PubMed:7769834 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	14-21	protein	denotes	pp90rsk
T2	26-54	DNA	denotes	early growth response-1 gene
T3	69-85	protein	denotes	pokeweed mitogen
T4	89-102	cell_type	denotes	human B cells
T5	153-169	protein	denotes	pokeweed mitogen
T6	171-174	protein	denotes	PWM
T7	196-224	DNA	denotes	early growth response-1 gene
T8	226-231	DNA	denotes	EGR-1
T9	236-256	cell_type	denotes	normal human B cells
T10	258-261	protein	denotes	PWM
T11	272-277	DNA	denotes	EGR-1
T12	390-414	DNA	denotes	EGR-1 promoter fragments
T13	429-473	DNA	denotes	chloramphenicol acetyltransferase (CAT) gene
T14	492-495	protein	denotes	PWM
T15	504-509	DNA	denotes	EGR-1
T16	544-554	DNA	denotes	CArG motif
T17	556-566	DNA	denotes	C C[AT]6GG
T18	575-589	DNA	denotes	EGR-1 promoter
T19	642-651	protein	denotes	S6 kinase
T20	653-660	protein	denotes	pp90rsk
T21	695-697	protein	denotes	S6
T22	743-762	cell_line	denotes	PWM treated B cells
T23	808-811	protein	denotes	PWM
T24	875-880	DNA	denotes	EGR-1
T25	894-914	cell_type	denotes	normal human B cells

Id	Subject	Object	Predicate	Lexical cue
S1	0-103	Sentence	denotes	Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells.
S2	104-257	Sentence	denotes	The present studies have examined the effects of pokeweed mitogen (PWM) on the induction of early growth response-1 gene (EGR-1) in normal human B cells.
S3	258-354	Sentence	denotes	PWM regulates EGR-1 gene expression by both transcriptional and post-transcriptional mechanisms.
S4	355-590	Sentence	denotes	Transient transfection assays with EGR-1 promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene demonstrated that PWM induced EGR-1 transcription is conferred by the CArG motif (C C[AT]6GG) in the EGR-1 promoter.
S5	591-763	Sentence	denotes	The results further demonstrated the activation of S6 kinase (pp90rsk), evidenced by phosphorylation of S6 and serum response factor (SRF) peptides, in PWM treated B cells.
S6	764-915	Sentence	denotes	Taken together, these findings suggest that PWM is able to initiate an intracytoplasmic signalling cascade and EGR-1 induction in normal human B cells.

Id	Subject	Object	Predicate	Lexical cue
C1	0-21	NP	denotes	Activation of pp90rsk
C2	26-65	NP	denotes	early growth response-1 gene expression
C3	69-85	NP	denotes	pokeweed mitogen
C4	153-175	NP	denotes	pokeweed mitogen (PWM)
C5	179-232	NP	denotes	the induction of early growth response-1 gene (EGR-1)
C6	236-256	NP	denotes	normal human B cells
C7	258-261	NP	denotes	PWM
C8	624-661	NP	denotes	the activation of S6 kinase (pp90rsk)
C9	808-811	NP	denotes	PWM
C10	875-890	NP	denotes	EGR-1 induction
C11	894-914	NP	denotes	normal human B cells
R1	C4	C3	coref-ident	pokeweed mitogen (PWM),pokeweed mitogen
R2	C5	C2	coref-ident	the induction of early growth response-1 gene (EGR-1),early growth response-1 gene expression
R3	C7	C4	coref-ident	PWM,pokeweed mitogen (PWM)
R4	C8	C1	coref-ident	the activation of S6 kinase (pp90rsk),Activation of pp90rsk
R5	C9	C7	coref-ident	PWM,PWM
R6	C10	C5	coref-ident	EGR-1 induction,the induction of early growth response-1 gene (EGR-1)
R7	C11	C6	coref-ident	normal human B cells,normal human B cells

Id	Subject	Object	Predicate	Lexical cue
T1	14-21	protein_molecule	denotes	pp90rsk
T2	26-54	DNA_domain_or_region	denotes	early growth response-1 gene
T3	69-85	protein_molecule	denotes	pokeweed mitogen
T4	89-102	cell_type	denotes	human B cells
T5	153-169	protein_molecule	denotes	pokeweed mitogen
T6	171-174	protein_molecule	denotes	PWM
T7	196-224	DNA_domain_or_region	denotes	early growth response-1 gene
T8	226-231	DNA_domain_or_region	denotes	EGR-1
T9	236-242	cell_type	denotes	normal
T10	243-256	cell_type	denotes	human B cells
T11	258-261	protein_molecule	denotes	PWM
T12	272-277	DNA_domain_or_region	denotes	EGR-1
T13	355-384	other_name	denotes	Transient transfection assays
T14	390-395	DNA_domain_or_region	denotes	EGR-1
T15	429-462	protein_molecule	denotes	chloramphenicol acetyltransferase
T16	464-467	protein_molecule	denotes	CAT
T17	492-495	protein_molecule	denotes	PWM
T18	504-509	DNA_domain_or_region	denotes	EGR-1
T19	544-554	DNA_domain_or_region	denotes	CArG motif
T20	556-566	DNA_domain_or_region	denotes	C C[AT]6GG
T21	575-580	DNA_domain_or_region	denotes	EGR-1
T22	642-651	protein_molecule	denotes	S6 kinase
T23	653-660	protein_molecule	denotes	pp90rsk
T24	676-691	other_name	denotes	phosphorylation
T25	695-697	protein_molecule	denotes	S6
T26	702-738	peptide	denotes	serum response factor (SRF) peptides
T27	743-746	protein_molecule	denotes	PWM
T28	808-811	protein_molecule	denotes	PWM
T29	835-870	other_name	denotes	intracytoplasmic signalling cascade
T30	875-880	DNA_domain_or_region	denotes	EGR-1
T31	894-900	cell_type	denotes	normal
T32	901-914	cell_type	denotes	human B cells