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PubMed:7864072 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 65-105 cell_type denotes human peripheral blood mononuclear cells
T2 229-249 protein denotes transcription factor
T3 289-310 protein denotes transcription factors
T4 312-331 protein denotes activator protein-1
T5 333-337 protein denotes AP-1
T6 340-362 protein denotes nuclear factor kappa B
T7 364-374 protein denotes NF kappa B
T8 381-420 protein denotes cAMP-responsive element binding protein
T9 422-426 protein denotes CREB
T10 441-465 protein denotes glucocorticoid receptors
T11 467-469 protein denotes GR
T12 487-527 cell_type denotes human peripheral blood mononuclear cells
T13 635-639 protein denotes AP-1
T14 695-699 protein denotes CREB
T15 798-829 DNA denotes glucocorticoid response element
T16 961-969 protein denotes cytokine
T17 1062-1064 protein denotes GR
T18 1102-1123 protein denotes transcription factors
T19 1159-1161 protein denotes GR
T20 1196-1237 protein denotes cytokine-stimulated transcription factors

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 0-7 cui:C1280500 denotes Effects
E2-ti-1 11-26 cui:C0017710 denotes glucocorticoids
E3-ti-1 44-50 cui:C1521761 denotes factor
E4-ti-1 30-61 cui:C0162493 denotes transcription factor activation
E5-ti-1 65-70 cui:C0020114 denotes human
E6-ti-1 71-105 cui:C1321301 denotes peripheral blood mononuclear cells
T1 0-7 AFFECTS denotes Effects
T2 65-105 PART_OF denotes human peripheral blood mononuclear cells
E1-ab-1 107-122 cui:C0017710 denotes Glucocorticoids
E2-ab-1 131-141 cui:C0243077 denotes inhibitory
E3-ab-1 142-148 cui:C1280500 denotes effect
E4-ab-1 152-164 cui:C0333348 denotes inflammatory
E5-ab-1 169-185 cui:C0301872 denotes immune responses
E6-ab-1 229-257 cui:C1149367 denotes transcription factor binding
E7-ab-1 261-264 cui:C0012854 denotes DNA
T3 131-141 INHIBITS denotes inhibitory
T4 215-225 AFFECTS denotes modulation
E1-ab-2 270-281 cui:C0687133 denotes interaction
E2-ab-2 289-310 cui:C0040648 denotes transcription factors
E3-ab-2 312-331 cui:C0085828 denotes activator protein-1
E4-ab-2 340-362 cui:C0079904 denotes nuclear factor kappa B
E5-ab-2 381-420 cui:C0056695 denotes cAMP-responsive element binding protein
E6-ab-2 433-436 cui:C0012854 denotes DNA
E7-ab-2 441-465 cui:C0034809 denotes glucocorticoid receptors
E8-ab-2 487-492 cui:C0020114 denotes human
E9-ab-2 493-527 cui:C1321301 denotes peripheral blood mononuclear cells
E10-ab-2 531-556 cui:C0596608 denotes gel mobility shift assays
T5 270-281 INTERACTS_WITH denotes interaction
T6 487-527 PART_OF denotes human peripheral blood mononuclear cells
T7 484-486 LOCATION_OF denotes in
E1-ab-3 558-567 cui:C1448177 denotes TNF-alpha
E2-ab-3 569-578 cui:C0021753 denotes IL-1 beta
E3-ab-3 583-608 cui:C0039654 denotes phorbol myristate acetate
E4-ab-3 635-639 cui:C0085828 denotes AP-1
E5-ab-3 644-654 cui:C0079904 denotes NF kappa B
E6-ab-3 655-666 cui:C1148673 denotes DNA binding
E7-ab-3 685-694 cui:C0205216 denotes decreased
E8-ab-3 695-699 cui:C0205342 denotes CREB
E9-ab-3 695-699 cui:C0013879 denotes CREB
E10-ab-3 695-707 cui:C0033618 denotes CREB binding
E11-ab-3 714-718 cui:C0205136 denotes over
E12-ab-3 724-727 cui:C1524031 denotes min
E13-ab-3 728-739 cui:C0449247 denotes time course
T8 625-634 STIMULATES denotes increased
T9 625-634 STIMULATES denotes increased
T10 625-634 STIMULATES denotes increased
E1-ab-4 741-754 cui:C0011777 denotes Dexamethasone
E2-ab-4 766-771 cui:C0439831 denotes rapid
E3-ab-4 776-785 cui:C0443318 denotes sustained
E4-ab-4 786-794 cui:C0442805 denotes increase
E5-ab-4 798-812 cui:C0017710 denotes glucocorticoid
