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PubMed:7885039 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 203-242 DRI_Background denotes It is well documented that treatment of
T2 260-388 DRI_Background denotes cells with 10(-7) M all-trans retinoic acid (all-trans RA) induces neutrophil differentiation, whereas treatment with 10(-7) M 1
T3 415-464 DRI_Background denotes D3(D3) induces differentiation towards monocytes.
T4 909-1069 DRI_Approach denotes Treatment of serum-free grown HL60 cells with 5 x 10(-7) M all-trans RA or 9-cis RA resulted in sub-optimal neutrophil differentiation (up to 25% mature cells).
T5 1070-1161 DRI_Approach denotes As shown for all-trans RA, 9-cis RA cooperated with D3 to promote monocyte differentiation.
T6 1162-1547 DRI_Approach denotes Culture of HL60 cells in 5 x 10(-7) M 9-cis RA together with a wide range of concentrations of D3 resulted in promotion of neutrophil differentiation at 10(-15)-10(-12) D3, a failure to differentiate and apoptosis at 10(-11)-10(-10) M D3, followed by co-operativity between 9-cis RA and 5 x 10(-9) M D3 in inducing monocyte differentiation in the absence of neutrophil differentiation.
T7 1548-1687 DRI_Approach denotes Similar results were obtained when HL60 cells were treated with 5 x 10(-7) all-trans RA together with a wide range of concentrations of D3.
T8 1688-1963 DRI_Background denotes Cross titration analyses of the effects of 9-cis RA and D3 on HL60 cell differentiation were undertaken to determine the boundaries of the concentrations of each agent, alone and in combination, that give rise to optimal neutrophil and monocyte differentiation of HL60 cells.
T9 1964-2139 DRI_Approach denotes The observed cooperativities between either 9-cis RA or all-trans RA and D3 have important implications for the use of combinations of these agents in differentiation therapy.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 13-23 cell_line denotes HL60 cells
T2 133-144 cell_type denotes neutrophils
T3 148-157 cell_type denotes monocytes
T4 243-265 cell_line denotes serum-grown HL60 cells
T5 327-337 cell_type denotes neutrophil
T6 454-463 cell_type denotes monocytes
T7 497-524 cell_line denotes serum-free grown HL60 cells
T8 690-698 cell_type denotes monocyte
T9 868-878 cell_line denotes HL60 cells
T10 922-949 cell_line denotes serum-free grown HL60 cells
T11 1173-1183 cell_line denotes HL60 cells
T12 1583-1593 cell_line denotes HL60 cells
T13 1750-1759 cell_line denotes HL60 cell
T14 1952-1962 cell_line denotes HL60 cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-202 Sentence denotes Treatment of HL60 cells with various combinations of retinoids and 1 alpha,25 dihydroxyvitamin D3 results in differentiation towards neutrophils or monocytes or a failure to differentiate and apoptosis.
S2 203-464 Sentence denotes It is well documented that treatment of serum-grown HL60 cells with 10(-7) M all-trans retinoic acid (all-trans RA) induces neutrophil differentiation, whereas treatment with 10(-7) M 1 alpha,25 dihydroxyvitamin D3(D3) induces differentiation towards monocytes.
S3 465-731 Sentence denotes In recent investigations, using serum-free grown HL60 cells, we observed that all-trans RA, at 10(-7) M, did not induce neutrophil differentiation and that all-trans RA, at 10(-8) M, reduced the D3 concentration required for monocyte differentiation to 5 x 10(-9) M.
S4 732-908 Sentence denotes In this study, co-operative interactions between all-trans and 9-cis RA and D3 which promote neutrophil and monocyte differentiation of HL60 cells have been analysed in detail.
S5 909-1069 Sentence denotes Treatment of serum-free grown HL60 cells with 5 x 10(-7) M all-trans RA or 9-cis RA resulted in sub-optimal neutrophil differentiation (up to 25% mature cells).
S6 1070-1161 Sentence denotes As shown for all-trans RA, 9-cis RA cooperated with D3 to promote monocyte differentiation.
S7 1162-1547 Sentence denotes Culture of HL60 cells in 5 x 10(-7) M 9-cis RA together with a wide range of concentrations of D3 resulted in promotion of neutrophil differentiation at 10(-15)-10(-12) D3, a failure to differentiate and apoptosis at 10(-11)-10(-10) M D3, followed by co-operativity between 9-cis RA and 5 x 10(-9) M D3 in inducing monocyte differentiation in the absence of neutrophil differentiation.
