PubMed:7815555 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":24,"end":33},"obj":"DNA"},{"id":"T2","span":{"begin":86,"end":130},"obj":"cell_type"},{"id":"T3","span":{"begin":157,"end":172},"obj":"DNA"},{"id":"T4","span":{"begin":220,"end":235},"obj":"cell_type"},{"id":"T5","span":{"begin":329,"end":333},"obj":"protein"},{"id":"T6","span":{"begin":367,"end":391},"obj":"cell_type"},{"id":"T7","span":{"begin":437,"end":453},"obj":"DNA"},{"id":"T8","span":{"begin":461,"end":470},"obj":"DNA"},{"id":"T9","span":{"begin":538,"end":578},"obj":"cell_line"},{"id":"T10","span":{"begin":639,"end":664},"obj":"cell_line"},{"id":"T11","span":{"begin":724,"end":748},"obj":"cell_type"},{"id":"T12","span":{"begin":753,"end":763},"obj":"protein"},{"id":"T13","span":{"begin":937,"end":960},"obj":"protein"},{"id":"T14","span":{"begin":1001,"end":1012},"obj":"protein"},{"id":"T15","span":{"begin":1014,"end":1017},"obj":"protein"},{"id":"T16","span":{"begin":1050,"end":1087},"obj":"protein"},{"id":"T17","span":{"begin":1131,"end":1135},"obj":"protein"},{"id":"T18","span":{"begin":1136,"end":1151},"obj":"DNA"},{"id":"T19","span":{"begin":1164,"end":1178},"obj":"DNA"},{"id":"T20","span":{"begin":1200,"end":1225},"obj":"protein"},{"id":"T21","span":{"begin":1247,"end":1261},"obj":"protein"},{"id":"T22","span":{"begin":1361,"end":1376},"obj":"cell_type"}],"text":"Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site.\nEpstein-Barr virus (EBV) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as CD48, characteristically expressed on normal activated B cells. Here, we report on the identification of an enhancer element in the CD48 gene which reproducibly confers strong transcriptional activity only in EBV-positive B-lymphoblastoid cell lines. The element is not activated upon infection of established EBV-negative B-cell lines, indicating that EBV fails to drive these cells to a fully lymphoblastoid phenotype. An NF-kappa B binding site is an essential component of the element but alone is not sufficient to account for the activity or the specificity of the element. We have detected a specific nuclear protein complex that binds to the element and show that NF-kappa B1 (p50) is a part of this complex. The EBV-encoded latent membrane protein 1 is capable of transactivating the isolated CD48 NF-kappa B site but not the intact element, suggesting that the latent membrane protein 1-driven activation of NF-kappa B/Rel must interact with other regulatory pathways to control expression of cellular genes as EBV drives resting B cells into the cell cycle."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"7815555-1#155#159#gene962","span":{"begin":329,"end":333},"obj":"gene962"},{"id":"7815555-1#20#34#diseaseC0149678","span":{"begin":194,"end":208},"obj":"diseaseC0149678"}],"relations":[{"id":"155#159#gene96220#34#diseaseC0149678","pred":"associated_with","subj":"7815555-1#155#159#gene962","obj":"7815555-1#20#34#diseaseC0149678"}],"text":"Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site.\nEpstein-Barr virus (EBV) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as CD48, characteristically expressed on normal activated B cells. Here, we report on the identification of an enhancer element in the CD48 gene which reproducibly confers strong transcriptional activity only in EBV-positive B-lymphoblastoid cell lines. The element is not activated upon infection of established EBV-negative B-cell lines, indicating that EBV fails to drive these cells to a fully lymphoblastoid phenotype. An NF-kappa B binding site is an essential component of the element but alone is not sufficient to account for the activity or the specificity of the element. We have detected a specific nuclear protein complex that binds to the element and show that NF-kappa B1 (p50) is a part of this complex. The EBV-encoded latent membrane protein 1 is capable of transactivating the isolated CD48 NF-kappa B site but not the intact element, suggesting that the latent membrane protein 1-driven activation of NF-kappa B/Rel must interact with other regulatory pathways to control expression of cellular genes as EBV drives resting B cells into the cell cycle."