PubMed:7885039 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/7885039","sourcedb":"PubMed","sourceid":"7885039","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7885039","text":"Treatment of HL60 cells with various combinations of retinoids and 1 alpha,25 dihydroxyvitamin D3 results in differentiation towards neutrophils or monocytes or a failure to differentiate and apoptosis.\nIt is well documented that treatment of serum-grown HL60 cells with 10(-7) M all-trans retinoic acid (all-trans RA) induces neutrophil differentiation, whereas treatment with 10(-7) M 1 alpha,25 dihydroxyvitamin D3(D3) induces differentiation towards monocytes. In recent investigations, using serum-free grown HL60 cells, we observed that all-trans RA, at 10(-7) M, did not induce neutrophil differentiation and that all-trans RA, at 10(-8) M, reduced the D3 concentration required for monocyte differentiation to 5 x 10(-9) M. In this study, co-operative interactions between all-trans and 9-cis RA and D3 which promote neutrophil and monocyte differentiation of HL60 cells have been analysed in detail. Treatment of serum-free grown HL60 cells with 5 x 10(-7) M all-trans RA or 9-cis RA resulted in sub-optimal neutrophil differentiation (up to 25% mature cells). As shown for all-trans RA, 9-cis RA cooperated with D3 to promote monocyte differentiation. Culture of HL60 cells in 5 x 10(-7) M 9-cis RA together with a wide range of concentrations of D3 resulted in promotion of neutrophil differentiation at 10(-15)-10(-12) D3, a failure to differentiate and apoptosis at 10(-11)-10(-10) M D3, followed by co-operativity between 9-cis RA and 5 x 10(-9) M D3 in inducing monocyte differentiation in the absence of neutrophil differentiation. Similar results were obtained when HL60 cells were treated with 5 x 10(-7) all-trans RA together with a wide range of concentrations of D3. Cross titration analyses of the effects of 9-cis RA and D3 on HL60 cell differentiation were undertaken to determine the boundaries of the concentrations of each agent, alone and in combination, that give rise to optimal neutrophil and monocyte differentiation of HL60 cells. The observed cooperativities between either 9-cis RA or all-trans RA and D3 have important implications for the use of combinations of these agents in differentiation therapy.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":13,"end":23},"obj":"NP"},{"id":"C2","span":{"begin":67,"end":97},"obj":"NP"},{"id":"C3","span":{"begin":109,"end":157},"obj":"NP"},{"id":"C4","span":{"begin":243,"end":265},"obj":"NP"},{"id":"C5","span":{"begin":271,"end":318},"obj":"NP"},{"id":"C6","span":{"begin":327,"end":353},"obj":"NP"},{"id":"C7","span":{"begin":378,"end":421},"obj":"NP"},{"id":"C8","span":{"begin":430,"end":463},"obj":"NP"},{"id":"C9","span":{"begin":497,"end":524},"obj":"NP"},{"id":"C10","span":{"begin":543,"end":568},"obj":"NP"},{"id":"C11","span":{"begin":585,"end":611},"obj":"NP"},{"id":"C12","span":{"begin":656,"end":676},"obj":"NP"},{"id":"C13","span":{"begin":690,"end":714},"obj":"NP"},{"id":"C14","span":{"begin":781,"end":810},"obj":"NP"},{"id":"C15","span":{"begin":811,"end":816},"obj":"NP"},{"id":"C16","span":{"begin":825,"end":864},"obj":"NP"},{"id":"C17","span":{"begin":868,"end":878},"obj":"NP"},{"id":"C18","span":{"begin":922,"end":949},"obj":"NP"},{"id":"C19","span":{"begin":955,"end":992},"obj":"NP"},{"id":"C20","span":{"begin":1083,"end":1095},"obj":"NP"},{"id":"C21","span":{"begin":1