E6-ab-4 813-829 cui:C0600508 denotes response element
E7-ab-4 844-855 cui:C1516780 denotes concomitant
E8-ab-4 863-871 cui:C0547047 denotes decrease
E9-ab-4 875-879 cui:C0085828 denotes AP-1
E10-ab-4 881-891 cui:C0079904 denotes NF kappa B
E11-ab-4 897-901 cui:C0056695 denotes CREB
E12-ab-4 902-913 cui:C1148673 denotes DNA binding
E13-ab-4 934-942 cui:C0205195 denotes combined
E14-ab-4 943-956 cui:C0011777 denotes dexamethasone
E15-ab-4 961-969 cui:C0079189 denotes cytokine
E16-ab-4 973-976 cui:C0039654 denotes PMA
T11 830-837 INTERACTS_WITH denotes binding
T12 863-871 INHIBITS denotes decrease
T13 863-871 INHIBITS denotes decrease
T14 923-930 AFFECTS denotes blocked
T15 923-930 AFFECTS denotes blocked
E1-ab-5 1001-1008 cui:C1280500 denotes effects
E2-ab-5 1021-1030 cui:C0442805 denotes increases
E3-ab-5 1038-1045 cui:C0521447 denotes nuclear
E4-ab-5 1046-1058 cui:C1524110 denotes localization
E5-ab-5 1062-1064 cui:C0034809 denotes GR
E6-ab-5 1066-1069 cui:C1518422 denotes not
E7-ab-5 1073-1080 cui:C0392756 denotes reduced
E8-ab-5 1081-1088 cui:C1265611 denotes amounts
E9-ab-5 1102-1123 cui:C0040648 denotes transcription factors
T16 1021-1030 AUGMENTS denotes increases
E1-ab-6 1153-1158 cui:C0007634 denotes cells
E2-ab-6 1159-1161 cui:C0034809 denotes GR
E3-ab-6 1196-1204 cui:C0079189 denotes cytokine
E4-ab-6 1216-1237 cui:C0040648 denotes transcription factors
E5-ab-6 1245-1252 cui:C1522240 denotes process
T17 1153-1161 PART_OF denotes cells GR
T18 1181-1190 INTERACTS_WITH denotes interacts
E1-ab-7 1297-1311 cui:C0596968 denotes molecular site
E2-ab-7 1315-1322 cui:C0038317 denotes steroid
R1 E2-ti-1 T1 subjectOf glucocorticoids,Effects
R2 E4-ti-1 T1 objectOf transcription factor activation,Effects
R3 E6-ti-1 T2 subjectOf peripheral blood mononuclear cells,human peripheral blood mononuclear cells
R4 E5-ti-1 T2 objectOf human,human peripheral blood mononuclear cells
R5 E1-ab-1 T3 subjectOf Glucocorticoids,inhibitory
R6 E7-ab-1 T3 objectOf DNA,inhibitory
R7 E5-ab-1 T4 subjectOf immune responses,modulation
R8 E6-ab-1 T4 objectOf transcription factor binding,modulation
R9 E3-ab-2 T5 subjectOf activator protein-1,interaction
R10 E2-ab-2 T5 objectOf transcription factors,interaction
R11 E9-ab-2 T6 subjectOf peripheral blood mononuclear cells,human peripheral blood mononuclear cells
R12 E8-ab-2 T6 objectOf human,human peripheral blood mononuclear cells
R13 E9-ab-2 T7 subjectOf peripheral blood mononuclear cells,in
R14 E7-ab-2 T7 objectOf glucocorticoid receptors,in
R15 E2-ab-3 T8 subjectOf IL-1 beta,increased
R16 E4-ab-3 T8 objectOf AP-1,increased
R17 E3-ab-3 T9 subjectOf phorbol myristate acetate,increased
R18 E4-ab-3 T9 objectOf AP-1,increased
R19 E1-ab-3 T10 subjectOf TNF-alpha,increased
R20 E4-ab-3 T10 objectOf AP-1,increased
R21 E1-ab-4 T11 subjectOf Dexamethasone,binding
R22 E6-ab-4 T11 objectOf response element,binding
R23 E10-ab-4 T12 subjectOf NF kappa B,decrease
R24 E9-ab-4 T12 objectOf AP-1,decrease
R25 E11-ab-4 T13 subjectOf CREB,decrease
R26 E9-ab-4 T13 objectOf AP-1,decrease
R27 E14-ab-4 T14 subjectOf dexamethasone,blocked
R28 E12-ab-4 T14 objectOf DNA binding,blocked
R29 E15-ab-4 T15 subjectOf cytokine,blocked
R30 E12-ab-4 T15 objectOf DNA binding,blocked
R31 E5-ab-5 T16 subjectOf GR,increases
R32 E4-ab-5 T16 objectOf localization,increases
R33 E2-ab-6 T17 subjectOf GR,cells GR
R34 E1-ab-6 T17 objectOf cells,cells GR
R35 E2-ab-6 T18 subjectOf GR,interacts
R36 E4-ab-6 T18 objectOf transcription factors,interacts

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-106 Sentence denotes Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.