S8 1548-1687 Sentence denotes Similar results were obtained when HL60 cells were treated with 5 x 10(-7) all-trans RA together with a wide range of concentrations of D3.
S9 1688-1963 Sentence denotes Cross titration analyses of the effects of 9-cis RA and D3 on HL60 cell differentiation were undertaken to determine the boundaries of the concentrations of each agent, alone and in combination, that give rise to optimal neutrophil and monocyte differentiation of HL60 cells.
S10 1964-2139 Sentence denotes The observed cooperativities between either 9-cis RA or all-trans RA and D3 have important implications for the use of combinations of these agents in differentiation therapy.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 13-23 NP denotes HL60 cells
C2 67-97 NP denotes 1 alpha,25 dihydroxyvitamin D3
C3 109-157 NP denotes differentiation towards neutrophils or monocytes
C4 243-265 NP denotes serum-grown HL60 cells
C5 271-318 NP denotes 10(-7) M all-trans retinoic acid (all-trans RA)
C6 327-353 NP denotes neutrophil differentiation
C7 378-421 NP denotes 10(-7) M 1 alpha,25 dihydroxyvitamin D3(D3)
C8 430-463 NP denotes differentiation towards monocytes
C9 497-524 NP denotes serum-free grown HL60 cells
C10 543-568 NP denotes all-trans RA, at 10(-7) M
C11 585-611 NP denotes neutrophil differentiation
C12 656-676 NP denotes the D3 concentration
C13 690-714 NP denotes monocyte differentiation
C14 781-810 NP denotes all-trans and 9-cis RA and D3
C15 811-816 NP denotes which
C16 825-864 NP denotes neutrophil and monocyte differentiation
C17 868-878 NP denotes HL60 cells
C18 922-949 NP denotes serum-free grown HL60 cells
C19 955-992 NP denotes 5 x 10(-7) M all-trans RA or 9-cis RA
C20 1083-1095 NP denotes all-trans RA
C21 1097-1105 NP denotes 9-cis RA
C22 1122-1124 NP denotes D3
C23 1136-1160 NP denotes monocyte differentiation
C24 1173-1183 NP denotes HL60 cells
C26 1257-1259 NP denotes D3
C25 1239-1259 NP denotes concentrations of D3
C27 1285-1311 NP denotes neutrophil differentiation
C28 1436-1444 NP denotes 9-cis RA
C29 1477-1501 NP denotes monocyte differentiation
C30 1520-1546 NP denotes neutrophil differentiation
C31 1583-1593 NP denotes HL60 cells
C32 1612-1635 NP denotes 5 x 10(-7) all-trans RA
C34 1684-1686 NP denotes D3
C33 1666-1686 NP denotes concentrations of D3
C35 1901-1948 NP denotes optimal neutrophil and monocyte differentiation
C36 1952-1962 NP denotes HL60 cells
C38 2008-2016 NP denotes 9-cis RA
C39 2020-2032 NP denotes all-trans RA
C40 2037-2039 NP denotes D3
C37 2008-2039 NP denotes 9-cis RA or all-trans RA and D3
C41 2099-2111 NP denotes these agents
R1 C4 C1 coref-ident serum-grown HL60 cells,HL60 cells
R2 C7 C2 coref-ident "10(-7) M 1 alpha,25 dihydroxyvitamin D3(D3)","1 alpha,25 dihydroxyvitamin D3"
R3 C9 C4 coref-ident serum-free grown HL60 cells,serum-grown HL60 cells
R4 C10 C5 coref-ident "all-trans RA, at 10(-7) M",10(-7) M all-trans retinoic acid (all-trans RA)
R5 C11 C6 coref-ident neutrophil differentiation,neutrophil differentiation
R6 C13 C8 coref-ident monocyte differentiation,differentiation towards monocytes
R7 C15 C14 coref-relat which,all-trans and 9-cis RA and D3
R8 C16 C3 coref-ident neutrophil and monocyte differentiation,differentiation towards neutrophils or monocytes
R9 C17 C1 coref-ident HL60 cells,HL60 cells
R10 C18 C9 coref-ident serum-free grown HL60 cells,serum-free grown HL60 cells
R11 C20 C5 coref-ident all-trans RA,10(-7) M all-trans retinoic acid (all-trans RA)
R12 C23 C13 coref-ident monocyte differentiation,monocyte differentiation
R13 C24 C17 coref-ident HL60 cells,HL60 cells
R14 C26 C22 coref-ident D3,D3
