PubMed:7719937 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":35,"end":54},"obj":"protein"},{"id":"T2","span":{"begin":80,"end":93},"obj":"protein"},{"id":"T3","span":{"begin":101,"end":109},"obj":"protein"},{"id":"T4","span":{"begin":148,"end":152},"obj":"protein"},{"id":"T5","span":{"begin":202,"end":206},"obj":"protein"},{"id":"T6","span":{"begin":295,"end":299},"obj":"protein"},{"id":"T7","span":{"begin":361,"end":374},"obj":"cell_type"},{"id":"T8","span":{"begin":463,"end":467},"obj":"protein"},{"id":"T9","span":{"begin":513,"end":534},"obj":"protein"},{"id":"T10","span":{"begin":558,"end":562},"obj":"protein"},{"id":"T11","span":{"begin":564,"end":598},"obj":"cell_type"},{"id":"T12","span":{"begin":632,"end":636},"obj":"protein"},{"id":"T13","span":{"begin":714,"end":747},"obj":"cell_line"},{"id":"T14","span":{"begin":756,"end":758},"obj":"cell_line"},{"id":"T15","span":{"begin":823,"end":847},"obj":"protein"},{"id":"T16","span":{"begin":883,"end":921},"obj":"protein"},{"id":"T17","span":{"begin":942,"end":968},"obj":"cell_type"},{"id":"T18","span":{"begin":1029,"end":1035},"obj":"protein"},{"id":"T19","span":{"begin":1076,"end":1080},"obj":"protein"}],"text":"Identification and purification of human Stat proteins activated in response to interleukin-2.\nA key cytokine induced during the immune response is IL-2. Following T cell activation, the genes encoding IL-2 and the various chains of its receptor are transcriptionally induced. In turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes. Several recent studies have implicated Jak kinases in the signaling pathway induced by IL-2. Following this lead, we set out to identify transcription factors induced in response to IL-2. Human peripheral blood lymphocytes were observed to contain several IL-2-inducible DNA binding activities. Similar activities were also observed in a transformed human lymphocyte line, termed YT. We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue. We hypothesize that activation of this protein, designated hStat5, helps govern the biological effects of IL-2 during the immune response."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":80,"end":93},"obj":"NP"},{"id":"C20","span":{"begin":125,"end":144},"obj":"NP"},{"id":"C2","span":{"begin":148,"end":152},"obj":"NP"},{"id":"C5","span":{"begin":164,"end":181},"obj":"NP"},{"id":"C4","span":{"begin":233,"end":236},"obj":"NP"},{"id":"C6","span":{"begin":463,"end":467},"obj":"NP"},{"id":"C7","span":{"begin":558,"end":562},"obj":"NP"},{"id":"C8","span":{"begin":632,"end":637},"obj":"NP"},{"id":"C11","span":{"begin":671,"end":689},"obj":"NP"},{"id":"C9","span":{"begin":712,"end":747},"obj":"NP"},{"id":"C10","span":{"begin":756,"end":758},"obj":"NP"},{"id":"C12","span":{"begin":777,"end":793},"obj":"NP"},{"id":"C13","span":{"begin":823,"end":828},"obj":"NP"},{"id":"C14","span":{"begin":809,"end":847},"obj":"NP"},{"id":"C15","span":{"begin":1004,"end":1016},"obj":"NP"},{"id":"C16","span":{"begin":990,"end":1016},"obj":"NP"},{"id":"C18","span":{"begin":1018,"end":1035},"obj":"NP"},{"id":"C19","span":{"begin":1076,"end":1080},"obj":"NP"},{"id":"C21","span":{"begin":1088,"end":1107},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-pron","subj":"C4","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C9"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C11"},{"id":"R8","pred":"coref-ident","subj":"C13","obj":"C8"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C14"},{"id":"R10","pred":"coref-appos","subj":"C18","obj":"C16"},{"id":"R11","pred":"coref-ident","subj":"C19","obj":"C13"},{"id":"R12","pred":"coref-ident","subj":"C21","obj":"C20"}],"text":"Identification and purification of human Stat proteins activated in response to interleukin-2.\nA key cytokine induced during the immune response is IL-2. Following T cell activation, the genes encoding IL-2 and the various chains of its receptor are transcriptionally induced. In turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes. Several recent studies have implicated Jak kinases in the signaling pathway induced by IL-2. Following this lead, we set out to identify transcription factors induced in response to IL-2. Human peripheral blood lymphocytes were observed to contain several IL-2-inducible DNA binding activities. Similar activities were also observed in a transformed human lymphocyte line, termed YT. We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue. We hypothesize that activation of this protein, designated hStat5, helps govern the biological effects of IL-2 during the immune response."