PubMed:7923175
Annnotations
jnlpba-st-training
{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":7},"obj":"cell_type"},{"id":"T2","span":{"begin":314,"end":321},"obj":"cell_type"},{"id":"T3","span":{"begin":629,"end":657},"obj":"cell_type"},{"id":"T4","span":{"begin":690,"end":697},"obj":"cell_type"},{"id":"T5","span":{"begin":807,"end":817},"obj":"protein"},{"id":"T6","span":{"begin":821,"end":848},"obj":"protein"},{"id":"T7","span":{"begin":907,"end":914},"obj":"cell_type"},{"id":"T8","span":{"begin":959,"end":984},"obj":"protein"},{"id":"T9","span":{"begin":1040,"end":1047},"obj":"cell_type"},{"id":"T10","span":{"begin":1076,"end":1080},"obj":"protein"},{"id":"T11","span":{"begin":1098,"end":1117},"obj":"protein"},{"id":"T12","span":{"begin":1146,"end":1164},"obj":"protein"},{"id":"T13","span":{"begin":1264,"end":1268},"obj":"protein"},{"id":"T14","span":{"begin":1327,"end":1334},"obj":"cell_type"},{"id":"T15","span":{"begin":1376,"end":1383},"obj":"cell_type"}],"text":"T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report.\nRecent data suggest that the poor induction of a T-cell response to human renal cell carcinoma (RCC) may be related to alterations in signal transduction pathways. We report that T cells from RCC patients have two alterations in kappa B motif-specific DNA-binding activity. The first alteration involves the constitutive expression of substantial kappa B-binding activity in nuclear extracts, which was observed in the electrophoretic mobility shift assay. The magnitude of kappa B activity in unstimulated patient T cells was similar to that observed in T cells from normal individuals that had been activated in vitro. On the basis of Western blotting experiments using antibodies to kappa B/Rel family proteins, the kappa B-binding activity constitutively expressed in T cells from RCC patients is composed mostly of the NF-kappa B1 (p50) subunit. The second abnormality in kappa B-binding activity in T cells from these patients is that RelA, a member of the Rel homology family which is part of the normal NF-kappa B complex, was not induced in the nucleus following activation. Western blotting analysis did not detect any RelA in nuclear extracts either before or after stimulation of T cells. The altered kappa B-binding activity in T cells from RCC patients may impair their capacity to respond normally to various stimuli."}
genia-medco-coref
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pubmed-sentences-benchmark
{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":134},"obj":"Sentence"},{"id":"S2","span":{"begin":135,"end":298},"obj":"Sentence"},{"id":"S3","span":{"begin":299,"end":408},"obj":"Sentence"},{"id":"S4","span":{"begin":409,"end":591},"obj":"Sentence"},{"id":"S5","span":{"begin":592,"end":755},"obj":"Sentence"},{"id":"S6","span":{"begin":756,"end":985},"obj":"Sentence"},{"id":"S7","span":{"begin":986,"end":1218},"obj":"Sentence"},{"id":"S8","span":{"begin":1219,"end":1335},"obj":"Sentence"},{"id":"S9","span":{"begin":1336,"end":1467},"obj":"Sentence"}],"text":"T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report.\nRecent data suggest that the poor induction of a T-cell response to human renal cell carcinoma (RCC) may be related to alterations in signal transduction pathways. We report that T cells from RCC patients have two alterations in kappa B motif-specific DNA-binding activity. The first alteration involves the constitutive expression of substantial kappa B-binding activity in nuclear extracts, which was observed in the electrophoretic mobility shift assay. The magnitude of kappa B activity in unstimulated patient T cells was similar to that observed in T cells from normal individuals that had been activated in vitro. On the basis of Western blotting experiments using antibodies to kappa B/Rel family proteins, the kappa B-binding activity constitutively expressed in T cells from RCC patients is composed mostly of the NF-kappa B1 (p50) subunit. The second abnormality in kappa B-binding activity in T cells from these patients is that RelA, a member of the Rel homology family which is part of the normal NF-kappa B complex, was not induced in the nucleus following activation. Western blotting analysis did not detect any RelA in nuclear extracts either before or after stimulation of T cells. The altered kappa B-binding activity in T cells from RCC patients may impair their capacity to respond normally to various stimuli."}
GENIAcorpus
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