R15 C25 C12 coref-ident concentrations of D3,the D3 concentration
R16 C27 C11 coref-ident neutrophil differentiation,neutrophil differentiation
R17 C28 C21 coref-ident 9-cis RA,9-cis RA
R18 C29 C23 coref-ident monocyte differentiation,monocyte differentiation
R19 C30 C27 coref-ident neutrophil differentiation,neutrophil differentiation
R20 C31 C24 coref-ident HL60 cells,HL60 cells
R21 C32 C19 coref-ident 5 x 10(-7) all-trans RA,5 x 10(-7) M all-trans RA or 9-cis RA
R22 C34 C26 coref-ident D3,D3
R23 C33 C25 coref-ident concentrations of D3,concentrations of D3
R24 C35 C16 coref-ident optimal neutrophil and monocyte differentiation,neutrophil and monocyte differentiation
R25 C36 C31 coref-ident HL60 cells,HL60 cells
R26 C38 C28 coref-ident 9-cis RA,9-cis RA
R27 C39 C5 coref-ident all-trans RA,10(-7) M all-trans retinoic acid (all-trans RA)
R28 C40 C34 coref-ident D3,D3
R29 C37 C14 coref-ident 9-cis RA or all-trans RA and D3,all-trans and 9-cis RA and D3
R30 C41 C37 coref-ident these agents,9-cis RA or all-trans RA and D3

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-23 cell_line denotes HL60 cells
T2 53-62 other_organic_compound denotes retinoids
T3 67-97 lipid denotes 1 alpha,25 dihydroxyvitamin D3
T4 133-144 cell_type denotes neutrophils
T5 148-157 cell_type denotes monocytes
T6 192-201 other_name denotes apoptosis
T7 243-254 cell_line denotes serum-grown
T8 255-265 cell_line denotes HL60 cells
T9 280-303 other_organic_compound denotes all-trans retinoic acid
T10 305-317 other_organic_compound denotes all-trans RA
T11 327-337 cell_type denotes neutrophil
T12 387-417 lipid denotes 1 alpha,25 dihydroxyvitamin D3
T13 418-420 lipid denotes D3
T14 454-463 cell_type denotes monocytes
T15 497-513 cell_line denotes serum-free grown
T16 514-524 cell_line denotes HL60 cells
T17 543-555 other_organic_compound denotes all-trans RA
T18 585-611 other_name denotes neutrophil differentiation
T19 621-633 other_organic_compound denotes all-trans RA
T20 660-662 lipid denotes D3
T21 690-698 cell_type denotes monocyte
T22 808-810 lipid denotes D3
T23 840-864 other_name denotes monocyte differentiation
T24 868-878 cell_line denotes HL60 cells
T25 922-938 cell_line denotes serum-free grown
T26 939-949 cell_line denotes HL60 cells
T27 968-980 other_organic_compound denotes all-trans RA
T28 984-992 other_organic_compound denotes 9-cis RA
T29 1017-1043 other_name denotes neutrophil differentiation
T30 1083-1095 other_organic_compound denotes all-trans RA
T31 1097-1105 other_organic_compound denotes 9-cis RA
T32 1122-1124 lipid denotes D3
T33 1136-1160 other_name denotes monocyte differentiation
T34 1173-1183 cell_line denotes HL60 cells
T35 1200-1208 other_organic_compound denotes 9-cis RA
T36 1257-1259 lipid denotes D3
T37 1285-1311 other_name denotes neutrophil differentiation
T38 1331-1333 lipid denotes D3
T39 1366-1375 other_name denotes apoptosis
T40 1397-1399 lipid denotes D3
T41 1436-1444 other_organic_compound denotes 9-cis RA
T42 1462-1464 lipid denotes D3
T43 1477-1501 other_name denotes monocyte differentiation
T44 1520-1546 other_name denotes neutrophil differentiation
T45 1583-1593 cell_line denotes HL60 cells
T46 1623-1635 other_organic_compound denotes all-trans RA
T47 1684-1686 lipid denotes D3
T48 1688-1712 other_name denotes Cross titration analyses
T49 1731-1739 other_organic_compound denotes 9-cis RA
T50 1744-1746 lipid denotes D3
T51 1750-1759 cell_line denotes HL60 cell
T52 1952-1962 cell_line denotes HL60 cells
T53 2008-2016 other_organic_compound denotes 9-cis RA
T54 2020-2032 other_organic_compound denotes all-trans RA
T55 2037-2039 lipid denotes D3
T56 2115-2138 other_name denotes differentiation therapy