PubMed:8009171 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":12,"end":24},"obj":"protein"},{"id":"T2","span":{"begin":39,"end":82},"obj":"cell_line"},{"id":"T3","span":{"begin":84,"end":96},"obj":"protein"},{"id":"T4","span":{"begin":111,"end":126},"obj":"cell_type"},{"id":"T5","span":{"begin":256,"end":276},"obj":"cell_line"},{"id":"T6","span":{"begin":357,"end":393},"obj":"protein"},{"id":"T7","span":{"begin":414,"end":421},"obj":"DNA"},{"id":"T8","span":{"begin":436,"end":473},"obj":"protein"},{"id":"T9","span":{"begin":521,"end":550},"obj":"protein"},{"id":"T10","span":{"begin":558,"end":562},"obj":"DNA"},{"id":"T11","span":{"begin":620,"end":641},"obj":"DNA"},{"id":"T12","span":{"begin":666,"end":704},"obj":"DNA"},{"id":"T13","span":{"begin":706,"end":722},"obj":"protein"},{"id":"T14","span":{"begin":738,"end":762},"obj":"protein"},{"id":"T15","span":{"begin":814,"end":843},"obj":"protein"},{"id":"T16","span":{"begin":845,"end":852},"obj":"DNA"},{"id":"T17","span":{"begin":858,"end":889},"obj":"protein"},{"id":"T18","span":{"begin":891,"end":898},"obj":"DNA"},{"id":"T19","span":{"begin":946,"end":952},"obj":"protein"},{"id":"T20","span":{"begin":989,"end":994},"obj":"protein"},{"id":"T21","span":{"begin":999,"end":1004},"obj":"protein"},{"id":"T22","span":{"begin":1034,"end":1071},"obj":"cell_line"},{"id":"T23","span":{"begin":1100,"end":1106},"obj":"protein"},{"id":"T24","span":{"begin":1111,"end":1117},"obj":"protein"},{"id":"T25","span":{"begin":1143,"end":1200},"obj":"cell_line"}],"text":"Analysis of Oct2-isoform expression in lipopolysaccharide-stimulated B lymphocytes.\nOct2-isoform expression in splenic B cells stimulated with lipopolysaccharide or lipopolysaccharide plus phorbol-di-butyrate was analysed by cDNA cloning. The frequency of Oct2-positive clones was 1/15,000 in both libraries. Two new isoforms were found that generate novel amino- or carboxy-terminal sequences. An isoform lacking exon 11 destroyed the carboxy-terminal leucin-zipper region and introduced a frame shift creating a novel, proline-rich carboxy terminus. A new exon containing a highly basic region (4c) was characterized, between exons 4 and 5. This exon was inserted between glutamine-rich regions 2 and 3, carboxy terminal of a tentative leucine-zipper structure. In addition, a new combination isoform containing Oct2a's amino terminal insert (exon 7a) and Oct2b's carboxy terminal insert (exon 13) was found that created a novel large isoform, Oct2ab. More frequent use of the classical Oct2a and Oct2b isoforms was observed in the lipopolysaccharide-stimulated B cells, while a preference for the Oct2ab and Oct2ba isoforms was observed in lipopolysaccharide plus phorbol-di-butyrate-treated cells."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"S2","span":{"begin":84,"end":238},"obj":"Sentence"},{"id":"S3","span":{"begin":239,"end":308},"obj":"Sentence"},{"id":"S4","span":{"begin":309,"end":394},"obj":"Sentence"},{"id":"S5","span":{"begin":395,"end":551},"obj":"Sentence"},{"id":"S6","span":{"begin":552,"end":642},"obj":"Sentence"},{"id":"S7","span":{"begin":643,"end":763},"obj":"Sentence"},{"id":"S8","span":{"begin":764,"end":953},"obj":"Sentence"},{"id":"S9","span":{"begin":954,"end":1201},"obj":"Sentence"}],"text":"Analysis of Oct2-isoform expression in lipopolysaccharide-stimulated B lymphocytes.