S2 107-265 Sentence denotes Glucocorticoids have an inhibitory effect on inflammatory and immune responses, and this may be through the modulation of transcription factor binding to DNA.
S3 266-557 Sentence denotes The interaction of the transcription factors, activator protein-1 (AP-1), nuclear factor kappa B (NF kappa B), and cAMP-responsive element binding protein (CREB) with DNA and glucocorticoid receptors (GR) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays.
S4 558-740 Sentence denotes TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.
S5 741-987 Sentence denotes Dexamethasone produced a rapid and sustained increase in glucocorticoid response element binding and a concomitant 40-50% decrease in AP-1, NF kappa B, and CREB DNA binding that was blocked by combined dexamethasone and cytokine or PMA treatment.
S6 988-1124 Sentence denotes These latter effects were due to increases in the nuclear localization of GR, not to reduced amounts of the other transcription factors.
S7 1125-1271 Sentence denotes This suggests that in these cells GR within the nucleus interacts with cytokine-stimulated transcription factors by the process of cross coupling.
S8 1272-1330 Sentence denotes This may be an important molecular site of steroid action.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 11-26 NP denotes glucocorticoids
C2 65-105 NP denotes human peripheral blood mononuclear cells
C3 107-122 NP denotes Glucocorticoids
C4 128-185 NP denotes an inhibitory effect on inflammatory and immune responses
C5 191-195 NP denotes this
C6 285-310 NP denotes the transcription factors
C8 441-470 NP denotes glucocorticoid receptors (GR)
C7 312-470 NP denotes activator protein-1 (AP-1), nuclear factor kappa B (NF kappa B), and cAMP-responsive element binding protein (CREB) with DNA and glucocorticoid receptors (GR)
C9 487-527 NP denotes human peripheral blood mononuclear cells
C10 635-666 NP denotes AP-1 and NF kappa B DNA binding
C11 875-913 NP denotes AP-1, NF kappa B, and CREB DNA binding
C12 914-918 NP denotes that
C13 1062-1064 NP denotes GR
C14 1147-1158 NP denotes these cells
C15 1159-1161 NP denotes GR
R1 C3 C1 coref-ident Glucocorticoids,glucocorticoids
R2 C5 C4 coref-pron this,an inhibitory effect on inflammatory and immune responses
R3 C7 C6 coref-appos "activator protein-1 (AP-1), nuclear factor kappa B (NF kappa B), and cAMP-responsive element binding protein (CREB) with DNA and glucocorticoid receptors (GR)",the transcription factors
R4 C9 C2 coref-ident human peripheral blood mononuclear cells,human peripheral blood mononuclear cells
R5 C11 C10 coref-ident "AP-1, NF kappa B, and CREB DNA binding",AP-1 and NF kappa B DNA binding
R6 C12 C11 coref-relat that,"AP-1, NF kappa B, and CREB DNA binding"
R7 C13 C8 coref-ident GR,glucocorticoid receptors (GR)
R8 C14 C9 coref-ident these cells,human peripheral blood mononuclear cells
R9 C15 C13 coref-ident GR,GR

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 11-26 lipid denotes glucocorticoids
T2 30-61 other_name denotes transcription factor activation
T3 65-105 cell_type denotes human peripheral blood mononuclear cells
T4 107-122 lipid denotes Glucocorticoids
T5 229-249 protein_family_or_group denotes transcription factor
T6 289-310 protein_family_or_group denotes transcription factors
T7 312-331 protein_molecule denotes activator protein-1
T8 333-337 protein_molecule denotes AP-1
T9 340-362 protein_molecule denotes nuclear factor kappa B
T10 364-374 protein_molecule denotes NF kappa B
T11 381-420 protein_molecule denotes cAMP-responsive element binding protein
T12 422-426 protein_molecule denotes CREB
T13 441-465 protein_family_or_group denotes glucocorticoid receptors
T14 467-469 protein_family_or_group denotes GR
T15 487-527 cell_type denotes human peripheral blood mononuclear cells
T16 531-556 other_name denotes gel mobility shift assays
T17 635-639 protein_molecule denotes AP-1
T18 695-699 protein_molecule denotes CREB
T19 741-754 lipid denotes Dexamethasone
T20 798-829 DNA_domain_or_region denotes glucocorticoid response element
T21 943-956 lipid denotes dexamethasone
T22 961-969 other_name denotes cytokine
T23 973-986 other_name denotes PMA treatment
T24 1038-1058 other_name denotes nuclear localization
T25 1062-1064 protein_family_or_group denotes GR
T26 1102-1123 protein_family_or_group denotes transcription factors
T27 1159-1161 protein_family_or_group denotes GR
T28 1196-1204 protein_family_or_group denotes cytokine
T29 1216-1237 protein_family_or_group denotes transcription factors
T30 1315-1322 lipid denotes steroid

metamap-sample

Id Subject Object Predicate Lexical cue
T1 488-493 C0086418 denotes uman
T2 66-71 C0086418 denotes uman
T3 1217-1238 C0040648 denotes ranscription factors
T4 1103-1124 C0040648 denotes ranscription factors.