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":173},"obj":"Sentence"},{"id":"S2","span":{"begin":174,"end":392},"obj":"Sentence"},{"id":"S3","span":{"begin":393,"end":579},"obj":"Sentence"},{"id":"S4","span":{"begin":580,"end":749},"obj":"Sentence"},{"id":"S5","span":{"begin":750,"end":908},"obj":"Sentence"},{"id":"S6","span":{"begin":909,"end":1045},"obj":"Sentence"},{"id":"S7","span":{"begin":1046,"end":1397},"obj":"Sentence"}],"text":"Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site.\nEpstein-Barr virus (EBV) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as CD48, characteristically expressed on normal activated B cells. Here, we report on the identification of an enhancer element in the CD48 gene which reproducibly confers strong transcriptional activity only in EBV-positive B-lymphoblastoid cell lines. The element is not activated upon infection of established EBV-negative B-cell lines, indicating that EBV fails to drive these cells to a fully lymphoblastoid phenotype. An NF-kappa B binding site is an essential component of the element but alone is not sufficient to account for the activity or the specificity of the element. We have detected a specific nuclear protein complex that binds to the element and show that NF-kappa B1 (p50) is a part of this complex. The EBV-encoded latent membrane protein 1 is capable of transactivating the isolated CD48 NF-kappa B site but not the intact element, suggesting that the latent membrane protein 1-driven activation of NF-kappa B/Rel must interact with other regulatory pathways to control expression of cellular genes as EBV drives resting B cells into the cell cycle."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":20,"end":33},"obj":"NP"},{"id":"C2","span":{"begin":47,"end":65},"obj":"NP"},{"id":"C3","span":{"begin":66,"end":70},"obj":"NP"},{"id":"C4","span":{"begin":144,"end":172},"obj":"NP"},{"id":"C5","span":{"begin":212,"end":235},"obj":"NP"},{"id":"C6","span":{"begin":243,"end":247},"obj":"NP"},{"id":"C7","span":{"begin":329,"end":333},"obj":"NP"},{"id":"C10","span":{"begin":457,"end":470},"obj":"NP"},{"id":"C9","span":{"begin":434,"end":470},"obj":"NP"},{"id":"C11","span":{"begin":471,"end":476},"obj":"NP"},{"id":"C8","span":{"begin":434,"end":578},"obj":"NP"},{"id":"C12","span":{"begin":580,"end":591},"obj":"NP"},{"id":"C13","span":{"begin":627,"end":664},"obj":"NP"},{"id":"C14","span":{"begin":682,"end":685},"obj":"NP"},{"id":"C15","span":{"begin":701,"end":712},"obj":"NP"},{"id":"C16","span":{"begin":750,"end":776},"obj":"NP"},{"id":"C17","span":{"begin":806,"end":817},"obj":"NP"},{"id":"C18","span":{"begin":896,"end":907},"obj":"NP"},{"id":"C19","span":{"begin":926,"end":960},"obj":"NP"},{"id":"C20","span":{"begin":961,"end":965},"obj":"NP"},{"id":"C21","span":{"begin":975,"end":986},"obj":"NP"},{"id":"C22","span":{"begin":1032,"end":1044},"obj":"NP"},{"id":"C23","span":{"begin":1350,"end":1353},"obj":"NP"},{"id":"C24","span":{"begin":1361,"end":1376},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-pron","subj":"C6","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C10","obj":"C7"},{"id":"R4","pred":"coref-relat","subj":"C11","obj":"C9"},{"id":"R5","pred":"coref-ident","subj":"C12","obj":"C8"},{"id":"R6","pred":"coref-ident","subj":"C15","obj":"C13"},{"id":"R7","pred":"coref-ident","subj":"C16","obj":"C4"},{"id":"R8","pred":"coref-ident","subj":"C17","obj":"C12"},{"id":"R9","pred":"coref-ident","subj":"C18","obj":"C17"},{"id":"R10","pred":"coref-relat","subj":"C20","obj":"C19"},{"id":"R11","pred":"coref-ident","subj":"C21","obj":"C18"},{"id":"R12","pred":"coref-ident","subj":"C22","obj":"C19"},{"id":"R13","pred":"coref-ident","subj":"C23","obj":"C14"},{"id":"R14","pred":"coref-ident","subj":"C24","obj":"C5"}],"text":"Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site.