097,"end":1105},"obj":"NP"},{"id":"C22","span":{"begin":1122,"end":1124},"obj":"NP"},{"id":"C23","span":{"begin":1136,"end":1160},"obj":"NP"},{"id":"C24","span":{"begin":1173,"end":1183},"obj":"NP"},{"id":"C26","span":{"begin":1257,"end":1259},"obj":"NP"},{"id":"C25","span":{"begin":1239,"end":1259},"obj":"NP"},{"id":"C27","span":{"begin":1285,"end":1311},"obj":"NP"},{"id":"C28","span":{"begin":1436,"end":1444},"obj":"NP"},{"id":"C29","span":{"begin":1477,"end":1501},"obj":"NP"},{"id":"C30","span":{"begin":1520,"end":1546},"obj":"NP"},{"id":"C31","span":{"begin":1583,"end":1593},"obj":"NP"},{"id":"C32","span":{"begin":1612,"end":1635},"obj":"NP"},{"id":"C34","span":{"begin":1684,"end":1686},"obj":"NP"},{"id":"C33","span":{"begin":1666,"end":1686},"obj":"NP"},{"id":"C35","span":{"begin":1901,"end":1948},"obj":"NP"},{"id":"C36","span":{"begin":1952,"end":1962},"obj":"NP"},{"id":"C38","span":{"begin":2008,"end":2016},"obj":"NP"},{"id":"C39","span":{"begin":2020,"end":2032},"obj":"NP"},{"id":"C40","span":{"begin":2037,"end":2039},"obj":"NP"},{"id":"C37","span":{"begin":2008,"end":2039},"obj":"NP"},{"id":"C41","span":{"begin":2099,"end":2111},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C7","obj":"C2"},{"id":"R3","pred":"coref-ident","subj":"C9","obj":"C4"},{"id":"R4","pred":"coref-ident","subj":"C10","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C6"},{"id":"R6","pred":"coref-ident","subj":"C13","obj":"C8"},{"id":"R7","pred":"coref-relat","subj":"C15","obj":"C14"},{"id":"R8","pred":"coref-ident","subj":"C16","obj":"C3"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C1"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C9"},{"id":"R11","pred":"coref-ident","subj":"C20","obj":"C5"},{"id":"R12","pred":"coref-ident","subj":"C23","obj":"C13"},{"id":"R13","pred":"coref-ident","subj":"C24","obj":"C17"},{"id":"R14","pred":"coref-ident","subj":"C26","obj":"C22"},{"id":"R15","pred":"coref-ident","subj":"C25","obj":"C12"},{"id":"R16","pred":"coref-ident","subj":"C27","obj":"C11"},{"id":"R17","pred":"coref-ident","subj":"C28","obj":"C21"},{"id":"R18","pred":"coref-ident","subj":"C29","obj":"C23"},{"id":"R19","pred":"coref-ident","subj":"C30","obj":"C27"},{"id":"R20","pred":"coref-ident","subj":"C31","obj":"C24"},{"id":"R21","pred":"coref-ident","subj":"C32","obj":"C19"},{"id":"R22","pred":"coref-ident","subj":"C34","obj":"C26"},{"id":"R23","pred":"coref-ident","subj":"C33","obj":"C25"},{"id":"R24","pred":"coref-ident","subj":"C35","obj":"C16"},{"id":"R25","pred":"coref-ident","subj":"C36","obj":"C31"},{"id":"R26","pred":"coref-ident","subj":"C38","obj":"C28"},{"id":"R27","pred":"coref-ident","subj":"C39","obj":"C5"},{"id":"R28","pred":"coref-ident","subj":"C40","obj":"C34"},{"id":"R29","pred":"coref-ident","subj":"C37","obj":"C14"},{"id":"R30","pred":"coref-ident","subj":"C41","obj":"C37"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C24","pred":"source","obj":"genia-medco-coref"},{"subj":"C26","pred":"source","obj":"genia-medco-coref"},{"subj":"C25","pred":"source","obj":"genia-medco-coref"},{"subj":"C27","pred":"source","obj":"genia-medco-coref"},{"subj":"C28","pred":"source","obj":"genia-medco-coref"},{"subj":"C29","pred":"source","obj":"genia-medco-coref"},{"subj":"C30","pred":"source","obj":"genia-medco-coref"},{"subj":"C31","pred":"source","obj":"genia-medco-coref"},{"subj":"C32","pred":"source","obj":"genia-medco-coref"},{"subj":"C34","pred":"source","obj":"genia-medco-coref"},{"subj":"C33","pred":"source","obj":"genia-medco-coref"},{"subj":"C35","pred":"source","obj":"genia-medco-coref"},{"subj":"C36","pred":"source","obj":"genia-medco-coref"},{"subj":"C38","pred":"source","obj":"genia-medco-coref"},{"subj":"C39","pred":"source","obj":"genia-medco-coref"},{"subj":"C40","pred":"source","obj":"genia-medco-coref"},{"subj":"C37","pred":"source","obj":"genia-medco-coref"},{"subj":"C41","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":13,"end":23},"obj":"cell_line"},{"id":"T2","span":{"begin":133,"end":144},"obj":"cell_type"},{"id":"T3","span":{"begin":148,"end":157},"obj":"cell_type"},{"id":"T4","span":{"begin":243,"end":265},"obj":"cell_line"},{"id":"T5","span":{"begin":327,"end":337},"obj":"cell_type"},{"id":"T6","span":{"begin":454,"end":463},"obj":"cell_type"},{"id":"T7","span":{"begin":497,"end":524},"obj":"cell_line"},{"id":"T8","span":{"begin":690,"end":698},"obj":"cell_type"},{"id":"T9","span":{"begin":868,"end":878},"obj":"cell_line"},{"id":"T10","span":{"begin":922,"end":949},"obj":"cell_line"},{"id":"T11","span":{"begin":1173,"end":1183},"obj":"cell_line"},{"id":"T12","span":{"begin":1583,"end":1593},"obj":"cell_line"},{"id":"T13","span":{"begin":1750,"end":1759},"obj":"cell_line"},{"id":"T14","span":{"begin":1952,"end":1962},"obj":"cell_line"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":202},"obj":"Sentence"},{"id":"S2","span":{"begin":203,"end":464},"obj":"Sentence"},{"id":"S3","span":{"begin":465,"end":731},"obj":"Sentence"},{"id":"S4","span":{"begin":732,"end":908},"obj":"Sentence"},{"id":"S5","span":{"begin":909,"end":1069},"obj":"Sentence"},{"id":"S6","span":{"begin":1070,"end":1161},"obj":"Sentence"},{"id":"S7","span":{"begin":1162,"end":1547},"obj":"Sentence"},{"id":"S8","span":{"begin":1548,"end":1687},"obj":"Sentence"},{"id":"S9","span":{"begin":1688,"end":1963},"obj":"Sentence"},{"id":"S10","span":{"begin":1964,"end":2139},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":13,"end":23},"obj":"cell_line"},{"id":"T2","span":{"begin":53,"end":62},"obj":"other_organic_compound"},{"id":"T3","span":{"begin":67,"end":97},"obj":"lipid"},{"id":"T4","span":{"begin":133,"end":144},"obj":"cell_type"},{"id":"T5","span":{"begin":148,"end":157},"obj":"cell_type"},{"id":"T6","span":{"begin":192,"end":201},"obj":"other_name"},{"id":"T7","span":{"begin":243,"end":254},"obj":"cell_line"},{"id":"T8","span":{"begin":255,"end":265},"obj":"cell_line"},{"id":"T9","span":{"begin":280,"end":303},"obj":"other_organic_compound"},{"id":"T10","span":{"begin":305,"end":317},"obj":"other_organic_compound"},{"id":"T11","span":{"begin":327,"end":337},"obj":"cell_type"},{"id":"T12","span":{"begin":387,"end":417},"obj":"lipid"},{"id":"T13","span":{"begin":418,"end":420},"obj":"lipid"},{"id":"T14","span":{"begin":454,"end":463},"obj":"cell_type"},{"id":"T15","span":{"begin":497,"end":513},"obj":"cell_line"},{"id":"T16","span":{"begin":514,"end":524},"obj":"cell_line"},{"id":"T17","span":{"begin":543,"end":555},"obj":"other_organic_compound"},{"id":"T18","span":{"begin":585,"end":611},"obj":"other_name"},{"id":"T19","span":{"begin":621,"end":633},"obj":"other_organic_compound"},{"id":"T20","span":{"begin":660,"end":662},"obj":"lipid"},{"id":"T21","span":{"begin":690,"end":698},"obj":"cell_type"},{"id":"T22","span":{"begin":808,"end":810},"obj":"lipid"},{"id":"T23","span":{"begin":840,"end":864},"obj":"other_name"},{"id":"T24","span":{"begin":868,"end":878},"obj":"cell_line"},{"id":"T25","span":{"begin