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sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells.
T2 103-240 Sentence denotes Monocyte-macrophage differentiation was used as a model system for studying gene regulation of the human vacuolar H(+)-ATPase (V-ATPase).
T3 241-487 Sentence denotes We examined mRNA levels of various V-ATPase subunits during differentiation of both native monocytes and the cell line THP-1, and found that transcriptional and post-transcriptional mechanisms could account for increases in cell V-ATPase content.
T4 488-641 Sentence denotes From nuclear runoff experiments, we found that one subunit in particular, the B2 isoform (Mr = 56,000), was amplified primarily by transcriptional means.
T5 642-715 Sentence denotes We have begun to examine the structure of the B2 subunit promoter region.
T6 716-849 Sentence denotes Isolation and sequencing of the first exon and 5'-flanking region of this gene reveal a TATA-less promoter with a high G + C content.
T7 850-955 Sentence denotes Primer extension and ribonuclease protection analyses indicate a single major transcriptional start site.
T8 956-1115 Sentence denotes We transfected promoter-luciferase reporter plasmids into THP-1 cells to define sequences that mediate transcriptional control during monocyte differentiation.
T9 1116-1263 Sentence denotes We found that sequences downstream from the transcriptional start site were sufficient to confer increased expression during THP-1 differentiation.
T10 1264-1419 Sentence denotes DNase I footprinting and sequence analysis revealed the existence of multiple AP2 and Sp1 binding sites in the 5'-untranslated and proximal coding regions.
T1 0-102 Sentence denotes Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells.
T2 103-240 Sentence denotes Monocyte-macrophage differentiation was used as a model system for studying gene regulation of the human vacuolar H(+)-ATPase (V-ATPase).
T3 241-487 Sentence denotes We examined mRNA levels of various V-ATPase subunits during differentiation of both native monocytes and the cell line THP-1, and found that transcriptional and post-transcriptional mechanisms could account for increases in cell V-ATPase content.
T4 488-641 Sentence denotes From nuclear runoff experiments, we found that one subunit in particular, the B2 isoform (Mr = 56,000), was amplified primarily by transcriptional means.
T5 642-715 Sentence denotes We have begun to examine the structure of the B2 subunit promoter region.
T6 716-849 Sentence denotes Isolation and sequencing of the first exon and 5'-flanking region of this gene reveal a TATA-less promoter with a high G + C content.
T7 850-955 Sentence denotes Primer extension and ribonuclease protection analyses indicate a single major transcriptional start site.
T8 956-1115 Sentence denotes We transfected promoter-luciferase reporter plasmids into THP-1 cells to define sequences that mediate transcriptional control during monocyte differentiation.
T9 1116-1263 Sentence denotes We found that sequences downstream from the transcriptional start site were sufficient to confer increased expression during THP-1 differentiation.
T10 1264-1419 Sentence denotes DNase I footprinting and sequence analysis revealed the existence of multiple AP2 and Sp1 binding sites in the 5'-untranslated and proximal coding regions.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1395-1403 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 34-70 DNA denotes vacuolar H(+)-ATPase B2 subunit gene
T2 74-101 cell_line denotes differentiating THP-1 cells
T3 202-228 protein denotes human vacuolar H(+)-ATPase
T4 230-238 protein denotes V-ATPase
T5 253-257 RNA denotes mRNA
T6 276-284 protein denotes V-ATPase
T7 325-341 cell_type denotes native monocytes
T8 350-359 cell_line denotes cell line
T9 360-365 cell_line denotes THP-1
T10 470-478 protein denotes V-ATPase
T11 566-576 protein denotes B2 isoform
T12 688-714 DNA denotes B2 subunit promoter region
T13 748-758 DNA denotes first exon
T14 763-781 DNA denotes 5'-flanking region
T15 804-822 DNA denotes TATA-less promoter
T16 871-883 protein denotes ribonuclease
T17 922-954 DNA denotes major transcriptional start site
T18 971-1008 DNA denotes promoter-luciferase reporter plasmids
T19 1014-1025 cell_line denotes THP-1 cells
T20 1241-1246 cell_line denotes THP-1
T21 1264-1271 protein denotes DNase I
T22 1342-1367 DNA denotes AP2 and Sp1 binding sites
T23 1375-1418 DNA denotes 5'-untranslated and proximal coding regions