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":94},"obj":"Sentence"},{"id":"S2","span":{"begin":95,"end":153},"obj":"Sentence"},{"id":"S3","span":{"begin":154,"end":276},"obj":"Sentence"},{"id":"S4","span":{"begin":277,"end":375},"obj":"Sentence"},{"id":"S5","span":{"begin":376,"end":468},"obj":"Sentence"},{"id":"S6","span":{"begin":469,"end":563},"obj":"Sentence"},{"id":"S7","span":{"begin":564,"end":670},"obj":"Sentence"},{"id":"S8","span":{"begin":671,"end":759},"obj":"Sentence"},{"id":"S9","span":{"begin":760,"end":969},"obj":"Sentence"},{"id":"S10","span":{"begin":970,"end":1108},"obj":"Sentence"}],"text":"Identification and purification of human Stat proteins activated in response to interleukin-2.\nA key cytokine induced during the immune response is IL-2. Following T cell activation, the genes encoding IL-2 and the various chains of its receptor are transcriptionally induced. In turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes. Several recent studies have implicated Jak kinases in the signaling pathway induced by IL-2. Following this lead, we set out to identify transcription factors induced in response to IL-2. Human peripheral blood lymphocytes were observed to contain several IL-2-inducible DNA binding activities. Similar activities were also observed in a transformed human lymphocyte line, termed YT. We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue. We hypothesize that activation of this protein, designated hStat5, helps govern the biological effects of IL-2 during the immune response."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":35,"end":54},"obj":"protein_family_or_group"},{"id":"T2","span":{"begin":80,"end":93},"obj":"protein_molecule"},{"id":"T3","span":{"begin":101,"end":109},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":129,"end":144},"obj":"other_name"},{"id":"T5","span":{"begin":148,"end":152},"obj":"protein_molecule"},{"id":"T6","span":{"begin":164,"end":181},"obj":"other_name"},{"id":"T7","span":{"begin":202,"end":206},"obj":"protein_molecule"},{"id":"T8","span":{"begin":295,"end":299},"obj":"protein_molecule"},{"id":"T9","span":{"begin":361,"end":374},"obj":"cell_type"},{"id":"T10","span":{"begin":434,"end":451},"obj":"other_name"},{"id":"T11","span":{"begin":463,"end":467},"obj":"protein_molecule"},{"id":"T12","span":{"begin":513,"end":534},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":558,"end":562},"obj":"protein_molecule"},{"id":"T14","span":{"begin":564,"end":598},"obj":"cell_type"},{"id":"T15","span":{"begin":632,"end":636},"obj":"protein_molecule"},{"id":"T16","span":{"begin":714,"end":747},"obj":"cell_line"},{"id":"T17","span":{"begin":756,"end":758},"obj":"cell_line"},{"id":"T18","span":{"begin":823,"end":827},"obj":"protein_molecule"},{"id":"T19","span":{"begin":883,"end":921},"obj":"protein_molecule"},{"id":"T20","span":{"begin":942,"end":968},"obj":"cell_type"},{"id":"T21","span":{"begin":1029,"end":1035},"obj":"protein_molecule"},{"id":"T22","span":{"begin":1076,"end":1080},"obj":"protein_molecule"},{"id":"T23","span":{"begin":1092,"end":1107},"obj":"other_name"}],"text":"Identification and purification of human Stat proteins activated in response to interleukin-2.\nA key cytokine induced during the immune response is IL-2. Following T cell activation, the genes encoding IL-2 and the various chains of its receptor are transcriptionally induced. In turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes. Several recent studies have implicated Jak kinases in the signaling pathway induced by IL-2. Following this lead, we set out to identify transcription factors induced in response to IL-2. Human peripheral blood lymphocytes were observed to contain several IL-2-inducible DNA binding activities. Similar activities were also observed in a transformed human lymphocyte line, termed YT. We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue. We hypothesize that activation of this protein, designated hStat5, helps govern the biological effects of IL-2 during the immune response."}