PubMed:7859290
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | protein | denotes | OBF-1 |
| T2 | 9-42 | protein | denotes | novel B cell-specific coactivator |
| T3 | 59-82 | DNA | denotes | immunoglobulin promoter |
| T4 | 117-141 | protein | denotes | octamer-binding proteins |
| T5 | 215-239 | protein | denotes | octamer-binding proteins |
| T6 | 240-245 | protein | denotes | Oct-1 |
| T7 | 250-255 | protein | denotes | Oct-2 |
| T8 | 263-280 | protein | denotes | B cell components |
| T9 | 341-369 | DNA | denotes | immunoglobulin gene promoter |
| T10 | 430-450 | DNA | denotes | B cell-derived cDNAs |
| T11 | 460-480 | protein | denotes | Oct-binding factor 1 |
| T12 | 482-487 | protein | denotes | OBF-1 |
| T13 | 540-545 | protein | denotes | Oct-1 |
| T14 | 550-555 | protein | denotes | Oct-2 |
| T15 | 594-599 | protein | denotes | OBF-1 |
| T16 | 657-668 | protein | denotes | POU domains |
| T17 | 672-677 | protein | denotes | Oct-1 |
| T18 | 682-687 | protein | denotes | Oct-2 |
| T19 | 706-711 | protein | denotes | Oct-4 |
| T20 | 716-721 | protein | denotes | Oct-6 |
| T21 | 727-737 | RNA | denotes | OBF-1 mRNA |
| T22 | 808-815 | cell_type | denotes | B cells |
| T23 | 912-917 | protein | denotes | OBF-1 |
| T24 | 921-931 | cell_line | denotes | HeLa cells |
| T25 | 981-1004 | DNA | denotes | immunoglobulin promoter |
| T26 | 1011-1023 | DNA | denotes | octamer site |
| T27 | 1048-1053 | protein | denotes | OBF-1 |
| T28 | 1092-1143 | protein | denotes | B cell-specific transcriptional coactivator protein |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-142 | Sentence | denotes | OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. |
| S2 | 143-379 | Sentence | denotes | Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. |
| S3 | 380-556 | Sentence | denotes | Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oct-binding factor 1 (OBF-1), a novel protein that specifically associates with Oct-1 and Oct-2. |
| S4 | 557-722 | Sentence | denotes | Biochemical studies demonstrate that OBF-1 has no intrinsic DNA-binding activity and recognizes the POU domains of Oct-1 and Oct-2, but not those of Oct-4 and Oct-6. |
| S5 | 723-884 | Sentence | denotes | The OBF-1 mRNA is expressed in a highly cell-specific manner, being most abundant in B cells and essentially absent in most of the other cells or tissues tested. |
| S6 | 885-1041 | Sentence | denotes | Furthermore, expression of OBF-1 in HeLa cells selectively stimulates the activity of a natural immunoglobulin promoter in an octamer site-dependent manner. |
| S7 | 1042-1144 | Sentence | denotes | Thus, OBF-1 has all the properties expected for a B cell-specific transcriptional coactivator protein. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-5 | NP | denotes | OBF-1 |
| C3 | 7-42 | NP | denotes | a novel B cell-specific coactivator |
| C4 | 43-47 | NP | denotes | that |
| C2 | 7-141 | NP | denotes | a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins |
| C5 | 211-255 | NP | denotes | the octamer-binding proteins Oct-1 and Oct-2 |
| C6 | 460-488 | NP | denotes | Oct-binding factor 1 (OBF-1) |
| C8 | 490-505 | NP | denotes | a novel protein |
| C9 | 506-510 | NP | denotes | that |
| C10 | 540-555 | NP | denotes | Oct-1 and Oct-2 |
| C7 | 490-555 | NP | denotes | a novel protein that specifically associates with Oct-1 and Oct-2 |
| C11 | 594-599 | NP | denotes | OBF-1 |
| C12 | 653-668 | NP | denotes | the POU domains |
| C13 | 672-687 | NP | denotes | Oct-1 and Oct-2 |
| C14 | 697-702 | NP | denotes | those |
| C15 | 912-917 | NP | denotes | OBF-1 |
| C16 | 1048-1053 | NP | denotes | OBF-1 |
| C17 | 1090-1143 | NP | denotes | a B cell-specific transcriptional coactivator protein |
