{"begin":767,"end":785},"obj":"cell_type"},{"id":"T18","span":{"begin":827,"end":837},"obj":"cell_type"},{"id":"T19","span":{"begin":885,"end":898},"obj":"DNA"},{"id":"T20","span":{"begin":903,"end":918},"obj":"DNA"},{"id":"T21","span":{"begin":933,"end":986},"obj":"DNA"},{"id":"T22","span":{"begin":1000,"end":1003},"obj":"protein"},{"id":"T23","span":{"begin":1076,"end":1086},"obj":"cell_type"},{"id":"T24","span":{"begin":1174,"end":1191},"obj":"cell_type"},{"id":"T25","span":{"begin":1193,"end":1199},"obj":"protein"},{"id":"T26","span":{"begin":1276,"end":1305},"obj":"protein"},{"id":"T27","span":{"begin":1306,"end":1310},"obj":"protein"},{"id":"T28","span":{"begin":1314,"end":1321},"obj":"protein"},{"id":"T29","span":{"begin":1355,"end":1364},"obj":"protein"},{"id":"T30","span":{"begin":1389,"end":1393},"obj":"protein"},{"id":"T31","span":{"begin":1408,"end":1426},"obj":"cell_type"},{"id":"T32","span":{"begin":1451,"end":1457},"obj":"protein"},{"id":"T33","span":{"begin":1483,"end":1487},"obj":"protein"}],"text":"Increased interleukin 2 transcription in murine lymphocytes by ciprofloxacin.\nThe fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. In this investigation an enhanced and prolonged IL-2 and IL-2 mRNA response was also detected in both stimulated (T cell mitogens or alloantigens) murine splenocytes and in the stimulated murine T cell line EL-4 in the presence of ciprofloxacin (5-80 micrograms/ml) as compared to control cells without antibiotics. However, in contrast to human lymphocytes, IFN-gamma production was inhibited and IFN-gamma mRNA levels were unaffected at 24 h and only slightly upregulated at 48 and 72 h of culture in murine splenocytes incubated with cipro (20 micrograms/ml). EL-4 cells were transfected with a plasmid containing the IL-2 promoter and enhancer region linked to the chloramphenicol acetyltransferase (CAT) reporter gene. Analysis of CAT activity revealed that cipro enhanced IL-2 gene induction. In addition, EL-4 cells incubated with ciprofloxacin showed an early peak and more activated nuclear factor of activated T cells (NFAT-1) as compared to control cells without antibiotics. Cipro did not affect the nuclear transcription factors AP-1 or NFIL-2A. Taken together, cipro inhibited IFN-gamma synthesis, but enhanced IL-2 production in murine lymphocytes by means of influencing NFAT-1 and causing an increased IL-2 transcription."}
pubmed-sentences-benchmark
{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"S2","span":{"begin":78,"end":263},"obj":"Sentence"},{"id":"S3","span":{"begin":264,"end":579},"obj":"Sentence"},{"id":"S4","span":{"begin":580,"end":826},"obj":"Sentence"},{"id":"S5","span":{"begin":827,"end":987},"obj":"Sentence"},{"id":"S6","span":{"begin":988,"end":1062},"obj":"Sentence"},{"id":"S7","span":{"begin":1063,"end":1250},"obj":"Sentence"},{"id":"S8","span":{"begin":1251,"end":1322},"obj":"Sentence"},{"id":"S9","span":{"begin":1323,"end":1502},"obj":"Sentence"}],"text":"Increased interleukin 2 transcription in murine lymphocytes by ciprofloxacin.\nThe fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. In this investigation an enhanced and prolonged IL-2 and IL-2 mRNA response was also detected in both stimulated (T cell mitogens or alloantigens) murine splenocytes and in the stimulated murine T cell line EL-4 in the presence of ciprofloxacin (5-80 micrograms/ml) as compared to control cells without antibiotics. However, in contrast to human lymphocytes, IFN-gamma production was inhibited and IFN-gamma mRNA levels were unaffected at 24 h and only slightly upregulated at 48 and 72 h of culture in murine splenocytes incubated with cipro (20 micrograms/ml). EL-4 cells were transfected with a plasmid containing the IL-2 promoter and enhancer region linked to the chloramphenicol acetyltransferase (CAT) reporter gene. Analysis of CAT activity revealed that cipro enhanced IL-2 gene induction. In addition, EL-4 cells incubated with ciprofloxacin showed an early peak and more activated nuclear factor of activated T cells (NFAT-1) as compared to control cells without antibiotics. Cipro did not affect the nuclear transcription factors AP-1 or NFIL-2A. Taken together, cipro inhibited IFN-gamma synthesis, but enhanced IL-2 production in murine lymphocytes by means of influencing NFAT-1 and causing an increased IL-2 transcription."}
genia-medco-coref
{"project":"genia-medco-coref","denotations":[{"id":"C2","span":{"begin":41,"end":59},"obj":"NP"},{"id":"C3","span":{"begin":63,"end":76},"obj":"NP"},{"id":"C1","span":{"begin":0,"end":76},"obj":"NP"},{"id":"C4","span":{"begin":78,"end":108},"obj":"NP"},{"id":"C5","span":{"begin":110,"end":131},"obj":"NP"},{"id":"C6","span":{"begin":545,"end":578},"obj":"NP"},{"id":"C7","span":{"begin":801,"end":806},"obj":"NP"},{"id":"C8","span":{"begin":827,"end":837},"obj":"NP"},{"id":"C9","span":{"begin":1027,"end":1032},"obj":"NP"},{"id":"C10","span":{"begin":1076,"end":1086},"obj":"NP"},{"id":"C11","span":{"begin":1216,"end":1249},"obj":"NP"},{"id":"C12","span":{"begin":1251,"end":1256},"obj":"NP"},{"id":"C13","span":{"begin":1339,"end":1344},"obj":"NP"},{"id":"C14","span":{"begin":1408,"end":1426},"obj":"NP"},{"id":"C15","span":{"begin":1470,"end":1501},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R2","pred":"coref-appos","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C5"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C8"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C6"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C9"},{"id":"R8","pred":"coref-ident","subj":"C13","obj":"C12"},{"id":"R9","pred":"coref-ident","subj":"C14","obj":"C2"},{"id":"R10","pred":"coref-ident","subj":"C15","obj":"C1"}],"text":"Increased interleukin 2 transcription in murine lymphocytes by ciprofloxacin.\nThe fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. In this investigation an enhanced and prolonged IL-2 and IL-2 mRNA response was also detected in both stimulated (T cell mitogens or alloantigens) murine splenocytes and in the stimulated murine T cell line EL-4 in the presence of ciprofloxacin (5-80 micrograms/ml) as compared to control cells without antibiotics. However, in contrast to human lymphocytes, IFN-gamma production was inhibited and IFN-gamma mRNA levels were unaffected at 24 h and only slightly upregulated at 48 and 72 h of culture in murine splenocytes incubated with cipro (20 micrograms/ml). EL-4 cells were transfected with a plasmid containing the IL-2 promoter and enhancer region linked to the chloramphenicol acetyltransferase (CAT) reporter gene. Analysis of CAT activity revealed that cipro enhanced IL-2 gene induction. In addition, EL-4 cells incubated with ciprofloxacin showed an early peak and more activated nuclear factor of activated T cells (NFAT-1) as compared to control cells without antibiotics. Cipro did not affect the nuclear transcription factors AP-1 or NFIL-2A. Taken together, cipro inhibited IFN-gamma synthesis, but enhanced IL-2 production in murine lymphocytes by means of influencing NFAT-1 and causing an increased IL-2 transcription."}
GENIAcorpus
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