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sentences

Id Subject Object Predicate Lexical cue
T1 0-169 Sentence denotes Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.
T2 170-301 Sentence denotes We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP.
T3 302-431 Sentence denotes Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor.
T4 432-633 Sentence denotes Indeed, transient transfection of HLA-DRA and DQB reporter constructs indicated that the affected factor operates via cis-elements located between -141 base pairs and the transcription initiation site.
T5 634-751 Sentence denotes A series of hybrid DRA/DQB reporter constructs was generated to further map the relevant cis-elements in this system.
T6 752-938 Sentence denotes Insertion of oligonucleotides spanning the DQB X-box (but not the DQB-W region or the DQB Y-box) upstream of -141 in a DRA reporter plasmid rescued expression to nearly wild-type levels.
T7 939-1097 Sentence denotes Substitution promoters were then generated where the entire X-box, or only the X1- or X2-boxes of HLA-DRA were replaced with the analogous regions of HLA-DQB.
T8 1098-1181 Sentence denotes The DQB X2-box was able to restore expression to the silent DRA reporter construct.
T9 1182-1314 Sentence denotes Moreover, replacement of the DQB X2-box with the DRA X2-box markedly diminished the activity of the DQB promoter in the mutant cell.
T10 1315-1453 Sentence denotes None of the hybrid reporter constructs were defective when transfected into the wild-type, HLA-DR/-DQ positive parental cell line, Jijoye.
T11 1454-1655 Sentence denotes These studies suggest that the divergent X2-box of the class II major histocompatibility complex promoters plays an important role in influencing differential expression of the human class II isotypes.
T1 0-169 Sentence denotes Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.
T2 170-301 Sentence denotes We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP.
T3 302-431 Sentence denotes Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor.
T4 432-633 Sentence denotes Indeed, transient transfection of HLA-DRA and DQB reporter constructs indicated that the affected factor operates via cis-elements located between -141 base pairs and the transcription initiation site.
T5 634-751 Sentence denotes A series of hybrid DRA/DQB reporter constructs was generated to further map the relevant cis-elements in this system.
T6 752-938 Sentence denotes Insertion of oligonucleotides spanning the DQB X-box (but not the DQB-W region or the DQB Y-box) upstream of -141 in a DRA reporter plasmid rescued expression to nearly wild-type levels.
T7 939-1097 Sentence denotes Substitution promoters were then generated where the entire X-box, or only the X1- or X2-boxes of HLA-DRA were replaced with the analogous regions of HLA-DQB.
T8 1098-1181 Sentence denotes The DQB X2-box was able to restore expression to the silent DRA reporter construct.
T9 1182-1314 Sentence denotes Moreover, replacement of the DQB X2-box with the DRA X2-box markedly diminished the activity of the DQB promoter in the mutant cell.
T10 1315-1453 Sentence denotes None of the hybrid reporter constructs were defective when transfected into the wild-type, HLA-DR/-DQ positive parental cell line, Jijoye.
T11 1454-1655 Sentence denotes These studies suggest that the divergent X2-box of the class II major histocompatibility complex promoters plays an important role in influencing differential expression of the human class II isotypes.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-31 protein denotes interaction site
T2 39-69 protein denotes defective transcription factor
T3 77-144 cell_line denotes class II major histocompatibility complex mutant cell line clone-13
T4 152-168 DNA denotes divergent X2-box
T5 201-234 cell_line denotes mutant B lymphoblastoid cell line
T6 236-245 cell_line denotes Clone-13,
T7 261-267 protein denotes HLA-DQ
T8 286-300 protein denotes HLA-DR and -DP
T9 393-430 protein denotes isotype-specific transcription factor
T10 466-501 DNA denotes HLA-DRA and DQB reporter constructs
T11 550-562 DNA denotes cis-elements
T12 579-594 DNA denotes -141 base pairs
T13 603-632 DNA denotes transcription initiation site
T14 646-680 DNA denotes hybrid DRA/DQB reporter constructs
T15 723-735 DNA denotes cis-elements
T16 795-804 DNA denotes DQB X-box
T17 818-830 DNA denotes DQB-W region
T18 838-847 DNA denotes DQB Y-box
T19 849-865 DNA denotes upstream of -141
T20 871-891 DNA denotes DRA reporter plasmid
T21 999-1004 DNA denotes X-box
T22 1018-1033 DNA denotes X1- or X2-boxes
T23 1037-1044 DNA denotes HLA-DRA
T24 1089-1096 DNA denotes HLA-DQB
T25 1102-1112 DNA denotes DQB X2-box
T26 1151-1180 DNA denotes silent DRA reporter construct
T27 1211-1221 DNA denotes DQB X2-box
T28 1231-1241 DNA denotes DRA X2-box
T29 1282-1294 DNA denotes DQB promoter
T30 1302-1313 cell_line denotes mutant cell
T31 1327-1353 DNA denotes hybrid reporter constructs
T32 1395-1404 protein denotes wild-type
T33 1406-1444 cell_line denotes HLA-DR/-DQ positive parental cell line
T34 1446-1452 cell_line denotes Jijoye
T35 1485-1501 DNA denotes divergent X2-box
T36 1509-1560 DNA denotes class II major histocompatibility complex promoters
T37 1631-1654 DNA denotes human class II isotypes

