PubMed:7864072 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/7864072","sourcedb":"PubMed","sourceid":"7864072","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7864072","text":"Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.\nGlucocorticoids have an inhibitory effect on inflammatory and immune responses, and this may be through the modulation of transcription factor binding to DNA. The interaction of the transcription factors, activator protein-1 (AP-1), nuclear factor kappa B (NF kappa B), and cAMP-responsive element binding protein (CREB) with DNA and glucocorticoid receptors (GR) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays. TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course. 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