| R1 | C4 | C3 | coref-relat | that,a novel B cell-specific coactivator |
| R2 | C2 | C1 | coref-appos | a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins,OBF-1 |
| R3 | C9 | C8 | coref-relat | that,a novel protein |
| R4 | C10 | C5 | coref-ident | Oct-1 and Oct-2,the octamer-binding proteins Oct-1 and Oct-2 |
| R5 | C7 | C6 | coref-appos | a novel protein that specifically associates with Oct-1 and Oct-2,Oct-binding factor 1 (OBF-1) |
| R6 | C11 | C6 | coref-ident | OBF-1,Oct-binding factor 1 (OBF-1) |
| R7 | C13 | C10 | coref-ident | Oct-1 and Oct-2,Oct-1 and Oct-2 |
| R8 | C14 | C12 | coref-pron | those,the POU domains |
| R9 | C15 | C11 | coref-ident | OBF-1,OBF-1 |
| R10 | C16 | C15 | coref-ident | OBF-1,OBF-1 |
| R11 | C17 | C3 | coref-ident | a B cell-specific transcriptional coactivator protein,a novel B cell-specific coactivator |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | protein_molecule | denotes | OBF-1 |
| T2 | 9-42 | protein_family_or_group | denotes | novel B cell-specific coactivator |
| T3 | 59-82 | DNA_domain_or_region | denotes | immunoglobulin promoter |
| T4 | 117-141 | protein_family_or_group | denotes | octamer-binding proteins |
| T5 | 215-239 | protein_family_or_group | denotes | octamer-binding proteins |
| T6 | 240-245 | protein_molecule | denotes | Oct-1 |
| T7 | 250-255 | protein_molecule | denotes | Oct-2 |
| T8 | 263-280 | protein_family_or_group | denotes | B cell components |
| T9 | 298-340 | other_name | denotes | lymphoid-restricted, octamer site-mediated |
| T10 | 341-369 | DNA_domain_or_region | denotes | immunoglobulin gene promoter |
| T11 | 430-450 | DNA_family_or_group | denotes | B cell-derived cDNAs |
| T12 | 460-480 | protein_molecule | denotes | Oct-binding factor 1 |
| T13 | 482-487 | protein_molecule | denotes | OBF-1 |
| T14 | 540-545 | protein_molecule | denotes | Oct-1 |
| T15 | 550-555 | protein_molecule | denotes | Oct-2 |
| T16 | 594-599 | protein_molecule | denotes | OBF-1 |
| T17 | 657-668 | protein_domain_or_region | denotes | POU domains |
| T18 | 672-677 | protein_molecule | denotes | Oct-1 |
| T19 | 682-687 | protein_molecule | denotes | Oct-2 |
| T20 | 706-711 | protein_molecule | denotes | Oct-4 |
| T21 | 716-721 | protein_molecule | denotes | Oct-6 |
| T22 | 727-732 | protein_molecule | denotes | OBF-1 |
| T23 | 808-815 | cell_type | denotes | B cells |
| T24 | 912-917 | protein_molecule | denotes | OBF-1 |
| T25 | 921-931 | cell_line | denotes | HeLa cells |
| T26 | 981-1004 | DNA_domain_or_region | denotes | immunoglobulin promoter |
| T27 | 1011-1023 | DNA_domain_or_region | denotes | octamer site |
| T28 | 1048-1053 | protein_molecule | denotes | OBF-1 |
| T29 | 1092-1143 | protein_family_or_group | denotes | B cell-specific transcriptional coactivator protein |
bionlp-st-gro-2013-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | Protein | denotes | OBF-1 |
| T2 | 15-21 | Cell | denotes | B cell |
| T3 | 31-42 | TranscriptionCoactivator | denotes | coactivator |
| T5 | 59-73 | Gene | denotes | immunoglobulin |
| T6 | 74-82 | Promoter | denotes | promoter |
| T14 | 240-245 | Protein | denotes | Oct-1 |
| T15 | 250-255 | Protein | denotes | Oct-2 |
| T16 | 263-269 | Cell | denotes | B cell |
| T17 | 319-331 | DNARegion | denotes | octamer site |
| T19 | 341-360 | Gene | denotes | immunoglobulin gene |
| T20 | 361-369 | Promoter | denotes | promoter |
| T21 | 430-436 | Cell | denotes | B cell |
| T22 | 445-450 | DNA | denotes | cDNAs |
| T23 | 460-480 | Protein | denotes | Oct-binding factor 1 |
| T24 | 482-487 | Protein | denotes | OBF-1 |
| T25 | 498-505 | Protein | denotes | protein |
| T27 | 540-545 | Protein | denotes | Oct-1 |