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 73-144 NP denotes the class II major histocompatibility complex mutant cell line clone-13
C2 148-168 NP denotes the divergent X2-box
C3 199-234 NP denotes a mutant B lymphoblastoid cell line
C4 236-244 NP denotes Clone-13
C5 246-250 NP denotes that
C6 261-267 NP denotes HLA-DQ
C7 348-362 NP denotes this cell line
C8 466-501 NP denotes HLA-DRA and DQB reporter constructs
C9 634-680 NP denotes A series of hybrid DRA/DQB reporter constructs
C10 791-804 NP denotes the DQB X-box
C11 988-1004 NP denotes the entire X-box
C12 1089-1096 NP denotes HLA-DQB
C13 1098-1112 NP denotes The DQB X2-box
C14 1207-1221 NP denotes the DQB X2-box
C15 1323-1353 NP denotes the hybrid reporter constructs
C16 1391-1444 NP denotes the wild-type, HLA-DR/-DQ positive parental cell line
C17 1446-1452 NP denotes Jijoye
C18 1481-1560 NP denotes the divergent X2-box of the class II major histocompatibility complex promoters
R1 C3 C1 coref-xxx a mutant B lymphoblastoid cell line,the class II major histocompatibility complex mutant cell line clone-13
R2 C4 C3 coref-appos Clone-13,a mutant B lymphoblastoid cell line
R3 C5 C4 coref-relat that,Clone-13
R4 C7 C3 coref-ident this cell line,a mutant B lymphoblastoid cell line
R5 C9 C8 coref-ident A series of hybrid DRA/DQB reporter constructs,HLA-DRA and DQB reporter constructs
R6 C11 C10 coref-xxx the entire X-box,the DQB X-box
R7 C12 C6 coref-ident HLA-DQB,HLA-DQ
R8 C14 C13 coref-ident the DQB X2-box,The DQB X2-box
R9 C15 C9 coref-ident the hybrid reporter constructs,A series of hybrid DRA/DQB reporter constructs
R10 C17 C16 coref-appos Jijoye,"the wild-type, HLA-DR/-DQ positive parental cell line"
R11 C18 C2 coref-ident the divergent X2-box of the class II major histocompatibility complex promoters,the divergent X2-box