T5 290-311 C0040648 denotes ranscription factors,
T6 31-51 C0040648 denotes ranscription factor
T7 52-62 C1879547 denotes ctivation
T8 45-51 C1521761 denotes actor
T9 1160-1162 C0034809 denotes R
T10 1063-1065 C0034809 denotes R,
T11 442-466 C0034809 denotes lucocorticoid receptors
T12 876-880 C0085828 denotes P-1,
T13 636-640 C0085828 denotes P-1
T14 313-332 C0085828 denotes ctivator protein-1
T15 974-977 C0039654 denotes MA
T16 882-892 C0079904 denotes F kappa B,
T17 645-655 C0079904 denotes F kappa B
T18 742-754 C0011777 denotes examethasone
T19 944-957 C0011777 denotes examethasone
T20 799-813 C0017710 denotes lucocorticoid
T21 108-123 C0017710 denotes lucocorticoids
T22 898-902 C0056695 denotes REB
T23 382-421 C0056695 denotes AMP-responsive element binding protein
T24 814-829 C0600508 denotes esponse element
T25 1197-1205 C0079189 denotes ytokine-
T26 962-970 C0079189 denotes ytokine
T27 1174-1181 C0007610 denotes ucleus
T28 570-579 C0021753 denotes L-1 beta
T29 434-437 C0012854 denotes NA
T30 262-265 C0012854 denotes NA.
T31 559-568 C0041368 denotes NF-alpha,
T32 696-708 C0033618 denotes REB binding
T33 132-142 C3463820 denotes nhibitory
T34 656-667 C1148673 denotes NA binding
T35 978-987 C0087111 denotes reatment.
T36 616-625 C0087111 denotes reatment
T37 1002-1009 C1280500 denotes ffects
T38 143-149 C1280500 denotes ffect
T39 1022-1031 C0442805 denotes ncreases
T40 787-795 C0442805 denotes ncrease
T41 1074-1081 C0392756 denotes educed
T42 864-872 C0392756 denotes ecrease
T43 1316-1323 C0038317 denotes teroid
T44 570-579 C1334112 denotes L-1 beta
T45 170-186 C0301872 denotes mmune responses,
T46 626-635 C0205217 denotes ncreased
T47 1246-1253 C1522240 denotes rocess
T48 767-772 C0439831 denotes apid
T49 1131-1139 C1705535 denotes uggests
T50 532-557 C0596608 denotes el mobility shift assays.
T51 1263-1271 C1948027 denotes oupling.
T52 729-740 C0449247 denotes ime course.
T53 1257-1262 C2828360 denotes ross
T54 1047-1059 C1744691 denotes ocalization
T55 1015-1021 C0678226 denotes ue to
T56 230-258 C1149367 denotes ranscription factor binding
T57 1308-1315 C2945843 denotes ite of
T58 924-931 C0332206 denotes locked
T59 935-943 C0205195 denotes ombined
T60 1154-1159 C0007634 denotes ells
T61 271-282 C1704675 denotes nteraction
T62 1067-1069 C1518422 denotes ot
T63 1082-1089 C1265611 denotes mounts
T64 1206-1215 C1948023 denotes timulated
T65 476-484 C0936012 denotes nalyzed
T66 201-203 C2987476 denotes e
T67 216-226 C0443264 denotes odulation
T68 696-700 C3158668 denotes REB
T69 1039-1046 C0521447 denotes uclear
T70 725-728 C0702093 denotes in
T71 686-695 C0205216 denotes ecreased
T72 153-165 C0333348 denotes nflammatory
T73 831-838 C1167622 denotes inding
T74 1324-1330 C0441472 denotes ction.
T75 1298-1307 C1521991 denotes olecular
T76 777-786 C0443318 denotes ustained
T77 857-859 C0439509 denotes 0-
T78 845-856 C0521115 denotes oncomitant