\nEpstein-Barr virus (EBV) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as CD48, characteristically expressed on normal activated B cells. Here, we report on the identification of an enhancer element in the CD48 gene which reproducibly confers strong transcriptional activity only in EBV-positive B-lymphoblastoid cell lines. The element is not activated upon infection of established EBV-negative B-cell lines, indicating that EBV fails to drive these cells to a fully lymphoblastoid phenotype. An NF-kappa B binding site is an essential component of the element but alone is not sufficient to account for the activity or the specificity of the element. We have detected a specific nuclear protein complex that binds to the element and show that NF-kappa B1 (p50) is a part of this complex. The EBV-encoded latent membrane protein 1 is capable of transactivating the isolated CD48 NF-kappa B site but not the intact element, suggesting that the latent membrane protein 1-driven activation of NF-kappa B/Rel must interact with other regulatory pathways to control expression of cellular genes as EBV drives resting B cells into the cell cycle."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":24,"end":33},"obj":"DNA_domain_or_region"},{"id":"T2","span":{"begin":86,"end":104},"obj":"virus"},{"id":"T3","span":{"begin":157,"end":167},"obj":"protein_molecule"},{"id":"T4","span":{"begin":174,"end":192},"obj":"virus"},{"id":"T5","span":{"begin":194,"end":197},"obj":"virus"},{"id":"T6","span":{"begin":220,"end":235},"obj":"cell_type"},{"id":"T7","span":{"begin":329,"end":333},"obj":"protein_molecule"},{"id":"T8","span":{"begin":367,"end":391},"obj":"cell_type"},{"id":"T9","span":{"begin":437,"end":453},"obj":"DNA_domain_or_region"},{"id":"T10","span":{"begin":461,"end":465},"obj":"protein_molecule"},{"id":"T11","span":{"begin":505,"end":529},"obj":"other_name"},{"id":"T12","span":{"begin":538,"end":541},"obj":"virus"},{"id":"T13","span":{"begin":639,"end":642},"obj":"virus"},{"id":"T14","span":{"begin":682,"end":685},"obj":"virus"},{"id":"T15","span":{"begin":724,"end":748},"obj":"cell_type"},{"id":"T16","span":{"begin":753,"end":763},"obj":"protein_molecule"},{"id":"T17","span":{"begin":937,"end":960},"obj":"protein_complex"},{"id":"T18","span":{"begin":1001,"end":1012},"obj":"protein_subunit"},{"id":"T19","span":{"begin":1014,"end":1017},"obj":"protein_subunit"},{"id":"T20","span":{"begin":1050,"end":1053},"obj":"virus"},{"id":"T21","span":{"begin":1131,"end":1135},"obj":"protein_molecule"},{"id":"T22","span":{"begin":1136,"end":1146},"obj":"protein_molecule"},{"id":"T23","span":{"begin":1164,"end":1178},"obj":"DNA_domain_or_region"},{"id":"T24","span":{"begin":1200,"end":1225},"obj":"protein_molecule"},{"id":"T25","span":{"begin":1247,"end":1261},"obj":"protein_molecule"},{"id":"T26","span":{"begin":1350,"end":1353},"obj":"virus"},{"id":"T27","span":{"begin":1361,"end":1376},"obj":"cell_type"},{"id":"T28","span":{"begin":1386,"end":1396},"obj":"other_name"}],"text":"Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site.\nEpstein-Barr virus (EBV) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as CD48, characteristically expressed on normal activated B cells. Here, we report on the identification of an enhancer element in the CD48 gene which reproducibly confers strong transcriptional activity only in EBV-positive B-lymphoblastoid cell lines. The element is not activated upon infection of established EBV-negative B-cell lines, indicating that EBV fails to drive these cells to a fully lymphoblastoid phenotype. An NF-kappa B binding site is an essential component of the element but alone is not sufficient to account for the activity or the specificity of the element. We have detected a specific nuclear protein complex that binds to the element and show that NF-kappa B1 (p50) is a part of this complex. The EBV-encoded latent membrane protein 1 is capable of transactivating the isolated CD48 NF-kappa B site but not the intact element, suggesting that the latent membrane protein 1-driven activation of NF-kappa B/Rel must interact with other regulatory pathways to control expression of cellular genes as EBV drives resting B cells into the cell cycle."}