PubMed:7989745 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":27,"end":42},"obj":"DNA"},{"id":"T2","span":{"begin":43,"end":48},"obj":"DNA"},{"id":"T3","span":{"begin":53,"end":58},"obj":"DNA"},{"id":"T4","span":{"begin":62,"end":75},"obj":"cell_type"},{"id":"T5","span":{"begin":94,"end":98},"obj":"protein"},{"id":"T6","span":{"begin":104,"end":127},"obj":"protein"},{"id":"T7","span":{"begin":128,"end":132},"obj":"protein"},{"id":"T8","span":{"begin":153,"end":168},"obj":"cell_type"},{"id":"T9","span":{"begin":173,"end":177},"obj":"cell_type"},{"id":"T10","span":{"begin":238,"end":245},"obj":"cell_type"},{"id":"T11","span":{"begin":249,"end":252},"obj":"protein"},{"id":"T12","span":{"begin":377,"end":400},"obj":"protein"},{"id":"T13","span":{"begin":474,"end":478},"obj":"protein"},{"id":"T14","span":{"begin":544,"end":548},"obj":"protein"},{"id":"T15","span":{"begin":558,"end":561},"obj":"protein"},{"id":"T16","span":{"begin":563,"end":566},"obj":"protein"},{"id":"T17","span":{"begin":568,"end":573},"obj":"protein"},{"id":"T18","span":{"begin":578,"end":581},"obj":"protein"},{"id":"T19","span":{"begin":608,"end":618},"obj":"RNA"},{"id":"T20","span":{"begin":652,"end":657},"obj":"DNA"},{"id":"T21","span":{"begin":670,"end":674},"obj":"protein"},{"id":"T22","span":{"begin":698,"end":703},"obj":"DNA"},{"id":"T23","span":{"begin":724,"end":747},"obj":"protein"},{"id":"T24","span":{"begin":797,"end":838},"obj":"protein"},{"id":"T25","span":{"begin":887,"end":891},"obj":"protein"},{"id":"T26","span":{"begin":915,"end":925},"obj":"RNA"},{"id":"T27","span":{"begin":1036,"end":1041},"obj":"DNA"},{"id":"T28","span":{"begin":1046,"end":1050},"obj":"DNA"},{"id":"T29","span":{"begin":1085,"end":1095},"obj":"DNA"},{"id":"T30","span":{"begin":1137,"end":1144},"obj":"cell_type"},{"id":"T31","span":{"begin":1167,"end":1171},"obj":"protein"}],"text":"Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.\nThe T cell surface molecule CD28 binds to ligands on accessory cells and APCs, playing an important costimulatory role in the response of T cells to Ags. Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete. In addition to activation of phospholipase C gamma 1, ligation of this receptor also seems to activate a calcium-independent, CD28-specific pathway. In this paper, we report that cross-linking of CD28 (but not CD2, CD5, LFA-1, or CD7) leads to an elevation of c-jun mRNA, with only minimal activation of c-fos expression. CD28-dependent induction of c-jun expression requires protein tyrosine kinase activity, but does not depend on activation of a phorbol ester-responsive protein kinase C or elevation of cytosolic calcium. Furthermore, CD28-dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability. A mechanism is suggested whereby expression of c-jun and junB, in the absence of members of the fos family, can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":99},"obj":"Sentence"},{"id":"S2","span":{"begin":100,"end":253},"obj":"Sentence"},{"id":"S3","span":{"begin":254,"end":347},"obj":"Sentence"},{"id":"S4","span":{"begin":348,"end":496},"obj":"Sentence"},{"id":"S5","span":{"begin":497,"end":669},"obj":"Sentence"},{"id":"S6","span":{"begin":670,"end":873},"obj":"Sentence"},{"id":"S7","span":{"begin":874,"end":988},"obj":"Sentence"},{"id":"S8","span":{"begin":989,"end":1220},"obj":"Sentence"}],"text":"Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.\nThe T cell surface molecule CD28 binds to ligands on accessory cells and APCs, playing an important costimulatory role in the response of T cells to Ags. Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete. In addition to activation of phospholipase C gamma 1, ligation of this receptor also seems to activate a calcium-independent, CD28-specific pathway. In this paper, we report that cross-linking of CD28 (but not CD2, CD5, LFA-1, or CD7) leads to an elevation of c-jun mRNA, with only minimal activation of c-fos expression. CD28-dependent induction of c-jun expression requires protein tyrosine kinase activity, but does not depend on activation of a phorbol ester-responsive protein kinase C or elevation of cytosolic calcium. Furthermore, CD28-dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability. A mechanism is suggested whereby expression of c-jun and junB, in the absence of members of the fos family, can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":94,"end":98},"obj":"NP"},{"id":"C2","span":{"begin":100,"end":132},"obj":"NP"},{"id":"C3","span":{"begin":319,"end":332},"obj":"NP"},{"id":"C4","span":{"begin":414,"end":427},"obj":"NP"},{"id":"C5","span":{"begin":544,"end":548},"obj":"NP"},{"id":"C6","span":{"begin":608,"end":618},"obj":"NP"},{"id":"C7","span":{"begin":915,"end":925},"obj":"NP"},{"id":"C8","span":{"begin":1167,"end":1171},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C5","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C5"}],"text":"Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.