\nOct2-isoform expression in splenic B cells stimulated with lipopolysaccharide or lipopolysaccharide plus phorbol-di-butyrate was analysed by cDNA cloning. The frequency of Oct2-positive clones was 1/15,000 in both libraries. Two new isoforms were found that generate novel amino- or carboxy-terminal sequences. An isoform lacking exon 11 destroyed the carboxy-terminal leucin-zipper region and introduced a frame shift creating a novel, proline-rich carboxy terminus. A new exon containing a highly basic region (4c) was characterized, between exons 4 and 5. This exon was inserted between glutamine-rich regions 2 and 3, carboxy terminal of a tentative leucine-zipper structure. In addition, a new combination isoform containing Oct2a's amino terminal insert (exon 7a) and Oct2b's carboxy terminal insert (exon 13) was found that created a novel large isoform, Oct2ab. More frequent use of the classical Oct2a and Oct2b isoforms was observed in the lipopolysaccharide-stimulated B cells, while a preference for the Oct2ab and Oct2ba isoforms was observed in lipopolysaccharide plus phorbol-di-butyrate-treated cells."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":12,"end":35},"obj":"NP"},{"id":"C2","span":{"begin":39,"end":82},"obj":"NP"},{"id":"C3","span":{"begin":84,"end":107},"obj":"NP"},{"id":"C4","span":{"begin":111,"end":208},"obj":"NP"},{"id":"C5","span":{"begin":309,"end":325},"obj":"NP"},{"id":"C6","span":{"begin":337,"end":341},"obj":"NP"},{"id":"C7","span":{"begin":552,"end":600},"obj":"NP"},{"id":"C8","span":{"begin":643,"end":652},"obj":"NP"},{"id":"C9","span":{"begin":674,"end":704},"obj":"NP"},{"id":"C10","span":{"begin":706,"end":762},"obj":"NP"},{"id":"C11","span":{"begin":777,"end":899},"obj":"NP"},{"id":"C12","span":{"begin":910,"end":914},"obj":"NP"},{"id":"C13","span":{"begin":923,"end":944},"obj":"NP"},{"id":"C14","span":{"begin":946,"end":952},"obj":"NP"},{"id":"C15","span":{"begin":1030,"end":1071},"obj":"NP"},{"id":"C16","span":{"begin":1143,"end":1200},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C1"},{"id":"R2","pred":"coref-relat","subj":"C6","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C8","obj":"C7"},{"id":"R4","pred":"coref-appos","subj":"C10","obj":"C9"},{"id":"R5","pred":"coref-relat","subj":"C12","obj":"C11"},{"id":"R6","pred":"coref-appos","subj":"C14","obj":"C13"},{"id":"R7","pred":"coref-ident","subj":"C15","obj":"C2"},{"id":"R8","pred":"coref-ident","subj":"C16","obj":"C4"}],"text":"Analysis of Oct2-isoform expression in lipopolysaccharide-stimulated B lymphocytes.\nOct2-isoform expression in splenic B cells stimulated with lipopolysaccharide or lipopolysaccharide plus phorbol-di-butyrate was analysed by cDNA cloning. The frequency of Oct2-positive clones was 1/15,000 in both libraries. Two new isoforms were found that generate novel amino- or carboxy-terminal sequences. An isoform lacking exon 11 destroyed the carboxy-terminal leucin-zipper region and introduced a frame shift creating a novel, proline-rich carboxy terminus. A new exon containing a highly basic region (4c) was characterized, between exons 4 and 5. This exon was inserted between glutamine-rich regions 2 and 3, carboxy terminal of a tentative leucine-zipper structure. In addition, a new combination isoform containing Oct2a's amino terminal insert (exon 7a) and Oct2b's carboxy terminal insert (exon 13) was found that created a novel large isoform, Oct2ab. More frequent use of the classical Oct2a and Oct2b isoforms was observed in the lipopolysaccharide-stimulated B cells, while a preference for the Oct2ab and Oct2ba isoforms was observed in lipopolysaccharide plus phorbol-di-butyrate-treated cells."