":922,"end":938},"obj":"cell_line"},{"id":"T26","span":{"begin":939,"end":949},"obj":"cell_line"},{"id":"T27","span":{"begin":968,"end":980},"obj":"other_organic_compound"},{"id":"T28","span":{"begin":984,"end":992},"obj":"other_organic_compound"},{"id":"T29","span":{"begin":1017,"end":1043},"obj":"other_name"},{"id":"T30","span":{"begin":1083,"end":1095},"obj":"other_organic_compound"},{"id":"T31","span":{"begin":1097,"end":1105},"obj":"other_organic_compound"},{"id":"T32","span":{"begin":1122,"end":1124},"obj":"lipid"},{"id":"T33","span":{"begin":1136,"end":1160},"obj":"other_name"},{"id":"T34","span":{"begin":1173,"end":1183},"obj":"cell_line"},{"id":"T35","span":{"begin":1200,"end":1208},"obj":"other_organic_compound"},{"id":"T36","span":{"begin":1257,"end":1259},"obj":"lipid"},{"id":"T37","span":{"begin":1285,"end":1311},"obj":"other_name"},{"id":"T38","span":{"begin":1331,"end":1333},"obj":"lipid"},{"id":"T39","span":{"begin":1366,"end":1375},"obj":"other_name"},{"id":"T40","span":{"begin":1397,"end":1399},"obj":"lipid"},{"id":"T41","span":{"begin":1436,"end":1444},"obj":"other_organic_compound"},{"id":"T42","span":{"begin":1462,"end":1464},"obj":"lipid"},{"id":"T43","span":{"begin":1477,"end":1501},"obj":"other_name"},{"id":"T44","span":{"begin":1520,"end":1546},"obj":"other_name"},{"id":"T45","span":{"begin":1583,"end":1593},"obj":"cell_line"},{"id":"T46","span":{"begin":1623,"end":1635},"obj":"other_organic_compound"},{"id":"T47","span":{"begin":1684,"end":1686},"obj":"lipid"},{"id":"T48","span":{"begin":1688,"end":1712},"obj":"other_name"},{"id":"T49","span":{"begin":1731,"end":1739},"obj":"other_organic_compound"},{"id":"T50","span":{"begin":1744,"end":1746},"obj":"lipid"},{"id":"T51","span":{"begin":1750,"end":1759},"obj":"cell_line"},{"id":"T52","span":{"begin":1952,"end":1962},"obj":"cell_line"},{"id":"T53","span":{"begin":2008,"end":2016},"obj":"other_organic_compound"},{"id":"T54","span":{"begin":2020,"end":2032},"obj":"other_organic_compound"},{"id":"T55","span":{"begin":2037,"end":2039},"obj":"lipid"},{"id":"T56","span":{"begin":2115,"end":2138},"obj":"other_name"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"},{"subj":"T49","pred":"source","obj":"GENIAcorpus"},{"subj":"T50","pred":"source","obj":"GENIAcorpus"},{"subj":"T51","pred":"source","obj":"GENIAcorpus"},{"subj":"T52","pred":"source","obj":"GENIAcorpus"},{"subj":"T53","pred":"source","obj":"GENIAcorpus"},{"subj":"T54","pred":"source","obj":"GENIAcorpus"},{"subj":"T55","pred":"source","obj":"GENIAcorpus"},{"subj":"T56","pred":"source","obj":"GENIAcorpus"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":203,"end":242},"obj":"DRI_Background"},{"id":"T2","span":{"begin":260,"end":388},"obj":"DRI_Background"},{"id":"T3","span":{"begin":415,"end":464},"obj":"DRI_Background"},{"id":"T4","span":{"begin":909,"end":1069},"obj":"DRI_Approach"},{"id":"T5","span":{"begin":1070,"end":1161},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":1162,"end":1547},"obj":"DRI_Approach"},{"id":"T7","span":{"begin":1548,"end":1687},"obj":"DRI_Approach"},{"id":"T8","span":{"begin":1688,"end":1963},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1964,"end":2139},"obj":"DRI_Approach"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#93ecdb","default":true},{"id":"jnlpba-st-training","color":"#ecc193"},{"id":"pubmed-sentences-benchmark","color":"#a793ec"},{"id":"GENIAcorpus","color":"#98ec93"},{"id":"PubMed_ArguminSci","color":"#ec93b2"}]}]}}