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PubMed:7989745 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 27-42 DNA denotes proto-oncogenes
T2 43-48 DNA denotes c-jun
T3 53-58 DNA denotes c-fos
T4 62-75 cell_type denotes T lymphocytes
T5 94-98 protein denotes CD28
T6 104-127 protein denotes T cell surface molecule
T7 128-132 protein denotes CD28
T8 153-168 cell_type denotes accessory cells
T9 173-177 cell_type denotes APCs
T10 238-245 cell_type denotes T cells
T11 249-252 protein denotes Ags
T12 377-400 protein denotes phospholipase C gamma 1
T13 474-478 protein denotes CD28
T14 544-548 protein denotes CD28
T15 558-561 protein denotes CD2
T16 563-566 protein denotes CD5
T17 568-573 protein denotes LFA-1
T18 578-581 protein denotes CD7
T19 608-618 RNA denotes c-jun mRNA
T20 652-657 DNA denotes c-fos
T21 670-674 protein denotes CD28
T22 698-703 DNA denotes c-jun
T23 724-747 protein denotes protein tyrosine kinase
T24 797-838 protein denotes phorbol ester-responsive protein kinase C
T25 887-891 protein denotes CD28
T26 915-925 RNA denotes c-jun mRNA
T27 1036-1041 DNA denotes c-jun
T28 1046-1050 DNA denotes junB
T29 1085-1095 DNA denotes fos family
T30 1137-1144 cell_type denotes T cells
T31 1167-1171 protein denotes CD28

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-99 Sentence denotes Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.
S2 100-253 Sentence denotes The T cell surface molecule CD28 binds to ligands on accessory cells and APCs, playing an important costimulatory role in the response of T cells to Ags.
S3 254-347 Sentence denotes Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete.
S4 348-496 Sentence denotes In addition to activation of phospholipase C gamma 1, ligation of this receptor also seems to activate a calcium-independent, CD28-specific pathway.
S5 497-669 Sentence denotes In this paper, we report that cross-linking of CD28 (but not CD2, CD5, LFA-1, or CD7) leads to an elevation of c-jun mRNA, with only minimal activation of c-fos expression.
S6 670-873 Sentence denotes CD28-dependent induction of c-jun expression requires protein tyrosine kinase activity, but does not depend on activation of a phorbol ester-responsive protein kinase C or elevation of cytosolic calcium.
S7 874-988 Sentence denotes Furthermore, CD28-dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability.
S8 989-1220 Sentence denotes A mechanism is suggested whereby expression of c-jun and junB, in the absence of members of the fos family, can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 94-98 NP denotes CD28
C2 100-132 NP denotes The T cell surface molecule CD28
C3 319-332 NP denotes this receptor
C4 414-427 NP denotes this receptor
C5 544-548 NP denotes CD28
C6 608-618 NP denotes c-jun mRNA
C7 915-925 NP denotes c-jun mRNA
C8 1167-1171 NP denotes CD28
R1 C2 C1 coref-ident The T cell surface molecule CD28,CD28
R2 C4 C3 coref-ident this receptor,this receptor
R3 C5 C2 coref-ident CD28,The T cell surface molecule CD28
R4 C7 C6 coref-ident c-jun mRNA,c-jun mRNA
R5 C8 C5 coref-ident CD28,CD28

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 27-42 DNA_family_or_group denotes proto-oncogenes
T2 43-48 DNA_domain_or_region denotes c-jun
T3 53-58 DNA_domain_or_region denotes c-fos
T4 62-75 cell_type denotes T lymphocytes
T5 94-98 protein_molecule denotes CD28
T6 104-127 protein_family_or_group denotes T cell surface molecule
T7 128-132 protein_molecule denotes CD28
T8 153-168 cell_type denotes accessory cells
T9 173-177 cell_type denotes APCs
T10 238-245 cell_type denotes T cells
T11 249-252 protein_family_or_group denotes Ags
T12 275-307 other_name denotes intracellular signaling pathways
T13 377-400 protein_molecule denotes phospholipase C gamma 1
T14 453-460 atom denotes calcium
T15 474-478 protein_molecule denotes CD28
T16 544-548 protein_molecule denotes CD28
T17 558-561 protein_molecule denotes CD2
T18 563-566 protein_molecule denotes CD5
T19 568-573 protein_molecule denotes LFA-1
T20 578-581 protein_molecule denotes CD7
T21 608-613 DNA_domain_or_region denotes c-jun
T22 652-657 DNA_domain_or_region denotes c-fos
T23 670-674 protein_molecule denotes CD28
T24 698-703 DNA_domain_or_region denotes c-jun
T25 724-747 protein_molecule denotes protein tyrosine kinase
T26 797-810 other_organic_compound denotes phorbol ester
T27 855-872 atom denotes cytosolic calcium
T28 887-891 protein_molecule denotes CD28
T29 915-920 DNA_domain_or_region denotes c-jun
T30 973-987 other_name denotes mRNA stability
T31 1036-1041 DNA_domain_or_region denotes c-jun
T32 1046-1050 DNA_domain_or_region denotes junB
T33 1085-1095 DNA_family_or_group denotes fos family
T34 1137-1144 cell_type denotes T cells
T35 1167-1171 protein_molecule denotes CD28
T36 1201-1219 other_name denotes antigenic stimulus