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":12,"end":24},"obj":"protein_family_or_group"},{"id":"T2","span":{"begin":39,"end":57},"obj":"lipid"},{"id":"T3","span":{"begin":84,"end":96},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":111,"end":126},"obj":"cell_type"},{"id":"T5","span":{"begin":143,"end":161},"obj":"lipid"},{"id":"T6","span":{"begin":165,"end":183},"obj":"lipid"},{"id":"T7","span":{"begin":189,"end":208},"obj":"other_artificial_source"},{"id":"T8","span":{"begin":225,"end":237},"obj":"other_name"},{"id":"T9","span":{"begin":256,"end":276},"obj":"cell_line"},{"id":"T10","span":{"begin":414,"end":421},"obj":"DNA_domain_or_region"},{"id":"T11","span":{"begin":436,"end":473},"obj":"protein_domain_or_region"},{"id":"T12","span":{"begin":521,"end":528},"obj":"amino_acid_monomer"},{"id":"T13","span":{"begin":558,"end":562},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":620,"end":641},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":666,"end":673},"obj":"DNA_domain_or_region"},{"id":"T16","span":{"begin":674,"end":704},"obj":"DNA_domain_or_region"},{"id":"T17","span":{"begin":706,"end":722},"obj":"protein_domain_or_region"},{"id":"T18","span":{"begin":814,"end":819},"obj":"protein_molecule"},{"id":"T19","span":{"begin":845,"end":852},"obj":"DNA_domain_or_region"},{"id":"T20","span":{"begin":858,"end":863},"obj":"protein_molecule"},{"id":"T21","span":{"begin":891,"end":898},"obj":"DNA_domain_or_region"},{"id":"T22","span":{"begin":946,"end":952},"obj":"protein_molecule"},{"id":"T23","span":{"begin":989,"end":994},"obj":"protein_molecule"},{"id":"T24","span":{"begin":999,"end":1004},"obj":"protein_molecule"},{"id":"T25","span":{"begin":1034,"end":1052},"obj":"lipid"},{"id":"T26","span":{"begin":1100,"end":1106},"obj":"protein_molecule"},{"id":"T27","span":{"begin":1111,"end":1117},"obj":"protein_molecule"},{"id":"T28","span":{"begin":1143,"end":1161},"obj":"lipid"},{"id":"T29","span":{"begin":1167,"end":1186},"obj":"other_artificial_source"}],"text":"Analysis of Oct2-isoform expression in lipopolysaccharide-stimulated B lymphocytes.\nOct2-isoform expression in splenic B cells stimulated with lipopolysaccharide or lipopolysaccharide plus phorbol-di-butyrate was analysed by cDNA cloning. The frequency of Oct2-positive clones was 1/15,000 in both libraries. Two new isoforms were found that generate novel amino- or carboxy-terminal sequences. An isoform lacking exon 11 destroyed the carboxy-terminal leucin-zipper region and introduced a frame shift creating a novel, proline-rich carboxy terminus. A new exon containing a highly basic region (4c) was characterized, between exons 4 and 5. This exon was inserted between glutamine-rich regions 2 and 3, carboxy terminal of a tentative leucine-zipper structure. In addition, a new combination isoform containing Oct2a's amino terminal insert (exon 7a) and Oct2b's carboxy terminal insert (exon 13) was found that created a novel large isoform, Oct2ab. More frequent use of the classical Oct2a and Oct2b isoforms was observed in the lipopolysaccharide-stimulated B cells, while a preference for the Oct2ab and Oct2ba isoforms was observed in lipopolysaccharide plus phorbol-di-butyrate-treated cells."}