| T28 | 550-555 | Protein | denotes | Oct-2 |
| T29 | 594-599 | Protein | denotes | OBF-1 |
| T31 | 657-668 | ProteinDomain | denotes | POU domains |
| T32 | 672-677 | Protein | denotes | Oct-1 |
| T33 | 682-687 | Protein | denotes | Oct-2 |
| T34 | 727-732 | Protein | denotes | OBF-1 |
| T35 | 733-737 | MessengerRNA | denotes | mRNA |
| T37 | 763-767 | Cell | denotes | cell |
| T38 | 808-815 | Cell | denotes | B cells |
| T39 | 860-865 | Cell | denotes | cells |
| T40 | 869-876 | Tissue | denotes | tissues |
| T42 | 912-917 | Protein | denotes | OBF-1 |
| T43 | 921-931 | Cell | denotes | HeLa cells |
| T45 | 981-995 | Gene | denotes | immunoglobulin |
| T46 | 996-1004 | Promoter | denotes | promoter |
| T47 | 1011-1023 | DNARegion | denotes | octamer site |
| T48 | 1048-1053 | Protein | denotes | OBF-1 |
| T49 | 1092-1098 | Cell | denotes | B cell |
| T50 | 1108-1143 | TranscriptionCoactivator | denotes | transcriptional coactivator protein |
| T8 | 117-141 | Protein | denotes | octamer-binding proteins |
| T9 | 215-239 | Protein | denotes | octamer-binding proteins |
| E1 | 48-58 | Increase | denotes | stimulates |
| E2 | 100-111 | BindingToProtein | denotes | association |
| E5 | 332-340 | RegulatoryProcess | denotes | mediated |
| E6 | 524-534 | BindingToProtein | denotes | associates |
| E8 | 741-750 | TranscriptionOfGene | denotes | expressed |
| E9 | 898-908 | GeneExpression | denotes | expression |
| E10 | 944-954 | Increase | denotes | stimulates |
| R1 | T5 | T6 | hasPart | immunoglobulin,promoter |
| R2 | T22 | T23 | encodes | cDNAs,Oct-binding factor 1 |
| R3 | T32 | T31 | hasPart | Oct-1,POU domains |
| R4 | T33 | T31 | hasPart | Oct-2,POU domains |
| R5 | T35 | T34 | encodes | mRNA,OBF-1 |
| R6 | E8 | T37 | locatedIn | expressed,cell |
| R7 | E8 | T38 | locatedIn | expressed,B cells |
| R8 | E9 | T43 | locatedIn | expression,HeLa cells |
| R9 | T45 | T46 | hasPart | immunoglobulin,promoter |
| R10 | T3 | T2 | locatedIn | coactivator,B cell |
| R11 | T50 | T49 | locatedIn | transcriptional coactivator protein,B cell |
| R13 | T1 | E1 | hasAgent | OBF-1,stimulates |
| R14 | T6 | E1 | hasPatient | promoter,stimulates |
| R15 | T8 | E2 | hasPatient | octamer-binding proteins,association |
| R16 | T17 | E5 | hasAgent | octamer site,mediated |
| R17 | T20 | E5 | hasPatient | promoter,mediated |
| R18 | T25 | E6 | hasPatient | protein,associates |
| R19 | T27 | E6 | hasPatient | Oct-1,associates |
| R20 | T28 | E6 | hasPatient | Oct-2,associates |
| R21 | T35 | E8 | hasPatient | mRNA,expressed |
| R22 | T42 | E9 | hasPatient | OBF-1,expression |
| R23 | E9 | E10 | hasAgent | expression,stimulates |
| R24 | T46 | E10 | hasPatient | promoter,stimulates |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 15-21 | Body_part | denotes | B cell | http://purl.obolibrary.org/obo/CL_0000236 |
| T2 | 263-269 | Body_part | denotes | B cell | http://purl.obolibrary.org/obo/CL_0000236 |
| T3 | 430-436 | Body_part | denotes | B cell | http://purl.obolibrary.org/obo/CL_0000236 |
| T4 | 1092-1098 | Body_part | denotes | B cell | http://purl.obolibrary.org/obo/CL_0000236 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 15-21 | Cell | denotes | B cell | http://purl.obolibrary.org/obo/CL:0000236 |
| T2 | 263-269 | Cell | denotes | B cell | http://purl.obolibrary.org/obo/CL:0000236 |
| T3 | 430-436 | Cell | denotes | B cell | http://purl.obolibrary.org/obo/CL:0000236 |
| T4 | 808-815 | Cell | denotes | B cells | http://purl.obolibrary.org/obo/CL:0000236 |
| T5 | 1090-1098 | Cell | denotes | a B cell | http://purl.obolibrary.org/obo/CL:4023097 |
| T6 | 1092-1098 | Cell | denotes | B cell | http://purl.obolibrary.org/obo/CL:0000236 |