\nThe T cell surface molecule CD28 binds to ligands on accessory cells and APCs, playing an important costimulatory role in the response of T cells to Ags. Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete. In addition to activation of phospholipase C gamma 1, ligation of this receptor also seems to activate a calcium-independent, CD28-specific pathway. In this paper, we report that cross-linking of CD28 (but not CD2, CD5, LFA-1, or CD7) leads to an elevation of c-jun mRNA, with only minimal activation of c-fos expression. CD28-dependent induction of c-jun expression requires protein tyrosine kinase activity, but does not depend on activation of a phorbol ester-responsive protein kinase C or elevation of cytosolic calcium. Furthermore, CD28-dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability. A mechanism is suggested whereby expression of c-jun and junB, in the absence of members of the fos family, can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":27,"end":42},"obj":"DNA_family_or_group"},{"id":"T2","span":{"begin":43,"end":48},"obj":"DNA_domain_or_region"},{"id":"T3","span":{"begin":53,"end":58},"obj":"DNA_domain_or_region"},{"id":"T4","span":{"begin":62,"end":75},"obj":"cell_type"},{"id":"T5","span":{"begin":94,"end":98},"obj":"protein_molecule"},{"id":"T6","span":{"begin":104,"end":127},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":128,"end":132},"obj":"protein_molecule"},{"id":"T8","span":{"begin":153,"end":168},"obj":"cell_type"},{"id":"T9","span":{"begin":173,"end":177},"obj":"cell_type"},{"id":"T10","span":{"begin":238,"end":245},"obj":"cell_type"},{"id":"T11","span":{"begin":249,"end":252},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":275,"end":307},"obj":"other_name"},{"id":"T13","span":{"begin":377,"end":400},"obj":"protein_molecule"},{"id":"T14","span":{"begin":453,"end":460},"obj":"atom"},{"id":"T15","span":{"begin":474,"end":478},"obj":"protein_molecule"},{"id":"T16","span":{"begin":544,"end":548},"obj":"protein_molecule"},{"id":"T17","span":{"begin":558,"end":561},"obj":"protein_molecule"},{"id":"T18","span":{"begin":563,"end":566},"obj":"protein_molecule"},{"id":"T19","span":{"begin":568,"end":573},"obj":"protein_molecule"},{"id":"T20","span":{"begin":578,"end":581},"obj":"protein_molecule"},{"id":"T21","span":{"begin":608,"end":613},"obj":"DNA_domain_or_region"},{"id":"T22","span":{"begin":652,"end":657},"obj":"DNA_domain_or_region"},{"id":"T23","span":{"begin":670,"end":674},"obj":"protein_molecule"},{"id":"T24","span":{"begin":698,"end":703},"obj":"DNA_domain_or_region"},{"id":"T25","span":{"begin":724,"end":747},"obj":"protein_molecule"},{"id":"T26","span":{"begin":797,"end":810},"obj":"other_organic_compound"},{"id":"T27","span":{"begin":855,"end":872},"obj":"atom"},{"id":"T28","span":{"begin":887,"end":891},"obj":"protein_molecule"},{"id":"T29","span":{"begin":915,"end":920},"obj":"DNA_domain_or_region"},{"id":"T30","span":{"begin":973,"end":987},"obj":"other_name"},{"id":"T31","span":{"begin":1036,"end":1041},"obj":"DNA_domain_or_region"},{"id":"T32","span":{"begin":1046,"end":1050},"obj":"DNA_domain_or_region"},{"id":"T33","span":{"begin":1085,"end":1095},"obj":"DNA_family_or_group"},{"id":"T34","span":{"begin":1137,"end":1144},"obj":"cell_type"},{"id":"T35","span":{"begin":1167,"end":1171},"obj":"protein_molecule"},{"id":"T36","span":{"begin":1201,"end":1219},"obj":"other_name"}],"text":"Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.\nThe T cell surface molecule CD28 binds to ligands on accessory cells and APCs, playing an important costimulatory role in the response of T cells to Ags. Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete. In addition to activation of phospholipase C gamma 1, ligation of this receptor also seems to activate a calcium-independent, CD28-specific pathway. In this paper, we report that cross-linking of CD28 (but not CD2, CD5, LFA-1, or CD7) leads to an elevation of c-jun mRNA, with only minimal activation of c-fos expression. CD28-dependent induction of c-jun expression requires protein tyrosine kinase activity, but does not depend on activation of a phorbol ester-responsive protein kinase C or elevation of cytosolic calcium. Furthermore, CD28-dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability. A mechanism is suggested whereby expression of c-jun and junB, in the absence of members of the fos family, can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus."}