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 90-101 NP denotes THP-1 cells
C2 103-138 NP denotes Monocyte-macrophage differentiation
C3 535-546 NP denotes one subunit
C4 562-590 NP denotes the B2 isoform (Mr = 56,000)
C5 785-794 NP denotes this gene
C6 1014-1025 NP denotes THP-1 cells
C7 1036-1045 NP denotes sequences
C8 1046-1050 NP denotes that
C9 1090-1114 NP denotes monocyte differentiation
R1 C4 C3 coref-ident "the B2 isoform (Mr = 56,000)",one subunit
R2 C5 C4 coref-ident this gene,"the B2 isoform (Mr = 56,000)"
R3 C6 C1 coref-ident THP-1 cells,THP-1 cells
R4 C8 C7 coref-relat that,sequences
R5 C9 C2 coref-ident monocyte differentiation,Monocyte-macrophage differentiation

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-102 Sentence denotes Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells.
S2 103-240 Sentence denotes Monocyte-macrophage differentiation was used as a model system for studying gene regulation of the human vacuolar H(+)-ATPase (V-ATPase).
S3 241-487 Sentence denotes We examined mRNA levels of various V-ATPase subunits during differentiation of both native monocytes and the cell line THP-1, and found that transcriptional and post-transcriptional mechanisms could account for increases in cell V-ATPase content.
S4 488-641 Sentence denotes From nuclear runoff experiments, we found that one subunit in particular, the B2 isoform (Mr = 56,000), was amplified primarily by transcriptional means.
S5 642-715 Sentence denotes We have begun to examine the structure of the B2 subunit promoter region.
S6 716-849 Sentence denotes Isolation and sequencing of the first exon and 5'-flanking region of this gene reveal a TATA-less promoter with a high G + C content.
S7 850-955 Sentence denotes Primer extension and ribonuclease protection analyses indicate a single major transcriptional start site.
S8 956-1115 Sentence denotes We transfected promoter-luciferase reporter plasmids into THP-1 cells to define sequences that mediate transcriptional control during monocyte differentiation.
S9 1116-1263 Sentence denotes We found that sequences downstream from the transcriptional start site were sufficient to confer increased expression during THP-1 differentiation.
S10 1264-1419 Sentence denotes DNase I footprinting and sequence analysis revealed the existence of multiple AP2 and Sp1 binding sites in the 5'-untranslated and proximal coding regions.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-26 other_name denotes Transcriptional regulation
T2 34-65 protein_subunit denotes vacuolar H(+)-ATPase B2 subunit
T3 74-101 cell_line denotes differentiating THP-1 cells
T4 103-138 other_name denotes Monocyte-macrophage differentiation
T5 179-194 other_name denotes gene regulation
T6 202-228 protein_molecule denotes human vacuolar H(+)-ATPase
T7 230-238 protein_molecule denotes V-ATPase
T8 253-257 RNA_family_or_group denotes mRNA
T9 276-284 protein_molecule denotes V-ATPase
T10 325-341 cell_type denotes native monocytes
T11 350-359 cell_line denotes cell line
T12 360-365 cell_line denotes THP-1
T13 465-469 other_name denotes cell
T14 470-478 protein_molecule denotes V-ATPase
T15 566-576 protein_subunit denotes B2 isoform
T16 619-640 other_name denotes transcriptional means
T17 688-698 protein_subunit denotes B2 subunit
T18 699-714 DNA_domain_or_region denotes promoter region
T19 748-758 DNA_domain_or_region denotes first exon
T20 763-781 DNA_domain_or_region denotes 5'-flanking region
T21 804-822 DNA_domain_or_region denotes TATA-less promoter
T22 835-836 nucleotide denotes G
T23 839-840 nucleotide denotes C
T24 850-866 other_name denotes Primer extension
T25 871-883 protein_molecule denotes ribonuclease
T26 922-954 DNA_domain_or_region denotes major transcriptional start site
T27 971-1008 DNA_molecule denotes promoter-luciferase reporter plasmids
T28 1014-1025 cell_line denotes THP-1 cells
T29 1059-1082 other_name denotes transcriptional control
T30 1090-1114 other_name denotes monocyte differentiation
T31 1241-1246 cell_line denotes THP-1
T32 1264-1271 protein_molecule denotes DNase I
T33 1289-1306 other_name denotes sequence analysis

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1395-1403 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 202-207 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 103-111 Body_part denotes Monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T3 112-122 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T4 332-341 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T6 857-866 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T7 1090-1098 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 103-111 Cell denotes Monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 112-122 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T5 332-341 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T7 1090-1098 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054