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-169 Sentence denotes Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.
S2 170-301 Sentence denotes We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP.
S3 302-431 Sentence denotes Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor.
S4 432-633 Sentence denotes Indeed, transient transfection of HLA-DRA and DQB reporter constructs indicated that the affected factor operates via cis-elements located between -141 base pairs and the transcription initiation site.
S5 634-751 Sentence denotes A series of hybrid DRA/DQB reporter constructs was generated to further map the relevant cis-elements in this system.
S6 752-938 Sentence denotes Insertion of oligonucleotides spanning the DQB X-box (but not the DQB-W region or the DQB Y-box) upstream of -141 in a DRA reporter plasmid rescued expression to nearly wild-type levels.
S7 939-1097 Sentence denotes Substitution promoters were then generated where the entire X-box, or only the X1- or X2-boxes of HLA-DRA were replaced with the analogous regions of HLA-DQB.
S8 1098-1181 Sentence denotes The DQB X2-box was able to restore expression to the silent DRA reporter construct.
S9 1182-1314 Sentence denotes Moreover, replacement of the DQB X2-box with the DRA X2-box markedly diminished the activity of the DQB promoter in the mutant cell.
S10 1315-1453 Sentence denotes None of the hybrid reporter constructs were defective when transfected into the wild-type, HLA-DR/-DQ positive parental cell line, Jijoye.
S11 1454-1655 Sentence denotes These studies suggest that the divergent X2-box of the class II major histocompatibility complex promoters plays an important role in influencing differential expression of the human class II isotypes.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-31 protein_domain_or_region denotes interaction site
T2 39-48 protein_family_or_group denotes defective
T3 49-69 protein_family_or_group denotes transcription factor
T4 77-144 cell_line denotes class II major histocompatibility complex mutant cell line clone-13
T5 152-168 DNA_domain_or_region denotes divergent X2-box
T6 201-234 cell_line denotes mutant B lymphoblastoid cell line
T7 236-245 cell_line denotes Clone-13,
T8 261-267 protein_molecule denotes HLA-DQ
T9 393-430 protein_family_or_group denotes isotype-specific transcription factor
T10 550-562 DNA_family_or_group denotes cis-elements
T11 579-594 DNA_domain_or_region denotes -141 base pairs
T12 603-632 DNA_domain_or_region denotes transcription initiation site
T13 646-660 DNA_family_or_group denotes hybrid DRA/DQB
T14 661-680 DNA_family_or_group denotes reporter constructs
T15 723-735 DNA_family_or_group denotes cis-elements
T16 765-781 polynucleotide denotes oligonucleotides
T17 795-804 DNA_domain_or_region denotes DQB X-box
T18 818-830 DNA_domain_or_region denotes DQB-W region
T19 838-847 DNA_domain_or_region denotes DQB Y-box
T20 849-865 DNA_domain_or_region denotes upstream of -141
T21 871-891 DNA_molecule denotes DRA reporter plasmid
T22 921-937 other_name denotes wild-type levels
T23 999-1004 DNA_domain_or_region denotes X-box
T24 1037-1044 DNA_domain_or_region denotes HLA-DRA
T25 1089-1096 DNA_domain_or_region denotes HLA-DQB
T26 1102-1112 DNA_domain_or_region denotes DQB X2-box
T27 1151-1180 DNA_molecule denotes silent DRA reporter construct
T28 1211-1221 DNA_domain_or_region denotes DQB X2-box
T29 1231-1241 DNA_domain_or_region denotes DRA X2-box
T30 1282-1294 DNA_domain_or_region denotes DQB promoter
T31 1302-1313 cell_line denotes mutant cell
T32 1327-1333 DNA_family_or_group denotes hybrid
T33 1334-1353 DNA_family_or_group denotes reporter constructs
T34 1395-1404 protein_family_or_group denotes wild-type
T35 1406-1444 cell_line denotes HLA-DR/-DQ positive parental cell line
T36 1446-1452 cell_line denotes Jijoye
T37 1485-1501 DNA_domain_or_region denotes divergent X2-box
T38 1509-1550 protein_complex denotes class II major histocompatibility complex
T39 1600-1623 other_name denotes differential expression
T40 1631-1654 DNA_family_or_group denotes human class II isotypes

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 470-473 Disease denotes DRA http://purl.obolibrary.org/obo/MONDO_0019440
T2 653-656 Disease denotes DRA http://purl.obolibrary.org/obo/MONDO_0019440
T3 871-874 Disease denotes DRA http://purl.obolibrary.org/obo/MONDO_0019440
T4 1041-1044 Disease denotes DRA http://purl.obolibrary.org/obo/MONDO_0019440
T5 1158-1161 Disease denotes DRA http://purl.obolibrary.org/obo/MONDO_0019440
T6 1231-1234 Disease denotes DRA http://purl.obolibrary.org/obo/MONDO_0019440

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1631-1636 OrganismTaxon denotes human 9606